34 Works
Additional file 2 of Effector protein Hcp2a of avian pathogenic Escherichia coli interacts with the endoplasmatic reticulum associated RPL23 protein of chicken DF-1 fibroblasts
Zhe Chen, Zhao Qi, Ziqi Li, Zichao Song, Xiaoru Wang, Ying Shao, Jian Tu & Xiangjun Song
Additional file 2. GO functional annotation of Hcp2a-interacting proteins. GO functional annotation of Hcp2a-specific prey proteins screened by pull-down.
Additional file 2 of Effector protein Hcp2a of avian pathogenic Escherichia coli interacts with the endoplasmatic reticulum associated RPL23 protein of chicken DF-1 fibroblasts
Zhe Chen, Zhao Qi, Ziqi Li, Zichao Song, Xiaoru Wang, Ying Shao, Jian Tu & Xiangjun Song
Additional file 2. GO functional annotation of Hcp2a-interacting proteins. GO functional annotation of Hcp2a-specific prey proteins screened by pull-down.
Additional file 6 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 6: The newly downloaded dataset of microbe-drug associations.
Additional file 8 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 8: The newly downloaded dataset of microbe-microbe interactions.
Identification of hsa_circ_0002024 as a prognostic competing endogenous RNA (ceRNA) through the hsa_miR_129-5p/Anti-Silencing Function 1B Histone Chaperone (ASF1B) axis in renal cell carcinoma
Zhe Chen, Dehua Ou, Zhuangkai Huang & Peilin Shen
We aimed to identify novel circular RNAs (circRNAs) as prognostic competing endogenous RNAs (ceRNAs) to serve as genetic biomarkers and therapeutic targets for renal cell carcinoma (RCC). High-throughput sequencing data of circRNAs from Gene Expression Omnibus (GEO) and of microRNAs (miRNAs) and messenger RNAs (mRNAs) from The Cancer Genome Atlas (TCGA) were retrieved to identify differentially expressed RNAs (DERNAs). DEmRNAs were subjected to weighted gene coexpression network analysis (WGCNA) to identify prognostic DEmRNA (proDEmRNA) modules....
MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma
Xijing Zhuang, Feng Gao, Lei Shi, Wei Liu, Wenjun Wang, Xuezhi He & Yang Gao
MicroRNAs are crucial regulators in the phenotype switch of vascular smooth muscle cells (VSMCs). Nonetheless, the role of miR-146b-3p in VSMCs remains unclear. In the present study, platelet-derived growth factor-BB (PDGF-BB) at different concentrations was employed to stimulate VSMCs for different times, to establish the model of VSMC dysfunction. The relative expression of miR-146b-3p was quantified by quantitative real-time polymerase chain reaction (qRT-PCR). The proliferation of VSMCs was measured by BrdU assay. Flow cytometry analysis...
Additional file 3 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 3: The newly downloaded dataset of microbes.
Additional file 5 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 5: The newly downloaded dataset of drug-drug interactions.
Additional file 7 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 7: The newly downloaded dataset of microbe-disease associations.
Additional file 1 of Effector protein Hcp2a of avian pathogenic Escherichia coli interacts with the endoplasmatic reticulum associated RPL23 protein of chicken DF-1 fibroblasts
Zhe Chen, Zhao Qi, Ziqi Li, Zichao Song, Xiaoru Wang, Ying Shao, Jian Tu & Xiangjun Song
Additional file 1. Prey proteins identified by LC-MS/MS. Prey proteins were screened by Pulldown and analyzed by LC-MS/MS by BGI (Shenzhen, China). Enriched proteins not found in the biotin control were screened and considered as specific prey proteins for biotinylated Hcp2a.
HOTAIR knockdown impairs metastasis of cervical cancer cells by down-regulating metastasis-related genes
Lei Shi, Dehui Zhang, Huijuan Han, Liangyu Zhang, Sirui Li, Fang Yang & Caijun He
This study investigated the role of LncRNA HOTAIR knockdown in the biological impacts on cervical cancer cells. The HOTAIR gene in two human cervical cancer cell lines was silenced with small interfering (si) RNA siHOTAIR. Proliferation, apoptosis, migration and invasion of cells were assessed following the knockdown. The expressions of Notch1, EpCAM, E-cadherin, vimentin and STAT3 were assessed using qRT-PCR and Western blotting analysis. Compared with controls, HOTAIR levels were reduced significantly, the OD values...
Additional file 1 of Effector protein Hcp2a of avian pathogenic Escherichia coli interacts with the endoplasmatic reticulum associated RPL23 protein of chicken DF-1 fibroblasts
Zhe Chen, Zhao Qi, Ziqi Li, Zichao Song, Xiaoru Wang, Ying Shao, Jian Tu & Xiangjun Song
Additional file 1. Prey proteins identified by LC-MS/MS. Prey proteins were screened by Pulldown and analyzed by LC-MS/MS by BGI (Shenzhen, China). Enriched proteins not found in the biotin control were screened and considered as specific prey proteins for biotinylated Hcp2a.
Additional file 2 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 2: The newly downloaded dataset of drugs.
Additional file 3 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 3: The newly downloaded dataset of microbes.
Additional file 1 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 1: The newly downloaded dataset of diseases.
