338 Works

Dietary analysis of the House Swift, Apus nipalensis, in Hong Kong using prey DNA in faecal samples

Chun Ting Chung, Hok Sze Wong, Man Long Kwok, Qi Meng & King Ming Chan
Background To understand the dietary composition of the highly aerial swift (Apodidae), ecologists conventionally depend on the morphological identification of prey items from food boluses or stomach contents, but these techniques are often invasive, require expertise in identification, and often cannot produce accurate identifications at the species level. Methods In this study, DNA barcoding was used to analyse the dietary composition of House Swifts (Apus nipalensis) in Hong Kong. Faecal samples from five different colonial...

Effects of inoculation concentration, photoperiod and temperature on growth, conidiation and conidial germination of Bionectria ochroleuca

Yi Zheng, Yichun Xie, Yan Xie & Shixiao Yu
The short-term stock of Bionectria ochroleuca ochroleuca at 4°C was activated, sub-cultured, and grown at 25°C on PDA medium for 10 days to obtain a working culture. To determine the effect of temperature on fungal growth, the plates were incubated at 15, 20, 25, and 30°C under continuous darkness or an 8 h light/16 h dark regime for 10 days. To investigate the effect of photoperiod on fungal growth and reproduction, fungal cultures were incubated...

Sweeping analysis of transcript profile in Dengue virus serotype 3 infection and Antibody-Dependent Enhancement of Infection

Mingwang Long, Yue Pan, Junying Chen, Fan Jia, Han Wang, Daiying Li, Kai feng, Lingmei Yan, Xiaodan Wang, Xuelei Ning, Lijuan Qiu, Juan Zhang & Qiangming Sun
Dengue virus infection mainly causes dengue hemorrhagic fever (DHF) and/or dengue shock syndrome (DSS). However, ADE (antibody-dependent enhancement) is one of the main pathogenic factors, and its pathogenic mechanism has not been fully elucidated. Recently, with the development of high-throughput sequencing, an increased number of RNAs have been confirmed to play a vital regulatory role in the process of virus infection. However, there is a lack of research on dengue virus infection and ADE. In...

Quantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains

Hong Wang, Li Wan, Jiahui Shi, Tao Zhang, Huiming Zhu, Songhao Jiang, Shuhong Meng, Shujia Wu, Jinshuai Sun, Lei Chang, Liqun Zhang, Kanglin Wan, Jiaqi Yang, Xiuqin Zhao, Haican Liu, Yao Zhang, Erhei Dai & Ping Xu
Although members of the Mycobacterium tuberculosis complex (MTBC) exhibit high similarity, they are characterized by differences with respect to virulence, immune response, and transmissibility. To understand the virulence of these bacteria and identify potential novel therapeutic targets, we systemically investigated the total cell protein contents of virulent H37Rv, attenuated H37Ra, and avirulent M. bovis BCG vaccine strains at the log and stationary phases, based on tandem mass tag (TMT) quantitative proteomics. Data analysis revealed that...

Identification of microRNA hsa-miR-30c-5p as an inhibitory factor in the progression of hepatocellular carcinoma and investigation of its regulatory network via comprehensive analysis

Shangshang Hu, Jinyan Zhang, Xiaoyu Fang, Guoqing Guo, Jing Dai, Zhiyong Sheng, Dongdong Li, Jiasheng Chen, Li Zhang, Chuanmiao Liu & Yu Gao
Hepatocellular carcinoma (HCC) is a primary liver cancer with high morbidity and mortality. An increasing number of abnormal gene expressions were identified to be associated with the progression of HCC. Previous studies showed that the hsa-miR-30 c-5p (miR-30 c), one of the miR-30 family members, might play a role in suppressing tumor progression in a variety of tumors. The present study aims to examine miR-30 c effects in the development of HCC. The role of...

