31 Works

Land-use and elevation interact to shape bird functional and phylogenetic diversity and structure: Implications for designing optimal agriculture landscapes

Rachakonda Sreekar, Xingfeng Si, Katerina Sam, Jiajia Liu, Salindra Dayananda, Uromi Goodale, Sarath Kotagama & Eben Goodale
Conversion of rainforests into agriculture resulted in massive changes in species diversity and community structure. Although the conservation of the remaining rainforests is of utmost importance, identifying and creating biodiversity-friendly agriculture landscape is vital for preserving biodiversity and their functions. Biodiversity studies in agriculture have often been conducted at low elevations. In this study, we compared the functional diversity (FD), phylogenetic diversity (PD), and community structure of birds along an interacting gradient of land-use (protected...

Plant genotypic diversity effects on soil nematodes vary with trophic level

Jihua Wu, Jun Yan, Youzheng Zhang, Kerri M. Crawford, Xiaoyong Chen & Shuo Yu
At local spatial scales, loss of genetic diversity within species can lead to species loss. Few studies, however, have examined plant genotypic diversity effects across trophic levels. We investigated genotypic diversity effects of Phragmites australis on belowground biomass and soil nematode communities. Our results revealed belowground plant biomass and nematode abundance responses to plant genotypic diversity were uncoupled. Decreasing plant genotypic diversity decreased the abundance of lower, but not higher trophic level nematodes. Low plant...

Data from: Substantia nigra integrity correlates with sequential working memory in Parkinson’s disease

Zheng Ye, Lirong Jin, Thomas F. Muente, Wenyue Liu, Changpeng Wang, Tingting He, Minghong Su, Yuan Lu & Guanyu Zhang
Maintaining and manipulating sequential information online is essential for daily activities such as planning. In Parkinson’s disease (PD), deficits in sequential working memory have been associated with altered regional activation and functional connectivity within the basal ganglia. This study demonstrated that the substantia nigra (SN) integrity correlates with basal ganglia dysfunction during sequential working memory. We included 29 patients with PD and 29 healthy controls (HC). We assessed the SN integrity using neuromelanin-sensitive MRI and...

Far Eastern Curlew and Whimbrel prefer flying low: wind support and good visibility appear only secondary factors in determining migratory flight altitude

Batbayar Galtbalt, Amanda Lilleyman, Jonathan T Coleman, Chuyu Cheng, Zhijun Ma, Danny I Rogers, Bradley K Woodworth, Richard A Fuller, Stephen T Garnett & Marcel Klaassen
Background: In-flight conditions are hypothesized to influence the timing and success of long-distance migration. Wind assistance and thermal uplift are thought to reduce the energetic costs of flight, humidity, air pressure and temperature may affect the migrants’ water balance, and clouds may impede navigation. Recent advances in animal-borne long-distance tracking enable evaluating the importance of these factors in determining animals’ flight altitude. Methods: Here we determine the effects of wind, humidity, temperature, cloud cover, and...

An invasive species erodes the performance of coastal wetland protected areas

Junlin Ren, Jianshe Chen, Changlin Xu, Johan Van De Koppel, Mads Thomsen, Shi-Yun Qiu, Fangyan Cheng, Wanjuan Song, Quan-Xing Liu, Chi Xu, Junhong Bai, Yihui Zhang, Baoshan Cui, Mark Bertness, Brian Silliman, Bo Li & Qiang He
The world has increasingly relied upon protected areas (PAs) to rescue highly valued ecosystems from human activities, but whether PAs will fare well with bioinvasions remains unknown. By analyzing three decades of seven largest coastal PAs in China, including multiple World Natural Heritage and/or Wetlands of International Importance sites, we show that although PAs are achieving success in rescuing iconic wetlands and critical shorebird habitats from once widespread reclamation, this success is counteracted by escalating...

Alleviation of refractory IgA nephropathy by intensive fecal microbiota transplantation: the first case reports

Jin Zhao, Ming Bai, Xiaoxia Yang, Yan Wang, Rong Li & Shiren Sun
Gut dysbiosis may be implicated in the pathogenesis of IgA nephropathy (IgAN) through immune and/or metabolite pathways. Fecal microbiota transplantation (FMT) could reestablish the micro-ecological balance in IgAN, although this has never been attempted before. We explored whether FMT could be efficacious in treating IgAN in two patients with refractory IgAN. Two Chinese female patients with IgAN failed to achieve clinical remission after receiving several rounds of immunosuppressive therapy and suffered from unbearable adverse effects...

Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis

Lin Zhao, Shu Li & Ying Gao
Studies have shown that the use of statins could significantly improve lipid profiles; however, it remains controversial whether the use of statins could improve renal function in patients with chronic kidney disease (CKD). Therefore, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of statins on renal function in patients with CKD. We systematically searched PubMed, EMBASE, and the Cochrane Library databases for eligible RCTs from inception to October 2020. Pooled...

A Unified Framework for Specification Tests of Continuous Treatment Effect Models

Wei Huang, Oliver Linton & Zheng Zhang
We propose a general framework for the specification testing of continuous treatment effect models. We assume a general residual function, which includes the average and quantile treatment effect models as special cases. The null models are identified under the unconfoundedness condition and contain a nonparametric weighting function. We propose a test statistic for the null model in which the weighting function is estimated by solving an expanding set of moment equations. We establish the asymptotic...

Analysis of paralogs in target enrichment data pinpoints multiple ancient polyploidy events in Alchemilla s.l. (Rosaceae)

Diego F. Morales-Briones, Berit Gehrke, Chien-Hsun Huang, Aaron Liston, Hong Ma, Hannah Marx, David Tank & Ya Yang
Target enrichment is becoming increasingly popular for phylogenomic studies. Although baits for enrichment are typically designed to target single-copy genes, paralogs are often recovered with increased sequencing depth, sometimes from a significant proportion of loci, especially in groups experiencing whole-genome duplication (WGD) events. Common approaches for processing paralogs in target enrichment data sets include random selection, manual pruning, and mainly, the removal of entire genes that show any evidence of paralogy. These approaches are prone...

Consistent pattern of higher lability of leaves from high latitudes for both native Phragmites australis and exotic Spartina alterniflora

Youzheng Zhang, Steven Pennings, Zixia Liu, Bo Li & Jihua Wu
1. Global variation in litter decomposition rates is driven by climate, decomposer taxa and litter quality. Most large-scale studies of litter quality have made comparisons across species, rather than within a species sourced from different latitudes. Here, we aim to explore latitudinal variation in leaf litter decomposition rate and litter quality within a species. 2. We investigated whether the typical interspecific pattern of increased litter lability at higher latitudes also holds within plant species, by...

Daphnia sinensis genome

Xiuping Zhang
The genomic mechanism by which aquatic organisms adapt to high-altitude environments remains unknown. In this study, we provide a high-quality chromosome-level genome assembly (~133 Mb, scaffold N50 11.3 Mb) of a water flea (Daphnia sinensis). This enabled us to discover that there have been chromosomal rearrangements between two subgenera of Daphnia. We further show that the D. sinensis population living on the Tibetan Plateau exhibits several key genomic adaptive features (e.g., enhanced expression of genes...

LncRNA MALAT1-deficiency restrains lipopolysaccharide (LPS)-induced pyroptotic cell death and inflammation in HK-2 cells by releasing microRNA-135b-5p

Jie Huang & Chen Xu
Long non-coding RNAs (LncRNAs) participate in the regulation of chronic kidney disease (CKD), and acute kidney injury (AKI) is identified as an important risk factor for CKD. This study investigated the involvement of a novel LncRNA MALAT1 in regulating lipopolysaccharide (LPS)-induced cell pyroptosis and inflammation in the human renal tubular epithelial HK-2 cells. Here, the HK-2 cells were subjected to LPS (2 μg/mL) treatment to establish cellular AKI models in vitro, and we validated that...

Hypophosphatemia is an independent risk factor for AKI among hospitalized patients with COVID-19 infection

Zijin Chen, Chenni Gao, Haijin Yu, Lin Lu, Jialin Liu, Wei Chen, Xiaogang Xiang, Hafiz Muhammad Jafar Hussain, Benjamin J. Lee, Chuanlei Li, Wenjie Wei, Yuhan Huang, Xiang Li, Zhengying Fang, Shuwen Yu, Qinjie Weng, Yan Ouyang, Xiaofan Hu, Jun Tong, Jian Liu, Li Lin, Mingyu Liu, Xiaoman Xu, Dan Liu, Yuan Song … & Jingyuan Xie
This study sought to investigate incidence and risk factors for acute kidney injury (AKI) in hospitalized COVID-19. In this retrospective study, we enrolled 823 COVID-19 patients with at least two evaluations of renal function during hospitalization from four hospitals in Wuhan, China between February 2020 and April 2020. Clinical and laboratory parameters at the time of admission and follow-up data were recorded. Systemic renal tubular dysfunction was evaluated via 24-h urine collections in a subgroup...

