21 Works

Data from: Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission.

André Lin Ouédraogo, Teun Bousema, Petra Schneider, Sake J. De Vlas, Edith Ilboudo-Sanogo, Nadine Cuzin-Ouattara, Issa Nébié, Will Roeffen, Jan Peter Verhave, Adrian J.F. Luty & Robert Sauerwein
Background: Man to mosquito transmission of malaria depends on the presence of the sexual stage parasites, gametocytes, that often circulate at low densities. Gametocyte densities below the microscopical threshold of detection may be sufficient to infect mosquitoes but the importance of submicroscopical gametocyte carriage in different transmission settings is unknown. Methodology/Principal Findings: Membrane feeding experiments were carried out on 80 children below 14 years of age at the end of the wet season in an...

Data from: Juveniles and migrants as drivers for seasonal epizootics of avian influenza virus

Jacintha G. B. Van Dijk, Bethany J. Hoye, Josanne H. Verhagen, Bart A. Nolet, Ron A. M. Fouchier & Marcel Klaassen
1. Similar to other infectious diseases, the prevalence of low pathogenic avian influenza viruses (LPAIV) has been seen to exhibit marked seasonal variation. However, mechanisms driving this variation in wild birds have yet to be tested. We investigated the validity of three previously suggested drivers for the seasonal dynamics in LPAIV infections in wild birds: (1) host density, (2) immunologically-naïve young, and (3) increased susceptibility in migrants. 2. To address these questions, we sampled a...

Data from: Whole-cell properties of cerebellar nuclei neurons in vivo

Cathrin B. Canto, Laurens Witter & Chris I. De Zeeuw
Cerebellar nuclei neurons integrate sensorimotor information and form the final output of the cerebellum, projecting to premotor brainstem targets. This implies that, in contrast to specialized neurons and interneurons in cortical regions, neurons within the nuclei encode and integrate complex information that is most likely reflected in a large variation of intrinsic membrane properties and integrative capacities of individual neurons. Yet, whether this large variation in properties is reflected in a heterogeneous physiological cell population...

Data from: SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor learning-specific memory traces

Giorgio Grasselli, Henk-Jan Boele, Heather K. Titley, Nora Bradford, Lisa Van Beers, Lindsey Jay, Chris I. De Zeeuw, Martijn Schonewille, Christian Hansel, Gerco Beekhof & Silas Busch
Neurons store information by changing synaptic input weights. In addition, they can adjust their membrane excitability to alter spike output. Here, we demonstrate a role of such ‘intrinsic plasticity’ in behavioral learning in a mouse model that allows us to detect consequences of absent excitability modulation, without alterations in synaptic plasticity. SK2-type, calcium-dependent K+ conductances are involved in excitability control as they contribute to the afterhyperpolarization (AHP) following spike bursts. SK2 channels are downregulated in...

Data from: Coverage of the 2011 Q fever vaccination campaign in the Netherlands, using retrospective population-based prevalence estimation of cardiovascular risk-conditions for chronic Q fever

Patricia E. Vermeer-De Bondt, Teske Schoffelen, Ann M. Vanrolleghem, Leslie D. Isken, Marcel Van Deuren, Miriam C. J. M. Sturkenboom & Aura Timen
Background: In 2011, a unique Q fever vaccination campaign targeted people at risk for chronic Q fever in the southeast of the Netherlands. General practitioners referred patients with defined cardiovascular risk-conditions (age >15 years). Prevalence rates of those risk-conditions were lacking, standing in the way of adequate planning and coverage estimation. We aimed to obtain prevalence rates retrospectively in order to estimate coverage of the Q fever vaccination campaign. Methods: With broad search terms for...

Data from: The implicitome: a resource for rationalizing gene-disease associations

Kristina M. Hettne, Mark Thompson, Herman H. H. B. M. Van Haagen, Eelke Van Der Horst, Rajaram Kaliyaperumal, Eleni Mina, Zuotian Tatum, Jeroen F. J. Laros, Erik M. Van Mulligen, Martijn Schuemie, Emmelien Aten, Tong Shu Li, Richard Bruskiewich, Benjamin M. Good, Andrew I. Su, Jan A. Kors, Johan Den Dunnen, Gert-Jan Van Ommen, Marco Roos, , Barend Mons, Erik A. Schultes, Gert-Jan B. Van Ommen &
High-throughput experimental methods such as medical sequencing and genome-wide association studies (GWAS) identify increasingly large numbers of potential relations between genetic variants and diseases. Both biological complexity (millions of potential gene-disease associations) and the accelerating rate of data production necessitate computational approaches to prioritize and rationalize potential gene-disease relations. Here, we use concept profile technology to expose from the biomedical literature both explicitly stated gene-disease relations (the explicitome) and a much larger set of implied...

