4 Works

Data from: Zinc supplementation inhibits complement activation in age-related macular degeneration

Dzenita Smailhodzic, Freekje Van Asten, Anna M. Blom, Frida C. Mohlin, Anneke I. Den Hollander, Johannes P. H. Van De Ven, Ramon A. C. Van Huet, Joannes M. M. Groenewoud, Yuan Tian, Tos T. J. M. Berendschot, Yara T. E. Lechanteur, Sascha Fauser, Chris De Bruijn, Mohamed R. Daha, Gert Jan Van Der Wilt, Carel B. Hoyng & B. Jeroen Klevering
Age-related macular degeneration (AMD) is the leading cause of blindness in the Western world. AMD is a multifactorial disorder but complement-mediated inflammation at the level of the retina plays a pivotal role. Oral zinc supplementation can reduce the progression of AMD but the precise mechanism of this protective effect is as yet unclear. We investigated whether zinc supplementation directly affects the degree of complement activation in AMD and whether there is a relation between serum...

Data from: Anthropogenic hybridization between endangered migratory and commercially harvested stationary whitefish taxa (Coregonus spp.)

Jan Dierking, Luke Phelps, Kim Præbel, Gesine Ramm, Enno Prigge, Jost Borcherding, Matthias Brunke & Christophe Eizaguirre
Natural hybridization plays a key role in the process of speciation. However, anthropogenic (human induced) hybridization of historically isolated taxa raises conservation issues. Due to weak barriers to gene flow and the presence of endangered taxa, the whitefish species complex is an excellent study system to investigate the consequences of hybridization in conservation. We focused on three naturally reproductively isolated whitefish taxa in Germany: the endangered, anadromous North Sea houting (NSH) and Baltic houting (BH),...

Data from: Metabarcoding vs. morphological identification to assess diatom diversity in environmental studies

Jonas Zimmermann, Gernot Glöckner, Regine Jahn, Neela Enke & Birgit Gemeinholzer
Diatoms are frequently used for water quality assessments; however, identification to species level is difficult, time-consuming and needs in-depth knowledge of the organisms under investigation, as nonhomoplastic species-specific morphological characters are scarce. We here investigate how identification methods based on DNA (metabarcoding using NGS platforms) perform in comparison to morphological diatom identification and propose a workflow to optimize diatom fresh water quality assessments. Diatom diversity at seven different sites along the course of the river...

Data from: Role of pleiotropy during adaptation of TEM-1 β-lactamase to two novel antibiotics

Martijn F. Schenk, Sariette Witte, Merijn L. M. Salverda, Bertha Koopmanschap, Joachim Krug & J. Arjan G. M. De Visser
Pleiotropy is a key feature of the genotype–phenotype map, and its form and extent have many evolutionary implications, including for the dynamics of adaptation and the evolution of specialization. Similarly, pleiotropic effects of antibiotic resistance mutations may affect the evolution of antibiotic resistance in the simultaneous or fluctuating presence of different antibiotics. Here, we study the role of pleiotropy during the in vitro adaptation of the enzyme TEM-1 β-lactamase to two novel antibiotics, cefotaxime (CTX)...

Registration Year

  • 2014
    4

Resource Types

  • Dataset
    4

Affiliations

  • University of Cologne
    4
  • Lund University
    1
  • Leibniz Institute of Freshwater Ecology and Inland Fisheries
    1
  • Landesamt für Landwirtschaft, Umwelt und ländliche Räume
    1
  • GEOMAR Helmholtz Centre for Ocean Research Kiel
    1
  • University of Giessen
    1
  • University of Copenhagen
    1
  • Freie Universität Berlin
    1
  • Wageningen University & Research
    1
  • Max Planck Institute for Evolutionary Biology
    1