4 Works

Supplemental material: Astrocyte biomarkers in Alzheimer’s disease: a systematic review and meta-analysis

Bruna Bellaver, João Pedro Ferrari-Souza, Lucas Uglione Da Ros, Stephen F. Carter, Elena Rodriguez-Vieitez, Agneta Nordberg, Luc Pellerin, Pedro Rosa-Neto, Douglas Teixeira Leffa & Eduardo R. Zimmer
Objective: To perform a systematic review and meta-analysis to determine whether fluid and imaging astrocyte biomarkers are altered in Alzheimer's disease (AD). Methods: PubMed and Web of Science databases were searched for articles reporting fluid or imaging astrocyte biomarkers in AD. Pooled effect sizes were determined with mean differences (SMD) using the Hedge’s G method with random-effects to determine biomarker performance. Adapted questions from QUADAS-2 were applied for quality assessment. A protocol for this study...

Data from: Characteristics of patients with smear-negative pulmonary tuberculosis (TB) in a region with high TB and HIV prevalence

Leandro C. Campos, Marcus V. V. Rocha, Denise Maria Cunha Willers, Denise Rossato Silva & Marcos Vinícius Vieira Rocha
Introduction: Smear-negative pulmonary TB (SNPT) represents 30–60% of all pulmonary TB cases. The mortality of these patients can reach 25% in populations with high prevalence of HIV infection, and 10–20% of TB transmission at the population level are attributable to SNPT cases. Methods: We conducted a retrospective study to evaluate epidemiological, clinical, and radiological characteristics of patients with SNPT and to compare these with patients who were diagnosed as having smear-positive pulmonary TB (SPPT). All...

Data from: Characterization of advanced glycation end products and their receptor (RAGE) in an animal model of myocardial infarction

Luis Eduardo Rohde, Michael Andrades, Amanda Lopes, Virgílio Olsen, Juliana Oliveira Rangel, Nadine Clausell, Bianca De Moraes Fracasso, Fernanda Severo Curuja, Alessandra Gonçalves Machado & Andreia Biolo
Circulating advanced glycation end products (AGE) and their receptor, RAGE, are increased after a myocardial infarction (MI) episode and seem to be associated with worse prognosis in patients. Despite the increasing importance of these molecules in the course of cardiac diseases, they have never been characterized in an animal model of MI. Thus, the aim of this study was to characterize AGE formation and RAGE expression in plasma and cardiac tissue during cardiac remodeling after...

Data from: Advanced glycation end products (AGE) and receptor for AGE (RAGE) in patients with active tuberculosis, and their relationship between food intake and nutritional status

Lívia F. Da Silva, Erika C. Skupien, Tássia K. Lazzari, Sizuane R. Holler, Ellis G.C. De Almeida, Luísa R. Zampieri, Sandra E. Coutinho, Michael Andrades & Denise R. Silva
Introduction: The receptor for advanced glycation end products (RAGE) is expressed in normal lungs and is upregulated during infection. AGEs and RAGE cause oxidative stress and apoptosis in lung cells. The objective of this study is to evaluate levels of AGEs and its soluble receptor (sRAGE), and to investigate their relationship with food intake and nutritional status, in a university-affiliated hospital in Brazil. Methods: Case-control study, from June 2017 to June 2018. AGE (carboxymethyl lysine,...

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  • Hospital de Clínicas de Porto Alegre
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  • Federal University of Rio Grande do Sul
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  • University of Cambridge
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  • McGill University
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  • University of Poitiers
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  • Karolinska Institute
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