Data from: Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses

Ayşe Demirkan, Peter Henneman, Aswin Verhoeven, Harish Dharuri, Najaf Amin, Jan Bert Van Klinken, Lennart C. Karssen, Boukje De Vries, Axel Meissner, Sibel Göraler, Arn M. J. M. Van Den Maagdenberg, André M. Deelder, , Cornelia M. Van Duijn & Ko Willems Van Dijk
Metabolite quantitative traits carry great promise for epidemiological studies, and their genetic background has been addressed using Genome-Wide Association Studies (GWAS). Thus far, the role of less common variants has not been exhaustively studied. Here, we set out a GWAS for metabolite quantitative traits in serum, followed by exome sequence analysis to zoom in on putative causal variants in the associated genes. 1H Nuclear Magnetic Resonance (1H-NMR) spectroscopy experiments yielded successful quantification of 42 unique...

Sex differences in response to triptans: a systematic review and meta-analysis

Daphne Van Casteren, Tobias Kurth, A.H. Jan Danser, Gisela M. Terwindt & Antoinette MaassenVanDenBrink
Objective: To examine the effect of sex on clinical response to triptans and to determine whether these differences are related to pharmacokinetics of triptans in men and women, we performed a systematic review and meta-analysis. Methods: We searched clinical trials distinguishing clinical response to or pharmacokinetic parameters of triptans between sexes in PubMed, MEDLINE, Cochrane Library, Embase and Web of Science up to Dec 12, 2019. Analysis was based on data extracted from published reports....

Structural disconnectivity and the risk of dementia in the general population

Lotte Cremers, Frank Wolters, Marius De Groot, Kamran Ikram, Aad Van Der Lugt, Wiro Niessen, Meike Vernooij & Arfan Ikram
Objective: The disconnectivity hypothesis postulates that partial loss of connecting white matter fibers between brain regions contributes to the development of dementia. Using diffusion-magnetic resonance imaging (MRI) to quantify global and tract-specific white matter microstructural integrity, we tested this hypothesis in a longitudinal population-based setting. Methods: Global and tract-specific measures of fractional anisotropy (FA) and mean diffusivity (MD) were obtained in 4,415 non-demented persons (mean age 63.9 years (SD 11.0), 55.0% women) from the prospective...

Data from: A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

Isaie J. Reuling, Lisanne A Van De Schans, Luc E Coffeng, Kjerstin Lanke, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan Van Gemert, Karina Teelen, Rianne Siebelink-Stoter, Marga Van De Vegte-Bolmer, Quirijn De Mast, André J Van Der Ven, Karen Ivinson, Cornelus C Hermsen, Sake De Vlas, John Bradley, Katharine A Collins, Christian F Ockenhouse, James McCarthy, Robert W. Sauerwein & Teun Bousema
Background: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is currently unavailable. Here, we explore the use of the well-established Controlled Human Malaria Infection model (CHMI) to induce gametocyte carriage with different antimalarial drug regimens. Methods: In a single centre, open-label randomised trial, healthy malaria-naive participants (aged 18–35 years) were infected with Plasmodium falciparum...

Data from: Large scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

Gerrit L.J. Onderwater, Lannie Ligthart, Mariska Bot, Ayse Demirkan, Jingyuan Fu, Carla J.H. Van Der Kallen, Lisanne S. Vijfhuizen, René Pool, Jun Liu, Floris H.M. Vanmolkot, Marian Beekman, Hoyan Wen, Najaf Amin, Carisha S. Thesing, Judith A. Pijpers, Dennis A. Kies, Ronald Zielman, Irene De Boer, Marleen M.J. Van Greevenbroek, Ilja C.W. Arts, Yuri Milaneschi, Miranda T. Schram, Pieter C. Dagnelie, Lude Franke, M. Arfan Ikram … & Arn M.J.M. Van Den Maagdenberg
Objective: To identify a plasma metabolomic biomarker signature for migraine. Methods: Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a 1H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified and sex-stratified manner. Next, a global test...

