Encapsulation of ribozymes inside model protocells leads to faster evolutionary adaptation

Yei-Chen Lai, Ziwei Liu & Irene Chen
Functional biomolecules, such as RNA, encapsulated inside a protocellular membrane are believed to have comprised a very early, critical stage in the evolution of life, since membrane vesicles allow selective permeability and create a unit of selection enabling cooperative phenotypes. The biophysical environment inside a protocell would differ fundamentally from bulk solution, due to the microscopic confinement. However, the effect of the encapsulated environment on ribozyme evolution has not been previously studied experimentally. Here we...

Registration Year

  • 2021
    1

Resource Types

  • Dataset
    1

Affiliations

  • MRC Laboratory of Molecular Biology
    1
  • University of California Los Angeles
    1