Recognition of discrete export signals in flagellar subunits during bacterial Type III secretion

Owain Bryant, Paraminder Dhillon, Colin Hughes & Gillian Fraser
Type III Secretion Systems (T3SS) deliver subunits from the bacterial cytosol to nascent cell surface flagella. Early flagellar subunits that form the rod and hook substructures are unchaperoned and contain their own export signals. A gate recognition motif (GRM) docks them at the FlhBc component of the FlhAB-FliPQR export gate, but the gate must then be opened and subunits must be unfolded to pass through the flagellar channel. This induced us to seek further signals...

Registration Year

  • 2022
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Affiliations

  • Federation of European Biochemical Societies
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  • University of Cambridge
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  • University of Oxford
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