28 Works

Rare missense functional variants at COL4A1 and COL4A2 in sporadic intracerebral hemorrhage

Jaeyoon Chung, Graham Hamilton, Minsup Kim, Sandro Marini, Bailey Montgomery, Jonathan Henry, Art Cho, Devin Brown, Bradford Worrall, James Meschia, Scott Silliman, Magdy Selim, David Tirschwell, Chelsea Kidwell, Brett Kissela, Steven Greenberg, Anand Viswanathan, Joshua Goldstein, Carl Langefeld, Kristiina Rannikmae, Catherine Sudlow, Neshika Samarasekera, Mark Rodrigues, Rustam Salman, James Prendergast … & Christopher Anderson
Objective To test the genetic contribution of rare missense variants in COL4A1 and COL4A2 in which common variants are genetically associated with sporadic intracerebral hemorrhage (ICH), we performed rare variant analysis in multiple sequencing data for the risk for sporadic ICH. Methods We performed sequencing across 559Kbp at 13q34 including COL4A1 and COL4A2 among 2,133 individuals (1,055 ICH cases; 1,078 controls) in US-based and 1,492 individuals (192 ICH cases; 1,300 controls) from Scotland-based cohorts, followed...

We are what we eat, plus some per mill: Using stable isotopes to estimate diet composition in Gyps vultures over space and time

Allan Baino, Grant Hopcraft, Corinne Kendall, Linus Munishi, Abdelkader Behdenna, Jason Newton & Thomas Morrison
1. Dietary studies in birds of prey involve direct observation and examination of food remains at resting and nesting sites. Although these methods accurately identify diet in raptors, they are time consuming, resource intensive and associated with biases that stem from the feeding ecology of raptors like Gyps vultures (Gyps africanus and Gyps rueppelli). Our study set out to estimate diet composition in Gyps vultures informed by stable isotopes that provide a good representation of...

Data from: High heritability of telomere length and low heritability of telomere shortening in wild birds

Christina Bauch, Jelle J. Boonekamp, Peter Korsten, Ellis Mulder & Simon Verhulst
Telomere length and telomere shortening predict survival in many organisms. This raises the question of the contribution of genetic and environmental effects to variation in these traits, which is still poorly known, particularly for telomere shortening. We used experimental (cross-fostering) and statistical (quantitative genetic ‘animal’ models) means to disentangle and estimate genetic and environmental contributions to telomere length variation in pedigreed free-living jackdaws (Corvus monedula). Telomere length was measured twice in nestlings, at ages 4...

Data tables for carbon in global Palaeoproterozoic black shales

John Parnell & Connor Brolly
4 tables, and accompanying references, from paper entitled ‘Increased biomass and carbon burial 2 billion years ago triggered mountain building’. Tables record orogen depositional ages, deformation ages, Total Organic Carbon contents and organic carbon isotope compositions, for 20 orogens of Palaeoproterozoic age.

Loop mediated isothermal amplification as a powerful tool for early diagnosis of hepatitis C virus

Weronika Witkowska McConnell, Chris Davis, Suleman Sabir, Alice Garrett, Amanda Bradley-Stewart, Pawel Jajesniak, Julien Reboud, Gaolian Xu, Zhugen Yang, Rory Gunson, Emma Thomson & Jonathan Cooper

Reservoir dynamics of rabies in Southeast Tanzania and the roles of cross-species transmission and domestic dog vaccination

Kennedy Lushasi, Sarah Hayes, Elaine A Ferguson, Joel Changalucha, Sarah Cleaveland, Nicodem J Govella, Daniel T Haydon, Sambo Maganga, Geofrey J Mchau, Emmanuel A Mpolya, Zacharia Mtema, Hesron E Nonga, Rachel Steenson, Pierre Nouvellet, Christl A Donnelly & Katie Hampson
Understanding the role of different species in the transmission of multi-host pathogens, such as rabies virus, is vital for effective control strategies. Across most of sub-Saharan Africa domestic dogs (Canis familiaris) are considered the reservoir for rabies, but the role of wildlife has been long debated. Here we explore the multi-host transmission dynamics of rabies across southeast Tanzania. Between January 2011 and July 2019 data on probable rabies cases were collected in the regions of...

