135 Works

Data from: Multilevel and quasi-Monte Carlo methods for uncertainty quantification in particle travel times through random heterogeneous porous media

David Crevillen-Garcia & Henry Power
In this study, we apply four Monte Carlo simulation methods, namely, Monte Carlo, quasi-Monte Carlo, multilevel Monte Carlo and multilevel quasi-Monte Carlo to the problem of uncertainty quantification in the estimation of the average travel time during the transport of particles through random heterogeneous porous media. We apply the four methodologies to a model problem where the only input parameter, the hydraulic conductivity, is modelled as a log-Gaussian random field by using direct Karhunen–Loéve decompositions....

Data from: Nuclear magnetic resonance measurements of velocity distributions in an ultrasonically vibrated granular bed

Jonathan M. Huntley, Tahir Tarvaz, Mick D. Mantle, Andy J. Sederman, Lynn F. Gladden, Nadeem A. Sheikh & Ricky D. Wildman
We report the results of nuclear magnetic resonance imaging experiments on granular beds of mustard grains fluidized by vertical vibration at ultrasonic frequencies. The variation of both granular temperature and packing fraction with height was measured within the three-dimensional cell for a range of vibration frequencies, amplitudes and numbers of grains. Small increases in vibration frequency were found—contrary to the predictions of classical ‘hard-sphere’ expressions for the energy flux through a vibrating boundary—to result in...

Data from: Exploitation of interspecific diversity for monocot crop improvement

Julie King, Ian Armstead, John Harper, Luke Ramsay, John Snape, Robbie Waugh, Caron James, Ann Thomas, Dagmara Gasior, Rhys Kelly, Luned Roberts, Perry Gustafson, Ian King & L Ramsey
In many cultivated crop species there is limited genetic variation available for the development of new higher yielding varieties adapted to climate change and sustainable farming practises. The distant relatives of crop species provide a vast and largely untapped reservoir of genetic variation for a wide range of agronomically important traits that can be exploited by breeders for crop improvement. In this paper, in what we believe to be the largest introgression programme undertaken in...

Data from: Insecticide resistance mediated by an exon skipping event

Madeleine Berger, Alin Mirel Puinean, Emma Randall, Christoph T. Zimmer, Wellington M. Silva, Pablo Bielza, Linda M. Field, David Hughes, Ian Mellor, Keywan Hassani-Pak, Herbert A. A. Siqueira, Martin S. Williamson & Chris Bass
Many genes increase coding capacity by alternate exon usage. The gene encoding the insect nicotinic acetylcholine receptor (nAChR) α6 subunit, target of the bio-insecticide spinosad, is one example of this and expands protein diversity via alternative splicing of mutually exclusive exons. Here, we show that spinosad resistance in the tomato leaf miner, Tuta absoluta is associated with aberrant regulation of splicing of Taα6 resulting in a novel form of insecticide resistance mediated by exon skipping....

Data from: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

Michael Sulak, Lindsey Fong, Katelyn Mika, Sravanthi Chigurupati, Lisa Yon, Nigel P. Mongan, Richard D. Emes & Vincent J. Lynch
A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here we show that the elephant genome encodes 20 copies of the tumor suppressor gene TP53 and that the increase in TP53 copy number occurred coincident with the evolution of large body sizes, the...

Data from: Formin is associated with left-right asymmetry in the pond snail and the frog

Angus Davison, Gary S. McDowell, Jennifer M. Holden, Harriet F. Johnson, Georgios D. Koutsovoulos, M. Maureen Liu, Paco Hulpiau, Frans Van Roy, Christopher M. Wade, Ruby Banerjee, Fengtang Yang, Satoshi Chiba, John W. Davey, Daniel J. Jackson, Michael Levin & Mark L. Blaxter
While components of the pathway that establishes left-right asymmetry have been identified in diverse animals, from vertebrates to flies, it is striking that the genes involved in the first symmetry-breaking step remain wholly unknown in the most obviously chiral animals, the gastropod snails. Previously, research on snails was used to show that left-right signaling of Nodal, downstream of symmetry breaking, may be an ancestral feature of the Bilateria. Here, we report that a disabling mutation...

Data from: Non-coaxiality of sand under bi-directional shear loading

Yao Li & Yunming Yang
This study aims to investigate the effect of consolidation shear stress magnitude on the shear behaviour and noncoaxiality of soils. In previous drained bi-directional simple shear test on Leighton Buzzard sand, it is showed that the level of non-coaxiality, which is indicated by the angle difference between the principal axes of stresses and the corresponding principal axes of strain rate tensors, is increased by increasing angle difference between the direction of consolidation shear stress and...

Data from: Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal

Colin Selman, Jane S. McLaren, Andrew R. Collins, Garry G. Duthie & John R. Speakman
While oxidative damage due to reactive oxygen species (ROS) often increases with advancing age and is associated with many age-related diseases, its causative role in ageing is controversial. In particular, studies that have attempted to modulate ROS-induced damage, either upwards or downward, using antioxidant or genetic approaches, generally do not show a predictable effect on lifespan. Here we investigated whether dietary supplementation with either vitamin E (α-tocopherol) or vitamin C (ascorbic acid) affected oxidative damage...

