44 Works

Superoxide is promoted by sucrose and affects amplitude of circadian rhythms in the evening

Michael Haydon, John Davey & Ángela Román
Plants must coordinate photosynthetic metabolism with the daily environment and adapt rhythmic physiology and development to match carbon availability. Circadian clocks drive biological rhythms which adjust to environmental cues. Products of photosynthetic metabolism, including sugars and reactive oxygen species (ROS), are closely associated with the plant circadian clock and sugars have been shown to provide metabolic feedback to the circadian oscillator. Here, we report a comprehensive sugar-regulated transcriptome of Arabidopsis and identify genes associated with...

Ecological interactions shape the evolution of flower colour in communities across a temperate biodiversity hotspot

Alexander Skeels, Russell Dinnage, Iliana Medina & Marcel Cardillo
Processes driving the divergence of floral traits may be integral to the extraordinary richness of flowering plants and the assembly of diverse plant communities. Several models of pollinator-mediated floral evolution have been proposed; floral divergence may (i) be directly involved in driving speciation or may occur after speciation driven by (ii) drift or local adaptation in allopatry or (iii) negative interactions between species in sympatry. Here, we generate predictions for patterns of trait divergence and...

Male-biased sexual selection, but not sexual dichromatism, predicts speciation in birds

Justin Cally, Devi Stuart-Fox, Luke Holman, James Dale & Iliana Medina
Sexual selection is thought to shape phylogenetic diversity by affecting speciation or extinction rates. However, the net effect of sexual selection on diversification is hard to predict, because many of the hypothesised effects on speciation or extinction have opposing signs and uncertain magnitudes. Theoretical work also suggests that the net effect of sexual selection on diversification should depend strongly on ecological factors, though this prediction has seldom been tested. Here, we test whether variation in...

Condition-dependent sexual reproduction is driven by benefits, not costs of sex

Isobel Booksmythe, Jessica Lever, Sally Drapes & Matthew Hall
Facultative sexual organisms must allocate resources to both asexual and sexual reproduction. Optimal patterns of investment in sex depend on the relative costs and benefits of each reproductive mode, and may consequently be context- and condition-dependent. Two proposed explanations for the observed variation in investment in sex among facultative sexual lineages invoke alternative condition-dependent scenarios. Under the ‘fitness-associated sex’ hypothesis, sex is predicted when individuals are in poor condition or experience stressful environments. Under the...

Measurements of tree motion in the wind collated from multiple studies undertaken in the UK, Puerto Rico and Australia between 1987-2015

T. Jackson, A. Wellpott, S. Van Bloem, A. Achim, K. James & B. Gardiner
This dataset contains high resolution measurements of tree motion in response to wind at six sites. The data was collected using sensors mounted directly onto the tree trunk. The sites are: Rivox, Kershope, Kyloe and Clocaenog in the UK. Guanica in Puerto Rico and six open-grown trees from Australia.

The impact of indoor residual spraying on Plasmodium falciparum microsatellite variation in an area of high seasonal malaria transmission in Ghana, West Africa

Dionne Argyropoulos, Shazia Ruybal‐Pesántez, Samantha L. Deed, Abraham R. Oduro, Samuel K. Dadzie, Maxwell A. Appawu, Victor Asoala, Mercedes Pascual, Kwadwo A. Koram, Karen P. Day, Maxwell A. Appawu, Kathryn E. Tiedje, Victor Asoala, Mercedes Pascual, Kwadwo A. Koram, Karen P. Day & Kathryn E. Tiedje
Here, we report the first population genetic study to examine the impact of indoor residual spraying (IRS) on Plasmodium falciparum in humans. This study was conducted in an area of high seasonal malaria transmission in Bongo District, Ghana. IRS was implemented during the dry season (November-May) in three consecutive years between 2013 and 2015 to reduce transmission and attempt to bottleneck the parasite population in humans towards lower diversity with greater linkage disequilibrium. The study...