Identification of hsa_circ_0002024 as a prognostic competing endogenous RNA (ceRNA) through the hsa_miR_129-5p/Anti-Silencing Function 1B Histone Chaperone (ASF1B) axis in renal cell carcinoma
Zhe Chen, Dehua Ou, Zhuangkai Huang & Peilin Shen
We aimed to identify novel circular RNAs (circRNAs) as prognostic competing endogenous RNAs (ceRNAs) to serve as genetic biomarkers and therapeutic targets for renal cell carcinoma (RCC). High-throughput sequencing data of circRNAs from Gene Expression Omnibus (GEO) and of microRNAs (miRNAs) and messenger RNAs (mRNAs) from The Cancer Genome Atlas (TCGA) were retrieved to identify differentially expressed RNAs (DERNAs). DEmRNAs were subjected to weighted gene coexpression network analysis (WGCNA) to identify prognostic DEmRNA (proDEmRNA) modules....
Self-reported effects of perceived social support on marital quality in balanced translocation patients and their spouses undergoing preimplantation genetic testing in China: actor–partner interdependence model
Fengyi Mo, Xiaorui Hu, Qing Ma, Li Zhang & Lanfeng Xing
This study aimed to analyse the relationship between perceived social support and marital quality in balanced translocation patients and their spouses undergoing a preimplantation genetic testing (PGT) treatment cycle in China. The authors assessed the actor and partner effects of perceived social support on marital quality in patient–spouse dyads using a dyadic analysis approach. In total, 59 couples were assessed using self-report questionnaires for marital quality and perceived social support. There were significant differences in...
Comparative transcriptomic analysis reveal genes involved in the pathogenicity increase of Streptococcus suis epidemic strains
Jianping Wang, Pujun Liang, Hui Sun, Zongfu Wu, Marcelo Gottschalk, Kexin Qi & Han Zheng
Streptococcus suis epidemic strains were responsible for two outbreaks in China and possessed increased pathogenicity which was featured prominently by inducing an excessive inflammatory response at the early phase of infection. To discover the critical genes responsible for the pathogenicity increase of S. suis epidemic strains, the genome-wide transcriptional profiles of epidemic strain SC84 were investigated at the early phase of interaction with BV2 cells. The overall low expression levels of 89K pathogenicity island (PAI)...
Identification of hsa_circ_0002024 as a prognostic competing endogenous RNA (ceRNA) through the hsa_miR_129-5p/Anti-Silencing Function 1B Histone Chaperone (ASF1B) axis in renal cell carcinoma
Zhe Chen, Dehua Ou, Zhuangkai Huang & Peilin Shen
We aimed to identify novel circular RNAs (circRNAs) as prognostic competing endogenous RNAs (ceRNAs) to serve as genetic biomarkers and therapeutic targets for renal cell carcinoma (RCC). High-throughput sequencing data of circRNAs from Gene Expression Omnibus (GEO) and of microRNAs (miRNAs) and messenger RNAs (mRNAs) from The Cancer Genome Atlas (TCGA) were retrieved to identify differentially expressed RNAs (DERNAs). DEmRNAs were subjected to weighted gene coexpression network analysis (WGCNA) to identify prognostic DEmRNA (proDEmRNA) modules....
Investigation of EDTA concentration on the size of carbonated flowerlike hydroxyapatite microspheres
Shengkun Yao, Mei-Li Qi, Liang Qi, Yongling Ding, Min Chen & Yanmin Wang
Ethylenediamine tetraacetic acid (EDTA) is considered as an effective crystal growth modifier for template-assisted hydrothermal synthesis of hydroxyapatite (HA) materials. In this work, flowerlike carbonated HA (CHA) microspheres were synthesized using EDTA via a one-step hydrothermal route. The phase, functional groups, morphology, and particle size distribution of the products were examined by X-ray diffraction, Fourier transform infrared spectrometer, field-emission scanning electron microscopy as well as laser diffraction particle size analysis. Results show that the morphology...
MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma
Xijing Zhuang, Feng Gao, Lei Shi, Wei Liu, Wenjun Wang, Xuezhi He & Yang Gao
MicroRNAs are crucial regulators in the phenotype switch of vascular smooth muscle cells (VSMCs). Nonetheless, the role of miR-146b-3p in VSMCs remains unclear. In the present study, platelet-derived growth factor-BB (PDGF-BB) at different concentrations was employed to stimulate VSMCs for different times, to establish the model of VSMC dysfunction. The relative expression of miR-146b-3p was quantified by quantitative real-time polymerase chain reaction (qRT-PCR). The proliferation of VSMCs was measured by BrdU assay. Flow cytometry analysis...
Additional file 3 of Effector protein Hcp2a of avian pathogenic Escherichia coli interacts with the endoplasmatic reticulum associated RPL23 protein of chicken DF-1 fibroblasts
Zhe Chen, Zhao Qi, Ziqi Li, Zichao Song, Xiaoru Wang, Ying Shao, Jian Tu & Xiangjun Song
Additional file 3. KEGG enrichment analysis of Hcp2a-interacting proteins. KEGG enrichment analysis of Hcp2a-specific prey proteins screened by pull-down.
Additional file 4 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 4: The newly downloaded dataset of drug-disease associations.
Additional file 4 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 4: The newly downloaded dataset of drug-disease associations.
Additional file 5 of GACNNMDA: a computational model for predicting potential human microbe-drug associations based on graph attention network and CNN-based classifier
Qing Ma, Yaqin Tan & Lei Wang
Additional file 5: The newly downloaded dataset of drug-drug interactions.
Affiliations
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Shandong Jiaotong University34
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Chinese Academy of Medical Sciences & Peking Union Medical College31
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Zhejiang University29
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Shanghai Jiao Tong University29
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Anhui Agricultural University27
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Guangzhou University of Chinese Medicine24
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Sun Yat-sen University20
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Air Force Medical University20
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Sichuan University20
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Fudan University20