18 Works

Wide spectrum and high frequency of genomic structural variation, including transposable elements, in large double stranded DNA viruses

Clement Gilbert, Elisabeth Herniou, Yannis Moreau, Nicolas Lévêque, Carine Meignin, Laurent Daeffler, Brian Federici, Richard Cordaux & Vincent Loiseau
Our knowledge of the diversity and frequency of genomic structural variation segregating in populations of large double stranded (ds) DNA viruses is limited. Here we sequenced the genome of a baculovirus (AcMNPV) purified from beet armyworm (Spodoptera exigua) larvae at depths >195,000X using both short-read (Illumina) and long-read (PacBio) technologies. Using a pipeline relying on hierarchical clustering of structural variants (SVs) detected in individual short- and long-reads by six variant callers, we identified a total...

Data from: Glucocorticoid levels predict subsequent social tactic in females of a facultatively social mammal

Davina Hill, Neville Pillay & Carsten Schradin
Facultatively social species, in which individuals can switch between group- and solitary-living tactics, offer an opportunity to shed light on proximate mechanisms underlying alternative life histories. Promising hormonal mediators of social tactic include glucocorticoids, which control energy allocation and are negatively related to body condition, and testosterone which regulates numerous social behaviours. Here, we investigated hormonal profiles associated with social tactic in eight generations of free-living female striped mice (Rhabdomys pumilio). Females are group living...

Data from: Oceanic thermal structure mediates dive sequences in a foraging seabird

Xavier Meyer, Andrew MacIntosh, André Chiaradia, Akiko Kato, Francisco Ramírez, Cedric Sueur & Yan Ropert-Coudert
1. Changes in marine ecosystems are easier to detect in upper-level predators, like seabirds, which integrate trophic interactions throughout the food web. 2. Here, we examined whether diving parameters and complexity in the temporal organisation of foraging sequences of little penguins (Eudyptula minor) are influenced by sea surface temperature (SST), water stratification and wind speed – three oceanographic features influencing prey abundance and distribution in the water column. 3. Using fractal time series analysis, we...

The fast and the curious II: performance, personality and metabolism in Karoo bush rats

Paul Agnani, Jennifer Thomson, Carsten Schradin & Vincent Careau
Personality traits (e.g., activity, exploration, boldness) are frequently correlated with each other and with various other traits of biological importance. According to the performance, allocation, and independent models of energy management, the relationship between personality traits and resting metabolic rate (RMR) is predicted to be either positive, negative, or nil. As for the relationship between personality traits and locomotor performance, the trait compensation and co-specialisation hypotheses respectively predict a positive and negative relationship. To test...

Data from: Multi-scale quantification of tissue behavior during amniote embryo axis elongation

Bertrand Benazeraf, Mathias Beaupeux, Martin Tcherknookov, Allison Wallingford, Tasha Salisbury, Amelia Shirtz, Andrew Shirtz, David Huss, Olivier Pourquie, Paul Francois & Rusty Lansford
Embryonic axis elongation is a complex multi-tissue morphogenetic process responsible for the formation of the posterior part of the amniote body. How movements and growth are coordinated between the different posterior tissues (e.g. neural tube, axial and paraxial mesoderm, lateral plate, ectoderm, endoderm) to drive axis morphogenesis remain largely unknown. Here, we use quail embryos to quantify cell behavior and tissue movements during elongation. We quantify the tissue-specific contribution to axis elongation by using 3D...

Data from: A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

Renaud Prudent, Nathalie Demoncheaux, Hélène Diemer, Véronique Collin-Faure, Reuben Kapur, Fabrice Paublant, Laurence Lafanechère, Sarah Cianférani & Thierry Rabilloud
LIM kinases are located at a strategic crossroad, downstream of several signaling pathways and upstream of effectors such as microtubules and the actin cytoskeleton. Cofilin is the only LIM kinases substrate that is well described to date, and its phosphorylation on serine 3 by LIM kinases controls cofilin actin-severing activity. Consequently, LIM kinases inhibition leads to actin cytoskeleton disorganization and blockade of cell motility, which makes this strategy attractive in anticancer treatments. LIMK has also...