Data from: Heating rates are more strongly influenced by near-infrared than visible reflectance in beetles

Lu-Yi Wang, Amanda M Franklin, Jay R Black & Devi Stuart-Fox
Adaptations to control heat transfer through the integument are a key component of temperature regulation in animals. However, there remain significant gaps in our understanding of how different optical and morphological properties of the integument affect heating rates. To address these gaps, we examined the effect of reflectivity in both ultraviolet-visible and near-infrared wavelengths, surface micro-sculpturing, effective area (area subjected to illumination) and cuticle thickness on radiative heat gain in jewel beetles (Buprestidae). We measured...

Quality-controlled carbon-14 dates of steppe bison (Bison priscus) fossils

Julia Pilowsky, Sean Haythorne, Stuart C. Brown, Mario Krapp, Edward Armstrong, Barry W. Brook, Carsten Rahbek & Damien A Fordham
We gathered carbon-14-dated fossil records of the steppe bison (Bison priscus) from open access databases, quality-scored them using Barnosky & Lindsey criteria, and retained the records rated "reliable." We then calibrated the carbon-14 dates using the IntCal13 curve in OxCal.

The lived experience of carers who assist people with disability in Ernakulam, Kerala, India

Saju Madavanakadu Devassy, Danielle Green, Natania Cheguvera, Shilpa V. Yohannan, Nathan Grills & Lynette Joubert
Family members are preferred providers of care for people with disability in India. Despite this, research which evaluates the impact of caregiving is limited. This qualitative study provides a comprehensive, in-depth exploration of the lived experience of carers who provide assistance to persons with a disability in Southwest India. In this qualitative study, 20 carers who assist persons with disability were purposively selected to undertake semi-structured interviews across a variety of domains. Data analysis was...

Understanding caregiver perspectives on challenges and solutions to pediatric asthma care for children with a previous hospital admission: a multi-site qualitative study

Renee Jones, Brittany Turner, Prescilla Perera, Harriet Hiscock & Katherine Chen
Pediatric hospital admissions for asthma provide an opportunity to trigger a review of the current management with an aim of preventing readmissions. However, caregiver voices on how best to improve care are missing. As part of a larger, mixed methods cohort study, we identified caregivers of children aged 3–18 years who had an index hospital admission to a tertiary pediatric, mixed adult and pediatric, or regional hospital in Victoria, Australia, between 1st September 2017 and...

Raw data for: Extreme climate shifts pest dominance hierarchy through thermal evolution and transgenerational plasticity

Liang Zhu, Ary Hoffmann, Shimin Li & Chunsen Ma
We conducted an 8-year field survey to link extreme high-temperature events to the shift in dominance hierarchy of two worldwide cereal aphid species (Rhopalosiphum padi and Sitobion avenae), which may respond rapidly through evolutionary or plastic responses to thermal extremes due to their short generation duration, clonal structure and high thermal sensitivity. To further understand the mechanism involved in this change in species’ dominance, we characterised aphid heat tolerance and demography of the 2 species...

Genetic and phenotypic variation in Bathygobius cocosensis from East Australia (2014–2016)

Joshua Thia
Genetic and phenotypic data from an East Australian metapopulation of the intertidal goby, Bathygobius cocosensis (Bleeker 1854). Data was collected over three years (2014–2016) from juveniles and adult subpopulations at three sites: Point Cartwright, Hastings Point and Shellharbour. Genetic variation was characterised using genome-wide SNPs, obtained through pooled ezRAD sequencing. Phenotypic variation was characterised using geometric morphometric analysis of head shape morphology. The analyses contained in this repository are for a manuscript submitted to Molecular...

Clinicians’ opinions on recommending aspirin to prevent colorectal cancer to Australians aged 50 to 70 years: A qualitative study

Shakira Milton, Jennifer McIntosh, Thivagar Yogaparan, Pavithran Alphonse, Sibel Saya, Napin Karnchanachari, Peter Nguyen, Phyllis Lau, Finlay Macrae & Jon Emery
Objectives Australian guidelines recommend all 50 to 70-year-olds without existing contraindications consider taking low-dose aspirin (100 mg – 300 mg per day) for at least 2.5 years to reduce their risk of developing colorectal cancer. We aimed to explore clinicians’, practices, knowledge, opinions, and barriers and facilitators to the implementation of these new guidelines. Methods Semi-structured interviews were conducted with clinicians to whom the new guidelines may be applicable (familial cancer clinic staff (geneticists, oncologists...

