16 Works

Data from: Why on earth did I buy that? A study of regretted appliance purchases

Thomas Roberts, Aimie Hope & Alexandra Skelton
If targets to reduce greenhouse gas emissions and thereby tackle climate change are to be achieved, it will be necessary to reduce both embodied energy costs (e.g. in terms of producing and manufacturing the products and services that society consumes) and operational energy costs. Reducing the number of purchases that people regret could be a first step in changing the overall dynamic of consumption patterns. This research looks at some potentially adverse effects of consumption...

A practical introduction to sequentially Markovian coalescent methods for estimating demographic history from genomic data

Niklas Mather, Simon Ho & Samuel Traves
A common goal of population genomics and molecular ecology is to reconstruct the demographic history of a species of interest. A pair of powerful tools based on the sequentially Markovian coalescent have been developed to infer past population sizes using genome sequences. These methods are most useful when sequences are available for only a limited number of genomes and when the aim is to study ancient demographic events. The results of these analyses can be...

MOBIO

Chris McCool, Sébastien Marcel, Abdenour Hadid, Matti Pietikainen, Pavel Matejka, Jan Cernocky, Norman Poh, Josef Kittler, Anthony Larcher, Lévy Christophe, Driss Matrouf, jean-francois Bonastre, Phil Tresadern & Timothy Cootes
MOBIO is a dataset for mobile face and speaker recognition. The dataset consists of bi-modal (audio and video) data taken from 152 people. The dataset has a female-male ratio of nearly 1:2 (100 males and 52 females) and was collected from August 2008 until July 2010 in six different sites from five different countries. This led to a diverse bi-modal dataset with both native and non-native English speakers.

Socio-economic survey of domestic groundwater handling and use for source customers in Kisumu, Kenya in 2014

L.G. Okotto, J. Okotto-Okotto, H. Price, S. Pedley & J. Wright
This dataset contains the anonymised results of a survey of customers who buy groundwater for consumption in Kisumu, Kenya. Data includes information on the amount of water bought and ways in which this water was used and handled, as well as their use of water from other sources. Data about assets and services, including access to food, are also included. The surveys were carried out during February and March 2014 and include data from 137...

Groundwater microbiology and chemistry of shallow wells, boreholes and springs in Kisumu, Kenya in 2014

S. Pedley, J. Okotto-Okotto, L. Okotto, H. Price & J. Wright
This dataset contains free residual chlorine, turbidity, nitrate, chloride, sulphate, fluoride, phosphate and thermatolerant coliform concentrations in groundwater from a variety of sources within two neighbourhoods of Kisumu, Kenya. A total of 73 groundwater sources were tested between February and March 2014. The data were collected as part of the Groundwater2030 project, which aims to reduce the health problems that result from consumption of contaminated groundwater in urban areas of Africa. The project was co-ordinated...

Influence of reaction parameters on the catalytic upgrading of an acetone, butanol and ethanol (ABE) mixture: exploring new routes for modern biorefineries

Elham Ketabchi, , Harvey Arellano-Garcia & Tomas Ramirez Reina
Here we present a comprehensive study on the effect of reaction parameters on the upgrade of an acetone, butanol and ethanol mixture – key molecules and platform products of great interest within the chemical sector. Using a selected high performing catalyst, Fe/MgO-Al2O3, the variation of temperature, reaction time, catalytic loading and reactant molar ratio have been examined in this reaction. This work is aiming to not only optimise the reaction conditions previously used, but to...

Mosquito saliva enhances virus infection through sialokinin-dependent vascular leakage

Daniella Lefteri, Steven Bryden, Marieke Pingen, Sandra Terry, Ailish McCafferty, Emily Beswick, Georgi Georgiev, Marleen Van der Laan, Valeria Mastrullo, Paola Campagnolo, Robert Waterhouse, Margus Varjak, Andres Merits, Rennos Fragkoudis, Stephen Griffin, Kave Shams, Emilie Pondeville & Clive McKimmie
Viruses transmitted by Aedes mosquitoes are an increasingly important global cause of disease. Defining common determinants of host susceptibility to this large group of het- erogenous pathogens is key for informing the rational design of panviral medicines. Infection of the vertebrate host with these viruses is enhanced by mosquito saliva, a complex mixture of salivary-gland-derived factors and microbiota. We show that the enhancement of infection by saliva was dependent on vascular function and was inde-...

Data from: In vivo dynamics of skeletal muscle Dystrophin in zebrafish embryos revealed by improved FRAP analysis

Fernanda Bajanca, Vinicio Gonzalez-Perez, Sean J. Gillespie, Cyriaque Beley, Luis Garcia, Eric Theveneau, Richard P. Sear & Simon M. Hughes
Dystrophin forms an essential link between sarcolemma and cytoskeleton, perturbation of which causes muscular dystrophy. We analysed Dystrophin binding dynamics in vivo for the first time. Within maturing fibres of host zebrafish embryos, our analysis reveals a pool of diffusible Dystrophin and complexes bound at the fibre membrane. Combining modelling, an improved FRAP methodology and direct semi-quantitative analysis of bleaching suggests the existence of two membrane-bound Dystrophin populations with widely differing bound lifetimes: a stable,...

