338 Works

Protective effect of brain-derived neurotrophic factor and neurotrophin-3 overexpression by adipose-derived stem cells combined with silk fibroin/chitosan scaffold in spinal cord injury

Wen-Chen Ji, Meng Li, Wan-Ting Jiang, Xing Ma & Jia Li
Objectives: Spinal cord injury (SCI) is a most debilitating traumatic injury, and cytotherapy is a promising alternative treatment strategy. Here we investigated the effect and mechanism of adipose-derived stem/stromal cells (ASCs) with overexpressing brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) (BDNF-NT3) in combination with silk fibroin/chitosan scaffold (SFCS) in SCI. Methods: Female Sprague-Dawley rats were used as an SCI model. SFCS,SFCS and ASCs, or ASCs overexpressing NT3, BDNF, and BDNF-NT3 were implanted into SCI rats....

Epidemiology, evolution, and biological characteristics of H6 avian influenza viruses in China

Xiaohao Xu, Qi Chen, Min Tan, Jia Liu, Xiyan Li, Lei Yang, Yuelong Shu, Dayan Wang & Wenfei Zhu
H6 avian influenza virus (AIV) is one of the most prevalent AIV subtypes in birds globally. To investigate the current situation and characteristics of H6 AIVs circulating in China, we analysed the epidemiology, genetic evolution and pathogenic features of this subtype. During 2000-2021, H6 subtype AIVs spread widely through Southern China and presented high host diversity. On analysing 171 H6 viruses isolated during 2009-2021, dynamic reassortments were observed among H6 and other co-circulating AIV subtypes,...

Additional file 2 of Enhanced transcriptome-wide RNA G-quadruplex sequencing for low RNA input samples with rG4-seq 2.0

Jieyu Zhao, Eugene Yui-Ching Chow, Pui Yan Yeung, Qiangfeng Cliff Zhang, Ting-Fung Chan & Chun Kit Kwok
Additional file 2. Details of identified rG4 in each rG4-seq library.

Additional file 4 of Enhanced transcriptome-wide RNA G-quadruplex sequencing for low RNA input samples with rG4-seq 2.0

Jieyu Zhao, Eugene Yui-Ching Chow, Pui Yan Yeung, Qiangfeng Cliff Zhang, Ting-Fung Chan & Chun Kit Kwok
Additional file 4. The list of consensus rG4s across rG4-seq 2.0 libraries.

Additional file 8 of Enhanced transcriptome-wide RNA G-quadruplex sequencing for low RNA input samples with rG4-seq 2.0

Jieyu Zhao, Eugene Yui-Ching Chow, Pui Yan Yeung, Qiangfeng Cliff Zhang, Ting-Fung Chan & Chun Kit Kwok
Additional file 8. Raw data of Figures.

Additional file 6 of Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Additional file 6: Table S5. Summary of RNA-seq data.

Additional file 6 of Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Additional file 6: Table S5. Summary of RNA-seq data.

Additional file 1 of Colletotrichum species pathogenic to strawberry: discovery history, global diversity, prevalence in China, and the host range of top two species

Ying Ji, Xue Li, Qing-Hua Gao, Chunnv Geng & Ke Duan
Additional file 1: Table S1. The host range of the global top two most occurred Colletotrichum species. Data were largely retrieved on July 8, 2022 via website search at https://nt.ars-grin.gov/fungaldatabases/ and analyzed at https://www.iplant.cn/ . Y for hosted. Gray for common hosts shared by C. siamense and C. fructicola, orange for hosts of C. siamense only, light blue for those of C. fructicola. Letters in red for records from previous publication (Talhinhas and Baroncelli 2021).

Additional file 4 of A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology

Yongqun He, Hong Yu, Anthony Huffman, Asiyah Yu Lin, Darren A. Natale, John Beverley, Ling Zheng, Yehoshua Perl, Zhigang Wang, Yingtong Liu, Edison Ong, Yang Wang, Philip Huang, Long Tran, Jinyang Du, Zalan Shah, Easheta Shah, Roshan Desai, Hsin-hui Huang, Yujia Tian, Eric Merrell, William D. Duncan, Sivaram Arabandi, Lynn M. Schriml, Jie Zheng … & Barry Smith
Additional file 4: Supplemental Table 3. Protein Ontology representation of SARS-CoV-2 proteins. Comparative information in RefSeq and UniProtKB is also provided.