Male reproductive effort might be evolving in the face of devastating disease in a threatened amphibian

Laura Brannelly, Rebecca J Webb, Zhixuan Jiang, Lee Berger, Lee F Skerratt & Laura F Grogan
The devastating infectious disease chytridiomycosis has caused declines of amphibians across the globe, yet some populations are persisting and even recovering. One understudied effect of wildlife disease is changes in reproductive effort. Here we aimed to understand if disease has plastic effects on reproduction and if reproductive effort could evolve with disease endemism. We compared the effects of experimental pathogen exposure (trait plasticity) and population-level disease history (evolution in trait baseline) on reproductive effort using...

Variability, heritability and condition-dependence of the multidimensional male colour phenotype in a passerine bird

Marie Fan, Michelle Hall, Michael Roast, Anne Peters & Kaspar Delhey
Elaborate ornamental traits are commonly assumed to be honest signals of individual quality, owing to the presumed costs involved in their production and/or maintenance. Such traits are often highly variable, possibly because of condition-dependence and/or high underlying genetic variation, and it has been suggested that their expression should be more sensitive to condition and/or more heritable than non-ornamental traits. Many bird species display colourful plumage with multiple distinct patches of different developmental origins, forming complex...

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity

Jieqiong Lou, Alex McCann, Mehdi Moustaqil, Matthew Graus, Ailisa Blum, Frank Fontaine, Hui Liu, Winnie Luu, Peter Koopman, Emma Sierecki, Yann Gambin, Frédéric Meunier, Zhe Liu, Elizabeth Hinde & Mathias Francois
Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly poorly understood. Here, we studied the genome-wide mechanism underlying a dominant-negative form of the SOX18 transcription factor (SOX18RaOp) responsible for both the classical mouse mutant Ragged Opossum and the human genetic disorder Hypotrichosis-Lymphedema-Telangiectasia-Renal Syndrome. Combining three single-molecule imaging...

Sexual selection and the population genetics of a selfish gene

Thomas Keaney, Theresa Jones & Luke Holman
The segregation distorter allele (SD) found in Drosophila melanogaster distorts Medelian inheritance in heterozygous males by causing developmental failure of non-SD spermatids, such that >90% of the surviving sperm carry SD. This within-individual advantage should cause SD to rapidly fix, and yet SD is typically rare in wild populations. Here, we explore whether this paradox can be resolved by sexual selection, by testing if males carrying three different variants of SD suffer reduced pre or...

Too hot for the devil? Did climate change cause the mid-Holocene extinction of the Tasmanian devil (Sarcophilus harrisii) from mainland Australia?

Shane Morris, Michael Kearney, Christopher Johnson & Barry Brook
The possible role of climate change in late Quaternary animal extinctions is hotly debated, yet few studies have investigated its direct effects on animal physiology to assess whether past climate changes might have had significant impacts on now-extinct species. Here we test whether climate change could have imposed physiological stress on the Tasmanian devil (Sarcophilus harrisii) during the mid-Holocene, when the species went extinct on mainland Australia. Physiological values for the devil were quantified using...

Quality-controlled carbon-14 dates of steppe bison (Bison priscus) fossils

Julia Pilowsky, Sean Haythorne, Stuart C. Brown, Mario Krapp, Edward Armstrong, Barry W. Brook, Carsten Rahbek & Damien A Fordham
We gathered carbon-14-dated fossil records of the steppe bison (Bison priscus) from open access databases, quality-scored them using Barnosky & Lindsey criteria, and retained the records rated "reliable." We then calibrated the carbon-14 dates using the IntCal13 curve in OxCal.

Quality-controlled carbon-14 dates of steppe bison (Bison priscus) fossils

Julia Pilowsky, Sean Haythorne, Stuart C. Brown, Mario Krapp, Edward Armstrong, Barry W. Brook, Carsten Rahbek & Damien A Fordham
We gathered carbon-14-dated fossil records of the steppe bison (Bison priscus) from open access databases, quality-scored them using Barnosky & Lindsey criteria, and retained the records rated "reliable." We then calibrated the carbon-14 dates using the IntCal13 curve in OxCal.

