1,360 Works

Integrative analysis of a novel 5 methylated snoRNA genes prognostic signature in patients with glioma

Bing Zhao, Erbao Bian, Deran Zhang, Zhiwei Wang, Yu Wang, Zhigang Cheng, Zhihao Yang, Lianxin Li, Yinfei Zheng & Xiaoyu Yue
Supplementary Table 1 | Genes associated with risk scores.
Supplementary Table 2 | Expression levels and methylation levels of SNORA71B in gliomas (TCGA Database). Supplementary Table 3 | Fold change values of the 5 methylated snoRNA genes (TCGA Database).
Supplementary Table 4 | Methylation levels of five snoRNAs in gliomas (TCGA Database).
Supplementary Table 5 Clinic-pathological characteristics of 13 glioma patients.

Additional file 2 of Comprehensive characterization of ubiquitinome of human colorectal cancer and identification of potential survival-related ubiquitination

Wei Zhang, Yan Yang, Liewen Lin, Jingquan He, Jingjing Dong, Bin Yan, Wanxia Cai, Yumei Chen, Lianghong Yin, Donge Tang, Fanna Liu & Yong Dai
Additional file 2. Table S1. Ubiquitination annotation. Table S2. Protein annotation. Table S3. 42 proteins having ten or more than ten ubiquitination modifications. Table S4. 20 ubiquitin-binding motifs. Table S5. 2242 proteins with an upregulated ubiquitination and 1204 proteins with a down-regulated ubiquitination. Table S6. 1172 up-regulated proteins and 1700 down-regulated proteins. Table S7. 646 Secretory proteins. Table S8. 53 proteins having an upregulated expression simultaneously with a down-regulated ubiquitination and 116 proteins having down-regulated...

Additional file 2 of Oxidative stress genes in patients with esophageal squamous cell carcinoma: construction of a novel prognostic signature and characterization of tumor microenvironment infiltration

Wei Liu, Hao-Shuai Yang, Shao-Yi Zheng, Hong-He Luo, Yan-Fen Feng & Yi-Yan Lei
Additional file 2: Table S2. Median survival times for the high- and low- risk groups ESCC patients of survival curves stratified by these clinical characteristics in the training, testing, and entire sets.

Additional file 4 of Oxidative stress genes in patients with esophageal squamous cell carcinoma: construction of a novel prognostic signature and characterization of tumor microenvironment infiltration

Wei Liu, Hao-Shuai Yang, Shao-Yi Zheng, Hong-He Luo, Yan-Fen Feng & Yi-Yan Lei
Additional file 4: Table S3. The results of univariate Cox proportional hazards regression analyses between clinical features and risk score in the training, testing, and entire sets.

Additional file 1 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 1. Table S1: Patient demography.

Additional file 2 of Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study

Jinghuan Gan, Zhichao Chen, Zhihong Shi, Xudong Li, Shuai Liu, Yiming Liu, Hongcan Zhu, Lu Shen, Guili Zhang, Yong You, Qihao Guo, Nan Zhang, Yang Lv, Baozhi Gang, Junliang Yuan & Yong Ji
Additional file 2: Onset age groups (years old) and Age at last visit groups (years old).

EFFECT OF THE PROBLEM-BASED LEARNING METHOD ON STUDENT ELECTROENCEPHALOGRAMS AND MICROCIRCULATORY BLOOD PERFUSION IN THE TEACHING OF SPORTS PHYSIOLOGY

Xiaoli Liu, Huan Zhu, Shufeng Zhou, Yong Peng, Mei Yang, Fen Chen & Xiaoming Li
ABSTRACT Introduction Applying the problem-based learning (PBL) method to the teaching of sports physiology. Objective This study explored the mechanism of the PBL method to improve the interest and learning effectiveness of students. Methods Twenty male students at the Physical Education College of Hubei Minzu University were randomly divided into a PBL group (10) and a traditional teaching method group (TTM). During the test, the subjects in the TTM group sat quietly listening to the...

A review of building detection from very high resolution optical remote sensing images

Jiayi Li, Xin Huang, Lilin Tu, Tao Zhang & Leiguang Wang
Building detection from very high resolution (VHR) optical remote sensing images, which is an essential but challenging task in remote sensing, has attracted increased attention in recent years. However, despite the many methods that have been developed, an in-depth review of the recent literature on building extraction from VHR optical images is still lacking. In this article, we present a comprehensive review of the recent advances (since 2000) in this field. In total, we survey...