Data from: Functional and evolutionary consequences of cranial fenestration in birds

Sander W.S. Gussekloo, Michael A. Berthaume, Daniel R Pulaski, Irene Westbroek, Jan H. Waarsing, Robin Heinen, Ian R. Grosse, Elizabeth R. Dumont & Sander W. S. Gussekloo
Ostrich-like birds (Palaeognathae) show very little taxonomic diversity while their sister taxon (Neognathae) contains roughly 10000 species. The main anatomical differences between the two taxa are in the crania. Palaeognaths lack an element in the bill called the lateral bar that is present in both ancestral theropods and modern neognaths, have thin zones in the bones of the bill, and robust bony elements on the ventral surface of their crania. Here we use a combination...

Data from: Attitudes among transplant professionals regarding shifting paradigms in eligibility criteria for live kidney donation

Jeffrey A. Lafranca, Emerentia Q. W. Spoon, Jacqueline Van De Wetering, Jan N. M. Ijzermans & Frank J. M. F. Dor
Background The transplant community increasingly accepts extended criteria live kidney donors, however, great (geographical) differences are present in policies regarding the acceptance of these donors, and guidelines do not offer clarity. The aim of this survey was to reveal these differences and to get an insight in both centre policies as well as personal beliefs of transplant professionals. Methods An online survey was sent to 1128 ESOT-members. Questions were included about several extended donor criteria;...

Data from: Integrated analysis and visualization of group differences in structural and functional brain connectivity: applications in typical ageing and schizophrenia

Carolyn D. Langen, Tonya J. White, M. Arfan Ikram, Meike W. Vernooij & Wiro J. Niessen
Structural and functional brain connectivity are increasingly used to identify and analyze group differences in studies of brain disease. This study presents methods to analyze uni- and bi-modal brain connectivity and evaluate their ability to identify differences. Novel visualizations of significantly different connections comparing multiple metrics are presented. On the global level, “bi-modal comparison plots” show the distribution of uni- and bi-modal group differences and the relationship between structure and function. Differences between brain lobes...

Data from: The global antigenic diversity of swine influenza A viruses

Nicola S. Lewis, Colin A. Russell, Tavis K. Anderson, Kathryn Berger, David F. Burke, Judith M. Fonville, Ronald A.M. Fouchier, Paul Kellam, Bjorn F. Koel, Tung Nguyen, Bundit Nuansrichy, J. S. Malik Peiris, Takehiko Saito, Gaelle Simon, Eugene Skepner, Nobuhiro Takemae, ESNIP3 Consortium, Richard J. Webby, Kristien Van Reeth, Sharon M. Brookes, Lars Larsen, Ian H. Brown, Amy L. Vincent, Pinky Langat, Filip Bielejec … & JS Malik Peiris
Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the...

Data from: High bandwidth synaptic communication and frequency tracking in human neocortex

Guilherme Testa-Silva, Matthijs B. Verhoog, Daniele Linaro, Christiaan P. J. De Kock, Johannes C. Baayen, Rhiannon M. Meredith, Chris I. De Zeeuw, Michele Giugliano & Huibert D. Mansvelder
Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than rodent synapses. To test this, we recorded from connected pairs of pyramidal neurons in acute brain slices of adult human and mouse temporal cortex and probed the dynamical properties of use-dependent plasticity. We found that human synaptic connections were...

Data from: Type 1 interferon-inducible gene expression in QuantiFERON Gold TB-positive uveitis: a tool to stratify a high versus low risk of active tuberculosis?

Rina La Distia Nora, Ratna Sitompul, Marleen Bakker, Marjan A. Versnel, Sigrid M. A. Swagemakers, Peter J. Van Der Spek, Made Susiyanti, Lukman Edwar, Soedarman Sjamsoe, Gurmeet Singh, R. Diah Handayani, Aniki Rothova, P. Martin Van Hagen & Willem A. Dik
QuantiFERON-Gold TB (QFT)-positive patients with undetermined cause of uveitis are problematic in terms of whether to diagnose and treat them for tuberculosis (TB). Here, we investigated whether peripheral blood expression of type 1 interferon (IFN)-inducible genes may be of use to stratify QFT-positive patients with uveitis into groups of high versus low risk of having active TB-associated uveitis. We recruited all new uveitis patients in Cipto Mangunkusumo Hospital, Jakarta, Indonesia for one year. We included...

