75 Works

Contrasting patterns of phylogenetic diversity and alpine specialization across the alpine flora of the American mountain range system

Hector Fox Figueroa, Hannah E. Marx, Maria Beatriz De Souza Cortez, Charles J. Grady, Nicholas Engle-Wrye, Jim Beach, Aimee Stewart, Ryan A. Folk, Douglas E. Soltis, Pamela S. Soltis & Stephen A. Smith
Although mountainous habitats contribute substantially to global biodiversity, comparatively little is known about biogeographic patterns of distributions of alpine species across multiple mountain ranges. Here, we present a detailed analysis of the distributions and phylogenetic affinities of alpine seed plant lineages across North, Central, and South American mountain systems. Using a comprehensive dataset that characterized the elevational niches of American seed plants in a continuously valued way, we were able to quantitatively investigate how the...

Effect of data source on estimates of regional bird richness in northeastern United States

Roi Ankori-Karlinsky, Ronen Kadmon, Michael Kalyuzhny, Katherine F. Barnes, Andrew M. Wilson, Curtis Flather, Rosalind Renfrew, Joan Walsh & Edna Guk
Standardized data on large-scale and long-term patterns of species richness are critical for understanding the consequences of natural and anthropogenic changes in the environment. The North American Breeding Bird Survey (BBS) is one of the largest and most widely used sources of such data, but so far, little is known about the degree to which BBS data provide accurate estimates of regional richness. Here we test this question by comparing estimates of regional richness based...

Lack of phenological shift leads to increased camouflage mismatch in mountain hares

Marketa Zimova
Understanding whether organisms will be able to adapt to human-induced stressors currently endangering their existence is an urgent priority. Globally, multiple species moult from a dark summer to white winter coat to maintain camouflage against snowy landscapes. Decreasing snow cover duration due to climate change is increasing mismatch in seasonal camouflage. To directly test for adaptive responses to recent changes in snow cover, we repeated historical (1950s) field studies of moult phenology in mountain hares...

Amborella pangenome and supplementary tables v4

, Ricky Hu, Armin Patrick Scheben, Brent Verpaalen, Soodeh Tirnaz, Jacqueline Batley, Douglas E. Soltis, Dave Edwards & Richard G.J. Hodel

Data and code from: Spring phenological escape is critical for the survival of temperate tree seedlings

Benjamin Lee & Ines Ibanez
Understory plants in deciduous forests often rely on access to ephemeral light availability before the canopy closes in spring and after the canopy reopens in fall, a strategy commonly referred to as phenological escape. Although there is evidence for a relationship between understory plant phenology and demographic performance, a mechanistic link is still missing. In this study, we bridged this gap by estimating annual carbon assimilation as a function of foliar phenology and photosynthetic capacity...

Unraveling the roles of genotype and environment in the expression of plant defense phenotypes

Abigail Potts & Mark Hunter
1. Phenotypic variability results from interactions between genotype and environment and is a major driver of ecological and evolutionary interactions. Measuring the relative contributions of genetic variation, the environment, and their interaction to phenotypic variation remains a fundamental goal of evolutionary ecology. 2. In this study, we assess the question: How do genetic variation and local environmental conditions interact to influence phenotype within a single population? We explored this question using seed from a single...

Genetic mechanisms and correlational selection structure trait variation in a coral snake mimic

John David Curlis, Alison Davis Rabosky, Iris Holmes, Timothy Renney & Christian Cox
Covariation among traits shapes both phenotypic evolution and ecological interactions across space and time. However, rampant geographic variation in the strength and direction of such correlations can be particularly difficult to explain through generalized mechanisms. By integrating population genomics, surveys of natural history collections, and spatially-explicit analyses, we tested multiple drivers of trait correlations in a coral snake mimic that exhibits remarkable polymorphism in mimetic and non-mimetic color traits. We found that although such traits...

The oldest Devonian circumpolar ray-finned fish?