Diet and temperature modify the relationship between energy use and ATP production to influence behaviour in zebrafish (Danio rerio)

Amélie Le Roy, Geoffrey Mazué, Neil Metcalfe & Frank Seebacher
Food availability and temperature influence energetics of animals, and can alter behavioural responses such as foraging and spontaneous activity. Food availability, however, is not necessarily a good indictator of energy (ATP) available for cellular processes. The efficiency of energy transduction from food-derived substrate to ATP in mitochondria can change with environmental context. Our aim was to determine whether the interaction between food availability and temperature affects mitochondrial efficiency and behaviour in zebrafish (Danio rerio). We...

Color of artificial light at night affects incubation behavior in the great tit, Parus major

Natalie Van Dis, Kamiel Spoelstra, Marcel Visser & Davide Dominoni
Artificial light at night (ALAN) has been recognized as a biodiversity threat due to the drastic effects it can have on many organisms. In wild birds, artificial illumination alters many natural behaviors that are important for fitness, including chick provisioning. Although incubation is a key determinant of the early developmental environment, studies into the effects of ALAN on bird incubation behavior are lacking. We measured nest temperature in nest boxes of great tits during the...

Forecasts, neural networks, and results from the paper: 'Seasonal Arctic sea ice forecasting with probabilistic deep learning'

Tom R. Andersson & J. Scott Hosking
This dataset encompasses data produced in the study 'Seasonal Arctic sea ice forecasting with probabilistic deep learning', published in Nature Communications. The study introduces a new Arctic sea ice forecasting AI system, IceNet, which predicts monthly-averaged sea ice probability (SIP; probability of sea ice concentration > 15%) up to 6 months ahead at 25 km resolution. The study demonstrated IceNet's superior seasonal forecasting skill over a state-of-the-art physics-based sea ice forecasting system, ECMWF SEAS5, and...

Data from: Sudden unexpected death in epilepsy: a personalised prediction tool

Ashwani Jha, Cheongeun Oh, Dale Hesdorffer, Beate Diehl, Sasha Devore, Martin Brodie, Torbjörn Tomson, Josemir W. Sander, Thaddeus S. Walczak & Orrin Devinsky
Objective: To develop and validate a tool for individualised prediction of Sudden Unexpected Death in Epilepsy (SUDEP) risk, we re-analysed data from one cohort and three case-control studies undertaken 1980-2005. Methods: We entered 1273 epilepsy cases (287 SUDEP, 986 controls) and 22 clinical predictor variables into a Bayesian logistic regression model. Results: Cross-validated individualized model predictions were superior to baseline models developed from only average population risk or from generalised tonic-clonic seizure frequency (pairwise difference...

Pathogen dynamics across the diversity of ageing

Jessica Clark, Luke McNally & Tom Little
Reproduction, mortality and immune function often change with age, but do not invariably deteriorate. Across the tree of life, there is extensive variation in age-specific performance and changes to key life-history traits. These changes occur on a spectrum from classic senescence, where performance declines with age, to juvenescence, where performance improves with age. Reproduction, mortality and immune function are also important factors influencing the spread of infectious disease, yet there exists no comprehensive investigation into...

Improving assessments of data-limited populations using life-history theory

Cat Horswill, Andrea Manica, Francis Daunt, Mark Newell, Sarah Wanless, Matthew Wood & Jason Matthiopoulos
1. Predicting how populations may respond to climate change and anthropogenic pressures requires detailed knowledge of demographic traits, such as survival and reproduction. However, the availability of these data varies greatly across space and taxa. Therefore, it is common practice to conduct population assessments by filling in missing values from surrogate species or other populations of the same species. Using these independent surrogate values concurrently with observed data neglects the life‐history trade‐offs that connect the...

Within-year and among-year variation in impacts of targeted conservation management on juvenile survival in a threatened population

Sarah Fenn, Eric Bignal, Sue Bignal, Amanda Trask, Davy McCracken, Pat Monaghan & Jane Reid
1. Overall impacts of targeted conservation interventions on population growth rate (λ) will depend on within-year and among-year variation in exposure of target individuals to interventions, and in intervention efficacy in increasing vital rates of exposed individuals. Juvenile survival is one key vital rate that commonly varies substantially within and among years, and consequently drives variation in λ. However, within-year, among-year and overall impacts of targeted interventions on population-wide survival probabilities of potentially mobile juveniles...