Uncovering antiobesity-related hypertension targets and mechanisms of metformin, an antidiabetic medication

Lu Yang, Jianxin Yang, Xiao Liang, Wenjun Huang, Xiaoxi Zhang & Rong Li
Metformin, a common clinical drug used to treat diabetes mellitus, is found with potential antiobese actions as reported in increasing evidences. However, the detailed mechanisms of metformin-antiobesity-related hypertension remain unrevealed. We have utilized the bioinformatics strategy, including network pharmacology and molecular docking analyses, to uncover pharmacological targets and molecular pathways of bioactive compounds against clinical disorders, such as cancers, coronavirus disease 2019. In this report, the in-silico approaches using network pharmacology and molecular docking was...

Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis

Qijin Pan, Ka Wu, Jiachang Tan, Yu Li, Xiao Liang & Min Su
Environmentally, bisphenol A (BPA) is a well-known pollutant caused human health risk, including osteosarcoma (OS). OS, a deadly bone neoplasia, may occur in children and adults. However, the anti-OS pharmacotherapy prescribes limitedly in clinical practice. Interestingly, previous experimental evidences indicate calycosin-exerting potential anti-OS actions. Thus, in this report, we aimed to further characterize and detail the therapeutic targets and molecular mechanisms of calycosin-anti-BPA-related OS by using network pharmacology and molecular docking analyses. In results, the...

Quantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains

Hong Wang, Li Wan, Jiahui Shi, Tao Zhang, Huiming Zhu, Songhao Jiang, Shuhong Meng, Shujia Wu, Jinshuai Sun, Lei Chang, Liqun Zhang, Kanglin Wan, Jiaqi Yang, Xiuqin Zhao, Haican Liu, Yao Zhang, Erhei Dai & Ping Xu
Although members of the Mycobacterium tuberculosis complex (MTBC) exhibit high similarity, they are characterized by differences with respect to virulence, immune response, and transmissibility. To understand the virulence of these bacteria and identify potential novel therapeutic targets, we systemically investigated the total cell protein contents of virulent H37Rv, attenuated H37Ra, and avirulent M. bovis BCG vaccine strains at the log and stationary phases, based on tandem mass tag (TMT) quantitative proteomics. Data analysis revealed that...

Geochronology and Sr-Nd-Pb-Hf isotopic geochemistry of middle-late Permian granitic and volcanic rocks within the eastern margin of the Khanka Massif: petrogenesis and implications for the tectonic nature

Chen-Ying Sui, Feng Wang, Wen-Liang Xu, Yi-Ni Wang, A.A. Sorokin, A.V. Grebennikov & I.V. Kemkin
The Khanka Massif forms the easternmost part of the Central Asian Orogenic Belt (CAOB) and represents an ideal location for examination of the timing and processes involved in the transition from the Palaeo-Asian to Palaeo-Pacific Ocean tectonic systems. However, it is obstructed because the late Palaeozoic tectonic attributes of the eastern margin of this massif remain unclear. In this paper, we provide zircon U-Pb ages and Hf isotopic, as well as the whole-rock Sr-Nd-Pb-Hf isotopic...

Analysis of the different characteristics between omental preadipocytes and differentiated white adipocytes using bioinformatics methods

Xinyu Yang, Lu Li, Canming Xu, Meichen Pi, Changhua Wang & Yemin Zhang
Obesity is emerging as an epidemiological issue, being associated with the onset and progress of various metabolism-related disorders. Obesity is characterized by the white adipose expansion, which encounters white adipocyte hypertrophy and hyperplasia. White adipocyte hyperplasia is defined as adipogenesis with the increase in the number of the white adipocytes from the preadipocytes. Adipogenesis contributes to distributing excess triglycerides among the smaller newly formed adipocytes, reducing the number of hypertrophic adipocytes and secreting anti-inflammatory factor....

Numerical investigation of asymmetric weld fusion geometry in laser welding of aluminium alloy with beam oscillation

Xi Chen, Nan Jiang, Meng Jiang, Yang Du, Shengchong Ma, Yuan Chen, Caiwang Tan, Zhenglong Lei, Sicong Zhao & Yanbin Chen
In this work, the asymmetric weld fusion geometry in oscillating laser beam welding (OLBW) of aluminium alloy was reported and investigated using a numerical approach. A multi-physics heat transfer and fluid flow model of OLBW was developed and validated with the corresponding experimental results. The weld fusion geometry, temperature fields, and fluid flow behaviours for four commonly used oscillation modes, line, circle, eight, and infinity, were calculated to analyse the origin of the asymmetric weld...

