279 Works

Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM)

Liang Liu, Shan Xiao, Yan Wang, Zifeng Zhu, Yiyao Cao, Sen Yang, Rongkang Mai & Yong Zheng
Circular RNAs (circRNAs) are closely associated with cancer development in glioblastoma (GBM), and this study aims to explore the molecular mechanisms of a novel circular RNA circZNF652 in regulating GBM aggressiveness. The present study found that CircZNF652 and SERPINE1 were upregulated, while miR-486-5p was downregulated in GBM tissues and cell lines, and GBM patients with high expression of CircZNF652 and SERPINE1, and patients with low expression of miR-486-5p tended to have a worse prognosis. Further...

Polygonum cuspidatum inhibits the growth of osteosarcoma cells via impeding Akt/ERK/EGFR signaling pathways

Jun Zhao, Boyu Pan, Xinglu Zhou, Chunnuan Wu, Fengcheng Hao, Jie Zhang & Liren Liu
Osteosarcoma (OS), the most prevalent bone malignancy, mainly affects children and adolescents. Despite recent advances in multimodal therapy, the overall survival rate for OS patients remains poor. Chinese herb medicine (CHM) is an alternative therapeutic option for multifaceted diseases such as malignant tumors. For centuries in China, polygonum cuspidatum, a classic CHM, has been used to treat several diseases, nevertheless, the mechanisms underlying its therapeutic effects have not been fully elucidated. Through network pharmacology and...

New Model-Free Daily Inversion of NOx Emissions using TROPOMI (MCMFE-NOx): Deducing a See-Saw of Halved Well Regulated Sources and Doubled New Sources

Kai Qin, Jincheng Shi, Qin He, Weizhi Deng, Shuo Wang, Jian Liu & Jason Cohen
This dataset contains all of the data underlying the figures in the accompanying paper "70% Increase in Northwest China’s NOx Emissions Driven by Increases from New Sources and Simultaneous Reductions in Well-Regulated Sources". These are listed respectively as: fig2.mat fig3.mat fig4.mat fig5.mat fig6.mat All subplots are respectively given as fig2a, fig2b, etc.
The daily emissions dataset, and monthly a1, a2, and a3 datasets are respectively found in the file dailyresults.mat
Supplemental Figures S1-ii,...

Upregulated miR-322-5p regulates cell cycle and promotes cell proliferation and apoptosis by directly targeting Wee1 in mice liver injury

He Tong, Li Wang, Jing Shi, Haowei Jin, Kefan Zhang, Yulong Bao, Yongshuai Wu, Yipeng Cheng, Pengxia Liu & Changshan Wang
Liver injury from any number of causes (e.g. chemical material, drugs and diet, viral infection) is a global health problem, and its mechanism is not clearly understood. MicroRNAs (miRNAs) expression profiling is gaining popularity because miRNAs, as key regulators in gene expression networks, can influence many biological processes and have also shown promise as biomarkers for disease. Previous studies reported the regulation effects of miRNAs in liver injury, whereas function and molecular mechanisms of miR-322-5p...

RNA-Seq and lipidomics reveal different adipogenic processes between bovine perirenal and intramuscular adipocytes

Xiaoyu Wang, Chengcheng Liang, Anning Li, Gong Cheng, Feng Long, Rajwali Khan, Jianfang Wang, Yu Zhang, Sen Wu, Yujuan Wang, Ju Qiu, Chugang Mei, Wucai Yang & Linsen Zan
Adipogenesis involves complex interactions between transcription and metabolic signalling. Exploration of the developmental characteristics of intramuscular adipocyte will provide targets for enhancing beef cattle marbling without increasing obesity. Few reports have compared bovine perirenal and intramuscular adipocyte transcriptomes using the combined analysis of transcriptomes and lipid metabolism to explore differences in adipogenic characteristics. We identified perirenal preadipocytes (PRA) and intramuscular preadipocytes (IMA) in Qinchuan cattle. We found that IMA were highly prolific in the early...

Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens

Yongqi Yue, Yonglin Hua, Jing Zhang, Yu Guo, Dan Zhao, Wentao Huo, Yan Xiong, Fenfen Chen, Yaqiu Lin, Xianrong Xiong & Jian Li
The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak...