Additional file 1 of Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia

Mei-si Lin, Hui-Yun Zhong, Rita Lok-Hay Yim, Qi-Yan Chen, Hong-ling Du, Hao-qi He, Ke Lin, Peng Zhao, Ru Gao, Fei Gao & Min-Yue Zhang
Additional file 1: Supplementary Table S1. Statistical results of Student’s T-test for TNFAIP2 expression level among different subtypes of AML patients from TCGA cohort in the distribution of FAB classifications. The results were analyzed by UALCAN. Supplementary Table S2. Statistical results of Student’s T-test for TNFAIP2 expression level among different subtypes of AML patients in the microarray data of GSE14468 from the GEO database in the distribution of FAB classifications. Supplementary Table S3. The co-expressed...

Additional file 1 of Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia

Mei-si Lin, Hui-Yun Zhong, Rita Lok-Hay Yim, Qi-Yan Chen, Hong-ling Du, Hao-qi He, Ke Lin, Peng Zhao, Ru Gao, Fei Gao & Min-Yue Zhang
Additional file 1: Supplementary Table S1. Statistical results of Student’s T-test for TNFAIP2 expression level among different subtypes of AML patients from TCGA cohort in the distribution of FAB classifications. The results were analyzed by UALCAN. Supplementary Table S2. Statistical results of Student’s T-test for TNFAIP2 expression level among different subtypes of AML patients in the microarray data of GSE14468 from the GEO database in the distribution of FAB classifications. Supplementary Table S3. The co-expressed...

Additional file 4 of Genome-wide identification of key enzyme-encoding genes and the catalytic roles of two 2-oxoglutarate-dependent dioxygenase involved in flavonoid biosynthesis in Cannabis sativa L.

Xuewen Zhu, Yaolei Mi, Xiangxiao Meng, Yiming Zhang, Weiqiang Chen, Xue Cao, Huihua Wan, Wei Yang, Jun Li, Sifan Wang, Zhichao Xu, Atia Tul Wahab, Shilin Chen & Wei Sun
Additional file 4:Table S3. Secondary structure predication of the CsFLS proteins in C. sativa.

Additional file 2 of Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

Jonathan Higham, Lyndsay Kerr, Qian Zhang, Rosie M. Walker, Sarah E. Harris, David M. Howard, Emma L. Hawkins, Anca-Larisa Sandu, J. Douglas Steele, Gordon D. Waiter, Alison D. Murray, Kathryn L. Evans, Andrew M. McIntosh, Peter M. Visscher, Ian J. Deary, Simon R. Cox & Duncan Sproul
Additional file 2: Supplementary tables Table S1-7.

Eltrombopag modulates the phenotypic evolution and potential immunomodulatory roles of monocytes/macrophages in immune thrombocytopenia

Feifei Yang, Hui Zong, Feng Li, Shulin Luo, Xiuqun Zhang, Yanli Xu & Xuezhong Zhang
Primary immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease. Loss of immune tolerance plays a crucial role in the pathogenesis of ITP. Monocytes and macrophages play an indispensable role in the pathophysiology of hematopoietic malignancies and have been implicated as key players in platelet destruction. Approximately 80% of adult patients with ITP exhibit corticosteroid treatment failure or become dependent, requiring novel therapy. Thrombopoietin (TPO) receptor agonists (TPO-RAs) have been used clinically to manage ITP...

Additional file 8 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 8: Table S4. The summary of imprinted lncRNA identified in 12 DAP sunflower endosperm.

Additional file 1 of Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1

Jian Gao, Yong-Qiang Ao, Ling-Xian Zhang, Jie Deng, Shuai Wang, Hai-Kun Wang, Jia-Hao Jiang & Jian-Yong Ding
Additional file 1. The mass spectromy data of the band at 70kDa of circZNF451 RNA pulldown in macrophages.

Additional file 3 of Pseudomonas aeruginosa biofilm dispersion by the mouse antimicrobial peptide CRAMP

Yang Zhang, Peng Cheng, Shiyuan Wang, Xiaofen Li, Lianci Peng, Rendong Fang, Jing Xiong, Hui Li, Cui Mei, Jiye Gao, Zhenhui Song, Dengfeng Xu, Lizhi Fu, Chenghong Li, Xueqing Wu, Yuzhang He & Hongwei Chen
Additional file 3. Differentially expressed protein data.