Data from: Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

Natanja Oosterom, Pieter H. Griffioen, Marissa A. H. Den Hoed, Rob Pieters, Robert De Jonge, Wim J.E. Tissing, Marry M. Van Den Heuvel-Eibrink, Sandra G. Heil & Wim J. E. Tissing
BACKGROUND Children with acute lymphoblastic leukemia (ALL) often suffer from toxicity of chemotherapeutic drugs such as Methotrexate (MTX). Previously, we reported that 20% of patients receiving high-dose MTX developed oral mucositis. MTX inhibits folate metabolism, which is essential for DNA methylation. We hypothesize that MTX inhibits DNA methylation, which results into adverse effects. We studied DNA methylation markers during high-dose methotrexate treatment in pediatric acute lymphoblastic leukemia (ALL) in relation to developing oral mucositis. MATERIALS...

Supplemental Materials Eikelboom et al. Neuropsychiatric and cognitive symptoms across the Alzheimer's disease clinical spectrum

Willem Eikelboom, Esther Van Den Berg, Ellen Singleton, Sara Baart, Michiel Coesmans, Annebet Leeuwis, Charlotte Teunissen, Bart Van Berckel, Yolande Pijnenburg, Philip Scheltens, Wiesje Van Der Flier, Rik Ossenkoppele & Janne Papma
The objective of this study was to investigate the prevalence and trajectories of neuropsychiatric symptoms (NPS) in relation to cognitive functioning in a cohort of amyloid-β positive individuals across the Alzheimer’s disease (AD) clinical spectrum. In this single-center observational study, we included all individuals who visited the Alzheimer Center Amsterdam and had 1) a clinical diagnosis of subjective cognitive decline (SCD), mild cognitive impairment (MCI), or probable AD dementia, and 2) were amyloid-β positive (A+)....

Association of common genetic variants with brain microbleeds: A genome-wide association study

Maria Knol
Objective: To identify common genetic variants associated with the presence of brain microbleeds (BMB). Methods: We performed genome-wide association studies in 11 population-based cohort studies and 3 case-control or case-only stroke cohorts. Genotypes were imputed to the Haplotype Reference Consortium or 1000 Genomes reference panel. BMB were rated on susceptibility-weighted or T2*-weighted gradient echo magnetic resonance imaging sequences, and further classified as lobar, or mixed (including strictly deep and infratentorial, possibly with lobar BMB). In...

A randomized clinical trial to compare P. falciparum gametocytaemia and infectivity following blood-stage or mosquito bite induced controlled malaria infection

Teun Bousema, Manon Alkema, Isaie Reuling, Gerdie De Jong, Kjerstin Lanke, Luc Coffeng, Geert-Jan Van Gemert, Marga Van De Vegte-Bolmer, Quirijn De Mast, Reinout Van Crevel, Christian Ockenhouse, Karen Ivinson, James McCarthy, Robert Sauerwein & Katharine Collins
For malaria elimination efforts, it is important to better understand parasite transmission to mosquitoes and to develop models to allow early clinical evaluation of transmission-blocking interventions. We previously described a Controlled Human Malaria Infection protocol for induction of gametocytemia in malaria naïve volunteers by mosquito bite (CHMI-trans) (Reuling et al., 2018). Here, we compared gametocyte production and infectivity in the CHMI-trans model after bites of Plasmodium falciparum (Pf)- infected mosquitoes to that after intravenous administration...

Registration Year

  • 2022
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  • 2013

Resource Types

  • Dataset


  • Erasmus University Medical Center
  • Leiden University Medical Center
  • VU University Medical Center
  • QIMR Berghofer Medical Research Institute
  • VU University Amsterdam
  • London School of Hygiene & Tropical Medicine
  • Radboud University Nijmegen
  • Nederlands Instituut voor Ecologie
  • University of Edinburgh
  • University Medical Center Groningen