Data associated with \"Phase domain boundary motion and memristance in gradient-doped FeRh nanopillars induced by spin injection\"

Rowan Temple, Mark C. Rosamond, Jamie Massey, Trevor Almeida, Edmund Linfield, Damien McGrouther, Stephen McVitie, Thomas Moore & Christopher Marrows
The B2-ordered alloy FeRh shows a metamagnetic phase transition, transforming from antiferromagnetic (AF) to ferromagnetic (FM) order at a temperature $T_\mathrm{t} \sim 380 $~K in bulk. As well as temperature, the phase transition can be triggered by many means such as strain, chemical doping, or magnetic or electric fields. Its first-order nature means that phase coexistence is possible. Here we show that a phase boundary in a 300~nm diameter nanopillar, controlled by a doping gradient...

Plasmodium falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso

Teun Bousema, Elamaran Meibalan, Aissata Barry, Matthew Gibbins, Shehu Awandu, Lisette Meerstein-Kessel, Fiona Achar, Selina Bopp, Christopher Moxon, Amidou Diarra, Siaka Debe, Nicolas Ouedraogo, Ines Barry-Some, Emilie Badoum, Traore Fagnima, Kjerstin Lanke, Bronner Goncalves, John Bradley, Dyann Wirth, Chris Drakeley, Wamdaogo Guelbeogo, Alfred Tiono, Matthias Marti, Matthew P Gibbins, Fiona Achcar … & Alfred B Tiono
Background Plasmodium falciparum transmission depends on mature gametocytes that can be ingested by mosquitoes taking a blood meal on human skin. Although gametocyte skin sequestration has long been hypothesized as important contributor to efficient malaria transmission, this has never been formally tested. Methods In naturally infected gametocyte carriers from Burkina Faso, we assessed infectivity to mosquitoes by direct skin feeding and membrane feeding. We directly quantified male and female gametocytes and asexual parasites in finger-prick...

R script used for: Telomeres in a spatial context: a tool for understanding ageing pattern variation in wild populations

Pablo Burraco, Pablo M. Lucas & Pablo Salmón
Ageing refers to the loss of organismal functionality with age, a process that is characterised by decreased reproduction and survival probability. In natural populations, it is expected that environmental conditions influence an individual’s ageing trajectory. Understanding the role of environmental heterogeneity on ageing variation could provide criticleinsights into population resilience and species distribution but remains overlooked. Telomeres, the end cap of chromosomes, are a promising integrative physiological marker of an individual’s health and a possible...

Growth acceleration results in faster telomere shortening later in life

Pablo Salmón, Caroline Millet, Colin Selman & Pat Monaghan
There is a wealth of evidence for a lifespan penalty when environmental conditions influence an individual´s growth trajectory such that growth rate is accelerated to attain a target size within a limited time period. Given this empirically demonstrated relationship between accelerated growth and lifespan, and the links between lifespan and telomere dynamics, increased telomere loss could underpin this growth-lifespan trade. We experimentally modified the growth trajectory of nestling zebra finches (Taeniopygia guttata), inducing a group...

Frog nest foams exhibit pharmaceutical foam-like properties

Paul Hoskisson, Sarah Brozio, Erin M O Shaughnessy, Stuart Woods, Ivan Hall-Barrientos, Patrica Martin, Malcolm Kennedy, Dimitrios Lamprou & Paul Hoskisson
Foams have frequently been used as systems for the delivery of cosmetic and therapeutic molecules; however, there is high variability in the foamability and long-term stability of synthetic foams. The development of pharmaceutical foams that exhibit desirable foaming properties, delivering appropriate amounts of the active pharmaceutical ingredient (API) and that have excellent biocompatibility is of great interest. The production of stable foams is rare in the natural world; however, certain species of frogs have adopted...

Altruistic bet-hedging and the evolution of cooperation in a Kalahari bird

Pablo Capilla-Lasheras, Xavier Harrison, Emma Wood, Alastair Wilson & Andrew Young
Analyses of the global biogeography of altruism suggest that unpredictable environments have favoured the evolution of altruistic helping behaviour (helping to rear the offspring of others). It has therefore been hypothesised that selection for altruism may frequently arise because helping reduces variance in the reproductive success of relatives in unpredictable environments (a scenario termed ‘altruistic bet-hedging’). Here we show that helping behaviour does reduce environmentally-induced variance in the reproductive success of relatives in a wild...

