3 Works

Optical maps refine the bread wheat Triticum aestivum cv Chinese Spring genome assembly

Tingting Zhu, Le Wang, Hélène Rimbert, Juan Rodriguez, Karin Deal, Romain De Oliveira, Frédéric Choulet, Gabriel Keeble-Gagnère, Josquin Tibbits, Jane Rogers, Kellye Eversole, Rudi Appels, Yong Gu, Martin Mascher, Jan Dvorak, Ming-Cheng Luo, Juan C. Rodriguez, Karin R. Deal, Gabriel Keeble‐Gagnère, Yong Q. Gu & Ming‐Cheng Luo
This dataset contains a single whole-genome optical map file (.CMAP) for bread wheat (Triticum aestivum) cv Chinese Spring (CS). The methods for constructing this optical map and the properties of this map are described below. The definition of the CMAP format is documented in https://bionanogenomics.com/wp-content/uploads/2017/03/30039-CMAP-File-Format-Specification-Sheet.pdf. The extracted ultra-high-molecular weight DNA molecules of CS were labeled with the DLE-1 enzyme (Bionano Genomics, San Diego, CA, USA) and were then stained with the Bionano PrepTM DLS Kit...

Effects of high and low-efficacy therapy in secondary progressive multiple sclerosis

Izanne Roos, Emmanuelle Leray, Romain Casey, Dana Horakova, Eva Havrdova, Guillermo Izquierdo, Sara Eichau, Francesco Patti, Gilles Edan, Marc Debouverie, Jean Pelletier, Serkan Ozakbas, Maria Pia Amato, Pierre Clavelou, Pierre Grammond, Cavit Boz, Katherine Buzzard, Olga Skibina, Jonathan Ciron, Oliver Gerlach, Francois Grand'Maison, Jeannette Lechner-Scott, Charles Malpas, Helmut Butzkueven, Sandra Vukusic … & Tomas Kalincik
Objective: To compare the clinical effectiveness of high- and low-efficacy treatments in patients with recently active and inactive secondary progressive multiple sclerosis (SPMS) after accounting for therapeutic lag. Methods: Patients treated with high- (natalizumab, alemtuzumab, mitoxantrone, ocrelizumab, rituximab, cladribine, fingolimod) or low-efficacy (interferon β, glatiramer acetate, teriflunomide) therapies after SPMS onset were selected from MSBase and OFSEP, two large observational cohorts. Therapeutic lag was estimated for each patient based on their demographic and clinical characteristics....

Simulation of sheared granular layers activated by fluid pressurization

Nho Gia Hien Nguyen, Luc Scholtès, Yves Guglielmi, Frédéric Victor Donzé, Zady Ouraga & Mountaka Souley
Fluid pressurization of critically stressed sheared zones can trigger slip mechanisms at play in many geological rupture processes, including earthquakes or landslides. The increasing fluid pressure reduces the effective stress, giving possibility to the shear zone to reactivate. Nonetheless, the mechanisms that dictate the mode of slip, from aseismic steady creep to seismic dynamic rupture, remain poorly understood. By using discrete element modeling, we simulate pore-pressure-step creep test experiments on a sheared granular layer under...

Registration Year

  • 2021
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Resource Types

  • Dataset
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Affiliations

  • University of Clermont Auvergne
    3
  • Dokuz Eylül University
    1
  • University of Newcastle Australia
    1
  • Hospices Civils de Lyon
    1
  • University of Rennes 1
    1
  • Hospital Universitario Virgen Macarena
    1
  • Centre Hospitalier Universitaire de Toulouse
    1
  • University of Melbourne
    1
  • University of Lyon System
    1
  • Charles University
    1