540 Works

The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment

Qin Zhou, Xiaoyu Gu, Jiachen Dong, Chao Zhu, Zhen Cai, Dongmei He, Chi Yang, Ling Xu & Jiawei Zheng
The repair of periodontal bone tissue defects in patients with periodontitis is one of the major challenges for dentists. Stem cell-based bone regeneration has been considered as a promising strategy to restore the lost periodontal bone tissue. However, the local inflammatory environment of periodontal tissue affects stem cell-based periodontal bone regeneration. Toll-like receptor 2 (TLR2), a member of the TLR family, plays an important role in regulating immunoreaction. Previous studies have shown that the activation...

The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment

Qin Zhou, Xiaoyu Gu, Jiachen Dong, Chao Zhu, Zhen Cai, Dongmei He, Chi Yang, Ling Xu & Jiawei Zheng
The repair of periodontal bone tissue defects in patients with periodontitis is one of the major challenges for dentists. Stem cell-based bone regeneration has been considered as a promising strategy to restore the lost periodontal bone tissue. However, the local inflammatory environment of periodontal tissue affects stem cell-based periodontal bone regeneration. Toll-like receptor 2 (TLR2), a member of the TLR family, plays an important role in regulating immunoreaction. Previous studies have shown that the activation...

Additional file 3 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 3: Table S3. GO Gene Ontology analysis of co-expressed protein-coding genes with all candidate lncRNAs.

Additional file 2 of Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Tilman L. B. Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J. Jacobi, Cornelius M. Funk, Florian H. Geyer, Jing Li, Ignazio Piseddu, Bruno L. Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G. P. Grünewald & Maximilian M. L. Knott
Additional file 2: Additional Tables 1-5.

Additional file 1 of A potential pathogenic hypoxia-related gene HK2 in necrotizing enterocolitis (NEC) of newborns

Yujie Han, Xianghong Liu, Lili Kang, Dong Chen, Yongqing Li, Huiping Zhang, Mingying Sun, Hui Gao, Zhongtao Gai & Xiaoying Li
Additional file 1. Detailed functional results of DEmRNAs.

Cancer-associated fibroblast-released extracellular vesicles carrying miR-199a-5p induces the progression of​ gastric cancer through regulation of FKBP5-mediated AKT1/mTORC1 signaling pathway

Yan Wang, Tao Li, Lei Yang, Xunlei Zhang, Xiaoli Wang, Xiaoqin Su, Congfei Ji & Zhenxin Wang
Accumulating evidence has unfolded the significance of extracellular vesicles (EVs) in diseases and cancers. Here, we attempted to discuss the role of cancer-associated fibroblasts (CAFs)-derived EVs containing miR-199a-5p in gastric tumorigenesis. Upregulated miR-199a-5p was first identified in cancer cells. Then, we selected CAFs for isolation of EVs which were co-cultured with AGS cells. We observed successful delivery of miR-199a-5p via CAF-derived EVs. Besides, miR-199a-5p promoted malignant properties of AGS cells. Moreover, miR-199a-5p downregulated FKBP5, leading...

Additional file 2 of Assessing the causal association between human blood metabolites and the risk of epilepsy

Jiahao Cai, Xiaoyu Li, Shangbin Wu, Yang Tian, Yani Zhang, Zixin Wei, Zixiang Jin, Xiaojing Li, Xiong Chen & Wen-Xiong Chen
Additional file 2: Table S1. List of the identification (ID) for each of the 486 blood metabolites. Table S2. Harmonization data_482 blood metabolites and overall documented epilepsy from the ILAE consortium. Table S3. Results for the Mendelian randomization estimates and sensitivity analysis in epilepsy-subgroup (focal and generalized epilepsy) analysis. Table S4. Leave one out analysis for the causal association between blood metabolites and epilepsy subtypes.

Additional file 8 of ELOVL gene family plays a virtual role in response to breeding selection and lipid deposition in different tissues in chicken (Gallus gallus)

Dandan Wang, Xinyan Li, Panpan Zhang, Yuzhu Cao, Ke Zhang, Panpan Qin, Yulong Guo, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Xiaojun Liu & Hong Li
Additional file 8: Table S6. All genomic SNPs in gene body and 2 kb promoter of ELOVL gene family used for PCA analysis.

