37 Works

Localized carry-over effects of pond drying on survival, growth, and pathogen defenses in amphibians

Emily Le Sage
Climate change is increasing variability in precipitation patterns in many parts of the globe. Unpredictable changes in water availability can be particularly challenging for organisms that rely on precipitation-fed water sources for completing their life cycle, such as many amphibian species. Although developmental plasticity can mitigate the impacts of changing environments for some species, this strategy can come at a cost to other fitness-linked traits, such as immune function. We investigated localized variation in the...

How early does the selfing syndrome arise? Associations between selfing ability and flower size within populations of the mixed mater Collinsia verna

Robert M McElderry, Rachel B Spigler, Donna W Vogler & Susan Kalisz
Widespread associations between selfing rate and floral size within and among taxa suggest that these traits may evolve in concert. Does this association develop immediately, because of shared genetic/developmental control, or stepwise with selection shaping the evolution of one trait following the other? If the former, then association ought to appear within and across populations. We explore this fundamental question in three populations of the mixed-mater Collinsia verna where autonomous selfing (AS) ability has been...

Additional file 3 of Pharmacological mechanism and therapeutic efficacy of Icariside II in the treatment of acute ischemic stroke: a systematic review and network pharmacological analysis

Xu Wang, Jinjian Li, Lifang Liu, Jun-Ming Kan, Ping Niu, Zi-Qiao Yu, Chunyu Ma, Fuxiang Dong, Mo-Xuan Han, Jinhua Li & De-xi Zhao
Additional file 3. Quality assessment of CAMARADES and ARRIVE.

Additional file 3 of Pharmacological mechanism and therapeutic efficacy of Icariside II in the treatment of acute ischemic stroke: a systematic review and network pharmacological analysis

Xu Wang, Jinjian Li, Lifang Liu, Jun-Ming Kan, Ping Niu, Zi-Qiao Yu, Chunyu Ma, Fuxiang Dong, Mo-Xuan Han, Jinhua Li & De-xi Zhao
Additional file 3. Quality assessment of CAMARADES and ARRIVE.

Additional file 4 of Pharmacological mechanism and therapeutic efficacy of Icariside II in the treatment of acute ischemic stroke: a systematic review and network pharmacological analysis

Xu Wang, Jinjian Li, Lifang Liu, Jun-Ming Kan, Ping Niu, Zi-Qiao Yu, Chunyu Ma, Fuxiang Dong, Mo-Xuan Han, Jinhua Li & De-xi Zhao
Additional file 4. Information of AIS and ICS II targets.

N(6)-adenosine-methyltransferase-14 promotes glioma tumorigenesis by repressing argininosuccinate synthase 1 expression in an m6A-dependent manner

You-Qing Miao, Wei Chen, Jianfeng Zhou, Qiyang Shen, Ying Sun, Tao Li & Sheng-Chan Wang
Glioma is one of the leading causes of tumor-related deaths worldwide, but its potential mechanism remains unclear. This study aimed to explore the biological role and potential mechanism of argininosuccinate synthase 1 (ASS1) in glioma. The relative expression levels of ASS1 in glioma specimens and cell lines were calculated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting. The biological functions of ASS1 were demonstrated using the 5-ethynyl-2ʹ-deoxyuridine (EdU) assay, transwell assay, and in...

Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy

Zicheng Ma, Juan Bai, Chenlong Jiang, Huixin Zhu, Depeng Liu, Mengjiao Pan, Xianwei Wang, Jiang Pi, Ping Jiang & Xing Liu
Alpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts and has developed multiple strategies to counteract the host defense. Here, we demonstrate that the tegument protein UL21 (unique long region 21) in pseudorabies virus (PRV) dampens type I interferon signaling by triggering the degradation of CGAS (cyclic GMP-AMP synthase) through the macroautophagy/autophagy-lysosome pathway. Mechanistically, the UL21 protein scaffolds the E3 ligase UBE3C (ubiquitin protein ligase E3C) to catalyze the K27-linked ubiquitination...

Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy

Zicheng Ma, Juan Bai, Chenlong Jiang, Huixin Zhu, Depeng Liu, Mengjiao Pan, Xianwei Wang, Jiang Pi, Ping Jiang & Xing Liu
Alpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts and has developed multiple strategies to counteract the host defense. Here, we demonstrate that the tegument protein UL21 (unique long region 21) in pseudorabies virus (PRV) dampens type I interferon signaling by triggering the degradation of CGAS (cyclic GMP-AMP synthase) through the macroautophagy/autophagy-lysosome pathway. Mechanistically, the UL21 protein scaffolds the E3 ligase UBE3C (ubiquitin protein ligase E3C) to catalyze the K27-linked ubiquitination...

Additional file 4 of Expanding known viral diversity in plants: virome of 161 species alongside an ancient canal

Shixing Yang, Qingqing Mao, Yan Wang, Jingxian He, Jie Yang, Xu Chen, Yuqing Xiao, Yumin He, Min Zhao, Juan Lu, Zijun Yang, Ziyuan Dai, Qi Liu, Yuxin Yao, Xiang Lu, Hong Li, Rui Zhou, Jian Zeng, Wang Li, Chenglin Zhou, Xiaochun Wang, Quan Shen, Hui Xu, Xutao Deng, Eric Delwart … & Wen Zhang
Additional file 4. Table S2: Information of viruses with complete genomes determined in the present study.

Additional file 4 of Expanding known viral diversity in plants: virome of 161 species alongside an ancient canal

Shixing Yang, Qingqing Mao, Yan Wang, Jingxian He, Jie Yang, Xu Chen, Yuqing Xiao, Yumin He, Min Zhao, Juan Lu, Zijun Yang, Ziyuan Dai, Qi Liu, Yuxin Yao, Xiang Lu, Hong Li, Rui Zhou, Jian Zeng, Wang Li, Chenglin Zhou, Xiaochun Wang, Quan Shen, Hui Xu, Xutao Deng, Eric Delwart … & Wen Zhang
Additional file 4. Table S2: Information of viruses with complete genomes determined in the present study.

Additional file 1 of Expanding known viral diversity in plants: virome of 161 species alongside an ancient canal

Shixing Yang, Qingqing Mao, Yan Wang, Jingxian He, Jie Yang, Xu Chen, Yuqing Xiao, Yumin He, Min Zhao, Juan Lu, Zijun Yang, Ziyuan Dai, Qi Liu, Yuxin Yao, Xiang Lu, Hong Li, Rui Zhou, Jian Zeng, Wang Li, Chenglin Zhou, Xiaochun Wang, Quan Shen, Hui Xu, Xutao Deng, Eric Delwart … & Wen Zhang
Additional file 1. Table S1: Plant species and library information.

Water chemistry dataset in eastern Siberian rivers

Ping Wang, Shiqi Liu, Qiwei Huang, Olga Gabysheva, Zehong Li, Jialing Zhang, Ekaterina Kazak, Yu Liu, Tcogto Bazarzhapov, Raisa Shpakova, Victor Gabyshev, Sergey Pozdniakov & Natalia Frolova
The dataset includes major ion (Ca, Mg, Na, K, HCO3, SO4, and Cl) data spanning 1940-2019, with 9487 groups of chemical results from 1434 water samples collected mainly in six large river basins in eastern Siberia.

Water chemistry dataset in eastern Siberian rivers

Ping Wang, Shiqi Liu, Qiwei Huang, Olga Gabysheva, Zehong Li, Jialing Zhang, Ekaterina Kazak, Yu Liu, Tcogto Bazarzhapov, Raisa Shpakova, Victor Gabyshev, Sergey Pozdniakov & Natalia Frolova
The dataset includes major ion (Ca, Mg, Na, K, HCO3, SO4, and Cl) data spanning 1940-2019, with 9487 groups of chemical results from 1434 water samples collected mainly in six large river basins in eastern Siberia.

