Data from: The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals

David W. Johnson, Jesse R. Llop, Sara F. Farrell, Jie Yuan, Lindsay R. Stolzenburg & Andrew Vaughn Samuelson
The Myc family of transcription factors regulates a variety of biological processes, including the cell cycle, growth, proliferation, metabolism, and apoptosis. In Caenorhabditis elegans, the “Myc interaction network” consists of two opposing heterodimeric complexes with antagonistic functions in transcriptional control: the Myc-Mondo:Mlx transcriptional activation complex and the Mad:Max transcriptional repression complex. In C. elegans, Mondo, Mlx, Mad, and Max are encoded by mml-1, mxl-2, mdl-1, and mxl-1, respectively. Here we show a similar antagonistic role...

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  • Northwestern University
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  • Rochester Institute of Technology
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  • University of Rochester
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