2 Works

Data from: A revised design for microarray experiments to account for experimental noise and uncertainty of probe response

Alex E. Pozhitkov, Peter A. Noble, Jaroslaw Bryk, Diethard Tautz & Jarosław Bryk
Background: Although microarrays are analysis tools in biomedical research, they are known to yield noisy output that usually requires experimental confirmation. To tackle this problem, many studies have developed rules for optimizing probe design and devised complex statistical tools to analyze the output. However, less emphasis has been placed on systematically identifying the noise component as part of the experimental procedure. One source of noise is the variance in probe binding, which can be assessed...

Data from: Tracing the dynamics of gene transcripts after organismal death

Alexander E. Pozhitkov, Rafik Neme, Tomislav Domazet-Lošo, Brian G. Leroux, Shivani Soni, Diethard Tautz & Peter A. Noble
In life, genetic and epigenetic networks precisely coordinate the expression of genes—but in death, it is not known if gene expression diminishes gradually or abruptly stops or if specific genes and pathways are involved. We studied this by identifying mRNA transcripts that apparently increase in relative abundance after death, assessing their functions, and comparing their abundance profiles through postmortem time in two species, mouse and zebrafish. We found mRNA transcript profiles of 1063 genes became...

Registration Year

  • 2016
    1
  • 2014
    1

Resource Types

  • Dataset
    2

Affiliations

  • University of Washington
    2
  • Alabama State University
    2
  • Max Planck Institute for Evolutionary Biology
    2
  • Rudjer Boskovic Institute
    1
  • University of Reading
    1