6 Works

Data from: The plover neurotranscriptome assembly: transcriptomic analysis in an ecological model species without a reference genome

Hooman K. Moghadam, Peter W. Harrison, Gergely Zachar, Tamás Székely & Judith E. Mank
We assembled a de novo transcriptome of short-read Illumina RNA-Seq data generated from telencephalon and diencephalon tissue samples from the Kentish plover, Charadrius alexandrinus. This is a species of considerable interest in behavioural ecology for its highly variable mating system and parental behaviour, but it lacks genomic resources and is evolutionarily distant from the few available avian draft genome sequences. We assembled and identified over 21 000 transcript contigs with significant expression in our samples,...

Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish

Elisa Thoral, Damien Roussel, Christos Chinopoulos, Loïc Teulier & Karine Salin
Aerobic metabolism of aquatic ectotherms is highly sensitive to fluctuating climates. Many mitochondrial traits exhibit phenotypic plasticity in response to acute variations in temperature and oxygen availability. These responses are critical for understanding the effects of environmental variations on aquatic ectotherms performance. Using the European seabass, Dicentrarchus labrax, we determined the effects of acute warming and deoxygenation in vitro on mitochondrial respiratory capacities and mitochondrial efficiency to produce ATP (ATP/O ratio). We show that acute...

Data from: Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome

Dorottya Kelen, Csilla Andorka, Miklós Szabó, Aleksander Alafuzoff, Kai Kaila & Milla Summanen
The objective of this study was to evaluate the early changes in serial serum levels of copeptin and neuron-specific enolase (NSE) in neonates diagnosed with birth asphyxia, and to determine whether these biomarkers measured in the first 168 hours after birth are predictive of long-term neurodevelopmental outcome. Copeptin and NSE levels were measured from serum samples collected 6, 12, 24, 48, 72, and 168 hours after birth from 75 term neonates diagnosed with hypoxic-ischemic encephalopathy...

Data from: The demanding grey zone: sport indices by cardiac magnetic resonance imaging differentiate hypertrophic cardiomyopathy from athlete's heart

Csilla Czimbalmos, Ibolya Csecs, Attila Toth, Orsolya Kiss, Ferenc I. Suhai, Nora Sydo, Zsofia Dohy, Astrid Apor, Bela Merkely & Hajnalka Vago
Background: We aimed to characterize gender specific left ventricular hypertrophy using a novel, accurate and less time demanding cardiac magnetic resonance (CMR) quantification method to differentiate physiological hypertrophy and hypertrophic cardiomyopathy based on a large population of highly trained athletes and hypertrophic cardiomyopathy patients. Methods and Results: Elite athletes (n=150,>18 training hours/week), HCM patients (n=194) and athletes with hypertrophic cardiomyopathy (n=10) were examined by CMR. CMR based sport indices such as maximal end-diastolic wall thickness...

Data from: Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence

Andrea Vereczkei, Zsolt Demetrovics, Anna Szekely, Peter Sarkozy, Peter Antal, Agnes Szilagyi, Maria Sasvari-Szekely & Csaba Barta
BACKGROUND: Heroin dependence is a debilitating psychiatric disorder with complex inheritance. Since the dopaminergic system has a key role in rewarding mechanism of the brain, which is directly or indirectly targeted by most drugs of abuse, we focus on the effects and interactions among dopaminergic gene variants. OBJECTIVE: To study the potential association between allelic variants of dopamine D2 receptor (DRD2), ANKK1 (ankyrin repeat and kinase domain containing 1), dopamine D4 receptor (DRD4), Catechol-O-methyl transferase...

Data from: Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost

Karine Salin, Eugenia M. Villasevil, Graeme J. Anderson, Sonya K. Auer, Colin Selman, Richard C. Hartley, William Mullen, Christos Chinopoulos & Neil B. Metcalfe
1. Many animals experience periods of food shortage in their natural environment. It has been hypothesised that the metabolic responses of animals to naturally-occurring periods of food deprivation may have long-term negative impacts on their subsequent life-history. 2. In particular, reductions in energy requirements in response to fasting may help preserve limited resources but potentially come at a cost of increased oxidative stress. However, little is known about this trade-off since studies of energy metabolism...

Registration Year

  • 2020
  • 2018
  • 2017
  • 2013

Resource Types

  • Dataset


  • Semmelweis University
  • University of Bath
  • University of Glasgow
  • University of Western Brittany
  • Eötvös Loránd University
  • Claude Bernard University Lyon 1
  • University College London
  • University of Helsinki