Avian community mist net survey data from Luba/Ureca road elevational gradient, Bioko Island, Equatorial Guinea

Steven Miller, Joris Wiethase, Amancio Etingue, Elaine Franklin, Maximiliano Fero, Jared Wolfe, Mary Gonder & Luke Powell
Understanding interactive effects between anthropogenic disturbance and abiotic factors on species turnover can help identify and prioritize conservation of potentially vulnerable tropical bird communities. We investigated potential factors influencing avian understory community composition along a recently constructed road across three elevations (300, 800 and 1200 m), each with two sampling sites (road edge vs interior forest), over a four-year period on Bioko Island, Equatorial Guinea. Obligate ant following species were the most abundant guild sampled...

Data from: Longitudinal evidence that older parents produce offspring with longer telomeres in a wild social bird

Antony Brown, Emma Wood, Pablo Capilla-Lasheras, Xavier Harrison & Andrew Young
As telomere length (TL) often predicts survival and lifespan, there is considerable interest in the origins of inter-individual variation in TL. Cross-generational effects of parental age on offspring TL are thought to be a key source of variation, but the rarity of longitudinal studies that examine the telomeres of successive offspring born throughout the lives of parents leaves such effects poorly understood. Here, we exploit TL measures of successive offspring produced throughout the long breeding...

Data from: Telomere length is highly heritable and independent of growth rate manipulated by temperature in field crickets

Jelle Boonekamp, Rolando Rodríguez-Muñoz, Paul Hopwood, Erica Zuidersma, Ellis Mulder, Alastair Wilson, Simon Verhulst & Tom Tregenza
Many organisms are capable of growing faster than they do. Restrained growth rate has functionally been explained by negative effects on lifespan of accelerated growth. However, the underlying mechanisms remain elusive. Telomere attrition has been proposed as a causal agent and has been mostly studied in endothermic vertebrates. We established that telomeres exist as chromosomal-ends in a model insect, the field cricket G. campestris, using terminal restriction fragment and Bal 31 methods. Telomeres comprised TTAGGn...

Environmental conditions but not nest composition affect reproductive success in an urban bird

Pablo Capilla-Lasheras, Blanca Bondía & Jose Ignacio Aguirre
Birds can influence the environmental conditions that eggs and offspring experience by adjusting the composition of their nests. They often use feathers to build nests, presumably due to their insulating properties. The amount of feathers in nests is often associated with increased nestling survival and body condition. However, it is unclear whether these putative beneficial effects of adding feathers to nests are relevant in a wide range of environmental conditions or, instead, depend on the...

Linking alternative reproductive tactics and habitat selection in Northern chamois

Luca Corlatti, Antonella Cotza & Luca Nelli
In polygynous ungulates, males may achieve fertilization through the use of alternative reproductive tactics (ARTs), discrete phenotypic variations evolved to maximize fitness. ARTs are often associated with different male spatial strategies during the rut, from territoriality to female-following. Although variation in space use patterns of rutting male ungulates is known to be largely affected by the spatial distribution of females, information on the year-round habitat selection of alternative reproductive types is scant. Here, we investigate...

Habitat restoration weakens negative environmental effects on telomere dynamics

Darryl McLennan, Sonya Auer, Simon McKelvey, Lynn McKelvey, Graeme Anderson, Winnie Boner, Jessica Duprez & Neil B. Metcalfe
Habitat quality can have far-reaching effects on organismal fitness, an issue of concern given the current scale of habitat degradation. Many temperate upland streams have reduced nutrient levels due to human activity. Nutrient restoration confers benefits in terms of invertebrate food availability and subsequent fish growth rates. Here we test whether these mitigation measures also affect the rate of cellular ageing of the fish, measured in terms of the telomeres that cap the ends of...

Registration Year

  • 2021

Resource Types

  • Dataset


  • University of Glasgow
  • University College London
  • University of Exeter
  • University of Washington
  • University of Groningen
  • University of Cambridge
  • University of Aberdeen
  • University of Edinburgh
  • Nelson Mandela African Institution of Science and Technology
  • Massachusetts General Hospital