Panax notoginseng saponins (PNS) have been reported to have good anti-inflammatory effects. However, the anti-inflammatory effect mechanism in rheumatoid arthritis (RA) remains unknown. The focus of this research was to investigate the molecular mechanism of PNS in the treatment of RA. The primary active components of PNS were tested utilizing the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and Analysis Platform based on oral bioavailability and drug-likeness. The target databases for knee osteoarthritis were created...

Additional file 3: Table S2. The changes of metabolite levels upon methionine restriction in livers of HCC mouce models.

Additional file 11: Table S4. Taxa associated with TMA metabolism using the Mann-Whitney U-test.

Additional file 1: Supplementary Figures. The full-length blots of WB in Fig. 5B. Whole-cell extracts were resolved on 10% SDS-PAGE by bio-rad Mini-PROTEAN with 10 sample Wells (1Marker, 2space, 3Blank group, 4CSP I-plus group, 5Endostar group, 6rES-CSP group, 7rES-CSP+ heparin group, 8DDP group, 9space, 10Marker), and then electrotransferred onto a polyvinylidene difluoride (PVDF) membrane (Millipore). The membranes were then probed with respective primary antibodies against VEGFA, MMP2, integrinβ1, and E-cadherin procured from Abcam, β-actin from...

Additional file 4. Table S4. Network statistics of differential metabolites and related genes.

Additional file 4:

Additional file 2: Table S3. CRs genetic interactions related to drug response in cancers.

Additional file 10: Table S6. Expression of the identified AI-2 synthases and receptors in rumen metatranscriptome datasets.

Additional file 14: Table S7. The network among the rumen bacterial taxa and AI-2.

Additional file 3: Table S3. The rumen microbiota and the presence of quorum sensing molecules in the rumen ecosystems of species including cattle, sheep, moose, deer, and bison (as the control group).

Additional file 3: Table S3. The rumen microbiota and the presence of quorum sensing molecules in the rumen ecosystems of species including cattle, sheep, moose, deer, and bison (as the control group).

Additional file 3: Supplementary Table S7. List of the predict target genes of miR-130b-3p from prediction softwares TargetScan, RNA22, PicTar, miRDB and miRWalk.

Additional file 2: Table S2. Effects of 14 candidate SNPs on growth, carcass and meat quality traits.

Additional file 6: Table S4. List of lipids in intramuscular fat correlated with ELOVL3 expression in pectorals.

Additional file 2: Supplementary Table S2

Additional file 4: Supplementary Table S4

Additional file 5: Supplementary Table S5

Additional file 8: Table S6. All genomic SNPs in gene body and 2 kb promoter of ELOVL gene family used for PCA analysis.

Additional file 9: Table S7. Gene specific primers used for qRT-PCR.

The files here include the data of carbonate reservoir rocks in the Longmen Shan belt, South China. In detail, Table S1 is the data of isothermal remanent magnetization component uxmixing analysis (Table S1); Table S2 is the result of Total Organic Content (TOC) and natural remanent magnetism (NRM) values for hydrocarbon-bearing carbonate samples; Table S3 is the result of vitrinite reflectance in oil (Ro) value. Table S4 is the reuslt of Sr isotope values. There...

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar...

Additional file 3: Table S2. Differentially expressed genes for simple steatosis.

Additional file 4: Table S3. Differentially expressed genes for NASH.

Additional file 7. Detailed methods for the construction of risk signature with UrCCGs, discovery and validation of the subtypes by the UBE2T-related cell cycle genes, and investigation of different tumor-associated cellular and molecular states and immunotherapy sensitivity among the four UrCCG subtypes.

Additional file 3: Table S2. Differentially expressed genes for simple steatosis.