Subfornical organ (SFO) is vital in chronic kidney disease (CKD) progression caused by high salt levels. The current study investigated the effects of high salt on phosphoproteomic changes in SFO in CKD rats. 5/6 nephrectomized rats were fed a normal-salt diet (0.4%) (NC group) or a high-salt diet (4%) (HC group) for three weeks, while sham-operated rats were fed a normal-salt diet (0.4%) (NS group). For phosphoproteomic analysis of SFO in different groups, TiO2 enrichment,...

Additional file 6: Fig S6. Standard Plot for ALA measurement. x: the absorbance at 554 nm; y: ALA concentration of sample after diluted (mg/L).

Additional file 3: Table S3. Codon-based tests for selection on Pvs230 in China–Myanmar border and Myanmar isolates.

Additional file 3.

Additional file 5.

Objectives: Spinal cord injury (SCI) is a most debilitating traumatic injury, and cytotherapy is a promising alternative treatment strategy. Here we investigated the effect and mechanism of adipose-derived stem/stromal cells (ASCs) with overexpressing brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) (BDNF-NT3) in combination with silk fibroin/chitosan scaffold (SFCS) in SCI. Methods: Female Sprague-Dawley rats were used as an SCI model. SFCS,SFCS and ASCs, or ASCs overexpressing NT3, BDNF, and BDNF-NT3 were implanted into SCI rats....

Additional file 1: Table S1. List of DNA primer sequences designed for qPCR.

Additional file 1.

Micronutrients are clinically important in managing COVID-19, and numerous studies have been conducted, but inconsistent findings exist. To explore the association between micronutrients and COVID-19. PubMed, Web of Science, Embase, Cochrane Library and Scopus for study search on July 30, 2022 and October 15, 2022. Literature selection, data extraction and quality assessment were performed in a double-blinded, group discussion format. Meta-analysis with overlapping associations were reconsolidated using random effects models, and narrative evidence was performed...

We consider the model-free feature screening problem that aims to discard non-informative features before downstream analysis. Most of the existing feature screening approaches have at least quadratic computational cost with respect to the sample size n, thus may suffer from a huge computational burden when n is large. To alleviate the computational burden, we propose a scalable model-free sure independence screening approach. This approach is based on the so-called sliced-Wasserstein dependency, a novel metric that...

Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C. parapsilosis has emerged in several countries, but little is known about the susceptibility profile in China or about mechanisms of resistance. Here, we investigated the echinocandin susceptibilities of 2523 C. parapsilosis isolates collected from China and further explored the resistance mechanism among echinocandin-resistant isolates. Anidulafungin exhibited the highest...

Source data of XRD, .hkl file from 3D electron diffraction, and electrolysis data.

Additional file 1: Table S1. The host range of the global top two most occurred Colletotrichum species. Data were largely retrieved on July 8, 2022 via website search at https://nt.ars-grin.gov/fungaldatabases/ and analyzed at https://www.iplant.cn/ . Y for hosted. Gray for common hosts shared by C. siamense and C. fructicola, orange for hosts of C. siamense only, light blue for those of C. fructicola. Letters in red for records from previous publication (Talhinhas and Baroncelli 2021).

Additional file 2. Details of identified rG4 in each rG4-seq library.

Additional file 4. The list of consensus rG4s across rG4-seq 2.0 libraries.

Additional file 8. Raw data of Figures.

Additional file 6: Table S1. The primer sequences uesd in RT-qPCR.

Additional file 1: Table S1. Primers used for qRT-PCR.

Additional file 4: Supplemental Table 3. Protein Ontology representation of SARS-CoV-2 proteins. Comparative information in RefSeq and UniProtKB is also provided.

Additional file 10: Table S9. Sequences of primers used in this study.

Additional file 5: Table S4. Annotation and haplotype analysis of associated genes.

Additional file 6: Table S5. Summary of RNA-seq data.

Additional file 6: Table S5. Summary of RNA-seq data.

The South Texas Early Prevention Study-PreK, a cluster randomized trial, explored the Bienestar Coordinated School Health Program’s influence on health variables in South Texas children. Factors associated with food insecurity (FI) were analyzed. Income-to-poverty ratio, income, and food assistance (FA) program participation were all associated with FI. Forty percent of families (257/643) reporting FI did not utilize FA. Of those families with FI, but who reported no FA participation, 31.8% were FA eligible. Families experiencing...

Human coronavirus NL63 (HCoV-NL63) is primarily associated with common cold in children, elderly and immunocompromised individuals. Outbreaks caused by HCoV-NL63 are rare. Here we report a cluster of HCoV-NL63 cases with severe lower respiratory tract infection that arose in Guangzhou, China, in 2018. Twenty-three hospitalized children were confirmed to be HCoV-NL63 positive, and most of whom were hospitalized with severe pneumonia or acute bronchitis. Whole genomes of HCoV-NL63 were obtained using next-generation sequencing. Phylogenetic and...