Data from: Timing of host feeding drives rhythms in parasite replication

Kimberley F. Prior, Daan R. Van Der Veen, Aidan J. O'Donnell, Katherine Cumnock, David Schneider, Arnab Pain, Amit Subudhi, Abhinay Ramaprasad, Samuel S. C. Rund, Nicholas J. Savill, Sarah E. Reece & Aidan J. O’Donnell
Circadian rhythms enable organisms to synchronise the processes underpinning survival and reproduction to anticipate daily changes in the external environment. Recent work shows that daily (circadian) rhythms also enable parasites to maximise fitness in the context of ecological interactions with their hosts. Because parasite rhythms matter for their fitness, understanding how they are regulated could lead to innovative ways to reduce the severity and spread of diseases. Here, we examine how host circadian rhythms influence...

Sanitary risk inspections of shallow wells, boreholes and springs in Kisumu, Kenya in 2014

J. Okotto-Okotto, S. Pedley, L.G. Okotto, H. Price & J. Wright
This dataset contains the results of a sanitary risk inspection for different groundwater sources in Kisumu, Kenya. A total of 70 groundwater sources were surveyed between February and March 2014. The survey took the form of an observation checklist that identified contamination hazards at well heads and in their immediate surroundings. Data on well depth, electro-conductivity, pH and temperature were also collected. The data were collected as part of the Groundwater2030 project, which aims to...

Comparing antigenaemia - and microfilaraemia as criteria for stopping decisions in lymphatic filariasis elimination programmes in Africa

Wilma Stolk, Luc Edgar Coffeng, FATORMA BOLAY, Obiora Eneanya, Peter Fischer, T Deirdre Hollingsworth, Benjamin Koudou, Aboulaye Méité, Edwin Michael, Joaquin Miguel Prada Jimenez de Cisneros, Rocio Marilyn Caja Rivera, SWARNALI SHARMA, Panayiota Touloupou, Gary Weil & Sake J. de Vlas

Socio-economic survey of domestic groundwater handling and use for source owners in Kisumu, Kenya in 2014

L. Okotto, J. Okotto-Okotto, H. Price, S. Pedley & J. Wright
This datasets contains the anonymised results of a survey of well owners in Kisumu, Kenya. Data includes information on the amount of water abstracted daily from the well and ways in which this water was used and handled, information on other sources of water (e.g. piped utility water and rainwater) and how this is used, and the assets and services that the well owner has access to. Answers from questions to assess food poverty are...

Data from: Natural light exposure, sleep and depression among day workers and shiftworkers at Arctic and Equatorial latitudes

Elaine Cristina Marqueze, Suleima Vasconcelos, Johanna Garefelt, Debra J. Skene, Claudia Roberta Moreno & Arne Lowden
Objectives: This study aimed to investigate the relationship between individual natural light exposure, sleep need, and depression at two latitudes, one extreme with a few hours of light per day during winter, and the other with equal hours of light and darkness throughout the year. Methods: This cross-sectional study included a sample of Brazilian workers (Equatorial, n = 488 workers) and a Swedish sample (Arctic, n = 1,273). Results: The reported mean total natural light...

Data from: Trajectory energy minimisation for cell growth tracking and genealogy analysis

Yin Hu, Su Wang, Nan Ma, Suzanne M. Hingley-Wilson, Andrea Rocco, Johnjoe McFadden, Hongying Tang & Hongying Lilian Tang
Cell growth experiments with a microfluidic device produce large-scale time-lapse image data, which contain important information on cell growth and patterns in their genealogy. To extract such information, we propose a scheme to segment and track bacterial cells automatically. In contrast with most published approaches, which often split segmentation and tracking into two independent procedures, we focus on designing an algorithm that describes cell properties evolving between consecutive frames by feeding segmentation and tracking results...

Tandem RNA isolation reveals functional rearrangement of RNA-binding proteins on CDKN1B/p27Kip1 3’UTRs in cisplatin treated cells

Valentina Iadevaia, Maikel D. Wouters, Alexander Kanitz, Ana M. Matia-González, Emma E. Laing & André P. Gerber
Post-transcriptional control of gene expression is mediated via RNA-binding proteins (RBPs) that interact with mRNAs in a combinatorial fashion. While recent global RNA interactome capture experiments expanded the repertoire of cellular RBPs quiet dramatically, little is known about the assembly of RBPs on particular mRNAs; and how these associations change and control the fate of the mRNA in drug-treatment conditions. Here we introduce a novel biochemical approach, termed tobramycin-based tandem RNA isolation procedure (tobTRIP), to...

Tandem RNA isolation reveals functional rearrangement of RNA-binding proteins on CDKN1B/p27Kip1 3’UTRs in cisplatin treated cells

Valentina Iadevaia, Maikel D. Wouters, Alexander Kanitz, Ana M. Matia-González, Emma E. Laing & André P. Gerber
Post-transcriptional control of gene expression is mediated via RNA-binding proteins (RBPs) that interact with mRNAs in a combinatorial fashion. While recent global RNA interactome capture experiments expanded the repertoire of cellular RBPs quiet dramatically, little is known about the assembly of RBPs on particular mRNAs; and how these associations change and control the fate of the mRNA in drug-treatment conditions. Here we introduce a novel biochemical approach, termed tobramycin-based tandem RNA isolation procedure (tobTRIP), to...

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