Data from: Transgenerational effects of mild heat in Arabidopsis thaliana show strong genotype specificity that is explained by climate at originMaartje P. Groot, Alexander Kubisch, N. Joop Ouborg, Joern Pagel, Karl J. Schmid, Philippine Vergeer & Christian Lampei
Transgenerational environmental effects can trigger strong phenotypic variation. However, it is unclear how cues from different preceding generations interact. Also, little is known about genetic variation for these life-history-traits. Here we present effects of grandparental and parental mild heat, and their combination, on four traits of the third-generation phenotype of 14 Arabidopsis thaliana genotypes. We tested for correlations of these effects with climate and constructed a conceptual model to identify the environmental conditions that favour...
Data from: A quantitative theory of gamma synchronization in macaque V1Eric Lowet, Mark Jonathan Roberts, Alina Peter, Bart Gips & Peter De Weerd
Gamma-band synchronization coordinates brief periods of excitability in oscillating neuronal populations to optimize information transmission during sensation and cognition. Commonly, a stable, shared frequency over time is considered a condition for functional neural synchronization. Here, we demonstrate the opposite: instantaneous frequency modulations are critical to regulate phase relations and synchronization. In monkey visual area V1, nearby local populations driven by different visual stimulation showed different gamma frequencies. When similar enough, these frequencies continually attracted and...
Data from: Niche differentiation and expansion of plant species are associated with mycorrhizal symbiosisMaret Gerz, C. Guillermo Bueno, Wim A. Ozinga, Martin Zobel & Mari Moora
Mycorrhizal symbiosis is a widespread association between plant roots and mycorrhizal fungi, which is thought to contribute to plant niche differentiation and expansion. However, this has so far not been explicitly tested. To address the effect of mycorrhizal symbiosis on plants’ realized niches, we addressed how mycorrhizal status (i.e. the frequency of occurrence of mycorrhizal symbiosis), flexibility (i.e. the ability to grow both with and without mycorrhizal symbiosis) and type of a plant species affect...
Data from: Intergenerational environmental effects: functional signals in offspring transcriptomes and metabolomes after parental jasmonic acid treatment in apomictic dandelionKoen J. F. Verhoeven, Eline H. Verbon, Thomas P. Van Gurp, Carla Oplaat, Julie Ferreira De Carvalho, Alison M. Morse, Mark Stahl, Mirka Macel & Lauren M. McIntyre
Parental environments can influence offspring traits. However, the magnitude of the impact of parental environments on offspring molecular phenotypes is poorly understood. Here, we test the direct effects and intergenerational effects of jasmonic acid (JA) treatment, which is involved in herbivory-induced defense signaling, on transcriptomes and metabolomes in apomictic common dandelion (Taraxacum officinale). In a full factorial crossed design with parental and offspring JA and control treatments, we performed leaf RNA-seq gene expression analysis, LC-MS...
Data from: Belowground complementarity effects in a grassland biodiversity experiment are related to deep-rooting speciesNatalie J. Oram, Janneke M. Ravenek, Kathryn E. Barry, Alexandra Weigelt, Hongmei Chen, Arthur Gessler, Annette Gockele, Hans De Kroon, Jan Willem Van Der Paauw, Michael Scherer-Lorenzen, Annemiek Smit-Tiekstra, Jasper Van Ruijven & Liesje Mommer
1. Belowground resource partitioning is often proposed as the underlying mechanism for the positive relationship between plant species richness and productivity. For example, if species have different root distributions, a mixture of plant species may be able to use the available resources more completely than the individual species in a monoculture. However, there is little experimental evidence for differentiation in vertical root distributions among species and its contribution to biodiversity effects. 2. We determined species-specific...
Data from: Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunityWill J. R. Stone, Joseph J. Campo, André Lin Ouédraogo, Lisette Meerstein-Kessel, Isabelle Morlais, Dari Da, Anna Cohuet, Sandrine Nsango, Colin J. Sutherland, Marga Van De Vegte-Bolmer, Rianne Siebelink-Stoter, Geert-Jan Van Gemert, Wouter Graumans, Kjerstin Lanke, Adam D. Shandling, Jozelyn V. Pablo, Andy A. Teng, Sophie Jones, Roos M. De Jong, Amanda Fabra-García, John Bradley, Will Roeffen, Edwin Lasonder, Giuliana Gremo, Evelin Schwarzer … & Matthijs M. Jore
Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly...
Data from: Evolution of cross-resistance to medical triazoles in Aspergillus fumigatus through selection pressure of environmental fungicidesJianhua Zhang, Joost Van Den Heuvel, Alfons J. M. Debets, Paul E. Verweij, Willem J. G. Melchers, Bas J. Zwaan & Sijmen E. Schoustra
Resistance to medical triazoles in Aspergillus fumigatus is an emerging problem for patients at risk of aspergillus diseases. There are currently two presumed routes for medical triazole-resistance selection: (i) through selection pressure of medical triazoles when treating patients and (ii) through selection pressure from non-medical sterol-biosynthesis-inhibiting (SI) triazole fungicides which are used in the environment. Previous studies have suggested that SI fungicides can induce cross-resistance to medical triazoles. Therefore, to assess the potential of selection...