Pyrite oxidation under carbonate buffer and its environmental implications: a case study from the Shangmanggang gold deposit, southwest China

Yanyan Wang, Xuemin Liu & Qi Li
Supplement 2: the size of pyrite and goethite from the SMG.

sj-xlsx-2-cat-10.1177_10760296221139258 - Supplemental material for Establishment of a Predictive Model for Poor Prognosis of Incomplete Revascularization in Patients with Coronary Heart Disease and Multivessel Disease

Huan Lian, Zhuoyan Zhao, Kelin Ma, Zhenjiang Ding, Lixian Sun & Ying Zhang
Supplemental material, sj-xlsx-2-cat-10.1177_10760296221139258 for Establishment of a Predictive Model for Poor Prognosis of Incomplete Revascularization in Patients with Coronary Heart Disease and Multivessel Disease by Huan Lian, Zhuoyan Zhao, Kelin Ma, Zhenjiang Ding, Lixian Sun and Ying Zhang in Clinical and Applied Thrombosis/Hemostasis

Protection of intestinal immune barrier against ischemia/reperfusion injury in a swine model using anisodamine hydrobromide

Guijuan Dong, Jun Yang, Xin Zhao & Shubin Guo
Abstract Intestinal ischemia/reperfusion (I/R) causes barrier impairment and bacterial influx. This study explored the protective effects of anisodamine hydrobromide (AH) on intestinal I/R injury caused by cardiopulmonary resuscitation (CPR) after cardiac arrest (CA). After successful CPR, minipigs were randomly divided into two groups (n = 8): saline and AH (4 mg/kg), and then treated with saline or AH via central venous injection, respectively. The same procedures without ventricular fibrillation initiation were conducted in the Sham...

Additional file 1 of Genes related to allergen exposure in allergic rhinitis: a gene-chip-based study in a mouse model

Min Wang, Ying Li, Jun Yang, Xiangdong Wang & Luo Zhang
Additional file 1: Table S1. Primers used for qRT-PCR.

Multimodal molecular imaging in the second near-infrared window - Supplementary material

Menglin Wu, Xue Li, Xiaoyu Mu, Xuening Zhang, Hao Wang & Xiao-Dong Zhang
Near-infrared-II (NIR-II) fluorescence imaging has rapidly developed for the noninvasive investigation of physiological and pathological activities in living organisms with high spatiotemporal resolution. However, the penetration depth of fluorescence restricts its ability to provide deep anatomical information. Scientists integrate NIR-II fluorescence imaging with other imaging modes (such as photoacoustic and magnetic resonance imaging) to create multimodal imaging that can acquire detailed anatomical and quantitative information with deeper penetration by using multifunctional probes. This review offers...

Multimodal molecular imaging in the second near-infrared window - Supplementary material

Menglin Wu, Xue Li, Xiaoyu Mu, Xuening Zhang, Hao Wang & Xiao-Dong Zhang
Near-infrared-II (NIR-II) fluorescence imaging has rapidly developed for the noninvasive investigation of physiological and pathological activities in living organisms with high spatiotemporal resolution. However, the penetration depth of fluorescence restricts its ability to provide deep anatomical information. Scientists integrate NIR-II fluorescence imaging with other imaging modes (such as photoacoustic and magnetic resonance imaging) to create multimodal imaging that can acquire detailed anatomical and quantitative information with deeper penetration by using multifunctional probes. This review offers...

Additional file 6 of NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia

Ningning She, Yewen Shi, Yani Feng, Lina Ma, Yuqi Yuan, Yitong Zhang, Zine Cao, Xi Chen, Bingjie Zhao, Haiqin Liu & Xiaoyong Ren
Additional file 6: Table S1. The primer sequences uesd in RT-qPCR.

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

Yating Ning, Meng Xiao, David S. Perlin, Yanan Zhao, Minya Lu, Yi Li, Zhengyu Luo, Rongchen Dai, Shengjie Li, Jiajun Xu, Lingli Liu, Hong He, Yun Liu, Fushun Li, Yuguang Guo, Zhongju Chen, Yingchun Xu, Tianshu Sun & Li Zhang
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C. parapsilosis has emerged in several countries, but little is known about the susceptibility profile in China or about mechanisms of resistance. Here, we investigated the echinocandin susceptibilities of 2523 C. parapsilosis isolates collected from China and further explored the resistance mechanism among echinocandin-resistant isolates. Anidulafungin exhibited the highest...

The Relationship Between Food Insecurity and Food Assistance Program Participation in Families of Preschool Children in the Rio Grande Valley

Lisa Michelle Belzer Salinas, Michael Machiorlatti, Zasha Romero, Lin Wang, Elizabeth Alanis & Roberto Treviño-Peña
The South Texas Early Prevention Study-PreK, a cluster randomized trial, explored the Bienestar Coordinated School Health Program’s influence on health variables in South Texas children. Factors associated with food insecurity (FI) were analyzed. Income-to-poverty ratio, income, and food assistance (FA) program participation were all associated with FI. Forty percent of families (257/643) reporting FI did not utilize FA. Of those families with FI, but who reported no FA participation, 31.8% were FA eligible. Families experiencing...

Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018

Yanqun Wang, Xin Li, Wenkuan Liu, Mian Gan, Lu Zhang, Jin Wang, Zhaoyong Zhang, Airu Zhu, Fang Li, Jing Sun, Guoxian Zhang, Zhen Zhuang, Jiaying Luo, Dehui Chen, Shuyan Qiu, Li Zhang, Duo Xu, Chris Ka Pun Mok, Fuchun Zhang, Jingxian Zhao, Rong Zhou & Jincun Zhao
Human coronavirus NL63 (HCoV-NL63) is primarily associated with common cold in children, elderly and immunocompromised individuals. Outbreaks caused by HCoV-NL63 are rare. Here we report a cluster of HCoV-NL63 cases with severe lower respiratory tract infection that arose in Guangzhou, China, in 2018. Twenty-three hospitalized children were confirmed to be HCoV-NL63 positive, and most of whom were hospitalized with severe pneumonia or acute bronchitis. Whole genomes of HCoV-NL63 were obtained using next-generation sequencing. Phylogenetic and...