Long non-coding RNA LINC00649 regulates YES-associated protein 1 (YAP1)/Hippo pathway to accelerate gastric cancer (GC) progression via sequestering miR-16-5p

Hongyan Wang, Xin Di, Yingjie Bi, Shidong Sun & Tao Wang
Although long non-coding RNA (LncRNA) LINC00649 is reported to be closely associated with acute myeloid leukemia (AML), prostate cancer and colorectal cancer, its role in regulating other types of cancer, such as gastric cancer (GC), has not been studied. This study analyzed the expression status of LINC00649 in GC tissues and cells by performing Real-Time qPCR analysis, and we found that LINC00649 tended to be enriched in cancerous tissues and cells but not in their...

Explaining the worldwide distributions of two highly mobile species: Cakile edentula and C. maritima

Roger Cousens, Elliot Shaw, Rachael Fowler, Sara Ohadi, Michael Bayly, Rosemary Barrett, Josquin Tibbits, Allan Strand, Charles Willis, Kathleen Donohue & Philipp Robeck
Aim: If we are able to determine the geographic origin of an invasion, as well as its known area of introduction, we can better appreciate the innate environmental tolerance of a species and the strength of selection for adaptation that colonising populations have undergone. It also enables us to maximise the success of searches for effective biological control agents. We determined the number of successful colonisation events that have occurred throughout the world for two...

Effects of high and low-efficacy therapy in secondary progressive multiple sclerosis

Izanne Roos, Emmanuelle Leray, Romain Casey, Dana Horakova, Eva Havrdova, Guillermo Izquierdo, Sara Eichau, Francesco Patti, Gilles Edan, Marc Debouverie, Jean Pelletier, Serkan Ozakbas, Maria Pia Amato, Pierre Clavelou, Pierre Grammond, Cavit Boz, Katherine Buzzard, Olga Skibina, Jonathan Ciron, Oliver Gerlach, Francois Grand'Maison, Jeannette Lechner-Scott, Charles Malpas, Helmut Butzkueven, Sandra Vukusic … & Tomas Kalincik
Objective: To compare the clinical effectiveness of high- and low-efficacy treatments in patients with recently active and inactive secondary progressive multiple sclerosis (SPMS) after accounting for therapeutic lag. Methods: Patients treated with high- (natalizumab, alemtuzumab, mitoxantrone, ocrelizumab, rituximab, cladribine, fingolimod) or low-efficacy (interferon β, glatiramer acetate, teriflunomide) therapies after SPMS onset were selected from MSBase and OFSEP, two large observational cohorts. Therapeutic lag was estimated for each patient based on their demographic and clinical characteristics....

Code and data for: Increasing sensitivity of terrestrial nitrous oxide emissions to precipitation variations

Yuanyuan Huang, Philippe Ciais, Olivier Boucher, Ying-ping Wang, Hanqin Tian, FENG ZHOU, Jinfeng Chang, Zhaolei Li, Daniel S Goll, Ray L Langenfelds, Hao Shi, Naiqing Pan, HANG-WEI HU, Shu Kee Lam & Ning Dong
This dataset contains python code and datasets generated from the study: Increasing sensitivity of terrestrial nitrous oxide emissions to precipitation variations

Three periods of gold mineralization in the Liaodong Peninsula, North China Craton

Peng Zhang, Linlin Kou & Yang Zhao
The Liaodong gold province includes voluminous gold deposits, which occur in an Archean gneiss complex, Paleoproterozoic metamorphic rocks, and Mesozoic granite. However, the ore-forming age, the genesis, and the geodynamic setting of the gold deposits are not well constrained. In this study, we have summarized previous geochronology data, H-O-S-Pb isotopes, and He-Ar isotopic compositions of the gold deposits. Based on geochronology data, the gold mineralization was divided into Late Triassic, Early Jurassic, and Early Cretaceous....

Registration Year

  • 2021

Resource Types

  • Dataset


  • University of Melbourne
  • Huazhong University of Science and Technology
  • University of Queensland
  • Sun Yat-sen University
  • West China Second University Hospital of Sichuan University
  • West China Hospital of Sichuan University
  • Fudan University Shanghai Cancer Center
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Chinese Academy of Sciences
  • First Affiliated Hospital of Zhengzhou University