RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). Although pharmacological inhibition of RAS has been challenging, KRAS(G12C)-specific inhibitors have recently entered the clinic. While KRAS(G12C) is frequently expressed in lung cancers, it is rare in PDAC. Thus, more broadly efficacious RAS inhibitors are...

Objective: The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in...

A striking global property of genomes observable across all domains of life is their universal inverse symmetry, manifest as equivalent frequencies of inverse complementary sequence motifs on the same strand of duplex DNA, as originally stated in Chargaff’s Second Parity Rule (CPR2) for mononucleotides. Simple mechanistic explanations of CPR2 have proven unsatisfactory. In contrast, we use a conservation principle to explain not only inverse symmetry and its global nature, but also how it breaks down....

RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). Although pharmacological inhibition of RAS has been challenging, KRAS(G12C)-specific inhibitors have recently entered the clinic. While KRAS(G12C) is frequently expressed in lung cancers, it is rare in PDAC. Thus, more broadly efficacious RAS inhibitors are...

read-tv The main paper is about, read-tv, open-source software for longitudinal data visualization. We uploaded sample use case surgical flow disruption data to highlight read-tv's capabilities. We scrubbed the data of protected health information, and uploaded it as a single CSV file. A description of the original data is described below. Data source Surgical workflow disruptions, defined as “deviations from the natural progression of an operation thereby potentially compromising the efficiency or safety of care”,...