57 Works

Identification of microRNA hsa-miR-30c-5p as an inhibitory factor in the progression of hepatocellular carcinoma and investigation of its regulatory network via comprehensive analysis

Shangshang Hu, Jinyan Zhang, Xiaoyu Fang, Guoqing Guo, Jing Dai, Zhiyong Sheng, Dongdong Li, Jiasheng Chen, Li Zhang, Chuanmiao Liu & Yu Gao
Hepatocellular carcinoma (HCC) is a primary liver cancer with high morbidity and mortality. An increasing number of abnormal gene expressions were identified to be associated with the progression of HCC. Previous studies showed that the hsa-miR-30 c-5p (miR-30 c), one of the miR-30 family members, might play a role in suppressing tumor progression in a variety of tumors. The present study aims to examine miR-30 c effects in the development of HCC. The role of...

LncRNA-UCA1 regulates lung adenocarcinoma progression through competitive binding to miR-383

Li Tang, Sheng Wang, Yapeng Wang, Kang Li & Qiang Li
The present study aimed to assess the role of the long non-coding RNA-urothelial cancer associated 1 (lncRNA-UCA1)/microRNA (miR)-383/vascular endothelial growth factor A (VEGFA) axis in regulating lung adenocarcinoma physiology through in vivo and in vitro experiments. The expression profile of lncRNA-UCA1 was analyzed by genome-wide analysis from GSE146459. The cell counting Kit-8, colony formation, wound healing and transwell assays were performed to evaluate the effects of lncRNA-UCA1 in vitro. In addition, luciferase reporter assays were...

Self-reported effects of perceived social support on marital quality in balanced translocation patients and their spouses undergoing preimplantation genetic testing in China: actor–partner interdependence model

Fengyi Mo, Xiaorui Hu, Qing Ma, Li Zhang & Lanfeng Xing
This study aimed to analyse the relationship between perceived social support and marital quality in balanced translocation patients and their spouses undergoing a preimplantation genetic testing (PGT) treatment cycle in China. The authors assessed the actor and partner effects of perceived social support on marital quality in patient–spouse dyads using a dyadic analysis approach. In total, 59 couples were assessed using self-report questionnaires for marital quality and perceived social support. There were significant differences in...

Additional file 1 of Bacteriomes in lesions of pulmonary tuberculosis and its association with status of Mycobacterium tuberculosis excretion

Weili Du, Yingli Zhao, Li Zhang, Jialu Che, Zichen Liu, Kun Li & Nanying Che
Additional file 1: Supplemental Table 1. Values of bacterial MetaCyc pathways of all TB lesions (40 TB-E and 42 TB-NE).

Additional file 2 of Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease

Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan & Jiequn Li
Additional file 2: Table S2. RNA-seq data of liver tissues of NAFLD patients and controls.

Additional file 6 of Exploring the pharmacological mechanism of Shengjing capsule on male infertility by a network pharmacology approach

Ming Wang, Qi Wang, Hui Jiang, Yongqiang Du & Xiansheng Zhang
Additional file 6:

Additional file 3 of Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease

Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan & Jiequn Li
Additional file 3: Table S3. Results of GO enrichment on differentially expressed genes from RNA-seq data.

Additional file 5 of Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease

Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan & Jiequn Li
Additional file 5: Table S5. Results of KEGG enrichment on differentially expressed genes from GSE159676 datasets.

Additional file 6 of Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease

Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan & Jiequn Li
Additional file 6: Table S6. Results of GO enrichment on differentially expressed genes from GSE159676 datasets.

Additional file 1 of Exploring the pharmacological mechanism of Shengjing capsule on male infertility by a network pharmacology approach

Ming Wang, Qi Wang, Hui Jiang, Yongqiang Du & Xiansheng Zhang
Additional file 1:

Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018

Yanqun Wang, Xin Li, Wenkuan Liu, Mian Gan, Lu Zhang, Jin Wang, Zhaoyong Zhang, Airu Zhu, Fang Li, Jing Sun, Guoxian Zhang, Zhen Zhuang, Jiaying Luo, Dehui Chen, Shuyan Qiu, Li Zhang, Duo Xu, Chris Ka Pun Mok, Fuchun Zhang, Jingxian Zhao, Rong Zhou & Jincun Zhao
Human coronavirus NL63 (HCoV-NL63) is primarily associated with common cold in children, elderly and immunocompromised individuals. Outbreaks caused by HCoV-NL63 are rare. Here we report a cluster of HCoV-NL63 cases with severe lower respiratory tract infection that arose in Guangzhou, China, in 2018. Twenty-three hospitalized children were confirmed to be HCoV-NL63 positive, and most of whom were hospitalized with severe pneumonia or acute bronchitis. Whole genomes of HCoV-NL63 were obtained using next-generation sequencing. Phylogenetic and...

Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018

Yanqun Wang, Xin Li, Wenkuan Liu, Mian Gan, Lu Zhang, Jin Wang, Zhaoyong Zhang, Airu Zhu, Fang Li, Jing Sun, Guoxian Zhang, Zhen Zhuang, Jiaying Luo, Dehui Chen, Shuyan Qiu, Li Zhang, Duo Xu, Chris Ka Pun Mok, Fuchun Zhang, Jingxian Zhao, Rong Zhou & Jincun Zhao
Human coronavirus NL63 (HCoV-NL63) is primarily associated with common cold in children, elderly and immunocompromised individuals. Outbreaks caused by HCoV-NL63 are rare. Here we report a cluster of HCoV-NL63 cases with severe lower respiratory tract infection that arose in Guangzhou, China, in 2018. Twenty-three hospitalized children were confirmed to be HCoV-NL63 positive, and most of whom were hospitalized with severe pneumonia or acute bronchitis. Whole genomes of HCoV-NL63 were obtained using next-generation sequencing. Phylogenetic and...

LncRNA-UCA1 regulates lung adenocarcinoma progression through competitive binding to miR-383

Li Tang, Sheng Wang, Yapeng Wang, Kang Li & Qiang Li
The present study aimed to assess the role of the long non-coding RNA-urothelial cancer associated 1 (lncRNA-UCA1)/microRNA (miR)-383/vascular endothelial growth factor A (VEGFA) axis in regulating lung adenocarcinoma physiology through in vivo and in vitro experiments. The expression profile of lncRNA-UCA1 was analyzed by genome-wide analysis from GSE146459. The cell counting Kit-8, colony formation, wound healing and transwell assays were performed to evaluate the effects of lncRNA-UCA1 in vitro. In addition, luciferase reporter assays were...

Self-reported effects of perceived social support on marital quality in balanced translocation patients and their spouses undergoing preimplantation genetic testing in China: actor–partner interdependence model

Fengyi Mo, Xiaorui Hu, Qing Ma, Li Zhang & Lanfeng Xing
This study aimed to analyse the relationship between perceived social support and marital quality in balanced translocation patients and their spouses undergoing a preimplantation genetic testing (PGT) treatment cycle in China. The authors assessed the actor and partner effects of perceived social support on marital quality in patient–spouse dyads using a dyadic analysis approach. In total, 59 couples were assessed using self-report questionnaires for marital quality and perceived social support. There were significant differences in...

Additional file 2 of CASA: a comprehensive database resource for the COVID-19 Alternative Splicing Atlas

Yaxin Chen, Gang Wang, Jingyi Li, Lei Xia, Lin Zhu, Wenxing Li, Qiang Luo, Yinlu Liao, Yao Lin, Liyun Bi, Hubin Chen, Jiemei Chu, Yueqi Li, Jinming Su, Li Ye, Jun-jun Jiang, Hao Liang, Weimin Li & Sanqi An
Additional file 2: Table S2. Summary of alternative splicing records in CASA.

Additional file 4 of Exploring the pharmacological mechanism of Shengjing capsule on male infertility by a network pharmacology approach

Ming Wang, Qi Wang, Hui Jiang, Yongqiang Du & Xiansheng Zhang
Additional file 4:

Additional file 1 of Bacteriomes in lesions of pulmonary tuberculosis and its association with status of Mycobacterium tuberculosis excretion

Weili Du, Yingli Zhao, Li Zhang, Jialu Che, Zichen Liu, Kun Li & Nanying Che
Additional file 1: Supplemental Table 1. Values of bacterial MetaCyc pathways of all TB lesions (40 TB-E and 42 TB-NE).

Additional file 2 of Bacteriomes in lesions of pulmonary tuberculosis and its association with status of Mycobacterium tuberculosis excretion

Weili Du, Yingli Zhao, Li Zhang, Jialu Che, Zichen Liu, Kun Li & Nanying Che
Additional file 2: Supplemental Table 2. Bacterial metabolic pathways that are significantly down/up regulated in TB-E compared to TB-NE.

