Additional file 2.

Additional file 2: Appendix 2. Hazard ratios and their 95% confidence limits of Ki67, PR, ER, and age. Figure 1. Hazard ratios and their 95% confidence limits for a series of binary variables of Ki67. Figure 2. Hazard ratios and their 95% confidence limits for a series of binary variables of ER. Figure 3. Hazard ratios and their 95% confidence limits for a series of binary variables of PR. Figure 4. Hazard ratios and their...

Additional file 5: Table S4. Non-HhaI amplicons used for cell selection.

Additional file 23: Table S1. Clinicopathologic Information and Multi-omics Data in PDAC Cohort. Table S1A Multi-omics information of PDAC cohort. Table S1B Clinicopathologic information of the 229 PDAC.

Additional file 7: Table S6. Analysis of cooperative miRNA effects by high-resolution mass spectrometry-based proteomics.

Additional file 4: Supplemental Table 1. Cloning primers for cloning of target gene 3’UTRs

Additional file 6: Supplemental Table 3: GeneTrail3 pathway analysis of predicted miR-34a-5p target genes in KEGG pathways

Data underlying the article: "Ultrahigh Dynamic Range and Low Noise Figure Programmable Integrated Microwave Photonic Filter". The data set consists of several different measurement results for the modulation transformer, double injection ring resonator, and microwave photonic filter responses as published in the resource article. All data is stored in files using the CSV-format. The set is structered to give the data per figure (subfigure), where each subfigure has a folder containing a README-file describing the...

Data underlying the article: "Ultrahigh Dynamic Range and Low Noise Figure Programmable Integrated Microwave Photonic Filter". The data set consists of several different measurement results for the modulation transformer, double injection ring resonator, and microwave photonic filter responses as published in the resource article. All data is stored in files using the CSV-format. The set is structured to give the data per figure (subfigure), where each subfigure has a folder containing a README-file describing the...

New SARS-CoV-2 mutants have been continuously indentified with enhanced transmission ever since its outbreak in early 2020. As an RNA virus, SARS-CoV-2 has a high mutation rate due to the low fidelity of RNA polymerase. To study the single nucleotide polymorphisms (SNPs) dynamics of SARS-CoV-2, 158 SNPs with high confidence were identified by deep meta-transcriptomic sequencing, and the most common SNP type was C > T. Analyses of intra-host population diversity revealed that intra-host quasispecies’...

Additional file 25: Table S3. Integrated Multi-omics Features in Tumor Tissues Compared with NATs of the PDAC. Table S3A Matrix of 7,055 protein groups and their relative intensities in at least 1/6 of the samples (226 tumors and 220 NATs). Table S3B 19,992 mRNA and their ratio of tumors/NATs (54 tumors and 51 NATs). Table S3C A list of protein identified both in protein and mRNA level. Table S3D A list of phosphosites used for...

Additional file 25: Table S3. Integrated Multi-omics Features in Tumor Tissues Compared with NATs of the PDAC. Table S3A Matrix of 7,055 protein groups and their relative intensities in at least 1/6 of the samples (226 tumors and 220 NATs). Table S3B 19,992 mRNA and their ratio of tumors/NATs (54 tumors and 51 NATs). Table S3C A list of protein identified both in protein and mRNA level. Table S3D A list of phosphosites used for...

Additional file 28: Table S6. Proteomic Subtypes of PDAC Patients. Table S6A Proteomic subtypes, transcriptomic subtypes and phosphoproteomic subtypes of PDAC patients. Table S6B A list of differentially expressed proteins among three subtypes. Table S6C Pathway alterations in the proteomic subtypes of the PDAC cohort. Table S6D Matrix of protein expression and kinase activity of kinase activated in S-III. Table S6E Matrix of differential pathway enrichment between patients located in H-PDAC and BT-PDAC. Table S6F...

Tigecycline is one of the last-resort antibiotics to treat severe infections. Recently, tigecycline resistance has sporadically emerged with an increasing trend, and Tet(X) family represents a new resistance mechanism of tigecycline. In this study, a novel chromosome-encoded tigecycline resistance gene, tet(X14), was identified in a tigecycline-resistant and colistin-resistant Empedobacter stercoris strain ES183 recovered from a pig fecal sample in China. Tet(X14) shows 67.14-96.39% sequence identity to the other variants [Tet(X) to Tet(X13)]. Overexpression of Tet(X14)...

A new type of polyhedral oligomeric silsesquioxanes bisDOPO-NH2-POSS flame retardant consisting of one polyhedral oligomeric silsesquioxane (POSS), two units of 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) and reactive –NH2 groups, was synthesized and characterized by FTIR, 1H NMR, and 31P NMR. It was applied to modified conventional environmentally friendly E0 grade urea formaldehyde (UF) resin to prepare flame-retardant plywood. Two other POSS structure flame retardants were used for comparison. The results showed that the addition of bisDOPO-NH2-POSS flame retardant...

High concentrations of antioxidants can exert pro-oxidative effects, elevate the level of intracellular reactive oxygen species (ROS), and cause oxidative stress in cells. We previously found that high concentrations of curcumin, a natural polyphenol antioxidant, elevated ROS levels and upregulated the expression of histone deacetylase 1 (HDAC1) in human gastric cancer cells (hGCCs); however, its potential mechanisms and subsequent functions have not been elucidated. In the present study, we treated hGCCs with high concentrations of...

High concentrations of antioxidants can exert pro-oxidative effects, elevate the level of intracellular reactive oxygen species (ROS), and cause oxidative stress in cells. We previously found that high concentrations of curcumin, a natural polyphenol antioxidant, elevated ROS levels and upregulated the expression of histone deacetylase 1 (HDAC1) in human gastric cancer cells (hGCCs); however, its potential mechanisms and subsequent functions have not been elucidated. In the present study, we treated hGCCs with high concentrations of...

Additional file 2: Table S1. Design overview of the panel of targeted regions.

Additional file 4: Table S3. Complete list of CpG methylation-sensitive endonucleases potentially compatible with scTAM-seq.

Additional file 7: Table S6. Doublet detection details per sample and condition.

Additional file 2: Dataset S1. The 130 unique cox1 haplotypes of Oncomelania hupensis from this study including two outgroups

Additional file 1.

Additional file 2.

Additional file 4: Supplemental Table 1. Cloning primers for cloning of target gene 3’UTRs

Additional file 5: Supplemental Table 2. Mutagenesis primers for mutation of miR-34a-5p target sites.