Additional file 6 of Metabolic engineering of Escherichia coli BW25113 for the production of 5-Aminolevulinic Acid based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modification

Changchuan Ye, Yuting Yang, Xi Chen, Lijie Yang, Xia Hua, Mengjie Yang, Xiangfang Zeng & Shiyan Qiao
Additional file 6: Fig S6. Standard Plot for ALA measurement. x: the absorbance at 554 nm; y: ALA concentration of sample after diluted (mg/L).

Additional file 2 of Causality of genetically determined metabolites on anxiety disorders: a two-sample Mendelian randomization study

Gui Xiao, Qingnan He, Li Liu, Tingting Zhang, Mengjia Zhou, Xingxing Li, Yijun Chen, Yanyi Chen & Chunxiang Qin
Additional file 2: Table S1. The formula used to calculate R2 and F statistic between exposure and outcome; Table S2. Summary statistics of the anxiety disorders; Table S3–S12. Mendelian Randomization estimation for Amino acid(Table S3); Carbohydrate (Table S4); Co-factor or vitamin(Table S5);Energy(Table S6); Lipid(Table S7); Nucleotide (Table S8); Peptide (Table S9); Xenobiotic(Table S10);X(unknow metabolites) (Table S11);known metabolites (Table S12) on the risk of anxiety disorders; Table S13. The characteristics of SNPs and their genetic associations...

CIED-Stack gas concentrations, 2015-2018

Ling Tang, Min Jia, Junai Yang, Ling Li, Xin Bo & Zhifu Mi
The Chinese Industrial Emissions Database (CIED) provides inventory of particulate matter (PM), SO2 and NOX from Chinese industries from 2015 to 2018, based on direct measurements from China’s continuous emission monitoring systems (CEMS) network. This document provides stack gas concentrations for China’s different industrial emission sources.

Additional file 1 of Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress

Shan Jiang, Xu Tian, Xiaolong Huang, Jiankang Xin & Huiqing Yan
Supplementary Material 1

Additional file 2 of Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress

Shan Jiang, Xu Tian, Xiaolong Huang, Jiankang Xin & Huiqing Yan
Supplementary Material 2

Additional file 8 of Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress

Shan Jiang, Xu Tian, Xiaolong Huang, Jiankang Xin & Huiqing Yan
Supplementary Material 8

Additional file 4 of Grapevine (Vitis vinifera) responses to salt stress and alkali stress: transcriptional and metabolic profiling

Xu Lu, Lei Ma, CongCong Zhang, HaoKai Yan, JinYu Bao, MeiShuang Gong, WenHui Wang, Sheng Li, ShaoYing Ma & BaiHong Chen
Additional file 4: Table S3. The DEGs involved in the ‘MAPK signaling pathway-plant’ pathway.

Additional file 5 of Grapevine (Vitis vinifera) responses to salt stress and alkali stress: transcriptional and metabolic profiling

Xu Lu, Lei Ma, CongCong Zhang, HaoKai Yan, JinYu Bao, MeiShuang Gong, WenHui Wang, Sheng Li, ShaoYing Ma & BaiHong Chen
Additional file 5: Table S4. The DEGs related to ion transport.

Immune persistence induced by two-dose BBIBP-CorV vaccine with different intervals, and immunogenicity and safety of a homologous booster dose in high-risk occupational population

Tian Yao, Xiaohong Zhang, Shengcai Mu, Yana Guo, Xiuyang Xu, Junfeng Huo, Zhiyun Wei, Ling Liu, Xiaoqing Li, Hong Li, Rongqin Xing, Yongliang Feng, Jing Chen, Lizhong Feng & Suping Wang
The immune persistence of neutralizing antibodies elicited by BBIBP-CorV vaccines on day 0–14, 0–21 and 0–28 schedule, and the immunogenicity and safety of a homologous booster dose after different priming vaccination regimens is scarcely reported. : Responders (GMT≥16) at day 28, after priming with the two-dose vaccine, were followed up at 3, 6, and 10 months. Eligible participants received a homologous booster dose at month 10 and were followed-up 28 days post-booster. The GMT of...

