291 Works

Long non-coding RNA MCM3AP antisense RNA 1 silencing upregulates microRNA-24-3p to accelerate proliferation and migration of vascular endothelial cells in myocardial infarction rats by reducing EIF4G2

Ke Chen, Min Xi, Qihong Huang, Hao Wu, Guirong Lu, Shaohui Song & Wei Shi
Long non-coding RNAs (lncRNAs) are crucial drivers in the progression of human diseases such as myocardial infarction (MI). However, the impact of lncRNA MCM3AP antisense RNA 1 (MCM3AP-AS1) on MI remains unknown. This research was determined to explore the effect of MCM3AP-AS1 modulating microRNA-24-3p (miR-24-3p) and eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) on MI. The rat MI models were constructed and, respectively, treated with altered MCM3AP-AS1, miR-24-3p or/and EIF4G2. Subsequently, the cardiac function,...

Two QTL for kernel number per spike identified from durum wheat

Jingtian Yang, Zhengqiao Liao, Baoguo Du, Kuan Zhang & Lei Liu
As one of the three yield components, kernel number per spike (KNPS) plays a key role in determining wheat yield. In this study, in combination with the previously constructed genetic map for a tetraploid wheat recombinant inbred line (RIL) population developed from the cross between a durum wheat and a wild emmer wheat and phenotype data from four environments, two major and stably expressed quantitative trait loci (QTL) for KNPS were identified. The phenotypic variation...

Outcomes and risk factors of hemorrhagic cystitis in pediatric allogeneic hematopoietic stem cell transplantation recipients using different graft source and condition with severe aplastic anemia

Bohan Li, Lijun Meng, Yuanyuan Tian, Qin Lu, Li Gao, Peifang Xiao, Jun Lu, Jie Li, Lin Wan, Zhiheng Li, Shaoyan Hu & Lingjun Kong
Hemorrhagic cystitis (HC) is a severe complication of allo-HSCT, characterized by irritative symptoms of the urinary tract and a higher morbidity rate. The risk factors and prognosis of HC are still unclear. The objective of this study is to identify risk factors and outcomes to improve treatment in pediatric SAA patients undergoing HSCTs in the Children's Hospital of Soochow University. A total of 97 SAA patients as a cohort were enrolled from 2010 to 2019...

Cancer-associated fibroblast-released extracellular vesicles carrying miR-199a-5p induces the progression of​ gastric cancer through regulation of FKBP5-mediated AKT1/mTORC1 signaling pathway

Yan Wang, Tao Li, Lei Yang, Xunlei Zhang, Xiaoli Wang, Xiaoqin Su, Congfei Ji & Zhenxin Wang
Accumulating evidence has unfolded the significance of extracellular vesicles (EVs) in diseases and cancers. Here, we attempted to discuss the role of cancer-associated fibroblasts (CAFs)-derived EVs containing miR-199a-5p in gastric tumorigenesis. Upregulated miR-199a-5p was first identified in cancer cells. Then, we selected CAFs for isolation of EVs which were co-cultured with AGS cells. We observed successful delivery of miR-199a-5p via CAF-derived EVs. Besides, miR-199a-5p promoted malignant properties of AGS cells. Moreover, miR-199a-5p downregulated FKBP5, leading...

Additional file 3 of mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A

Liang Zhao, Huizhao Su, Xiaomeng Liu, Hongquan Wang, Yukuan Feng, Yan Wang, Haiqiang Chen, Luo Dai, Shihui Lai, Siqi Xu, Chong Li, Jihui Hao & Bo Tang
Additional file 3: Table S2. The changes of metabolite levels upon methionine restriction in livers of HCC mouce models.

Additional file 11 of FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu & Jiangxia Zheng
Additional file 11: Table S4. Taxa associated with TMA metabolism using the Mann-Whitney U-test.

Additional file 1 of CSP I-plus modified rEndostatin inhibits hepatocellular carcinoma metastasis via down-regulation of VEGFA and integrinβ1

Xueqin Chen, Yan Wang, Hancong Liu, Jingjing Zhang, Jie Wang, Xiaobao Jin & Yan Ma
Additional file 1: Supplementary Figures. The full-length blots of WB in Fig. 5B. Whole-cell extracts were resolved on 10% SDS-PAGE by bio-rad Mini-PROTEAN with 10 sample Wells (1Marker, 2space, 3Blank group, 4CSP I-plus group, 5Endostar group, 6rES-CSP group, 7rES-CSP+ heparin group, 8DDP group, 9space, 10Marker), and then electrotransferred onto a polyvinylidene difluoride (PVDF) membrane (Millipore). The membranes were then probed with respective primary antibodies against VEGFA, MMP2, integrinβ1, and E-cadherin procured from Abcam, β-actin from...

Additional file 4 of Transcriptome and Metabolome Analyses Reveals the Pathway and Metabolites of Grain Quality Under Phytochrome B in Rice (Oryza sativa L.)

Fei Li, Ye Liu, Xiaohua Zhang, Lingzhi Liu, Yun Yan, Xin Ji, Fanshu Kong, Yafan Zhao, Junzhou Li, Ting Peng, Hongzheng Sun, Yanxiu Du & Quanzhi Zhao
Additional file 4. Table S4. Network statistics of differential metabolites and related genes.

