35 Works

Data from: Sierra Nevada mountain lake microbial communities are structured by temperature, resources, and geographic location

Marika Schulhof, Andrew Allen, Eric Allen, Natalie Mladenov, John McCrow, Natalie Jones, Jessica Blanton, Hamanda Badona Cavalheri, Drishti Kaul, Celia Symons & Jonathan Shurin
Warming, eutrophication (nutrient fertilization) and brownification (increased loading of allochthonous organic matter) are three global trends impacting lake ecosystems. However, the independent and synergistic effects of resource addition and warming on autotrophic and heterotrophic microorganisms are largely unknown. In this study, we investigate the independent and interactive effects of temperature, dissolved organic carbon (DOC, both allochthonous and autochthonous), and nitrogen (N) supply, in addition to the effect of spatial variables, on the composition, richness, and...

Oxygen exposure of common benthic megafauna off San Diego, CA

Ed Parnell
Oxygen decline poses increasing risks to global shelf communities. This study was conducted to measure species oxygen exposures in situ, and to assess risks of low oxygen based on the hypothesis that species risk varies spatially and is dependent on the interaction of shelf oxygen dynamics with habitat pattern, species mobility and tolerance to low oxygen. Here, we report concomitant observations of oxygen, depth, and habitat for the most common benthic and epibenthic megafauna on...

Data from: Anticholinergic medications: A potentially modifiable risk factor for development of MCI

Alexandra Weigand, Mark W. Bondi, Kelsey R. Thomas, Noll L Campbell, Douglas Galasko, David P. Salmon, Daniel Sewell, James B. Brewer, Howard H Feldman & Lisa Delano-Wood
Objective: To determine the cognitive consequences of anticholinergic medications (aCH) in cognitively normal older adults as well as interactive effects of genetic and cerebrospinal fluid (CSF) Alzheimer’s disease (AD) risk factors. Methods: 688 cognitively normal participants from the Alzheimer’s Disease Neuroimaging Initiative were evaluated (mean age = 73.5, 49.6% female). Cox regression examined risk of progression to mild cognitive impairment (MCI) over a 10-year period, and linear mixed effects models examined 3-year rates of decline...

Kelp forests at the end of the earth: 45 years later

Alan Friedlander, Enric Ballesteros, Tom Bell, Jennifer Caselle, Claudio Campagna, Mathias Hune, Alex Munoz, Pelayo Salinas-De-Leon, Enric Sala & Paul Dayton
The kelp forests of southern South America are some of the least disturbed on the planet. The remoteness of this region has, until recently, spared it from many of the direct anthropogenic stressors that have negatively affected these ecosystems elsewhere. Re-surveys of 11 locations at the easternmost extent of Tierra del Fuego originally conducted in 1973 showed no significant differences in the densities of adult and juvenile Macrocystis pyrifera kelp or kelp holdfast diameter between...

Phylogenomic analysis and morphological data suggest left-right swimming behavior evolved prior to the origin of the pelagic Phylliroidae (Gastropoda: Nudibranchia)

Jessica Goodheart & Heike Wägele
Evolutionary transitions from benthic to pelagic habitats are major adaptive shifts. Investigations into such shifts are critical for understanding the complex interaction between co-opting existing traits for new functions and novel traits that originate during or post-transition. Gastropod mollusks are of particular interest in regard to benthic-pelagic evolutionary transitions, as shifts from benthic to pelagic habitats are uncommon. Phylliroe is one such pelagic lineage in Phylliroidae, a family of holoplanktonic nudibranchs with a highly aberrant...

Data from: Allocation of gene products to daughter cells is determined by the age of the mother in single Escherichia coli cells

Ulla Rang, Chao Shi, Lin Chao, Audrey Proenca, Andrew Qiu & Jasper Chao
Gene expression and growth rate are highly stochastic in E. coli. Some of the growth rate variations result from the deterministic and asymmetric partitioning of damage by the mother to its daughters. One daughter, denoted the old daughter, receives more damage, grows more slowly, and ages. To determine if expressed gene products are also allocated asymmetrically, we compared the levels of expressed green fluorescence protein in growing daughters descending from the same mother. Our results...

Mitonuclear mismatch alters performance and reproductive success in naturally-introgressed populations of a montane leaf beetle

Nathan Rank, Nathan E Rank, Patrick Mardulyn, Sarah J Heidl, Kevin T Roberts, Nicolas A Zavala, John T Smiley & Elizabeth P Dahlhoff
Coordination between nuclear and mitochondrial genomes is critical to metabolic processes underlying animals' ability to adapt to local environments, yet consequences of mitonuclear interactions have rarely been investigated in populations where individuals with divergent mitochondrial and nuclear genomes naturally interbreed. Genetic variation in the leaf beetle Chrysomela aeneicollis was assessed along a latitudinal thermal gradient in California's Sierra Nevada. Variation at mitochondrial cytochrome oxidase II (COII) and the nuclear gene phosphoglucose isomerase (PGI) shows concordance...

Data from: Validation of serum neurofilaments as prognostic & potential pharmacodynamic biomarkers for ALS

Michael Benatar, Lanyu Zhang, Lily Wang, Volkan Granit, Jeffrey Statland, Richard Barohn, Andrea Swenson, John Ravitz, Carlayne Jackson, Ted Burns, Jaya Trivedi, Erik Pioro, James Caress, Jonathan Katz, Jacob McCauley, Rosa Rademakers, Andrea Malaspina, Lyle Ostrow & Joanne Wuu
Objective. Identify preferred neurofilament assays, and clinically validate serum NfL and pNfH as prognostic and potential pharmacodynamic biomarkers relevant to ALS therapy development. Methods. Prospective, multi-center, longitudinal observational study of patients with ALS (n=229), primary lateral sclerosis (PLS, n=20) and progressive muscular atrophy (PMA, n=11). Biological specimens were collected, processed and stored according to strict standard operating procedures (SOPs) 1. Neurofilament assays were performed in a blinded manner by independent contract research organizations (CROs). Results....

Legacy effects of fish but not elevation influence lake ecosystem response to environmental change

Celia Symons, Marika Schulhof, Hamanda Cavalheri & Jonathan Shurin
How communities reorganize during climate change depends on the distribution of diversity within ecosystems and across landscapes. Understanding how environmental and evolutionary history constrain community resilience is critical to predicting shifts in future ecosystem function. The goal of our study was to understand how communities with different histories respond to environmental change with regard to shifts in elevation (temperature, nutrients) and introduced predators. We hypothesized that community responses to the environment would differ in ways...

Data from: Phytoplankton growth and stoichiometric responses to warming, nutrient addition and grazing depend on lake productivity and cell size

Dedmer Van De Waal, Marika A. Schulhof, Jonathan B. Shurin & Steven A. J. Declerck
Global change involves shifts in multiple environmental factors that act in concert to shape ecological systems in ways that depend on local biotic and abiotic conditions. Little is known about the effects of combined global change stressors on phytoplankton communities, and particularly how these are mediated by distinct community properties such as productivity, grazing pressure and size distribution. Here, we tested for the effects of warming and eutrophication on phytoplankton net growth rate and C:N:P...

Registration Year

  • 2020

Resource Types

  • Dataset


  • University of California, San Diego
  • University of California, Irvine
  • University of Queensland
  • University of California, Berkeley
  • Netherlands Institute of Ecology
  • University of California, Santa Barbara
  • University of California, Riverside
  • Vrije Universiteit Brussel
  • University of Washington
  • University of Pretoria