Immune persistence induced by two-dose BBIBP-CorV vaccine with different intervals, and immunogenicity and safety of a homologous booster dose in high-risk occupational population

Tian Yao, Xiaohong Zhang, Shengcai Mu, Yana Guo, Xiuyang Xu, Junfeng Huo, Zhiyun Wei, Ling Liu, Xiaoqing Li, Hong Li, Rongqin Xing, Yongliang Feng, Jing Chen, Lizhong Feng & Suping Wang
The immune persistence of neutralizing antibodies elicited by BBIBP-CorV vaccines on day 0–14, 0–21 and 0–28 schedule, and the immunogenicity and safety of a homologous booster dose after different priming vaccination regimens is scarcely reported. : Responders (GMT≥16) at day 28, after priming with the two-dose vaccine, were followed up at 3, 6, and 10 months. Eligible participants received a homologous booster dose at month 10 and were followed-up 28 days post-booster. The GMT of...

Additional file 1 of The impact of human and livestock respiration on CO2 emissions from 14 global cities

Qixiang Cai, Ning Zeng, Fang Zhao, Pengfei Han, Di Liu, Xiaohui Lin & Jingwen Chen
Supplementary Material 1: Table S9 The HLR within 118 worldurban areas. Notes: The 118 world urban areas are selected onthe basis of area larger than 100 km2, being capitals, with populationsgreater than 1 million or have carbon monitoring sites.

Additional file 1 of Comparison of anther transcriptomes in response to cold stress at the reproductive stage between susceptible and resistant Japonica rice varieties

Zhenhua Guo, Wendong Ma, Lijun Cai, Tao Guo, Hao Liu, Linan Wang, Junliang Liu, Bo Ma, Yanjiang Feng, Chuanxue Liu & Guojun Pan
Supplementary Material 1

Additional file 1 of Comparison of anther transcriptomes in response to cold stress at the reproductive stage between susceptible and resistant Japonica rice varieties

Zhenhua Guo, Wendong Ma, Lijun Cai, Tao Guo, Hao Liu, Linan Wang, Junliang Liu, Bo Ma, Yanjiang Feng, Chuanxue Liu & Guojun Pan
Supplementary Material 1

Additional file 2 of Comparison of anther transcriptomes in response to cold stress at the reproductive stage between susceptible and resistant Japonica rice varieties

Zhenhua Guo, Wendong Ma, Lijun Cai, Tao Guo, Hao Liu, Linan Wang, Junliang Liu, Bo Ma, Yanjiang Feng, Chuanxue Liu & Guojun Pan
Supplementary Material 2

Additional file 2 of Comparison of anther transcriptomes in response to cold stress at the reproductive stage between susceptible and resistant Japonica rice varieties

Zhenhua Guo, Wendong Ma, Lijun Cai, Tao Guo, Hao Liu, Linan Wang, Junliang Liu, Bo Ma, Yanjiang Feng, Chuanxue Liu & Guojun Pan
Supplementary Material 2

Additional file 3 of Comparison of anther transcriptomes in response to cold stress at the reproductive stage between susceptible and resistant Japonica rice varieties

Zhenhua Guo, Wendong Ma, Lijun Cai, Tao Guo, Hao Liu, Linan Wang, Junliang Liu, Bo Ma, Yanjiang Feng, Chuanxue Liu & Guojun Pan
Supplementary Material 3

Additional file 9 of Comparison of anther transcriptomes in response to cold stress at the reproductive stage between susceptible and resistant Japonica rice varieties

Zhenhua Guo, Wendong Ma, Lijun Cai, Tao Guo, Hao Liu, Linan Wang, Junliang Liu, Bo Ma, Yanjiang Feng, Chuanxue Liu & Guojun Pan
Supplementary Material 9

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