Data for: Contemporizing island biogeography theory with anthropogenic drivers of species richness

Jason Gleditsch, Jocelyn Behm, Jacintha Ellers, Wendy Jesse & Matthew Helmus
Aim: Island biogeography theory states that species richness increases with habitat diversity and decreases with isolation from source pools. However, ecological theory must incorporate effects of human activity to explain contemporary patterns of biodiversity. We contemporized island biogeography theory by conceptualizing island trajectories of how species richness changes over time with accelerating land development and economic trade, which increase extinction and immigration rates, respectively. With this contemporized theory, we then articulate and empirically assess expected...

Endemism, invasion, and overseas dispersal: The phylogeographic history of the Lesser Antillean frog, Eleutherodactylus johnstonei

Michael Yuan, Jeffrey Frederick, Jimmy McGuire, Rayna Bell, Struan Smith, Calvin Fenton, Jourdan Cassius, Rudell Williams, Ian Wang, Robert Powell & S. Blair Hedges
Cryptogenic species, those whose native and introduced ranges are unknown, pose a challenge not only to conservation but also to studies of ecology, biogeography, and evolution. One such species is the Lesser Antillean frog, Eleutherodactylus johnstonei, which is broadly distributed through the Caribbean and mainland South America. The Lesser Antilles pose a particular challenge with regard to cryptogenic species because these islands have been anthropogenically connected since before recorded history. We combined genetic (available on...

Additional file 1 of Surface fungal diversity and several mycotoxin-related genes’ expression profiles during the Lunar Palace 365 experiment

Jianlou Yang, Zikai Hao, Lantao Zhang, Yuming Fu & Hong Liu
Additional file 1: Supplementary Table S1. qPCR primer sequences, mycotoxin types, producers, and toxic effects in humans. Supplementary Table S2. ASV abundances and potential ecological functions (F01-F70). Supplementary Table S3. ISS dust, AIT, ILMAH, and LP1 surfaces merged fungal ASV table. Supplementary Table S4. Species abundance tables at the phylum level. Supplementary Table S5. Species abundance tables at the genus level. Supplementary Table S6. Trophic modes of the fungal microbiome in the different crew groups...

Elemental inheritance evaluation for geochemical elements in soil of the Daliangshan, China

Zhen-Jie Zhang, Hong Liu & Yuan Ouyang
Table S1

Cancer-associated fibroblast-released extracellular vesicles carrying miR-199a-5p induces the progression of​ gastric cancer through regulation of FKBP5-mediated AKT1/mTORC1 signaling pathway

Yan Wang, Tao Li, Lei Yang, Xunlei Zhang, Xiaoli Wang, Xiaoqin Su, Congfei Ji & Zhenxin Wang
Accumulating evidence has unfolded the significance of extracellular vesicles (EVs) in diseases and cancers. Here, we attempted to discuss the role of cancer-associated fibroblasts (CAFs)-derived EVs containing miR-199a-5p in gastric tumorigenesis. Upregulated miR-199a-5p was first identified in cancer cells. Then, we selected CAFs for isolation of EVs which were co-cultured with AGS cells. We observed successful delivery of miR-199a-5p via CAF-derived EVs. Besides, miR-199a-5p promoted malignant properties of AGS cells. Moreover, miR-199a-5p downregulated FKBP5, leading...

Paninvasion severity assessment of a U.S. grape pest to disrupt the global wine market

Nicholas Huron, Jocelyn Behm & Matthew Helmus
Economic impacts from plant pests are often felt at the regional scale, yet some impacts expand to the global scale through the alignment of a pest’s invasion potentials. Such globally invasive species (i.e., paninvasives) are like the human pathogens that cause pandemics. Like pandemics, assessing paninvasion risk for an emerging regional pest is key for stakeholders to take early actions that avoid market disruption. Here, we develop the paninvasion severity assessment framework and use it...