Data from: An immunological marker of tolerance to infection in wild rodents

Joseph A. Jackson, Amy J. Hall, Ida M. Friberg, Catriona Ralli, Anne Lowe, Malgorzata Zawadzka, Andrew K. Turner, Alexander Stewart, Richard J. Birtles, Steve Paterson, Janette E. Bradley, Mike Begon & Ann Lowe
Hosts are likely to respond to parasitic infections by a combination of resistance (expulsion of pathogens) and tolerance (active mitigation of pathology). Of these strategies, the basis of tolerance in animal hosts is relatively poorly understood, with especially little known about how tolerance is manifested in natural populations. We monitored a natural population of field voles using longitudinal and cross-sectional sampling modes and taking measurements on body condition, infection, immune gene expression, and survival. Using...

Fatal and non-fatal events within 14 days after early, intensive mobilization post stroke

Julie Bernhardt, Karen Borschmann, Janice Collier, Amanda Thrift, Peter Langhorne, Sandy Middleton, Richard Lindley, Helen Dewey, Philip Bath, Catherine Said, Leonid Churilov, Fiona Ellery, Christopher Bladin, Christopher Reid, Judith Frayne, Velandai Srikanth, Stephen Read & Geoffrey Donnan
Objective: We examined fatal and non-fatal Serious Adverse Events (SAEs) at 14 days within AVERT. Method: A prospective, parallel group, assessor blinded, randomized international clinical trial comparing very early intensive mobilization training (VEM) with usual care (UC); with follow up to 3 months. Included: Patients with ischaemic and haemorrhagic stroke within 24 hours of onset and physiological parameters within set limits. Treatment with thrombolytics allowed. Excluded: Patients with severe premorbid disability and/or comorbidities. Interventions continued...

Validation of an eDNA-based method for the detection of wildlife pathogens in water

Natalie Sieber, Hanna Hartikainen & Christoph Vorburger
Monitoring the occurrence and density of parasites and pathogens can identify high infection-risk areas and facilitates disease control and eradication measures. Environmental DNA (eDNA) techniques are increasingly used for pathogen detection due to their relative ease of application. Since many factors affect the reliability and efficacy of eDNA-based detection, rigorous validation and assessment of method limitations is a crucial first step. We evaluated an eDNA detection method using in-situ filtration of large volume water samples,...

Data from: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

Berend J. Van Meer, Ana Krotenberg, Luca Sala, Richard P. Davis, Thomas Eschenhagen, Chris Denning, Leon G.J. Tertoolen & Christine L. Mummery
Cardiomyocytes from human induced pluripotent stem cells (hiPSC-CMs) are increasingly recognized as valuable for determining the effects of drugs on ion channels but they do not always accurately predict contractile responses of the human heart. This is in part attributable to their immaturity but the sensitivity of measurement tools may also be limiting. Measuring action potential, calcium flux or contraction individually misses critical information that is captured when interrogating the complete excitation-contraction coupling cascade simultaneously....

Research data supporting \"Tetralin and decalin h-donor effect on catalytic upgrading of heavy oil inductively heated with steel balls\"

Abarasi Hart, Mohamed Adam, John Robinson, Sean Rigby & Joseph Wood
Dataset includes Thermogravimetric simulated distillation analysis, thermogravimetric coking data and nitrogen adsorption data of the catalyst.

Corine land cover 2018 for the UK, Isle of Man, Jersey and Guernsey

B. Cole, B. De La Barreda, A. Hamer, T. Codd, M. Payne, L. Chan, G. Smith & H. Balzter
This dataset is the 2018 Corine Land Cover map, consisting of 44 classes in the hierarchical three level Corine nomenclature. Corine Land Cover (CLC) 2018, CLC change 2012-2018 and CLC 2012 revised are three of the datasets produced within the frame of the Copernicus programme on land monitoring. Corine Land Cover (CLC) provides consistent information on land cover and land cover changes across Europe; these two maps are the UK component of Europe. This inventory...

Heterogeneity and environmental stress resistance of wild yeast isolates

S. Hewitt, A. Warry, P.S. Dyer & S.V. Avery
This dataset contains analytical results for wild yeast isolates from soil samples at and near a disused metal smelting works in the north-east of the UK. The main contaminant from the smelting works was lead (Pb), but Cd was also elevated. The soil near the smelting works showed above-background levels of Pb. Yeasts of similar colony morphology on laboratory agar were isolated and proved to be mostly isolates of Saitozyma podzolica: 56 independent clonal isolates...

Corine land cover 2012 (revised) for the UK, Isle of Man, Jersey and Guernsey

B. Cole, B. De La Barreda, A. Hamer, T. Codd, M. Payne, L. Chan, G. Smith & H. Balzter
This dataset is the 2012 revised Corine Land Cover (CLC) map, consisting of 44 classes in the hierarchical three level Corine nomenclature, produced during the CLC2018 production to improve the CLC2012 inventory. CLC 2018, CLC change 2012-2018 and CLC 2012 revised are three of the datasets produced within the frame of the Copernicus programme on land monitoring. Corine Land Cover (CLC) provides consistent information on land cover and land cover changes across Europe; these two...

