13 Works

Cellular electrical properties of specific membrane capacitance and cytoplasmic conductivity

Mei Jiang
The submitted datasets contain the original data of the cell's electronic characteristic parameters of specific membrane capacitance and cytoplasmic conductivity. The cell types include H1299 cells treated with DMSO and 4-Mu, 95C cells treated with DMSO and 4-Mu, A549 control cells and A549 sg-RNA3 cells. The scatter plots and bar graphs demonstrated the differences of electroninc properties were according to these datasets.

Data from: Identification of biomarkers for Barcelona Clinic Liver Cancer staging and overall survival of patients with hepatocellular carcinoma

Wei Xu, Quan Rao, Yongbo An, Mengyi Li & Zhongtao Zhang
The aim of the current study was to identify biomarkers that correlate with the Barcelona Clinic Liver Cancer (BCLC) staging system and prognosis of patients with hepatocellular carcinoma (HCC). We downloaded 4 gene expression datasets from the Gene Expression Omnibus database (http://www.ncbi.nlm.nih.gov/geo), and screened for genes that were differentially expressed between HCC and normal liver tissues, using significance analysis of the microarray algorithm. We used a weighted gene co-expression network analysis (WGCNA) to identify hub...

Aetiology and prognostic risk factors of mortality in pneumonia patients receiving glucocorticoids alone or glucocorticoids and other immunosuppressants: a retrospective cohort study

Lijuan Li, Steven H Hsu, Xiaoying Gu, Shan Jiang, Lianhan Shang, Guolei Sun, Lingxiao Sun, Li Zhang, Chuan Wang, Yali Ren, Jinxiang Wang, Jianliang Pan, Jiangbo Liu & Bin Cao
Objectives: Long-term use of high-dose glucocorticoids can lead to severe immunosuppression and increased risk of treatment-resistant pneumonia and mortality. We investigated the aetiology and prognostic risk factors of mortality in hospitalised patients who developed pneumonia while receiving glucocorticoid therapy alone or glucocorticoid and other immunosuppressant therapies. Design: Retrospective cohort study Setting: Six secondary and tertiary academic hospitals in China Participants: Patients receiving glucocorticoids who were hospitalised with pneumonia between 1st January 2013 and 31st December...

MGMT promoter methylation and IDH mutation detected in 301 patients with GBM

Nan Ji
The datasets had listed the information of IDH mutation or wildtype at c.395G>A and MGMT promoter methylation status in 301 samples with GBM.

Data from: Cognitive function after spinal cord injury: a systematic review

Rahul Sachdeva, Feng Gao, Chetwyn C. H. Chan & Andrei V. Krassioukov
Objective: To systematically examine the incidence of cognitive impairment in individuals with spinal cord injury (SCI), as well as identify potential contributing and confounding factors. Methods: Studies quantitatively reporting cognitive ability after spinal cord injury were searched electronically via Medline, CINAHL, Embase, and PsycINFO. Manual screening for references within articles was also performed. A total of 2,481 studies were screened and a total of 70 were included in this review, 21 reporting cognitive function after...

Dietary nitrate supplementation prevents radiotherapy-induced xerostomia

Songlin Wang, Xiaoyu Feng, Zhifang Wu, Yipu Xu, Juji Xu, Bin Zhao, Baoxing Pang, Xingmin Qu, Liang Hu, Lei Hu, Zhipeng Fan, Luyuan Jin, Dengsheng Xia, Shimin Chang, Jinsong Wang & Chunmei Zhang
Management of salivary gland hypofunction caused by irradiation (IR) therapy for head and neck cancer remains lack of effective treatments. Salivary glands, especially the parotid gland, actively uptake dietary nitrate and secrete it into saliva. Here, we investigated the effect of dietary nitrate on the prevention and treatment of IR-induced parotid gland hypofunction in miniature pigs, and elucidated the underlying mechanism in human parotid gland cells (hPGCs). We found that nitrate administration prevented IR-induced parotid...

F2R polymorphisms and clopidogrel efficacy and safety in patients with minor stroke or TIA: supplemental figures and tables

Yuesong Pan, Runqi Wangqin, Hao Li, Yilong Wang, Xia Meng, S. Claiborne Johnston, Tabassome Simon, Jinxi Lin, Xingquan Zhao, Liping Liu, David Wang & Yongjun Wang
Objective: To investigate the association between protease-activated receptors-1 (PAR-1) gene F2R polymorphisms and efficacy of clopidogrel for minor stroke or transient ischemic attack (TIA). Methods: Three single-nucleotide polymorphisms (CYP2C19*2 [681G>A, rs4244285], CYP2C19*3 [636G>A, rs4986893] and F2R [IVSn-14 A/T, rs168753] were genotyped among 2,924 patients randomized to clopidogrel plus aspirin (n=1461) or aspirin alone (n=1463). The primary efficacy outcome was new stroke (ischemic or hemorrhagic) and the safety outcome was any bleeding. Results: Overall, 859(29.4%) were...