Data from: Regional paleoclimates and local consequences: Integrating GIS analysis of diachronic settlement patterns and process-based agroecosystem modeling of potential agricultural productivity in Provence (France)

Daniel Contreras, Eneko Hiriart, Alberte Bondeau, Alan Kirman, Joël Guiot, Loup Bernard, Romain Suarez, Sander Van Der Leeuw & Daniel A. Contreras
Holocene climate variability in the Mediterranean Basin is often cited as a potential driver of societal change, but the mechanisms of this putative influence are generally little explored. In this paper we integrate two tools - agro-ecosystem modeling of potential agricultural yields and spatial analysis of archaeological settlement pattern data - in order to examine the human consequences of past climatic changes. Focusing on a case study in Provence (France), we adapt an agro-ecosystem model...

Data from: The evolution of dual meat and milk cattle husbandry in Linearbandkeramik societies

Rosalind E. Gillis, Lenka Kovačiková, Stéphanie Brehard, Emilie Guthmann, Ivana Vostrovská, Hana Nohálová, Rose-Marie Arbogast, László Domboróczki, Joachim Pechtl, Alexandra Anders, Arkadiusz Marciniak, Anne Tresset & Jean-Denis Vigne
Cattle dominate archaeozoological assemblages from the north-central Europe between the sixth and fifth millennium BC and are frequently considered as exclusively used for their meat. Dairy products may have played a greater role than previously believed. Selective pressure on the lactase persistence mutation has been modelled to have begun between 6000 and 4000 years ago in central Europe. The discovery of milk lipids in late sixth millennium ceramic sieves in Poland may reflect an isolated...

Natural history, phenotypic spectrum, and discriminative features of multisystemic RFC1-disease

Andreas Traschütz, Andrea Cortese, Selina Reich, Natalia Dominik, Jennifer Faber, Heike Jacobi, Annette Hartmann, Dan Rujescu, Solveig Montaut, Andoni Echaniz-Laguna, Sevda Erer, Valerie Cornelia Schütz, Alexander Tarnutzer, Marc Sturm, Tobias Haack, Nadège Vaucamps-Diedhiou, Helene Puccio, Ludger Schöls, Thomas Klockgether, Bart P. Van De Warrenburg, Martin Paucar, Dagmar Timmann, Ralf-Dieter Hilgers, Jose Gazulla, Michael Strupp … & Matthis Synofzik
Objective: To delineate the full phenotypic spectrum, discriminative features, piloting longitudinal progression data, and sample size calculations of RFC1-repeat expansions, recently identified as causing cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS). Methods: Multimodal RFC1 repeat screening (PCR, southern blot, whole-exome/genome (WES/WGS)-based approaches) combined with cross-sectional and longitudinal deep-phenotyping in (i) cross-European cohort A (70 families) with ≥2 features of CANVAS and/or ataxia-with-chronic-cough (ACC); and (ii) Turkish cohort B (105 families) with unselected late-onset ataxia. Results:...

Data from: Social transmission in the wild reduces predation pressure on novel prey signals

Liisa Hämäläinen, William Hoppitt, Hannah Rowland, Johanna Mappes, Anthony Fulford, Sebastian Sosa & Rose Thorogood
Social transmission of information is taxonomically widespread and could have profound effects on the ecological and evolutionary dynamics of animal communities. Demonstrating this in the wild, however, has been challenging. Here we show by field experiment that social transmission among predators can shape how selection acts on prey defences. Using artificial prey and a novel approach in statistical analyses of social networks, we find that blue tit (Cyanistes caeruleus) and great tit (Parus major) predators...

French Global Network of Geomagnetic observatories

The Bureau Central de Magnétisme Terrestre (BCMT) is a French organization founded in 1921 and attached to the Institut de Physique du Globe de Paris (IPGP). Two French institutions are involved in BCMT operations: IPGP and École et Observatoire des Sciences de la Terre de Strasbourg (EOST). The primary mission of the BCMT is to provide ground geomagnetic observations of the highest quality to the scientific community, in France and abroad. To achieve its mission,...

French Global Network of Geomagnetic observatories

The Bureau Central de Magnétisme Terrestre (BCMT) is a French organization founded in 1921 and attached to the Institut de Physique du Globe de Paris (IPGP). Two French institutions are involved in BCMT operations: IPGP and École et Observatoire des Sciences de la Terre de Strasbourg (EOST). The primary mission of the BCMT is to provide ground geomagnetic observations of the highest quality to the scientific community, in France and abroad. To achieve its mission,...