The pathological involvement of spinal cord EphB2 in visceral sensitization in male rats

Tao Chen, Si Chen, Xuefeng Zheng, Yaofeng Zhu, Ziyun Huang, Linju Jia, Lisi OuYang & Wanlong Lei
Patients with post-traumatic stress disorder (PTSD) are usually at an increased risk for chronic disorders, such as irritable bowel syndrome (IBS), characterized by hyperalgesia and allodynia, but its subsequent effect on visceral hyperalgesia and the mechanism remain unclear. The present study employed single prolonged stress (SPS), a model of PTSD-pain comorbidity, behavioral evaluation, intrathecal drug delivery, immunohistochemistry, Western blotting, and RT-PCR techniques. When detecting visceral sensitivity, the score of the abdominal withdrawal reflex (AWR) induced...

New Model-Free Daily Inversion of NOx Emissions using TROPOMI (MCMFE-NOx) and its Uncertainty: Deducing a See-Saw of Halved Well Regulated Sources and Doubled New Sources

Kai Qin, Lingxiao Lu, Jian Liu, Qin He, Jincheng Shi, Weizhi Deng, Shuo Wang & Jason Cohen
This dataset contains all of the data underlying the figures in the accompanying paper "New Model-Free Daily Inversion of NOx Emissions using TROPOMI (MCMFE-NOx) and its Uncertainty: Deducing a See-Saw of Halved Well Regulated Sources and Doubled New Sources". These are listed respectively under: Coefficients.zip Figure3.zip Figure4.zip Figure5.zip Figure6.zip Figure7.zip Figure8.zip Figure9.zip Figure10.zip All data is provided as .nc files, and all plots are provided as .png files. All emissions are provided as a part...

Table S5.xlsx from Transcriptome analysis and mining of genes related to shade tolerance in foxtail millet (Setaria italica (L.) P. Beauv.)

Dan Liu, Yanjiao Cui, Zilong Zhao, Jing Zhang, Suying Li & Zhengli Liu
A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

Table S2.xlsx from Transcriptome analysis and mining of genes related to shade tolerance in foxtail millet (Setaria italica (L.) P. Beauv.)

Dan Liu, Yanjiao Cui, Zilong Zhao, Jing Zhang, Suying Li & Zhengli Liu
A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

Table S6.xlsx from Transcriptome analysis and mining of genes related to shade tolerance in foxtail millet (Setaria italica (L.) P. Beauv.)

Dan Liu, Yanjiao Cui, Zilong Zhao, Jing Zhang, Suying Li & Zhengli Liu
A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

Nutritional components and protein quality analysis of genetically modified phytase maize

Yichun Hu, Liqin Linghu, Min Li, Deqian Mao, Yu Zhang, Xiaoguang Yang & Lichen Yang
The nutritional components and protein quality of genetically modified maize expressing phytase gene (GM) were analyzed and evaluated in this study. The nutritional components were analyzed by Chinese national standard methods. The ileostomy Bama miniature pigs were utilized to analyze the true digestibility of protein and amino acids. The digestible indispensable amino acid score (DIAAS) was adopted to evaluate the protein quality of GM, its parental maize (PM) and commercial available maize Zhengdan 958 (ZD)....

Table S4.xlsx from Transcriptome analysis and mining of genes related to shade tolerance in foxtail millet (Setaria italica (L.) P. Beauv.)

Dan Liu, Yanjiao Cui, Zilong Zhao, Jing Zhang, Suying Li & Zhengli Liu
A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

Additional file 2 of Genome-wide characterization and expression analysis of the growth-regulating factor family in Saccharum

Zilin Wu, Xinglong Chen, Danwen Fu, Qiaoying Zeng, Xiaoning Gao, Nannan Zhang & Jiayun Wu
Supplementary Material 2

Additional file 3 of Genome-wide characterization and expression analysis of the growth-regulating factor family in Saccharum

Zilin Wu, Xinglong Chen, Danwen Fu, Qiaoying Zeng, Xiaoning Gao, Nannan Zhang & Jiayun Wu
Supplementary Material 3

