59 Works

Supplemental data for: Late Sandbian (Sa2) radiolarians of the Pingliang Formation from the Guanzhuang section, Gansu Province, China

Siyumini Perera & Jonathan C. Aitchison
A diverse, well-preserved radiolarian assemblage is reported from the Sandbian age Climacograptus bicornis Graptolite Biozone. This new assemblage recovered from the Pingliang Formation in the Guanzhuang section, China includes six new species along with 13 other previously described taxa. Geminusphaera new genus incorporates G. grandis n. sp and G. kongtongensis n. sp. and is proposed for inaniguttids constructed from two distinct porous spheres bearing seven or more primary spines. Protopylentonema new genus is introduced to...

Global sediment export based on InVEST Sediment Delivery Ratio model

Andrés F. Suarez Castro, Hawthorne L. Beyer, Caitlin D. Kuempel, Simon Linke, Pasquale Borrelli & Ove Hoegh-Guldberg
Sediment runoff from disturbed coastal catchments is a major threat to marine ecosystems. Understanding where sediments are produced and where they are delivered enables managers to design more effective strategies for improving water quality. In this context, targeted restoration of degraded terrestrial areas provides opportunities to reduce land-based runoff from coastal areas and consequently foster coral reef conservation. To do this strategically, a systematic approach is needed to identify watersheds where restoration actions will provide...

A genome-wide association study of total child psychiatric problems scores: summary statistics

Alexander Neumann, Ilja M. Nolte, Irene Pappa, Tarunveer S. Ahluwalia, Erik Pettersson, Alina Rodriguez, Andrew J.O. Whitehouse, Catharina van Beijsterveldt, Beben Benyamin, Anke Hammerschlag, Quinta Helmer, Ville Karhunen, Eva Krapohl, Yi Lu, Peter van der Most, Teemu Palviainen, Beate St. Pourcain, Ilkka Seppälä, Anna Suarez, Natalia Vilor-Tejedor, Carla M. T. Tiesler, Carol Wang, Amanda Wills, Ang Zhou, Silvia Alemany … & Henning Tiemeier
Summary statistics for EAGLE GWAS on total child psychiatric problems scores.
Data is provided in R binary format and can be loaded within R with load("total_child_psychiatric_GWAS.Rdata").
snp: SNP RS ID effect_allele: Effect allele other_allele: Other allele beta: Change in total psychiatric problem score in SD per number of effect allele se: Standard Error p: p-value n: Sample Size
For more information, see PLOS ONE publication:
Neumann A, Nolte IM, [...], Hartman...

Investigating ethnic inequalities in hearing aid use in England and Wales: a cross-sectional study

Harry Taylor, Piers Dawes, Dharmi Kapadia, Nick Shryane & Paul Norman
To establish whether ethnic inequalities exist in levels of self-reported hearing difficulty and hearing aid use among middle-aged adults. Cross-sectional data from the UK Biobank resource. 164,460 participants aged 40–69 who answered hearing questions at an assessment centre in England or Wales. After taking into account objectively assessed hearing performance and a corresponding correction for bias in non-native English speakers, as well as a range of correlates including demographic, socioeconomic, and health factors, there were...

Post‐agriculture rain forest succession on a tropical Pacific island

Edward L. Webb, Avele Iofi Lalogafu’afu’a, Martin Van De Bult, Wei Kit Lee, Siaifoi Fa'aumu, Muhammad Izuddin, Mark A. MacDonald, Roger Meyer, Rachel Rui Ying Oh, Alden P. Tagarino, Rachel C. Webb, Adam C. Miles & Martin Bult
We surveyed the tree and seedling community in 34 vegetation plots in mature and >50 y old secondary lowland rain forest on the Polynesian island of Tutuila, American Samoa. The main data set includes original data from the tree surveys as well as all repeat surveys of seedling plots. We also include all R code and data sets used in analyses, including soil and environmental data, species by plot matrices for NMDS, and processed data...

Single molecule tracking videos: SOX18 and its dominant-negative mutant SOX18RaOp

Alex McCann, Jieqiong Lou, Mehdi Moustaqil, Matthew Graus, Ailisa Blum, Frank Fontaine, Hui Liu, Winnie Luu, Peter Koopman, Emma Sierecki, Yann Gambin, Frédéric Meunier, Zhe Liu, Elizabeth Hinde & Mathias Francois
Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly poorly understood. Here, we studied the genome-wide mechanism underlying a dominant-negative form of the SOX18 transcription factor (SOX18RaOp) responsible for both the classical mouse mutant Ragged Opossum and the human genetic disorder Hypotrichosis-Lymphedema-Telangiectasia-Renal Syndrome. Combining three single-molecule imaging...

Identification of key genes involved in the recurrence of glioblastoma multiforme using weighted gene co-expression network analysis and differential expression analysis

Peng Ren, JingYa Wang, Lei Li, XiaoWan Lin, GuangHan Wu, JiaYi Chen, ZhiRui Zeng & HongMei Zhang
Glioblastoma multiforme (GBM) is the most fatal malignancy, and despite extensive treatment, tumors inevitably recur. This study aimed to identify recurrence-associated molecules in GBM. The gene expression profile GSE139533, containing 70 primary and 47 recurrent GBM tissues and their corresponding clinical traits, was downloaded from the Gene Expression Omnibus (GEO) database and used for weighted gene co-expression network analysis (WGCNA) and differentially expressed gene (DEG) analysis. After identifying the hub genes which differentially expressed in...

Millennial-scale change on a Caribbean reef system that experiences hypoxia

Blanca Figuerola, Ethan L. Grossman, Noelle Lucey, Nicole D. Leonard & Aaron O'Dea
Coastal hypoxia has become an increasingly acknowledged threat to coral reefs that is potentially intensifying because of increased input of anthropogenic nutrients. Almirante Bay (Caribbean Panama) is a semi-enclosed system that experiences hypoxia in deeper waters which occasionally expand into shallow coral reefs, suffocating most aerobic benthic life. To explore the long-term history of reefs in the bay we extracted reef matrix cores from two reefs that today experience contrasting patterns of oxygenation. We constructed...

Cell membrane-anchored anti-HIV single-chain antibodies and bifunctional inhibitors targeting the gp41 fusion protein: new strategies for HIV gene therapy

Yue Chen, Hongliang Jin, Xiaoran Tang, Li Li, Xiuzhu Geng, Yuanmei Zhu, Huihui Chong & Yuxian He
Emerging studies indicate that infusion of HIV-resistant cells could be an effective strategy to achieve a sterilizing or functional cure. We recently reported that glycosylphosphatidylinositol (GPI)-anchored nanobody or a fusion inhibitory peptide can render modified cells resistant to HIV-1 infection. In this study, we comprehensively characterized a panel of newly isolated HIV-1-neutralizing antibodies as GPI-anchored inhibitors. Fusion genes encoding the single-chain variable fragment (scFv) of 3BNC117, N6, PGT126, PGT128, 10E8, or 35O22 were constructed with...

Registration Year

  • 2021

Resource Types

  • Dataset


  • University of Queensland
  • Shanghai Jiao Tong University
  • Nanjing Medical University
  • Tongji University
  • Second Affiliated Hospital of Zhejiang University
  • Shanghai Mental Health Center
  • Huazhong University of Science and Technology
  • Capital Medical University
  • University of Melbourne
  • Lanzhou University