5 Works

Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes

Evan Janzen, Yuning Shen, Alberto Vazquez-Salazar, Ziwei Liu, Celia Blanco, Josh Kenchel & Irene Chen
The emergence of the genetic code was a major transition in the evolution from a prebiotic RNA world to the earliest modern cells. A prominent feature of the standard genetic code is error minimization, or the tendency of mutations to be unusually conservative in preserving biophysical features of the amino acid. While error minimization is often assumed to result from natural selection, it has also been speculated that error minimization may be a by-product of...

Data from: Neuropeptide signalling shapes feeding and reproductive behaviours in male C. elegans

Matthew Gadenne, Iris Hardege, Eviatar Yemini, Djordji Suleski, Paris Jaggers, Isabel Beets, William Schafer & Yee Lian Chew
Sexual dimorphism occurs where different sexes of the same species display differences in characteristics not limited to reproduction. For the nematode Caenorhabditis elegans, in which the complete neuroanatomy has been solved for both hermaphrodites and males, sexually dimorphic features have been observed both in terms of the number of neurons and in synaptic connectivity. In addition, male behaviours, such as food-leaving to prioritise searching for mates, have been attributed to neuropeptides released from sex-shared or...

Deep sequencing data for document titled: Rolling circle RNA synthesis catalysed by RNA

Emil L. Kristoffersen
RNA-catalysed RNA replication is widely considered a key step in the emergence of life’s first genetic system. However, RNA replication can be impeded by the extraordinary stability of duplex RNA products, which must be dissociated for re-initiation of the next replication cycle. Here we have explored rolling circle synthesis (RCS) as a potential solution to this strand separation problem. RCS on small circular RNAs - as indicated by molecular dynamics simulations - induces a progressive...

Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation

Henning J Falk, Takehito Tomita, Gregor Moenke, Katie McDole & Alexander Aulehla
A fundamental requirement for embryonic development is the coordination of signaling activities in space and time. A notable example in vertebrate embryos is found during somitogenesis, where gene expression oscillations linked to the segmentation clock are synchronized across cells in the presomitic mesoderm (PSM) and result in tissue-level wave patterns. To examine their onset during mouse embryo development, we studied the dynamics of the segmentation clock gene Lfng during gastrulation. To this end, we established...

Data supplement to: Quality control of image sensors using gaseous tritium light sources

David McFadden, Brad Amos & Rainer Heintzmann
In the article “Quality Control of Image Sensors using Gaseous Tritium Light Sources” (https://doi.org/10.1098/rsta.2021.0130) we propose a practical method for radiometrically calibrating cameras using widely available gaseous tritium light sources (betalights). This dataset includes all the recorded data along with the scripts necessary to reproduce the results and figures.

Registration Year

  • 2022

Resource Types

  • Dataset


  • MRC Laboratory of Molecular Biology
  • University of Wollongong
  • Flinders University
  • Leibniz Institute of Photonic Technology
  • University of California, Santa Barbara
  • European Molecular Biology Laboratory
  • University of Massachusetts Medical School
  • University of California Los Angeles
  • KU Leuven
  • Friedrich Schiller University Jena