8 Works

Data from: Ecosystem multifunctionality is promoted by organic farming and hedgerows at the local scale but not at the landscape scale

Audrey Alignier, Couthouis Eloïse, Aviron Stéphanie & Julien Pétillon
This dataset gathers information used for the paper Couthouis et al. "Ecosystem multifunctionality is promoted by organic farming and hedgerows at the local scale but not at the landscape scale", part of the BIOMHE project (2019-2022) funded by the Fondation de France. It contains data about (i) species richness and abundances used for calculating ecological performance, (ii) crop yield used for calculating agronomic performance, (iii) labour and semi-net margin used for calculating socio-economic performance. Combined,...

Eco-evolutionary consequences of living with close relatives: Resistance to herbivores and climatic stress increases with investment into mycorrhiza in adult oaks

Mickael Pihain, Andreas Prinzing, Alexis Ducousso, Pierre-Emmanuel Courty, Thomas Houet, Romain Georges, Olivier Jambon, Brigitte Musch & Pille Gerhold
1. Mycorrhizas are known to increase plant resistance to herbivores and climatic stress. However, it is unknown if particularly hostile environments select for increased investment of plants into mycorrhiza. 2. We studied hostile biotic environments: phylogenetically proximate neighbourhoods known to increase herbivory and pedoclimatic stress. In a common garden, we studied the resistances, tri-trophic interactions and microclimate of 28-years-old oaks (Quercus petraea), descending from provenances of contrasting phylogenetic neighbourhoods. 3. We found that oaks descending...

Additional file 2 of Host-plant adaptation as a driver of incipient speciation in the fall armyworm (Spodoptera frugiperda)

Estelle Fiteni, Karine Durand, Sylvie Gimenez, Robert L. Meagher, Fabrice Legeai, Gael J. Kergoat, Nicolas Nègre, Emmanuelle d’Alençon & Kiwoong Nam
Additional file 2: Table S4. The list of genes in the loci with potential selective sweeps.

Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis

Imran Khan, Catherine Marelia-Bennet, Julia Lefler, Mariyam Zuberi, Eric Denbaum, Akiko Koide, Dean M. Connor, Ann-Marie Broome, Thierry Pécot, Cynthia Timmers, Michael C. Ostrowski, Shohei Koide & John P. O’Bryan
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). Although pharmacological inhibition of RAS has been challenging, KRAS(G12C)-specific inhibitors have recently entered the clinic. While KRAS(G12C) is frequently expressed in lung cancers, it is rare in PDAC. Thus, more broadly efficacious RAS inhibitors are...

Additional file 2 of Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Additional file 2: Supplementary tables ST1-ST12. ST1 – Participants’ characteristics; ST2 - Global methylation analyses; ST3 - Inflation Factors; ST4 - Top 100 DMPs; ST5 - Replication Analysis; ST6 - DMRs; ST7 - Trait Enrichment; ST8 - Gene enrichment; ST9 - Sensitivity analyses of DMRs; ST10 - Association between blood pressure and cell-type composition; ST11 – Compositional mediation analysis; ST12 - Mediation analysis: role of the ratio Stromal/Syncytiotrophoblasts.

Additional file 2 of Host-plant adaptation as a driver of incipient speciation in the fall armyworm (Spodoptera frugiperda)

Estelle Fiteni, Karine Durand, Sylvie Gimenez, Robert L. Meagher, Fabrice Legeai, Gael J. Kergoat, Nicolas Nègre, Emmanuelle d’Alençon & Kiwoong Nam
Additional file 2: Table S4. The list of genes in the loci with potential selective sweeps.

When ancestors transmit their stress: Prenatal maternal stress transmission across generations in a precocial bird

Marion Charrier, Sophie Lumineau, Isabelle George, Maryse Meurisse, Marion Georgelin, Rupert Palme, Frédéric Angelier, Vincent Coustham, Céline Nicolle, Aline Bertin, Anne-Sophie Darmaillacq, Ludovic Dickel, Daniel Guémené, Ludovic Calandreau & Cécilia Houdelier
Prenatal maternal stress (PMS) induces life-long effects in offspring. Accumulating evidence suggests that these effects can be transmitted across generations. Although multigenerational effects (F0 mother to F2 grand-offspring) of PMS have been demonstrated in different species, transgenerational transmission (F0 mother to F3 great-grand-offspring) has been less explored. We showed previously in the Japanese quail that PMS increased F1 offspring’s emotional reactivity related to epigenetic marks levels in their brain and to modulation of testosterone concentrations...

Additional file 2 of Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Additional file 2: Supplementary tables ST1-ST12. ST1 – Participants’ characteristics; ST2 - Global methylation analyses; ST3 - Inflation Factors; ST4 - Top 100 DMPs; ST5 - Replication Analysis; ST6 - DMRs; ST7 - Trait Enrichment; ST8 - Gene enrichment; ST9 - Sensitivity analyses of DMRs; ST10 - Association between blood pressure and cell-type composition; ST11 – Compositional mediation analysis; ST12 - Mediation analysis: role of the ratio Stromal/Syncytiotrophoblasts.

Registration Year

  • 2022
    8

Resource Types

  • Dataset
    8

Affiliations

  • University of Rennes 1
    8
  • Institut de Recherche en Informatique et Systèmes Aléatoires
    2
  • Agricultural Research Service
    2
  • French National Centre for Scientific Research
    2
  • Inserm
    2
  • Diversity, Genomes and Insects-Microorganisms Interactions
    2
  • Harvard University
    2
  • University of Paris-Saclay
    2
  • University of Montpellier
    2
  • Institut Cochin
    2