11 Works

Data from: The expression of established cognitive brain states stabilizes with working memory development

David Florentino Montez, Finnegan J. Calabro & Beatriz Luna
We present results from a longitudinal study conducted over 10 years in a sample of 126 8-33 year olds demonstrating that adolescent development of working memory is supported by decreased variability in the amplitude of expression of whole brain states of task-related activity. fMRI analyses reveal that putative gain signals affecting maintenance and retrieval aspects of working memory processing stabilize during adolescence, while those affecting sensorimotor processes do not. We show that trial-to-trial variability in...

Data from: Magnetic resonance imaging and tensor-based morphometry in the MPTP non-human primate model of Parkinson’s disease

Michel Modo, William R. Crum, Madeline Gerwig, Anthony C. Vernon, Priya Patel, Michael J. Jackson, Sarah Rose, Peter Jenner & Mahmoud M. Iravani
Parkinson’s disease (PD) is the second most common neurodegenerative disorder producing a variety of motor and cognitive deficits with the causes remaining largely unknown. The gradual loss of the nigrostriatal pathway is currently considered the pivotal pathological event. To better understand the progression of PD and improve treatment management, defining the disease on a structural basis and expanding brain analysis to extra-nigral structures is indispensable. The anatomical complexity and the presence of neuromelanin, make the...

Data from: Soil microbial communities alter leaf chemistry and influence allelopathic potential among coexisting plant species

Scott J. Meiners, Kelsey K. Phipps, , Thomas Canam, Walter P. Carson & Thomas H. Pendergast
While both plant–soil feedbacks and allelochemical interactions are key drivers of plant community dynamics, the potential for these two drivers to interact with each other remains largely unexplored. If soil microbes influence allelochemical production, this would represent a novel dimension of heterogeneity in plant–soil feedbacks. To explore the linkage between soil microbial communities and plant chemistry, we experimentally generated soil microbial communities and evaluated their impact on leaf chemical composition and allelopathic potential. Four native...

Data from: Land use history and seed dispersal drive divergent plant community assembly patterns in urban vacant lots

Anna L. Johnson, Dorothy Borowy & Christopher M. Swan
1. Despite high levels of disturbance and habitat modification, urban ecosystems still host substantial levels of biodiversity. The processes that maintain existing levels of diversity, however, remain understudied. Identifying the links between urban ecological processes and patterns has, therefore, become a fundamental research goal to support urban biodiversity and ecosystem functioning. 2. We conducted a study to determine how the diversity and composition of urban plant communities is affected by spatially and temporally variable land...

Data from: Genetic mapping and phylogenetic analysis reveal intraspecific variation in sex chromosomes of the Virginian strawberry

Na Wei, Rajanikanth Govindarajulu, Jacob A. Tennessen, Aaron Liston & Tia-Lynn Ashman
With their extraordinary diversity in sexual systems, flowering plants offer unparalleled opportunities to understand sex determination and to reveal generalities in the evolution of sex chromosomes. Comparative genetic mapping of related taxa with good phylogenetic resolution can delineate the extent of sex chromosome diversity within plant groups, and lead the way to understanding the evolutionary drivers of such diversity. The North American octoploid wild strawberries provide such an opportunity. We performed linkage mapping using targeted...

Data from: The index case is not enough: variation among individuals, groups, and social networks modify bacterial transmission dynamics

Carl N. Keiser, Noa Pinter-Wollman, Michael J. Ziemba, Krishna S. Kothamasu & Jonathan N. Pruitt
1.The traits of the index case of an infectious disease outbreak, and the circumstances for their etiology, potentially influence the trajectory of transmission dynamics. However, these dynamics likely also depend on the traits of the individuals with whom the index case interacts. 2.We used the social spider Stegodyphus dumicola to test how the traits of the index case, group phenotypic composition, and group size interact to facilitate the transmission of a GFP-labeled cuticular bacterium. We...

Data from: Macroevolutionary synthesis of flowering plant sexual systems

Emma E. Goldberg, Sarah P. Otto, Jana C. Vamosi, Itay Mayrose, Niv Sabath, Ray Ming & Tia-Lynn Ashman
Sexual system is a key determinant of genetic variation and reproductive success, affecting evolution within populations and within clades. Much research in plants has focused on evolutionary transitions away from the most common state of hermaphroditism and toward the rare state of dioecy (separate sexes). Rather than transitions predominantly toward greater sexual differentiation, however, evolution may proceed in the direction of lesser sexual differentiation. We analyzed the macroevolutionary dynamics of sexual system in angiosperm genera...

Data from: Control of signaling alignment during the dynamic courtship display of a jumping spider

Sebastian A. Echeverri, Nathan I. Morehouse & Daniel B. Zurek
During communication, alignment between signals and sensors can be critical. Signals are often best perceived from specific angles, and sensory systems can also exhibit strong directional biases. However, we know little about how animals establish and maintain such signaling alignment during communication. To investigate this, we characterized the spatial dynamics of visual courtship signaling in the jumping spider Habronattus pyrrithrix. The male performs forward-facing displays involving complex color and movement patterns, with distinct long- and...

Data from: IL-33 mediated iLC2 activation and neutrophil IL-5 production in the lung response after severe trauma: a reverse translation study from a human cohort to a mouse trauma model

Jing Xu, Jesse Guardado, Rosemary Hoffman, Hui Xu, Rami Namas, Yoram Vodovotz, Li Xu, Mostafa Ramadan, Joshua Brown, Heth R. Turnquist & Timothy R. Billiar
Background: The immunosuppression and immune dysregulation that follows severe injury includes type 2 immune responses manifested by elevations in interleukin (IL) 4, IL5, and IL13 early after injury. We hypothesized that IL33, an alarmin released early after tissue injury and a known regulator of type 2 immunity, contributes to the early type 2 immune responses after systemic injury. Methods and findings: Blunt trauma patients admitted to the trauma intensive care unit of a level I...

Data from: Monoamine abnormalities in the SAPAP3 knockout model of obsessive-compulsive disorder-related behaviour

Jesse Wood, Zoe LaPalombara & Susanne E. Ahmari
Obsessive-compulsive disorder (OCD) is a leading cause of illness-related disability, but the neuralmechanisms underlying OCDsymptoms are unclear. One potential mechanism of OCD pathology is monoamine dysregulation. Because of the difficulty of studying monoamine signalling in patients, animal models offer a viable alternative to understanding this aspect of OCD pathophysiology. We used HPLC to characterize post-mortem monoamine levels in lateral orbitofrontal cortex (OFC), medial OFC, medial prefrontal cortex and dorsal and ventral striatum of SAPAP-3 knockout...

Data from: Selection for collective aggressiveness favors social susceptibility in social spiders

Jonathan N. Pruitt, Colin M. Wright, James L. L. Lichtenstein, Gregory T. Chism, Brendan L. McEwen, Ambika Kamath & Noa Pinter-Wollman
Particularly socially influential individuals are present in many groups, but it is unclear whether their emergence is determined by their social influence versus the social susceptibility of others. The social spider Stegodyphus dumicola shows regional variation in apparent leader-follower dynamics. We use this variation to evaluate the relative contributions of leader social influence versus follower social susceptibility in driving this social order. Using chimeric colonies that combine potential leaders and followers, we discover that leader-follower...

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  • 2017
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  • University of Pittsburgh
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  • Rice University
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  • Huazhong University of Science and Technology
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  • University of Georgia
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  • Oregon State University
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  • Sichuan University
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  • University of Minnesota
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  • King's College London
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