Chromosomal microarray analysis (CMA) has been widely applied to genetic diagnosis in miscarriages in clinical practice. However, the prognostic value of CMA testing of products of conception (POCs) after the first clinical miscarriage remains unknown. The aim of this study was to evaluate the reproductive outcomes after embryonic genetic testing by CMA in SM couples. In this retrospective study, a total of 1142 SM couples referred for embryonic genetic testing by CMA, and 1022 couples...

Motivated by a product warranty claims data set, we propose clustered coefficient regression models in a non-homogeneous Poisson process for recurrent event data. The proposed method, referred as CLUPP, can estimate the group structure and parameters simultaneously. In our proposed method, a penalized regression approach is used to identify the group structure. Numerical studies show that the proposed approach can identify the group structure well, and outperforms traditional methods such as hierarchical clustering and K-means....

Supplemental material, sj-xls-2-jcb-10.1177_0271678X231165653 for H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1 by Ting Lan, Liye Hu, Tingting Sun, Xuechun Wang, Zhongnan Xiao, Danmin Shen, Weihua Wu, Zhaoli Luo, Chao Wei, Xiaotong Wang, Meng Liu, Yi Guo, Liyong Wang, Yamei Wang, Yabin Lu, Yan Yu, Fei Yang, Chenguang Zhang and Qian Li in Journal of Cerebral Blood Flow & Metabolism

UXT (ubiquitously expressed prefoldin like chaperone), a small chaperone-like protein, is widely expressed in diverse human and mouse tissues and is more abundant in retina and kidney. However, the functional characterization of UXT at tissue level was largely unknown. Here, we reported that mice deficient in UXT exhibited salient features of retinal degenerative disease, similar to retinitis pigmentosa. Conditional knockout (CKO) of Uxt led to retinal degeneration and pigmentation in mice retina along with significant...

Additional file 4: Table S1. GC content of the CPGs of the six subgenus Gynopodium species.

Additional file 4: Table S1. GC content of the CPGs of the six subgenus Gynopodium species.

Additional file 6: Table S3. List of SSRs in the CPGs of six subgenus Gynopodium species.

Accumulating evidence has unfolded the significance of extracellular vesicles (EVs) in diseases and cancers. Here, we attempted to discuss the role of cancer-associated fibroblasts (CAFs)-derived EVs containing miR-199a-5p in gastric tumorigenesis. Upregulated miR-199a-5p was first identified in cancer cells. Then, we selected CAFs for isolation of EVs which were co-cultured with AGS cells. We observed successful delivery of miR-199a-5p via CAF-derived EVs. Besides, miR-199a-5p promoted malignant properties of AGS cells. Moreover, miR-199a-5p downregulated FKBP5, leading...

Additional file 4: Table S4. The microbes and the presence of quorum sensing molecules in the pig gut (as the negative control group).

Additional file 4: Table S4. The microbes and the presence of quorum sensing molecules in the pig gut (as the negative control group).

Additional file 8: Table S5. The diversity of predicted CahR-type receptors.

Additional file 8: Table S5. The diversity of predicted CahR-type receptors.

Additional file 8: Table S6. All genomic SNPs in gene body and 2 kb promoter of ELOVL gene family used for PCA analysis.

Additional file 4: Supplementary Table S8. List of the downregulated differentially expressed genes from RNA sequencing results in Tsc2-/- MEFs and Tsc2+/+ MEFs. All genes were identified with FDR-adjusted p-value<0.05 and absolute value of log2(FC)>1.

Additional file 5: Supplementary Table 9. List of the downregulated differentially expressed genes from DEGs in angiofibroma(AF) of TSC patients vs. normal skin. All genes were identified with FDR-adjusted p-value < 0.05 and absolute value of log2(FC) > 1.

Additional file 1.

This is a source data fileset for a work titled "Singularity arc in phase-locked Coriolis coupling".

Additional file 3. Publication bias.

Additional file 1: Table S1. The chemical properties of sample sites. Table S2. Node table for biotic interaction network in the less contaminatedsites. Table S3. Edge table for biotic interaction network in the lesscontaminated sites. Table S4. Node table for biotic interaction network in thehigh contaminated sites. Table S5. Edge table for biotic interaction network inthe high contaminated sites.

The immune persistence of neutralizing antibodies elicited by BBIBP-CorV vaccines on day 0–14, 0–21 and 0–28 schedule, and the immunogenicity and safety of a homologous booster dose after different priming vaccination regimens is scarcely reported. : Responders (GMT≥16) at day 28, after priming with the two-dose vaccine, were followed up at 3, 6, and 10 months. Eligible participants received a homologous booster dose at month 10 and were followed-up 28 days post-booster. The GMT of...

The immune persistence of neutralizing antibodies elicited by BBIBP-CorV vaccines on day 0–14, 0–21 and 0–28 schedule, and the immunogenicity and safety of a homologous booster dose after different priming vaccination regimens is scarcely reported. : Responders (GMT≥16) at day 28, after priming with the two-dose vaccine, were followed up at 3, 6, and 10 months. Eligible participants received a homologous booster dose at month 10 and were followed-up 28 days post-booster. The GMT of...

Supplementary Material 1: Original clinical data of 204 cases.

This dataset is for the paper "Plant and soil biodiversity are essential for supporting highly multifunctional forests during Mediterranean rewilding" on Functional Ecology.

Additional file 6: Supplementary Table S6

Additional file 8: Table S7. PPI network parameters.