Rodrigo Figueroa, Luiz Carlos Weinschütz & Matthew Friedman
Actinopterygians (ray-finned fishes) are the most diverse group of living fishes, but have a sparse early fossil record restricted to low palaeolatitudes. Here we report a new actinopterygian from the Paraná Basin of Brazil, an area that occupied a circumpolar position in the Palaeozoic. Available geological evidence supports a Middle Devonian or older age for this taxon, which shares features of the mandibular symphysis with the latest Devonian Tegeolepis. A phylogenetic analysis resolves these two...

High-resolution mapping of the period landscape reveals polymorphism in cell cycle frequency tuning

Zhengda Li, Shiyuan Wang, Meng Sun, Minjun Jin, Daniel Khain & Qiong Yang
Biological oscillators adapt to environmental changes with widely tunable frequencies, a property theoretical studies attributed to positive feedbacks. However, no experiments have tested this theory. Here, we created synthetic cells to independently tune the frequency and feedback strength of a cell-cycle oscillator, enabling continuous mapping of period landscape in response to network perturbations. We found that although inhibiting positive feedback of cyclin-dependent kinase (Cdk1) reduces the tunability, the reduction is not as significant as theoretically...

Social effects on annual fitness in red squirrels

Andrew McAdam, Quinn Webber, Ben Dantzer, Jeff Lane & Stan Boutin
When resources are limited, mean fitness is constrained and competition can cause genes and phenotypes to enhance an individual’s own fitness while reducing the fitness of their competitors. Negative social effects on fitness have the potential to constrain adaptation, but the interplay between ecological opportunity and social constraints on adaptation remains poorly studied in nature. Here, we tested for evidence of phenotypic social effects on annual fitness (survival and reproductive success) in a long-term study...

Data for: Freeze tolerance influenced forest cover and hydrology during the Pennsylvanian

William Matthaeus, Sophia I. Macarewich, Jon D. Richey, Jonathan P. Wilson, Jennifer C. McElwin, Isabel P. Montañez, William A. DiMichele, Michael T. Hren, Christopher J. Poulsen & Joseph D. White
Global forest cover affects the Earth system by altering surface mass and energy exchange. Physiology determines plant environmental limits and influences geographical vegetation distribution. Ancient plant physiology, therefore, likely affected vegetation-climate feedbacks. We combine climate modeling and ecosystem-process modeling to simulate arboreal vegetation in the late Paleozoic ice age. Using GENESIS V3 GCM simulations, varying pCO2, pO2, and ice extent for the Pennsylvanian, and fossil-derived leaf C:N, maximum stomatal conductance, and specific conductivity for several...

Urinary metals and maternal circulating extracellular vesicle microRNA in the MADRES pregnancy cohort

Caitlin G. Howe, Helen B. Foley, Shohreh F. Farzan, Thomas A. Chavez, Mark Johnson, John D. Meeker, Theresa M. Bastain, Carmen J. Marsit & Carrie V. Breton
Exposure to metals increases risk for pregnancy complications. Extracellular vesicle (EV) miRNA contribute to maternal-foetal communication and are dysregulated in pregnancy complications. However, metal impacts on maternal circulating EV miRNA during pregnancy are unknown. Our objective was to investigate the impact of multiple metal exposures on EV miRNA in maternal circulation during pregnancy in the MADRES Study. Associations between urinary concentrations of nine metals and 106 EV miRNA in maternal plasma during pregnancy were investigated...

Bioinformatics analysis reveals the competing endogenous RNA (ceRNA) coexpression network in the tumor microenvironment and prognostic biomarkers in soft tissue sarcomas

Dandan Zou, Yang Wang, Meng Wang, Bo Zhao, Fei Hu, Yanguo Li & Bingming Zhang
Soft tissue sarcomas (STSs) are rare, heterogeneous mesenchymal neoplasias. Understanding the tumor microenvironment (TME) and identifying potential biomarkers for prognosis associated with the TME of STS might provide effective clues for immune therapy. We evaluated the immune scores and stromal scores of STS patients by using the RNA sequencing dataset from The Cancer Genome Atlas (TCGA) database and the ESTIMATE algorithm. Then, the differentially expressed mRNAs (DEGs), miRNAs (DEMs) and lncRNAs (DELs) were identified after...