Fluid pH and major and minor element data from shale-acidic fluid interaction laboratory experiments

Yukun Ji & Veerle Vandeginste
This dataset presents major (ICP-OES) and minor (ICP-MS) element data and fluid pH during interaction of simulated fracturing fluids with the Bowland-Hodder shale at a variety of conditions, i.e. fluid acidity (pH 1-5), temperature (25-70 C), and rock/fluid ratio (from 0.2:200 to 20:200), as well as two end member mineralogical compositions (from 618 m depth and 673 m depth). The data was collected under the SECURe (Subsurface Evaluation of Carbon capture and storage and Unconventional...

Research data supporting \"Operando visualisation of battery chemistry and dendrite formation in a sodium ion battery by 23Na MRI\"

Melanie Britton, Claire Doswell, Josh Bray, Galina Pavlovskaya, Emma Kendrick, Brij Kishore, Lin Chen, Maria-Magdalene Titirici, Heather Au, Hande Alptekin & Thomas Meersmann
Data for the figures in the manuscript and supplementary information.

Inductive heating assisted‑catalytic dehydrogenation of tetralin as a hydrogen source for downhole catalytic upgrading of heavy oil

Hart Abarasi, Mohamed Adam, John Robinson, Sean Rigby & Joseph Wood
Dataset for publication with induction heating data, conversion and selectivity for the dehydrogenation of tetralin in a catalytic bed reactor

Data from Reis et al (2020) Causes and consequences of liana infestation in Southern Amazonia. Journal of Ecology DOI: 10.1111/1365-2745.13470

Simone Matias Reis, Beatriz Schwantes Marimon, Paulo S. Morandi, Fernando Elias, Adriane Esquivel‐Muelbert, Ben Hur Marimon Junior, Sophie Fauset, Edmar Almeida de Oliveira, Geertje M.F. van der Heijden, David Galbraith, Ted R. Feldpausch & Oliver L. Phillips

Peat properties from the Flow Country, Scotland, 2020, following wildfire in 2019

P. Fernandez-Garcia, R. Andersen, R. Schmidt, P.P.J. Gaffney, P. Gilbert, D.J. Large, C. Marshall, D. Mayor, A. Pickard & B. Williamson
Location of peat cores and peat properties including moisture, bulk density, ash and organic matter content for short cores (50 cm) collected 10 month post-fire in high, medium and low severity areas within a drained and a near natural area in the footprint of a severe wildfire that impacted >6500 ha of blanket bog and wet heath in the Flow Country of Northern Scotland.

Self‐Assembly, Adaptive Response, and in , out‐ Stereoisomerism of Large Orthoformate Cryptands

Max von Delius, Henrik Löw, Elena Mena‐Osteritz, Kathleen M. Mullen & Christof Jäger
Abstract We report on triethylene glycol-based orthoformate cryptands, which adapt their bridgehead configurations in response to metal templates and intramolecular hydrogen bonding in a complex ma...

Large scale manufacturing route to metamaterial coatings using thermal spray techniques and their response to solar radiation

Nadimul Faisal, Nazmi Sellami, Federico Venturi, Tanvir Hussain, Tapas Mallick, Firdaus Muhammad-Sukki, Alex Bishop, Hari Upadhyaya, Nirmal Kumar Katiyar & Saurav Goel
Metamaterials, an artificial periodic two- or three-dimensional configuration can change propagation characteristics of electromagnetic waves (i.e., reflection, transmission, absorption). The current challenges in the field of metamaterial coatings are their manufacturing in large scale and large length scale. There is a clear need to enhance process technologies and scalability of these. Thermal spraying is a method used to deposit small to large scale coatings where the sprayed layer is typically formed by successive impact of...

Palaeolimnological data from 5 Arctic lakes in Greenland, Alaska and Norway [Lakes and Arctic Carbon]

E.J. Whiteford, E. Hopla, N. Solovieva, J. Swales, S. Turner, M. Van Hardenbroek, E. Wiik, M.E. Edwards, V.J. Jones, P.G. Langdon, S. McGowan & N.J. Anderson
This dataset contains palaeolimnological data from sediment cores taken from five Arctic lakes. Two lakes located in Alaska were cored in July 2013, one lake located in Greenland was cored in April 2013, and two lakes located in Norway were cored in March 2014. The data includes macrofossil, chironomids and Cladocera analysis at 2 cm resolution; and loss on ignition, diatoms, biogenic silica, nitrogen and carbon isotopes, algal photosynthetic pigments and pollen analyses at 1...

Data from: Deliberation favours social efficiency by making people disregard their relative shares: evidence from USA and India

Valerio Capraro, Brice Corgnet, Antonio M. Espín & Roberto Hernán-González
Groups make decisions on both the production and the distribution of resources. These decisions typically involve a tension between increasing the total level of group resources (i.e. social efficiency) and distributing these resources among group members (i.e. individuals' relative shares). This is the case because the redistribution process may destroy part of the resources, thus resulting in socially inefficient allocations. Here we apply a dual-process approach to understand the cognitive underpinnings of this fundamental tension....

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