Additional file 4 of The effect of SNPs in lncRNA as ceRNA on the risk and prognosis of hepatocellular carcinoma

Han Mo, Xi Wang, Guohua Ji, Xiao Liang, Yi Yang, Wenjing Sun, Xueyuan Jia, Lidan Xu, Yuandong Qiao, Henan Zhou, Wenhui Zhao, Songbin Fu & Xuelong Zhang
Additional file 4:

Additional file 2 of A genetic map of the chromatin regulators to drug response in cancer cells

Bo Chen, Pengfei Li, Mingyue Liu, Kaidong Liu, Min Zou, Yiding Geng, Shuping Zhuang, Huanhuan Xu, Linzhu Wang, Tingting Chen, Yawei Li, Zhangxiang Zhao, Lishuang Qi & Yunyan Gu
Additional file 2: Table S3. CRs genetic interactions related to drug response in cancers.

Additional file 10 of Exploring AI-2-mediated interspecies communications within rumen microbial communities

Xiaozhen Liu, Qinmeng Liu, Sihuai Sun, Hengxi Sun, Yao Wang, Xihui Shen & Lei Zhang
Additional file 10: Table S6. Expression of the identified AI-2 synthases and receptors in rumen metatranscriptome datasets.

Additional file 14 of Exploring AI-2-mediated interspecies communications within rumen microbial communities

Xiaozhen Liu, Qinmeng Liu, Sihuai Sun, Hengxi Sun, Yao Wang, Xihui Shen & Lei Zhang
Additional file 14: Table S7. The network among the rumen bacterial taxa and AI-2.

Additional file 3 of Exploring AI-2-mediated interspecies communications within rumen microbial communities

Xiaozhen Liu, Qinmeng Liu, Sihuai Sun, Hengxi Sun, Yao Wang, Xihui Shen & Lei Zhang
Additional file 3: Table S3. The rumen microbiota and the presence of quorum sensing molecules in the rumen ecosystems of species including cattle, sheep, moose, deer, and bison (as the control group).

Additional file 3 of Exploring AI-2-mediated interspecies communications within rumen microbial communities

Xiaozhen Liu, Qinmeng Liu, Sihuai Sun, Hengxi Sun, Yao Wang, Xihui Shen & Lei Zhang
Additional file 3: Table S3. The rumen microbiota and the presence of quorum sensing molecules in the rumen ecosystems of species including cattle, sheep, moose, deer, and bison (as the control group).

Additional file 3 of STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu & Xiaojun Zha
Additional file 3: Supplementary Table S7. List of the predict target genes of miR-130b-3p from prediction softwares TargetScan, RNA22, PicTar, miRDB and miRWalk.

Additional file 2 of ELOVL gene family plays a virtual role in response to breeding selection and lipid deposition in different tissues in chicken (Gallus gallus)

Dandan Wang, Xinyan Li, Panpan Zhang, Yuzhu Cao, Ke Zhang, Panpan Qin, Yulong Guo, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Xiaojun Liu & Hong Li
Additional file 2: Table S2. Effects of 14 candidate SNPs on growth, carcass and meat quality traits.

Additional file 6 of ELOVL gene family plays a virtual role in response to breeding selection and lipid deposition in different tissues in chicken (Gallus gallus)

Dandan Wang, Xinyan Li, Panpan Zhang, Yuzhu Cao, Ke Zhang, Panpan Qin, Yulong Guo, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Xiaojun Liu & Hong Li
Additional file 6: Table S4. List of lipids in intramuscular fat correlated with ELOVL3 expression in pectorals.

Additional file 2 of Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma

Meng Li, Yujie Han, Chaochen Wang, Wenfeng Kang, Wenyan Jiang, Lei Zhang & Yujie Tang
Additional file 2: Supplementary Table S2

Additional file 4 of Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma

Meng Li, Yujie Han, Chaochen Wang, Wenfeng Kang, Wenyan Jiang, Lei Zhang & Yujie Tang
Additional file 4: Supplementary Table S4

Additional file 5 of Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma

Meng Li, Yujie Han, Chaochen Wang, Wenfeng Kang, Wenyan Jiang, Lei Zhang & Yujie Tang
Additional file 5: Supplementary Table S5

Additional file 8 of ELOVL gene family plays a virtual role in response to breeding selection and lipid deposition in different tissues in chicken (Gallus gallus)

Dandan Wang, Xinyan Li, Panpan Zhang, Yuzhu Cao, Ke Zhang, Panpan Qin, Yulong Guo, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Xiaojun Liu & Hong Li
Additional file 8: Table S6. All genomic SNPs in gene body and 2 kb promoter of ELOVL gene family used for PCA analysis.

Additional file 9 of ELOVL gene family plays a virtual role in response to breeding selection and lipid deposition in different tissues in chicken (Gallus gallus)

Dandan Wang, Xinyan Li, Panpan Zhang, Yuzhu Cao, Ke Zhang, Panpan Qin, Yulong Guo, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Xiaojun Liu & Hong Li
Additional file 9: Table S7. Gene specific primers used for qRT-PCR.

Additional file 3 of Correlation study on serum miR-222-3p and glucose and lipid metabolism in patients with polycystic ovary syndrome

Qin Wang, Chuanxiang Fang, Ying Zhao & Zhaoxia Liu
Additional file 3. Original data for Fig. 1 and Fig. 2.

Additional file 6 of Comparative analysis of the complete chloroplast genomes of six threatened subgenus Gynopodium (Magnolia) species

Huanhuan Xie, Lei Zhang, Cheng Zhang, Hong Chang, Zhenxiang Xi & Xiaoting Xu
Additional file 6: Table S3. List of SSRs in the CPGs of six subgenus Gynopodium species.

Additional file 7 of Comparative analysis of the complete chloroplast genomes of six threatened subgenus Gynopodium (Magnolia) species

Huanhuan Xie, Lei Zhang, Cheng Zhang, Hong Chang, Zhenxiang Xi & Xiaoting Xu
Additional file 7: Table S4. Accession numbers of the CPGs used in the phylogenetic analysis.

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  • Third Affiliated Hospital of Harbin Medical University
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