Hypophosphatemia is an independent risk factor for AKI among hospitalized patients with COVID-19 infection

Zijin Chen, Chenni Gao, Haijin Yu, Lin Lu, Jialin Liu, Wei Chen, Xiaogang Xiang, Hafiz Muhammad Jafar Hussain, Benjamin J. Lee, Chuanlei Li, Wenjie Wei, Yuhan Huang, Xiang Li, Zhengying Fang, Shuwen Yu, Qinjie Weng, Yan Ouyang, Xiaofan Hu, Jun Tong, Jian Liu, Li Lin, Mingyu Liu, Xiaoman Xu, Dan Liu, Yuan Song … & Jingyuan Xie
This study sought to investigate incidence and risk factors for acute kidney injury (AKI) in hospitalized COVID-19. In this retrospective study, we enrolled 823 COVID-19 patients with at least two evaluations of renal function during hospitalization from four hospitals in Wuhan, China between February 2020 and April 2020. Clinical and laboratory parameters at the time of admission and follow-up data were recorded. Systemic renal tubular dysfunction was evaluated via 24-h urine collections in a subgroup...

Association between atherosclerotic cardiovascular diseases risk and renal outcome in patients with type 2 diabetes mellitus

Honghong Ren, Lijun Zhao, Yutong Zou, Yiting Wang, Junlin Zhang, Yucheng Wu, Rui Zhang, Tingli Wang, Jiali Wang, Yitao Zhu, Ruikun Guo, Huan Xu, Lin Li, Mark E. Cooper & Fang Liu
Chronic kidney disease (CKD) and diabetes mellitus increase atherosclerotic cardiovascular diseases (ASCVD) risk. However, the association between renal outcome of diabetic kidney disease (DKD) and ASCVD risk is unclear. This retrospective study enrolled 218 type 2 diabetic patients with biopsy-proven DKD, and without known cardiovascular diseases. Baseline characteristics were obtained and the 10-year ASCVD risk score was calculated using the Pooled Cohort Equation (PCE). Renal outcome was defined as progression to end-stage renal disease (ESRD)....

Risk factors for mortality in hemodialysis patients with COVID-19: a systematic review and meta-analysis

Fengping Wang, Guangyu Ao, Yushu Wang, Fuqiang Liu, Mulong Bao, Ming Gao, Shulu Zhou & Xin Qi
New evidence from studies on risk factors for mortality in hemodialysis (HD) patients with COVID-19 became available. We aimed to review the clinical risk factors for fatal outcomes in these patients. We performed meta-analysis using the PubMed, EMBASE, and Cochrane databases. A fixed- or random-effects model was used for calculating heterogeneity. We used contour-enhanced funnel plot and Egger’s tests to assess potential publication bias. Twenty-one studies were included. The proportion of males was lower in...

LncRNA MALAT1-deficiency restrains lipopolysaccharide (LPS)-induced pyroptotic cell death and inflammation in HK-2 cells by releasing microRNA-135b-5p

Jie Huang & Chen Xu
Long non-coding RNAs (LncRNAs) participate in the regulation of chronic kidney disease (CKD), and acute kidney injury (AKI) is identified as an important risk factor for CKD. This study investigated the involvement of a novel LncRNA MALAT1 in regulating lipopolysaccharide (LPS)-induced cell pyroptosis and inflammation in the human renal tubular epithelial HK-2 cells. Here, the HK-2 cells were subjected to LPS (2 μg/mL) treatment to establish cellular AKI models in vitro, and we validated that...

A Unified Framework for Specification Tests of Continuous Treatment Effect Models

Wei Huang, Oliver Linton & Zheng Zhang
We propose a general framework for the specification testing of continuous treatment effect models. We assume a general residual function, which includes the average and quantile treatment effect models as special cases. The null models are identified under the unconfoundedness condition and contain a nonparametric weighting function. We propose a test statistic for the null model in which the weighting function is estimated by solving an expanding set of moment equations. We establish the asymptotic...

