215 Works

A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence

Hui-Li Yang, Zhen-Zhen Lai, Jia-Wei Shi, Wen-Jie Zhou, Jie Mei, Jiang-Feng Ye, Tao Zhang, Jian Wang, Jian-Yuan Zhao, Da-Jin Li & Ming-Qing Li
Massive infiltrated and enriched decidual macrophages (dMφ) have been widely regarded as important regulators of maternal-fetal immune tolerance and trophoblast invasion, contributing to normal pregnancy. However, the characteristics of metabolic profile and the underlying mechanism of dMφ residence remain largely unknown. Here, we observe that dMφ display an active glycerophospholipid metabolism. The activation of ENPP2-lysophosphatidic acid (LPA) facilitates the adhesion and retention, and M2 differentiation of dMφ during normal pregnancy. Mechanistically, this process is mediated...

A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence

Hui-Li Yang, Zhen-Zhen Lai, Jia-Wei Shi, Wen-Jie Zhou, Jie Mei, Jiang-Feng Ye, Tao Zhang, Jian Wang, Jian-Yuan Zhao, Da-Jin Li & Ming-Qing Li
Massive infiltrated and enriched decidual macrophages (dMφ) have been widely regarded as important regulators of maternal-fetal immune tolerance and trophoblast invasion, contributing to normal pregnancy. However, the characteristics of metabolic profile and the underlying mechanism of dMφ residence remain largely unknown. Here, we observe that dMφ display an active glycerophospholipid metabolism. The activation of ENPP2-lysophosphatidic acid (LPA) facilitates the adhesion and retention, and M2 differentiation of dMφ during normal pregnancy. Mechanistically, this process is mediated...

Additional file 2 of Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Additional file 2: Table S1. Descriptive statistics of phenotypic traits in natural populations.

Additional file 9 of Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Additional file 9: Table S8. Phenotypic data after 21 days of treatment.

Additional file 9 of Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Additional file 9: Table S8. Phenotypic data after 21 days of treatment.

Additional file 4 of Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Additional file 4: Table S3. Significant associated loci.

Additional file 8 of Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Additional file 8: Table S7. RNA-seq data of 58 genes.

Additional file 7 of Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Additional file 7: Table S6. RNA-seq data of the 14 differential expressed genes associated with nitrogen utilization.

Derivation and validation of a model to predict acute kidney injury following cardiac surgery in patients with normal renal function

Penghua Hu, Zhiming Mo, Yuanhan Chen, Yanhua Wu, Li Song, Li Zhang, Zhilian Li, Lei Fu, Huaban Liang, Yiming Tao, Shuangxin Liu, Zhiming Ye & Xinling Liang
The study aimed to construct a clinical model based on preoperative data for predicting acute kidney injury (AKI) following cardiac surgery in patients with normal renal function. A total of 22,348 consecutive patients with normal renal function undergoing cardiac surgery were enrolled. Among them, 15,701 were randomly selected for the training group and the remaining for the validation group. To develop a model visualized as a nomogram for predicting AKI, logistic regression was performed with...

Additional file 2 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 2. 1261 Differentially expressed genes between the WT and AF1_FFF uterus on GD3.

Additional file 11 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 11. qPCR Primer list.

Additional file 10 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 10. 1430 genes that are significantly regulated between EBP and Ctrl but not between EB and Ctrl.

Additional file 6 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 6. Common and unique EB regulated genes on GD 3 and GD 4.5.

Additional file 2 of Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Additional file 2: Table S2. The GO enrichment analysis of comparison analysis.

Additional file 5 of Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Additional file 5: Table S5. The GO enrichment analysis of coexpression modules.

Additional file 1 of Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Additional file 1: Table S1. Summary of sequencing quality.

Celastrol-based nanomedicine hydrogels eliminate posterior capsule opacification - Supplementary table

Ying Zhang, Ruixing Liu, Chengcheng Li, Liuqi Shi, Zhihua Guo, Lei Zhu, Wen Li, Jingguo Li & Zhanrong Li
Aim: To formulate an injectable thermosensitive micelle–hydrogel hybrid system loaded with celastrol (celastrol-loaded micelle hydrogel: CMG) to prevent posterior capsule opacification (PCO). Materials & methods: Celastrol-loaded micelles were embedded in a thermosensitive hydrogel matrix to enable controlled on-demand celastrol delivery into the residual capsule. The efficacy and mechanisms of the system for eliminating PCO were evaluated in rabbits. Results: Celastrol-loaded micelles inhibited the migration and proliferation of lens epithelial cells induced by TGF-β1. Celastrol prevents...