MicroRNA-624-mediated ARRDC3/YAP/HIF1α axis enhances esophageal squamous cell carcinoma cell resistance to cisplatin and paclitaxel

Jie Yan, Litong Shi, Shan Lin & Yi Li
Development of chemoresistance remains a major challenge in treating patients suffering from esophageal squamous cell carcinoma (ESCC), despite treatment advances. MicroRNAs (miRNAs) have been shown to play critical roles in the regulation of ESCC cell chemoresistance. Here, we aimed to investigate the role of miR-624 in ESCC and its molecular mechanism in mediating the resistance of ESCC cells to two common chemotherapeutic drugs, cisplatin (CIS) and paclitaxel (PT). Expression patterns of miR-624, arrestin domain-containing 3...

MicroRNA-624-mediated ARRDC3/YAP/HIF1α axis enhances esophageal squamous cell carcinoma cell resistance to cisplatin and paclitaxel

Jie Yan, Litong Shi, Shan Lin & Yi Li
Development of chemoresistance remains a major challenge in treating patients suffering from esophageal squamous cell carcinoma (ESCC), despite treatment advances. MicroRNAs (miRNAs) have been shown to play critical roles in the regulation of ESCC cell chemoresistance. Here, we aimed to investigate the role of miR-624 in ESCC and its molecular mechanism in mediating the resistance of ESCC cells to two common chemotherapeutic drugs, cisplatin (CIS) and paclitaxel (PT). Expression patterns of miR-624, arrestin domain-containing 3...

Data from: New forms of structure in ecosystems revealed with the Kuramoto model

John Vandermeer
This is the general Mathematica code for the article, "New forms of structure in ecosystems revealed with the Kuramoto model" by Vandermeer, Hajian-Forooshani, Medina and Perfecto. All results presented in the article can be obtained by running the code with appropriate parameter settings.

Behavioural plasticity in a native species is related to foraging resilience in the presence of an aggressive invader

Marian Wong, Melinda Keiller, Laura Lopez & Kai Paijmans
Competition between invasive and native species can result in exploitation of resources by the invader, reducing foraging rates of natives. However, it is increasingly recognised that multiple factors can enhance the resilience of native species competing for limiting resources with invaders. Although extensively studied in terrestrial species, little research has focused on behavioural plasticity in the aquatic realm and how this influences native species resilience. Here we examined the role of behavioural plasticity in interactions...

Habitat structure mediates vulnerability to climate change through its effects on thermoregulatory behavior

Lauren Neel, Michael Logan, Daniel Nicholson, Christina Miller, Albert Chung, Inbar Maayan, Zach Degon, Madeline DuBois, John David Curlis, Q Taylor, Kaitlin Keegan, Owen McMillan, Jonathan Losos & Christian Cox
Tropical ectotherms are thought to be especially vulnerable to climate change because they are thermal specialists, having evolved in aseasonal thermal environments. However, even within the tropics, habitat structure can influence opportunities for behavioral thermoregulation. Open (and edge) habitats likely promote more effective thermoregulation due to the high spatial heterogeneity of the thermal landscape, while forests are thermally homogenous and may constrain opportunities for behavioral buffering of environmental temperatures. Nevertheless, the ways in which behavior...

Phylogenomics, introgression, and demographic history of South American true toads (Rhinella)

Danielle Rivera, Ivan Prates, Thomas Firneno, Miguel Rodrigues, Janalee Caldwell & Matthew Fujita
The effects of genetic introgression on species boundaries and how they affect species’ integrity and persistence over evolutionary time have received increased attention. The increasing availability of genomic data has revealed contrasting patterns of gene flow across genomic regions, which impose challenges to inferences of evolutionary relationships and of patterns of genetic admixture across lineages. By characterizing patterns of variation across thousands of genomic loci in a widespread complex of true toads (Rhinella), we assess...