FADD phosphorylation contributes to development of renal fibrosis by accelerating epithelial-mesenchymal transition

Yan Lin, Fangfang Cai, Xiaoyang Wang, Yunwen Yang, Yongzhe Ren, Chun Yao, Xiaoxing Yin, Hongqin Zhuang & Zichun Hua
FADD, a classical apoptotic signaling adaptor, has recently been reported to exhibit a series of non-apoptotic functions. Here, we report that FADD may play a critical role in the development of renal fibrosis. Neutrophil infiltration in the renal interstitial part, glomerular mesangial cell proliferation, and base-membrane thickening were observed in FADD-D mice by H&E, PAS, and PASM staining. Immunofluorescence analysis revealed that macrophage infiltration was significantly enhanced in FADD-D mice. Renal fibrosis might be induced...

Additional file 3 of Physiological and protein profiling analysis provides insight into the underlying molecular mechanism of potato tuber development regulated by jasmonic acid in vitro

Jianlong Yuan, Lixiang Cheng, Huijun Li, Congcong An, Yuping Wang & Feng Zhang
Additional file 3: Table S3. The differential expression changes (Fold change ≥ 1.2 or ≤ 0.83, p < 0.05) of DEPs in each group (0.5 μM JA / control, 5 μM JA / control, 50 μM JA / control, 5 μM JA / 0.5 μM JA, 50 μM JA / 0.5 μM JA, 50 μM JA / 5 μM JA).

Additional file 4 of Physiological and protein profiling analysis provides insight into the underlying molecular mechanism of potato tuber development regulated by jasmonic acid in vitro

Jianlong Yuan, Lixiang Cheng, Huijun Li, Congcong An, Yuping Wang & Feng Zhang
Additional file 4: Table S4. The protein name and information of JA-responsive DEPs presented in the heatmap of Fig. 4B.

Additional file 1 of Bioinformatics methods in biomarkers of preeclampsia and associated potential drug applications

Ying Peng, Hui Hong, Na Gao, An Wan & Yuyan Ma
Additional file 1:

LncRNA-UCA1 regulates lung adenocarcinoma progression through competitive binding to miR-383

Li Tang, Sheng Wang, Yapeng Wang, Kang Li & Qiang Li
The present study aimed to assess the role of the long non-coding RNA-urothelial cancer associated 1 (lncRNA-UCA1)/microRNA (miR)-383/vascular endothelial growth factor A (VEGFA) axis in regulating lung adenocarcinoma physiology through in vivo and in vitro experiments. The expression profile of lncRNA-UCA1 was analyzed by genome-wide analysis from GSE146459. The cell counting Kit-8, colony formation, wound healing and transwell assays were performed to evaluate the effects of lncRNA-UCA1 in vitro. In addition, luciferase reporter assays were...

Gestational diabetes mellitus placentas exhibit epimutations at placental development genes

Laetitia P. Meyrueix, Raad Gharaibeh, Jing Xue, Cory Brouwer, Corbin Jones, Linda Adair, Shane A. Norris & Folami Ideraabdullah
Gestational diabetes mellitus (GDM) is a maternal metabolic disorder that perturbs placental development and increases the risk of offspring short- and long-term metabolic disorders. The mechanisms by which GDM impairs placental development remain poorly understood. Here, we defined the DNA methylome of GDM placentas and determined whether GDM perturbs methylation at genes important for placental development. We conducted an epigenome-wide association study of 42 placentas from pregnancies in the South African Soweto First 1000 days...

Additional file 6 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 6: Table S3. Differentially expressed protein-coding genes in atm mutated flies.

Additional file 8 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 8: Table S5. miRNA counts.

Clinical features of the first critical case of acute encephalitis caused by the avian influenza A (H5N6) virus

Libing Zhang, Kaituo Liu, Qin Su, Xiao Chen, Xiaoquan Wang, Qingfeng Li, Wenlei Wang, Xuhua Mao, Jinmei Xu, Xin Zhou, Qin Xu, Le Zhou, Xiufan Liu & Pinghu Zhang
Highly pathogenic avian influenza viruses (HPAIV), such as H5N1, H5N6, and H7N9, have been reported to frequently infect humans, but acute encephalitis caused by HPAIV in humans has been rarely reported. We report the first critical case of acute encephalitis with mild pneumonia caused by the H5N6 virus. On January 25 of 2022, a 6-year-old girl with severe neurological symptoms was admitted to our hospital and rapidly developed into seizures and coma. Brain imaging showed...

Registration Year

  • 2022
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  • Dataset
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Affiliations

  • Capital Medical University
    1,360
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    940
  • Zhejiang University
    797
  • Shanghai Jiao Tong University
    776
  • Huazhong University of Science and Technology
    680
  • Fudan University
    668
  • Sichuan University
    653
  • Chinese Academy of Sciences
    627
  • Sun Yat-sen University
    624
  • Nanjing Medical University
    605