Ranavirus infection-induced avoidance behavior in wood frog juveniles: Do amphibians socially distance?

Emily Le Sage
Hosts may limit exposure to pathogens through changes in behavior, such as avoiding infected individuals or contaminated areas. Here, we tested for a behavioral response to ranavirus infection in juvenile wood frogs (Rana sylvatica) because the majority of dispersal between populations occurs during this life stage. We hypothesized that if infections are transmissible and detectable at this life stage, then susceptibles would display avoidance behaviors when introduced to an infected conspecific. Despite no apparent signs...

Elemental inheritance evaluation for geochemical elements in soil of the Daliangshan, China

Zhen-Jie Zhang, Hong Liu & Yuan Ouyang
Table S1

Additional file 4 of Pharmacological mechanism and therapeutic efficacy of Icariside II in the treatment of acute ischemic stroke: a systematic review and network pharmacological analysis

Xu Wang, Jinjian Li, Lifang Liu, Jun-Ming Kan, Ping Niu, Zi-Qiao Yu, Chunyu Ma, Fuxiang Dong, Mo-Xuan Han, Jinhua Li & De-xi Zhao
Additional file 4. Information of AIS and ICS II targets.

Additional file 1 of Expanding known viral diversity in plants: virome of 161 species alongside an ancient canal

Shixing Yang, Qingqing Mao, Yan Wang, Jingxian He, Jie Yang, Xu Chen, Yuqing Xiao, Yumin He, Min Zhao, Juan Lu, Zijun Yang, Ziyuan Dai, Qi Liu, Yuxin Yao, Xiang Lu, Hong Li, Rui Zhou, Jian Zeng, Wang Li, Chenglin Zhou, Xiaochun Wang, Quan Shen, Hui Xu, Xutao Deng, Eric Delwart … & Wen Zhang
Additional file 1. Table S1: Plant species and library information.

Divergence time estimation using ddRAD data and an isolation-with-migration model applied to water vole populations of Arvicola

Jose Castresana, Alfonso Balmori-De La Puente, Jacint Ventura, Marcos Miñarro, Aitor Somoano & Jody Hey
Molecular dating methods of population splits are crucial in evolutionary biology, but they present important difficulties due to the complexity of the genealogical relationships of genes and past migrations between populations. Using the double digest restriction-site associated DNA (ddRAD) technique and an isolation-with-migration (IM) model, we studied the evolutionary history of water vole populations of the genus Arvicola, a group of complex evolution with fossorial and semi-aquatic ecotypes. To do this, we first estimated mutation...

Sequence conservation and structural features that are common within TRP channels

Deny Cabezas-Bratesco, Francisco A. McGee, Charlotte Colenso, Kattina Zavala, Danielle Granata, Vincenzo Carnevale, Juan Opazo & Sebastian Brauchi
TRP proteins are a large family of cation-selective channels, surpassed in variety only by voltage-gated potassium channels. Detailed molecular mechanisms governing how membrane voltage, ligand binding, or temperature can induce conformational changes promoting the open state in TRP channels are still a matter of debate. Aiming to unveil distinctive structural features common to the transmembrane domains within the TRP family, we performed phylogenetic reconstruction, sequence statistics, and structural analysis over a large set of TRP...

Registration Year

  • 2022
    37

Resource Types

  • Dataset
    37

Affiliations

  • Temple University
    37
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    21
  • Chinese Academy of Sciences
    21
  • Shanghai Jiao Tong University
    17
  • Zhejiang University
    14
  • Capital Medical University
    14
  • Ministry of Education of the People's Republic of China
    14
  • Tianjin Medical University Cancer Institute and Hospital
    12
  • Huazhong University of Science and Technology
    11
  • Fudan University
    11