Data from: Novel clinical evidence of an association between homocysteine and insulin resistance in patients with hypothyroidism or subclinical hypothyroidism

Ning Yang, Zhi Yao, Li Miao, Jia Liu, Xia Gao, Hui Fan, Yanjin Hu, Heng Zhang, Yuan Xu, Aijuan Qu & Guang Wang
Objective: Hypothyroidism (HO) can induce significant metabolic dysfunction and increase cardiovascular disease risk. In the present study, we investigated the relationship between homocysteine (Hcy) and insulin resistance (IR) in patients with HO or subclinical hypothyroidism (SHO). Methods: A total of 270 subjects were enrolled. All subjects were divided into the following three groups: HO, SHO and control. Plasma levels of Hcy were measured, and each patient’s homeostatic index of insulin resistance (HOMA-IR) was calculated. Statistical...

Metabolomics signatures in type 2 diabetes: a systematic review and integrative analysis

Yue Sun, Hao-Yu Gao, Zhi-Yuan Fan, Yan He & Yu-Xiang Yan
Objective Metabolic signatures have emerged as valuable signaling molecules in the biochemical process of type 2 diabetes (T2D). To summarize and identify metabolic biomarkers in T2D, we performed a systematic review and meta-analysis of the associations between metabolites and T2D using high-throughput metabolomics techniques. Methods We searched relevant studies from MEDLINE (PubMed), Embase, Web of Science, and Cochrane Library as well as Chinese databases (Wanfang, Vip, and CNKI) inception through 31 December 2018. Meta-analysis was...

Data from: Cough reflex sensitivity and urge-to-cough deterioration in dementia with Lewy bodies

Takae Ebihara, Peijun Gui, Chika Ooyama, Koichi Kozaki & Satoru Ebihara
Cough, an important respiratory symptom, predominantly involves the brainstem, and the urge-to-cough is modulated by the cerebral cortex. Lewy body disease is associated with decreased cough reflex sensitivity and central respiratory chemosensitivity. Additionally, the insula, associated with the urge-to-cough, shows decreased activation and atrophy in dementia with Lewy bodies (DLB). We investigated the relationships between cognition and cough reflex and the urge-to-cough and compared the differences in responses of patients with DLB and other dementia...

Data from: Anterior insular cortex plays a critical role in interoceptive attention

Xingchao Wang, Qiong Wu, Laura Egan, Xiaosi Gu, Pinan Liu, Hong Gu, Yihong Yang, Jing Luo, Yanhong Wu, Zhixian Gao & Jin Fan
Accumulating evidence indicates that the anterior insular cortex (AIC) mediates interoceptive attention, which refers to attention towards physiological signals arising from the body. However, the necessity of the AIC in this process has not been demonstrated. Using a novel task that directs attention toward breathing rhythm, we assessed the involvement of the AIC in interoceptive attention in healthy participants using functional magnetic resonance imaging and examined the necessity of the AIC in interoceptive attention in...

Data from: Modulation of functional activity and connectivity by acupuncture in patients with Alzheimer disease as measured by resting-state fMRI

Weimin Zheng, Zhuangzhi Su, Xingyun Liu, Hao Zhang, Ying Han, Haiqing Song, Jie Lu, Kuncheng Li & Zhiqun Wang
Acupuncture has been used in the therapy of Alzheimer disease (AD); however, its neural mechanisms are still unclear. The aim of this study is to examine the effect of acupuncture on the functional connectivity in AD by using resting-state functional magnetic resonance imaging (rs-fMRI). Twenty-eight subjects (14 AD and 14 normal controls) participated in this study. The rs-fMRI data were acquired before and after acupuncture stimulation at the acupoints of Tai chong (Liv3) and Hegu...

Data from: Human retinal pigment epithelium: in vivo cell morphometry, multispectral autofluorescence, and relationship to cone mosaic

Charles E. Granger, Qiang Yang, Hongxin Song, Kenichi Saito, Koji Nozato, Lisa R. Latchney, Bianca T. Leonard, Mina M. Chung, David R. Williams & Ethan A. Rossi
Purpose: To characterize in vivo morphometry and multispectral autofluorescence of the retinal pigment epithelial (RPE) cell mosaic and its relationship to cone cell topography across the macula. Methods: RPE cell morphometrics were computed in regularly spaced regions of interest (ROIs) from contiguous short-wavelength autofluorescence (SWAF) and photoreceptor reflectance images collected across the macula in one eye of 10 normal participants (23–65 years) by using adaptive optics scanning light ophthalmoscopy (AOSLO). Infrared autofluorescence (IRAF) images of...

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