Data from: Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensityBronner P. Gonçalves, Melissa C. Kapulu, Patrick Sawa, Wamdaogo M. Guelbéogo, Alfred B. Tiono, Lynn Grignard, Will Stone, Joel Hellewell, Kjerstin Lanke, Guido J. H. Bastiaens, John Bradley, Issa Nébié, Joyce M. Ngoi, Robin Oriango, Dora Mkabili, Maureen Nyaurah, Janet Midega, Dyann F. Wirth, Kevin Marsh, Thomas S. Churcher, Philip Bejon, Sodiomon B. Sirima, Chris Drakeley & Teun Bousema
A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a multi-regional assessment of population-wide malaria transmission potential based on 1209 mosquito feeding assays in endemic areas of Burkina Faso and Kenya. Across both sites, we identified 39 infectious individuals. In high endemicity settings, infectious individuals were identifiable by research-grade microscopy (92.6%; 25/27), whilst one of three infectious individuals in the lowest endemicity setting was detected by...
Data from: Warming advances top-down control and reduces producer biomass in a freshwater plankton communityMandy Velthuis, Lisette N. De Senerpont Domis, Thijs Frenken, Susanne Stephan, Garabet Kazanjian, Ralf Aben, Sabine Hilt, Sarian Kosten, Ellen Van Donk & Dedmer B. Van De Waal
Global warming has been shown to affect ecosystems worldwide. Warming may, for instance, disrupt plant herbivore synchrony and bird phenology in terrestrial systems, reduce primary production in oceans, and promote toxic cyanobacterial blooms in freshwater lakes. Responses of communities will not only depend on direct species-specific temperature effects, but also on indirect effects related to bottom-up and top-down processes. Here, we investigated the impact of warming on freshwater phytoplankton community dynamics, and assessed the relative...
Data from: Restoration of endangered fen communities: the ambiguity of iron-phosphorus binding and phosphorus limitationWillem-Jan Emsens, Camiel J.S. Aggenbach, Alfons J.P. Smolders, Dominik Zak, Ruurd Van Diggelen, C.J.S. Aggenbach, A.J.P. Smolders & W.-J. Emsens
1.Low phosphorus (P) availability limits plant biomass production in fens, which is a prerequisite for the persistence of many endangered plant species. We hypothesized that P limitation is linked to soil iron (Fe) content and soil Fe:P ratios as iron compounds provide binding sites for dissolved P, presumably reducing P availability to plants. 2.We sampled 30 fens in a trans-European field survey to determine how soil Fe pools relate to pools of P and Fe-bound...
Data from: Topical vancomycin reduces the cerebrospinal fluid shunt infection rate: a retrospective cohort studyErik J. Van Lindert, Martine Van Bilsen, Michiel Van Der Flier, Eva Kolwijck, Hans Delye & Jaap Ten Oever
Object: Despite many efforts at reduction, cerebrospinal fluid (CSF) shunt infections are a major cause of morbidity in shunt surgery, occurring in 5-15% of cases. To attempt to reduce the shunt infection rate at our institution, we added topical vancomycin (intrashunt and perishunt) to our existing shunt infection prevention protocol in 2012. Methods: We performed a retrospective cohort study comparing all shunted patients in January 2010 to December 2011 without vancomycin (control group, 263 procedures)...
Data from: Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: two open-label, randomized, safety trialsGuido Bastiaens, Alfred B. Tiono, Joseph Okebe, Helmi Pett, Sam A. Coulibaly, Bronner P. Gonçalves, Muna Affara, Alphonse Ouédraogo, Edith C. Bougouma, Guillaume S. Sanou, Issa Nébié, John Bradley, Kjerstin H. W. Lanke, Mikko Niemi, Sodiomon B. Sirima, Umberto D'Alessandro, Teun Bousema, Chris Drakeley, Guido J. H. Bastiaens, Helmi E. Pett & Umberto D’Alessandro
Background: Primaquine (PQ) actively clears mature Plasmodium falciparum gametocytes but in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals can cause hemolysis. We assessed the safety of low-dose PQ in combination with artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP) in G6PDd African males with asymptomatic P. falciparum malaria. Methods and findings: In Burkina Faso, G6PDd adult males were randomized to treatment with AL alone (n = 10) or with PQ at 0.25 (n = 20) or 0.40 mg/kg (n =...
Radboud University Nijmegen12
London School of Hygiene & Tropical Medicine3
Medical Research Council3
Wageningen University & Research3
Nederlands Instituut voor Ecologie2
Department of Disease Control1
University of Antwerp1
University of Hohenheim1
University of Würzburg1