Primates have adapted to numerous environments and lifestyles but very few species are native to high elevations. Here, we investigated high-altitude adaptations in the gelada (Theropithecus gelada), a monkey endemic to the Ethiopian Plateau. We examined genome-wide variation in conjunction with measurements of haematological and morphological traits. Our new gelada reference genome is highly intact and assembled at chromosome-length levels. Unexpectedly, we identified a chromosomal polymorphism in geladas that could potentially contribute to reproductive barriers...

The greater male variability (GMV) hypothesis proposes that traits are more variable among males than females, and is supported by numerous empirical studies. Interestingly, GMV is also observed for human brain size and internal brain structure, a pattern which may have implications for sex-biased neurological and psychiatric conditions. A better understanding of neuroanatomical variability in nonhuman primates may illuminate whether certain species are appropriate models for these conditions. Here, we tested for sex differences in...

Additional file 1: Table S1. The disease rates of the five varieties after inoculating RBSDV.

Additional file 5: Table S4. Top 20 hits of drugs identified by machine-learning aided drug repurposing pipeline in this study.

Additional file 9. Table S9: Relative expression levels of 8 selected genes under four different time treatments of 12% PEG6000.

Additional file 1: Supplementary Table 1. Predictors of RFS, DFS, and OS in Cox proportional hazards models. Adjusted models are adjusted for all other covariates shown here. Supplementary Table 2. Association of richness and the Shannon diversity index with RFS, DFS, and OS in Cox proportional hazards models. Analyses were performed on the tumor tissue microbiome data and normal tissue microbiome data. Adjusted models are adjusted for age, sex, race, histology, smoking, and chemotherapy. Supplementary...

Additional file 1. Additional materials including the module memberships and annotations of proteins/metabolites; the cross-sectional associations of modules and participant characteristics; the mortality associations of modules; and network representations of module 42 and 98.

Source_Data_Figure_2 and 3 R_Codes used in data analysis

To explore the clinicopathological features of anti-glomerular basement membrane (anti-GBM) glomerulonephritis (anti-GBM-GN) and the prognostic values of clinical and laboratory indicators at diagnosis on renal and patient survival. A total of 76 patients (34 males and 42 females) with anti-GBM-GN who were hospitalized in the First Affiliated Hospital of Nanjing Medical University between January 2010 and June 2021 were included in this study. The baseline clinical features, histopathological data from renal biopsies, and predictors of...

Acquired immunodeficiency syndrome (AIDS) cannot be completely cured, mainly due to the existence of a latent HIV-1 reservoir. However, our current understanding of the molecular mechanisms underlying the establishment and maintenance of HIV-1 latent reservoir is not comprehensive. Here, using a genome-wide CRISPR-Cas9 activation library screening, we identified E3 ubiquitin ligase F-box protein 34 (FBXO34) and the substrate of FBXO34, heterogeneous nuclear ribonucleoprotein U (hnRNP U) was identified by affinity purification mass spectrometry, as new...

Additional file 1.

Additional file 1: Table S1. Prier used in this study. Table S2. List of 392 Glycine soja accessions and acumulated temperature zones. Table S3. 92 SNPs that significantly associated with flowering time in average across the two-year experiment (2020 and 2021). Table S4. The genes conresponding to the genomic regions surrounding ~50Kb of 92 SNPs that signficantly associated with flowering time in average in 2020 and 2021. Table S5. 28 candidate genes related to flowering...

Source_Data_Figure_2 and 3 R_Codes used in data analysis

Additional file 2. Table S2: Analysis of the physical properties of CNX genes in G. hirsutum.

Additional file 3. Table S3: Primer pairs required for the qRT-PCR.

Additional file 5. Table S5: CNX family members cis-acting elements and their locations.

Background: The most used questionnaires for PTSD screening in adults were developed in English. Although many of these questionnaires were translated into other languages, the procedures used to translate them and to evaluate their reliability and validity have not been consistently documented. This comprehensive scoping review aimed to compile the currently available translated and evaluated questionnaires used for PTSD screening, and highlight important gaps in the literature. Objective: This review aimed to map the availability...

Additional file 2: Table S2. Comparison of gene signature of DIPG in six previously published data.

Additional file 2: Table S2. Comparison of gene signature of DIPG in six previously published data.

In 2018, over nine billion chickens were slaughtered in the United States. As the demand for chickens increases, so too have concerns regarding the welfare of the chickens in these systems and the damage such practices cause to the surrounding ecosystems. To address welfare concerns, there is large-scale interest in raising chickens on pasture and switching to slower-growing, higher-welfare breeds as soon as 2024. We created a box model of US chicken demographics to characterize...

Gap-junctional signaling mediates myriad cellular interactions in metazoans. Yet, how gap junctions control the positioning of cells in organs is not well understood. Innexins compose gap junctions in invertebrates and affect organ architecture. Here, we investigate the roles of gap-junctions in controlling distal somatic gonad architecture and its relationship to underlying germline stem cells in Caenorhabditis elegans. We show that a reduction of soma-germline gap-junctional activity causes displacement of distal sheath cells (Sh1) towards the...

High-grade serous ovarian cancer (HGSOC) is the most common and malignant type of ovarian cancer, accounting for 70%–80% of mortality. However, the treatment of HGSOC has improved little in the past few decades. Metformin is the first-line medication for the treatment of type 2 diabetes and has now gained more attention in cancer treatment. In this study, we sought to identify potential hub genes that metformin could target in the treatment of HGSOC. We downloaded...

Additional file 3: Table S2. The CDSs of ZmABCB family.

Additional file 4: Table S3. The primer sequences for the qRT-PCR.

Additional file 9: Supplementary Table 1. Detailed genes table.