Data from: Beak color dynamically signals changes in fasting status and parasite loads in king penguins

Quentin Schull, F. Stephen Dobson, Antoine Stier, Jean-Patrice Robin, Pierre Bize & Vincent A. Viblanc
Dynamic ornamental signals that vary over minutes, hours or weeks can yield continuous information on individual condition (e.g., energy reserves or immune status), and may therefore be under strong social and/or sexual selection. In vertebrates, the coloration of the integument is often viewed as a dynamic ornament, which in birds can be apparent in the beak. King penguins (Aptenodytes patagonicus) are monomorphic seabirds that possess conspicuous yellow–orange (YO) and ultraviolet (UV) beak spots that are...

Data from: Sex-specific effects of experimental ectoparasite infestation on telomere length in great tit nestlings

Barbara Tschirren, Ana Ángela Romero-Haro, Sandrine Zahn & François Cricuolo
Telomere length is a biomarker of biological ageing and lifespan in various vertebrate taxa. Evidence is accumulating that telomeres shorten more rapidly when an individual is exposed to environmental stressors. Parasites are potent selective agents that can cause physiological stress directly or indirectly through the activation of the host’s immune system. Yet to date, empirical evidence for a role of parasites in telomere dynamics in natural populations is limited. Here we show experimentally that exposure...

Flexible Viologen Cyclophanes: Odd/Even Effects on Intramolecular Interactions

Mathilde Berville, Sylvie Choua, Christophe Gourlaouen, Corinne Boudon, Laurent Ruhlmann, Corinne Bailly, Saioa Cobo, eric saint-aman, Jennifer Wytko & Jean WEISS
Abstract The ability of three bis-viologen cyclophanes to act as redox-triggered contractile switches is investigated. Odd/even effects in the formation of cyclic bis-viologens are circumvented by ...

Data from: Diffusion tensor imaging reveals diffuse white matter injuries in locked-in syndrome patients

Mylène L. Leonard, Felix R. Renard, Laura H. Harsan, Julien P. Pottecher, Marc B. Braun, Francis S. Schneider, Pierre F. Froehlig, Frédéric B. Blanc, Daniel R. Roquet, Sophie A. Achard, Nicolas M. Meyer & Stéphane K. Kremer
Locked-in syndrome (LIS) is a state of quadriplegia and anarthria with preserved consciousness, which is generally triggered by a disruption of specific white matter fiber tracts, following a lesion in the ventral part of the pons. However, the impact of focal lesions on the whole brain white matter microstructure and structural connectivity pathways remains unknown. We used diffusion tensor magnetic resonance imaging (DT-MRI) and tract-based statistics to characterise the whole white matter tracts in seven...

Data from: HMP-1/α-catenin promotes junctional mechanical integrity during morphogenesis

Thanh TK Vuong-Brender, Arthur Boutillon, David Rodriguez, Vincent Lavilley, Michel Labouesse & Thanh Thi Kim Vuong-Brender
Adherens junctions (AJs) are key structures regulating tissue integrity and maintaining adhesion between cells. During morphogenesis, junctional proteins cooperate closely with the actomyosin network to drive cell movement and shape changes. How the junctions integrate the mechanical forces in space and in time during an in vivo morphogenetic event is still largely unknown, due to a lack of quantitative data. To address this issue, we inserted a functional Fluorescence Resonance Energy Transfer (FRET)-based force biosensor...

Fluorescent Nanozeolite Receptors for the Highly Selective and Sensitive Detection of Neurotransmitters in Water and Biofluids

Laura Marie Grimm, Stephan Sinn, Marjan Krstić, Elisa D'Este, Ivo Sonntag, Eko Adi Prasetyanto, Thomas Kuner, Wolfgang Wenzel, Luisa De Cola & Frank Biedermann

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Affiliations

  • University of Strasbourg
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  • Institut De Physique Du Globe De Paris
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  • Commissariat à L'Énergie Atomique (CEA)
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  • Université de Strasbourg
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  • Université d'Antananarivo, Madagascar
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  • Vietnamese Academy Of Science And Technology (VAST), Vietnam
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