Celastrol-based nanomedicine hydrogels eliminate posterior capsule opacification - Supplementary table

Ying Zhang, Ruixing Liu, Chengcheng Li, Liuqi Shi, Zhihua Guo, Lei Zhu, Wen Li, Jingguo Li & Zhanrong Li
Aim: To formulate an injectable thermosensitive micelle–hydrogel hybrid system loaded with celastrol (celastrol-loaded micelle hydrogel: CMG) to prevent posterior capsule opacification (PCO). Materials & methods: Celastrol-loaded micelles were embedded in a thermosensitive hydrogel matrix to enable controlled on-demand celastrol delivery into the residual capsule. The efficacy and mechanisms of the system for eliminating PCO were evaluated in rabbits. Results: Celastrol-loaded micelles inhibited the migration and proliferation of lens epithelial cells induced by TGF-β1. Celastrol prevents...

Additional file 2 of A simplified multiplex methylated DNA testing for early detection of colorectal cancer in stool DNA

Yanmiao Dai, Guodong Zhao, Jun Yang, Xilang Zhou, Shangmin Xiong, Xirong Lu, Liming Gao, Jianfang Wu, Zouhua Xu, Sujuan Fei, Minxue Zheng & Hongwei Xu
Additional file 2: Supplemental Tables.

Label-free three-photon imaging of intact human cerebral organoids: Tracking early events in brain development and deficits in Rett Syndrome

Murat Yildirim, Chloe Delepine, Danielle Feldman, Vincent Pham, Stephanie Chou, Jacque Ip, Alexi Nott, Li-Huei Tsai, Guo-Li Ming, Peter So & Mriganka Sur
Human cerebral organoids are unique in their development of progenitor-rich zones akin to ventricular zones from which neuronal progenitors differentiate and migrate radially. Analyses of cerebral organoids thus far have been performed in sectioned tissue or in superficial layers due to their high scattering properties. Here, we demonstrate label-free three-photon imaging of whole, uncleared intact organoids (~2 mm depth) to assess early events of early human brain development. Optimizing a custom-made three-photon microscope to image...

Additional file 1 of A CT-based nomogram for differentiating invasive fungal disease of the lung from bacterial pneumonia

Meilin Gong, Jingmei Xu, Kang Li, Ke Li, Yuwei Xia, Yang Jing, Jiafei Chen, Jing Li, Jing Yang, Mingshan Du, Wenjing Hou, Yuan Ou, Lian Li & Wei Chen
Additional file 1. On the orininal data of the study.

Additional file 1 of Clinical value of fetal facial profile markers during the first trimester

Xiaofeng Zhou, Chunya Ji, Lingling Sun, Linliang Yin, Xuedong Deng, Qi Pan, Jun Zhang, Zhong Yang, Chenhan Zheng, Chen Ling, Liping Shi & Yanqing Wu
Additional file 1.

Learning Coefficient Heterogeneity over Networks: A Distributed Spanning-Tree-Based Fused-Lasso Regression

Xin Zhang, Jia Liu & Zhengyuan Zhu
Identifying the latent cluster structure based on model heterogeneity is a fundamental but challenging task arises in many machine learning applications. In this paper, we study the clustered coefficient regression problem in the distributed network systems, where the data are locally collected and held by nodes. Our work aims to improve the regression estimation efficiency by aggregating the neighbors’ information while also identifying the cluster membership for nodes. To achieve efficient estimation and clustering, we...

Additional file 3 of Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Additional file 3.

Corn 3D point clouds

Ying Zhang & Wei Su
This data are corn point clouds collected by Terrestrial laser scanning. They contain a total of 48 individual corn point clouds in three different growing seasons. The data format is pcd, and each point cloud data contains the (x,y,z) coordinates of the points.

Registration Year

  • 2022
    184
  • 2021
    12
  • 2020
    4
  • 2019
    5
  • 2018
    2
  • 2017
    1
  • 2016
    1
  • 2015
    2
  • 2014
    4

Resource Types

  • Dataset
    215

Affiliations

  • Chinese University of Hong Kong
    215
  • Chinese Academy of Sciences
    146
  • Zhejiang University
    129
  • University of Chinese Academy of Sciences
    120
  • Capital Medical University
    117
  • Central South University
    103
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    103
  • Sichuan University
    102
  • Peking University
    94
  • Southern Medical University
    93