Additional file 7 of Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease

Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan & Jiequn Li
Additional file 7: Table S7. Differentially expressed genes that appeared in both RNA-seq data and the GSE159676 datasets

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

Yating Ning, Meng Xiao, David S. Perlin, Yanan Zhao, Minya Lu, Yi Li, Zhengyu Luo, Rongchen Dai, Shengjie Li, Jiajun Xu, Lingli Liu, Hong He, Yun Liu, Fushun Li, Yuguang Guo, Zhongju Chen, Yingchun Xu, Tianshu Sun & Li Zhang
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C. parapsilosis has emerged in several countries, but little is known about the susceptibility profile in China or about mechanisms of resistance. Here, we investigated the echinocandin susceptibilities of 2523 C. parapsilosis isolates collected from China and further explored the resistance mechanism among echinocandin-resistant isolates. Anidulafungin exhibited the highest...

Identification of microRNA hsa-miR-30c-5p as an inhibitory factor in the progression of hepatocellular carcinoma and investigation of its regulatory network via comprehensive analysis

Shangshang Hu, Jinyan Zhang, Xiaoyu Fang, Guoqing Guo, Jing Dai, Zhiyong Sheng, Dongdong Li, Jiasheng Chen, Li Zhang, Chuanmiao Liu & Yu Gao
Hepatocellular carcinoma (HCC) is a primary liver cancer with high morbidity and mortality. An increasing number of abnormal gene expressions were identified to be associated with the progression of HCC. Previous studies showed that the hsa-miR-30 c-5p (miR-30 c), one of the miR-30 family members, might play a role in suppressing tumor progression in a variety of tumors. The present study aims to examine miR-30 c effects in the development of HCC. The role of...

Identification of microRNA hsa-miR-30c-5p as an inhibitory factor in the progression of hepatocellular carcinoma and investigation of its regulatory network via comprehensive analysis

Shangshang Hu, Jinyan Zhang, Xiaoyu Fang, Guoqing Guo, Jing Dai, Zhiyong Sheng, Dongdong Li, Jiasheng Chen, Li Zhang, Chuanmiao Liu & Yu Gao
Hepatocellular carcinoma (HCC) is a primary liver cancer with high morbidity and mortality. An increasing number of abnormal gene expressions were identified to be associated with the progression of HCC. Previous studies showed that the hsa-miR-30 c-5p (miR-30 c), one of the miR-30 family members, might play a role in suppressing tumor progression in a variety of tumors. The present study aims to examine miR-30 c effects in the development of HCC. The role of...

Dynamic transcriptome profiling reveals essential roles of the receptor tyrosine kinases (RTK) family in feather development of duck

Hehe Liu, Qian Xu, Yang Xi, Shengchao Ma, Jianmei Wang, Lili Bai, Chunchun Han, Hua He & Liang Li
1. The following study examined the expression profiles of the receptor tyrosine kinases (RTK) family in the developing feather follicles of Pekin ducks and Nonghua ducks at 6-9 weeks of age. The RTK subfamilies related to feather development were summarised, and other candidate genes related to feather development were enriched. 2. To reveal the potential role of all RTK members in feather development, the feather follicles of two duck breeds (Pekin and Nonghua ducks) at...

Additional file 1 of CASA: a comprehensive database resource for the COVID-19 Alternative Splicing Atlas

Yaxin Chen, Gang Wang, Jingyi Li, Lei Xia, Lin Zhu, Wenxing Li, Qiang Luo, Yinlu Liao, Yao Lin, Liyun Bi, Hubin Chen, Jiemei Chu, Yueqi Li, Jinming Su, Li Ye, Jun-jun Jiang, Hao Liang, Weimin Li & Sanqi An
Additional file 1: Table S1. Summary of samples in CASA.

Additional file 2 of Bacteriomes in lesions of pulmonary tuberculosis and its association with status of Mycobacterium tuberculosis excretion

Weili Du, Yingli Zhao, Li Zhang, Jialu Che, Zichen Liu, Kun Li & Nanying Che
Additional file 2: Supplemental Table 2. Bacterial metabolic pathways that are significantly down/up regulated in TB-E compared to TB-NE.

Registration Year

  • 2023
    7
  • 2022
    45
  • 2021
    4
  • 2020
    1

Resource Types

  • Dataset
    57

Affiliations

  • Beijing Chest Hospital
    57
  • Zhejiang University
    49
  • Second Military Medical University
    48
  • Chinese Academy of Sciences
    42
  • West China Hospital of Sichuan University
    40
  • Sichuan University
    40
  • Capital Medical University
    40
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    36
  • Shandong University
    35
  • Xuzhou Medical College
    34