A review of building detection from very high resolution optical remote sensing images

Jiayi Li, Xin Huang, Lilin Tu, Tao Zhang & Leiguang Wang
Building detection from very high resolution (VHR) optical remote sensing images, which is an essential but challenging task in remote sensing, has attracted increased attention in recent years. However, despite the many methods that have been developed, an in-depth review of the recent literature on building extraction from VHR optical images is still lacking. In this article, we present a comprehensive review of the recent advances (since 2000) in this field. In total, we survey...

Self-reported effects of perceived social support on marital quality in balanced translocation patients and their spouses undergoing preimplantation genetic testing in China: actor–partner interdependence model

Fengyi Mo, Xiaorui Hu, Qing Ma, Li Zhang & Lanfeng Xing
This study aimed to analyse the relationship between perceived social support and marital quality in balanced translocation patients and their spouses undergoing a preimplantation genetic testing (PGT) treatment cycle in China. The authors assessed the actor and partner effects of perceived social support on marital quality in patient–spouse dyads using a dyadic analysis approach. In total, 59 couples were assessed using self-report questionnaires for marital quality and perceived social support. There were significant differences in...

Additional file 2 of Proteomic alterations associated with residual disease in neoadjuvant chemotherapy treated ovarian cancer tissues

Emily R. Penick, Nicholas W. Bateman, Christine Rojas, Cuauhtemoc Magana, Kelly Conrads, Ming Zhou, Brian L. Hood, Guisong Wang, Niyati Parikh, Ying Huang, Kathleen M. Darcy, Yovanni Casablanca, Paulette Mhawech-Fauceglia, Thomas P. Conrads & G. Larry Maxwell
Additional file 2: Table S1. Proteins significantly altered between post versus pre-NACT tissues (LIMMA p-value<0.01). Table S2. Proteins significantly altered between R1 versus R0 patients in pre-NACT tissues (LIMMA p-value<0.05). Table S3. Significantly (LIMMA p<0.05) co-altered proteins between pre-NACT tumors from patients with any level of residual disease vs R0 patients from an independent ovarian cancer cohort (CPTAC 2016) that exhibit highly correlated abundance trends with the present ovarian cancer cohort. Table S4. Diseases and...

Additional file 6 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 6. Common and unique EB regulated genes on GD 3 and GD 4.5.

Additional file 11 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 11. qPCR Primer list.

Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284

Huimin Wang, Dan Wang, Qiong Wei, Chun Li, Chunyan Li & Jing Yang
Long non-coding RNAs (lncRNAs) have been widely studied and play crucial roles in cervical cancer (CC) progression. Here, we investigated the function and mechanism of lncRNA PGM5-AS1 action in CC cells. Using real-time quantitative polymerase chain reaction or western blotting, PGM5-AS1 and decorin (DCN) were downregulated in CC tissues and cells, whereas miR-4284 was upregulated. Luciferase assay, RNA pull-down assay, and western blotting showed that PGM5-AS1 could sponge miR-4284 to upregulate DCN expression in CC...

Comprehensive comparative analysis and expression profiles and effects on physiological response of DEAD-box RNA helicase genes in Lumnitzera littorea (Jack) Voigt under cold stress

LuLu Hao, Ying Zhang, Yin Li, Linxia Bai, Danfei Yue, Huiyu Zhang & Chunfang Zheng
The DEAD-box family has been shown to play an important role in a variety of abiotic stresses, but little is known in studies of mangrove plants. Here, the effects of cold stress on various physiological changes and the role of the DEAD-box RNA helicase family in response to cold stress were determined. First, we identified 73 DEAD-box RNA helicase family members in L. littorea. Second, the evolutionary relationships between the DEAD family in L. littorea...