Asynchrony among species and functional groups and temporal stability under perturbations: Patterns and consequences

Shurong Zhou
1. A number of theoretical and empirical studies have demonstrated effects of perturbations on ecosystem stability. Compensatory dynamics among taxonomic units have been proposed as a major mechanism regulating the temporal stability of biomass production (hereafter “temporal stability”). However, most studies have focused on the effects of species asynchrony on temporal stability in response to perturbations, and few studies examined how compensatory changes among functional groups affected temporal stability. 2. Here, we conducted a 4-year...

Effects of intensive blood pressure control on mortality and cardiorenal function in chronic kidney disease patients

Yong Zhang, Jing-Jing Li, An-Jun Wang, Bo Wang, Shou-Liang Hu, Heng Zhang, Tian Li & Yan-Hong Tuo
Blood pressure (BP) variability is highly correlated with cardiovascular and kidney outcomes in patients with chronic kidney disease (CKD). However, appropriate BP targets in patients with CKD remain uncertain. We searched PubMed, Embase, and the Cochrane Library for randomized controlled trials (RCTs) of CKD patients who underwent intensive BP management. Kappa score was used to assess inter-rater agreement. A good agreement between the authors was observed to inter-rater reliability of RCTs selection (kappa = 0.77;...

Dominant factors of the phosphorus regulatory network differ under various dietary phosphate loads in healthy individuals

Guoxin Ye, Jiaying Zhang, Zhaori Bi, Weichen Zhang, Minmin Zhang, Qian Zhang, Mengjing Wang & Jing Chen
The purpose of this study was to explore the contribution of each factor of the phosphorus metabolism network following phosphorus diet intervention via Granger causality analysis. In this study, a total of six healthy male volunteers were enrolled. All participants sequentially received regular, low-, and high-phosphorus diets. Consumption of each diet lasted for five days, with a 5-day washout period between different diets. Blood and urinary samples were collected on the fifth day of consumption...

Meta analysis data and fitness-related trait values

Zhiping Song
Crop-wild gene flow may alter the fitness performance of the recipient i.e. crop-wild hybrids, then potentially impact wild populations, especially for the gene flow carrying selective advantage crop alleles. Given the continuous crop-wild gene flow since crop domestication and the occasionally stressful environments, the extant wild populations of most crops are still "wild". This paradox hints some mechanisms may mitigate the effects of crop-wild gene flow but never been examined. We used wild rice (O....

Densities of mollusc species at different sites along the Chinese coast

He-Bo Peng, Ying-Chi Chan, Tanya Compton, Xue-Fei Cheng, David Melville, Shou-Dong Zhang, Zhengwang Zhang, Guangchun Lei, Zhijun Ma & Theunis Piersma
Aim: Molluscs are important grazers, filter and deposit feeders, scavengers and predators, which in turn are food for shorebirds, fish and people. Some species, targeted as human food, have been cultured along the Chinese coast for hundreds of years. To examine whether aquacultural practices have meanwhile affected biodiversity gradients, we measured mollusc community structure along the coast of China in habitats which are intensively used by humans. Location: Chinese coast Methods: We sampled 21 intertidal...

Genomic regions associated with adaptation to predation in Daphnia often include members of expanded gene families

Xiuping Zhang
Predation has been a major driver of the evolution of prey species, which consequently develop antipredator adaptations. However, little is known about the genetic basis underpinning the adaptation of prey to intensive predation. Here, we describe a high-quality chromosome-level genome assembly (approx. 145 Mb, scaffold N50 11.45 Mb) of Daphnia mitsukuri, a primary forage for many fish species. Transcriptional profiling of D. mitsukuri exposed to fish kairomone revealed that this cladoceran responds to predation risk...

A Unified Framework for Specification Tests of Continuous Treatment Effect Models

Wei Huang, Oliver Linton & Zheng Zhang
We propose a general framework for the specification testing of continuous treatment effect models. We assume a general residual function, which includes the average and quantile treatment effect models as special cases. The null models are identified under the unconfoundedness condition and contain a nonparametric weighting function. We propose a test statistic for the null model in which the weighting function is estimated by solving an expanding set of moment equations. We establish the asymptotic...

Registration Year

  • 2021
    31

Resource Types

  • Dataset
    31

Affiliations

  • Fudan University
    31
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    15
  • Capital Medical University
    11
  • Sichuan University
    10
  • Shanghai Jiao Tong University
    10
  • Zhejiang University
    9
  • Chinese Academy of Sciences
    9
  • North West Agriculture and Forestry University
    8
  • Sun Yat-sen University
    8
  • Central South University
    7