Additional file 1 of Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress

Shan Jiang, Xu Tian, Xiaolong Huang, Jiankang Xin & Huiqing Yan
Supplementary Material 1

Additional file 1 of Characteristics of oral microbiome of healthcare workers in different clinical scenarios: a cross-sectional analysis

Zhixia Zhang, Wenyi Yu, Guangyao Li, Yukun He, Zhiming Shi, Jing Wu, Xinqian Ma, Yu Zhu, Lili Zhao, Siqin Liu, Yue Wei, Jianbo Xue, Shuming Guo & Zhancheng Gao
Additional File 1: Supplementary Table S1

Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China

Canjia Zhang, Huan Chen, Shangxin Cui, Yeli Lin, Yongqiang Liang, Ping Zhao, Changyi Wang, Shan Xu, Xiaolin Peng, Hongen Chen, Li Wang, Dan Zhao, Ming Zhang, Dongsheng Hu, Yanmei Lou & Fulan Hu
This study aimed at investigating the relationships between Platelet-Lymphocyte ratio (PLR) and Neutrophil–Lymphocyte ratio (NLR) and their dynamic changes (∆PLR, ∆NLR) with type 2 diabetes mellitus (T2DM) in a Chinese cohort study. This study recruited 41,439 individuals who were diagnosed without T2DM at first health examination and completed at least one follow-up. The relationships between NLR, PLR, ∆PLR, ∆NLR and T2DM risk were analyzed using the Cox regression model with corresponding Hazard Ratios (HRs) and...

Additional file 2 of mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A

Liang Zhao, Huizhao Su, Xiaomeng Liu, Hongquan Wang, Yukuan Feng, Yan Wang, Haiqiang Chen, Luo Dai, Shihui Lai, Siqi Xu, Chong Li, Jihui Hao & Bo Tang
Additional file 2: Table S1. Detected gene levels upon methionine restriction in livers of HCC mouce models.

Additional file 1 of Deciphering chloramphenicol biotransformation mechanisms and microbial interactions via integrated multi-omics and cultivation-dependent approaches

Jiayu Zhang, Xiaoyan Li, Uli Klümper, Huaxin Lei, Thomas U. Berendonk, Fangliang Guo, Ke Yu, Chao Yang & Bing Li
Additional file 1: Table S1. The taxonomy, quality, and genome size of 18 MAGs. Table S2. The taxonomy, quality, and genomic information of seven isolated strains. Table S3. The information of proteins related to CAP biotransformation in Sphingomonas sp. CL5.1 revealed by proteomics.

Independent prognostic value of left ventricular mass index in patients with light-chain amyloidosis

Hejing Huang, Haiyan He, Yingyi Qin, Juan Du & Jialin Song
Echocardiographic-determined left ventricular mass index (LVMI) provides quantitative information on left-ventricular structure. However, its prognostic value on light-chain (AL) amyloidosis has not been clearly defined. We included 99 patients with newly diagnosed AL amyloidosis between July 2013 and March 2022. Clinical features and echocardiographic parameters were collected. LVMI ≥113.4 g/m2 was predictive for overall survival (OS) and progression-free survival (PFS) with respective hazard ratios (HRs) of 2.87 (95% CI: 1.04–7.79) and 2.91 (95% CI: 1.25–6.68)....

Additional file 14 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 14: Supplementary Table 2. The results of expression differences for pan-cancer analysis.

Additional file 14 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 14: Supplementary Table 2. The results of expression differences for pan-cancer analysis.

Additional file 22 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 22 Table S21. Significant association signals for deepwater in the full populaiton detected using FaST-LMM.

Additional file 23 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 23 Table S22. The cloned genes for deepwater and heat map of the ratio of RPKM.

Registration Year

  • 2022
    279

Resource Types

  • Dataset
    279

Affiliations

  • Tianjin University
    279
  • Sun Yat-sen University
    211
  • Zhejiang University
    197
  • Shanghai Jiao Tong University
    196
  • University of Chinese Academy of Sciences
    186
  • Huazhong University of Science and Technology
    177
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    176
  • Capital Medical University
    170
  • Shandong University
    156
  • Chinese Academy of Sciences
    154