Comprehensive understanding of guest compound intercalated layered double hydroxides: Design and applications in removal of potentially toxic elements

Shihao Cui, Yutao Peng, Xiao Yang, Xing Gao, Chung-Yu Guan, Beibei Fan, Xue Zhou & Qing Chen
Layered double hydroxides (LDHs) and LDHs-derived materials are emerging as potential engineered adsorbents for the protection of water environment. Particularly, LDHs intercalated with different guest compounds (GC-LDHs), which differ from traditional interlayer anions (such as Cl−, SO42−, NO3−, CO32−, and PO43−), are widely reported by recent studies showing their promising multifunctional roles in water purification. Herein, this review systematically presents the synthesis methods and characterization techniques of GC-LDHs and their application as adsorbents in removing...

Comprehensive comparative analysis and expression profiles and effects on physiological response of DEAD-box RNA helicase genes in Lumnitzera littorea (Jack) Voigt under cold stress

LuLu Hao, Ying Zhang, Ying Li, Linxia Bai, Danfei Yue, Huiyu Zhang & Chunfang Zheng
The DEAD-box family has been shown to play an important role in a variety of abiotic stresses, but little is known in studies of mangrove plants. Here, the effects of cold stress on various physiological changes and the role of the DEAD-box RNA helicase family in response to cold stress were determined. First, we identified 73 DEAD-box RNA helicase family members in L. littorea. Second, the evolutionary relationships between the DEAD family in L. littorea...

LncRNA-UCA1 regulates lung adenocarcinoma progression through competitive binding to miR-383

Li Tang, Sheng Wang, Yapeng Wang, Kang Li & Qiang Li
The present study aimed to assess the role of the long non-coding RNA-urothelial cancer associated 1 (lncRNA-UCA1)/microRNA (miR)-383/vascular endothelial growth factor A (VEGFA) axis in regulating lung adenocarcinoma physiology through in vivo and in vitro experiments. The expression profile of lncRNA-UCA1 was analyzed by genome-wide analysis from GSE146459. The cell counting Kit-8, colony formation, wound healing and transwell assays were performed to evaluate the effects of lncRNA-UCA1 in vitro. In addition, luciferase reporter assays were...

A comprehensive suite of earthquake catalogues for the 2016-2017 Central Italy seismic sequence

Lauro Chiaraluce, Maddalena Michele, Felix Waldhauser, Yen Joe Tan, Marcus Herrmann, Daniele Spallarossa, Gregory Beroza, Claudio Chiarabba, Pasquale De Gori, Raffaele Di Stefano, William Ellsworth, Ian Main, Simone Mancini, Lucia Margheriti, Warner Marzocchi, Men-Andrin Meyer, Davide Scafidi, David Schaff & Margarita Segou
A set of six large catalogues documenting the seismic sequence that occurred in central Italy between 2016 and 2017, characterized by a cascade of four MW5.5–6.5 events. The earthquake catalogues possess different levels of resolution and completeness that result from progressive enhancements in both detection sensitivity and hypocentral location determination. These quality differences reflect the subsequent application of advanced methods.

Mitogenome-wide association study on body measurement traits of Wenshang Barred chickens

Dan Wang, Jun Teng, Chao Ning, Wenwen Wang, Shuai Liu, Qin Zhang & Hui Tang
Mitochondria are best known for synthesizing ATP through the tricarboxylic acid cycle and oxidative phosphorylation. The cytoplasmic mitochondrial DNA (mtDNA) is important for maintaining the function. This study was designed to reveal the effect of mtDNA on chicken body measurement traits (BMTs). A population of 605 Wenshang Barred chickens were recorded BMTs, including body slope length, keel length, chest width, etc. The single-nucleotide polymorphisms (SNPs) of their mitogenomes were detected by PCR amplification and DNA...

Effect of Multi-Pass Rolling on the Performance of AZ31 Magnesium Alloy Anode in Mg-Air Battery

Jinchao Zou, Junpeng Wang, Zhiquan Huang & Tao Zhang
In this work, the influence of rolling passes on microstructure, corrosion behavior, electrochemical performance, and battery performance of AZ31 magnesium alloy was studied. The experimental results show that the grain size decreases first and then increases with rolling passes. Among them, the grain size of three passes rolled sample is the smallest, while the grain size of the four passes rolled sample is obviously refined and evenly distributed, accompanied by a small number of twins....

Additional file 8 of Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Additional file 8: Table S7. RNA-seq data of 58 genes.

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