Living in the concrete jungle: carnivore spatial ecology in urban parks

Siria Gámez & Nyeema C. Harris
People and wildlife are living in an increasingly urban world, replete with unprecedented human densities, sprawling built environments, and altered landscapes. Such anthropogenic pressures can affect multiple processes within an ecological community, from spatial patterns to interspecific interactions. We tested two competing hypotheses, human shields versus human competitors, to characterize how humans affect the carnivore community using multi-species occupancy models. From 2017-2020, we conducted the first camera survey of city parks in Detroit, Michigan, and...

Phylogenetic conflicts, combinability, and deep phylogenomics in plants

Stephen Smith, Joseph Walker, Joseph Brown & Nathanael Hale
Studies have demonstrated that pervasive gene tree conflict underlies several important phylogenetic relationships where different species tree methods produce conflicting results. Here, we present a means of dissecting the phylogenetic signal for alternative resolutions within a dataset in order to resolve recalcitrant relationships and, importantly, identify what the dataset is unable to resolve. These procedures extend upon methods for isolating conflict and concordance involving specific candidate relationships and can be used to identify systematic error...

Comparison of adult census size and effective population size support the need for continued protection of two Solomon Island endemics

Sarah A. Cowles, Brian C. Weeks, Lindsey Perrin, Nancy Chen & J. Albert C. Uy
Because a population’s ability to respond to rapid change is dictated by standing genetic variation, we can better predict a population’s long-term viability by estimating and then comparing adult census size (N) and effective population size (Ne). However, most studies only measure N or Ne, which can be misleading. Using a combination of field and genomic sequence data, we here estimate and compare N and Ne in two range-restricted endemics of the Solomon Islands. Two...

Density, parasitism, and sexual reproduction are strongly correlated in lake Daphnia populations

Meghan A. Duffy, Camden D. Gowler, Mary A. Rogalski, Clara L. Shaw & Katherine K. Hunsberger
Many organisms can reproduce both asexually and sexually. For cyclical parthenogens, periods of asexual reproduction are punctuated by bouts of sexual reproduction, and the shift from asexual to sexual reproduction has large impacts on fitness and population dynamics. We studied populations of Daphnia dentifera to determine the amount of investment in sexual reproduction as well as the factors associated with variation in investment in sex. To do so, we tracked host density, infections by nine...

The association between hand disease severity and fatigue in individuals with systemic sclerosis: a scoping review

Donnamarie Krause, Janet L. Poole, Dinesh Khanna & Susan L. Murphy
Hand disease severity in people with systemic sclerosis (SSc) arises from connective tissue and vascular changes causing functional limitations, pain, and disability. Fatigue is not well-understood in SSc and reported to be highly distressing. It is not known how fatigue relates to these disease changes. The objective of this study was to identify which elements of hand disease severity contribute to fatigue in individuals with SSc. Five online databases and Google Scholar were searched to...

Data from: Long-term trends in the occupancy of ants revealed through use of multi-sourced datasets

Julie Sheard, Carsten Rahbek, Robert Dunn, Nathan Sanders & Nick Isaac
We combined participatory science data and museum records to understand long-term changes in occupancy for 29 ant species in Denmark over 119 years. Bayesian occupancy modelling indicated change in occupancy for 15 species: five increased, four declined and six showed fluctuating trends. We consider how trends may have been influenced by life-history and habitat changes. Our results build on an emerging picture that biodiversity change in insects is more complex than implied by the simple...

Registration Year

  • 2021

Resource Types

  • Dataset


  • University of Michigan-Ann Arbor
  • University of Michigan–Ann Arbor
  • Fudan University
  • Zhejiang University
  • Central South University
  • Peking University
  • West China Hospital of Sichuan University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • University of California, Berkeley
  • Nanjing Medical University