Erxian herbal pair enhances bone formation in infected bone nonunion models and attenuates lipopolysaccharide-induced osteoblastinhibition by regulating miRNA-34a-5p

Li Zhang, Yang Zhang, Maomao Miao, Shaoqi Hu, Xuping Wang, Lisha Zhao, Xiaowen Huang, Gang Cao & Dan Shou
Bacterium-induced inflammatory responses cause bone nonunion. Although antibiotics suppress infection, bone loss after antibacterial treatment remains a critical challenge. Erxian herbal pair (EHP) has been proven effective in promoting bone formation. Our study aimed to investigate the effect of EHP on bone repair after anti-infection treatment, explore its effect on a lipopolysaccharide (LPS)-induced osteoblast. We evaluated effects of EHP on bone repair with Micro-CT, and morphology detecting. Chemical constituents of EHP and EHP-containing serum (EHP-CS)...

Mapping seagrass meadows in coastal China using GEE

Qi Li, Runjie Jin, Zhanjiang Ye, Jiali Gu, Li Dan, Junyu He, George Christakos, Susana Agusti, Carlos M. Duarte & Jiaping Wu
Seagrass meadows are virtual blue carbon ecosystems facing a dramatic decline on a global scale. Tracking the status and trends of seagrass meadows, which is still pending on large scales, is an emerging priority for their conservation and restoration. Here, we develop a semi-automatic procedure to identify and map seagrass meadows. Using Sentinel-2 data in Google Earth Engine (GEE) platform, a map is generated, showing a total of 11113.4 ha of seagrass meadows in coastal...

Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling

Dan Zhao, Cong Shen, Tingting Gao, Hong Li, Yueshuai Guo, Feng Li, Chenchen Liu, Yuanyuan Liu, Xia Chen, Xi Zhang, Yangyang Wu, Yi Yu, Meng Lin, Yan Yuan, Xiaofang Chen, Xiaoyan Huang, Shenmin Yang, Jun Yu, Jun Zhang & Bo Zheng
Myotubularin related protein 7 (MTMR7), a key member of the MTMR family, depicts phosphatase activity and is involved in myogenesis and tumor growth. We have previously identified MTMR7 in the proteomic profile of mouse spermatogonial stem cell (SSC) maturation and differentiation, implying that MTMR7 is associated with neonatal testicular development. In this study, to further explore the distribution and function of MTMR7 in mouse testis, we studied the effect of Mtmr7 knockdown on neonatal testicular...

Evolutionary biogeography of the reef-building coral genus Galaxea across the Indo-Pacific ocean

Patricia Wepfer, Yuichi Nakajima, Makamas Sutthacheep, Veronica Z. Radice, Zoe Richards, Put Ang, Tullia Terraneo, Mareike Sudek, Atsushi Fujimura, Robert J. Toonen, Alexander S. Mikheyev, Evan P. Economo & Satoshi Mitarai
Stony corals (Scleractinia) form the basis for some of the most diverse ecosystems on Earth, but we have much to learn about their evolutionary history and systematic relationships. In order to improve our understanding of species in corals, we here investigated phylogenetic relationships between morphologically defined species and genetic lineages in the genus Galaxea (Euphyllidae) using a combined phylogenomic and phylogeographic approach. Previous studies revealed the nominal species G. fascicularis included three genetically well-differentiated lineages...

IncRNA ZFAS1 contributes to the radioresistance of nasopharyngeal carcinoma cells by sponging hsa-miR-7-5p to upregulate ENO2

Jiaojiao Peng, Feng Liu, Hong Zheng, Qi Wu & Shixi Liu
Previous research revealed that lncRNA ZFAS1 could promote nasopharyngeal carcinoma (NPC) by inhibiting its downstream target axis. However, the association between ZFAS1 and radioresistant NPC cells is unclear. This study aimed to explore the roles of ZFAS1 in the radioresistance of NPC. Bioinformatics analysis was conducted to identify the significant factors (ENO2 and miR-7-5p) that contributed to the radioresistance of NPC cells. After performing qRT-PCR analysis, we found that the expression of ZFAS1 and ENO2...

Government management capacities and the containment of COVID-19: A repeated cross-sectional study across Chinese cities

Wenchao Li, Jing Li & Junjian Yi
Objectives: Better understanding of the dynamics of the COVID-19 (2019-novel coronavirus disease) pandemic to curb its spread is now a global imperative. While travel restrictions and control measures have been shown to limit the spread of the disease spread, the effectiveness of the enforcement of those measures should depend on the strength of the government. Whether, and how, the government plays a role in fighting the disease, however, has not been investigated. Here, we show...

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