7 Works

Data from: Health trajectories reveal the dynamic contributions of host genetic resistance and tolerance to infection outcome

Graham Lough, Ilias Kyriazakis, Andreas Lengeling, Silke Bergmann & Andrea B. Doeschl-Wilson
Resistance and tolerance are two alternative strategies hosts can adopt to survive infections. Both strategies may be genetically controlled. To date, the relative contribution of resistance and tolerance to infection outcome is poorly understood. A bioluminescent Listeria monocytogenes (Lm) infection challenge model on four genetically diverse mouse strains was used to study the genetic determination and dynamic contributions of host resistance and tolerance to listeriosis, a serious food-borne infectious disease in humans. Conventional statistical analyses...

Data from: Control of parental investment changes plastically over time with residual reproductive value

Mamoru Takata, Hayato Doi, Cathleen E. Thomas & Satoshi Koyama
Evolutionary conflict between parents and offspring over parental resource investment is a significant selective force on the traits of both parents and offspring. Empirical studies have shown that for some species, the amount of parental investment is controlled by the parents, whereas in other species, it is controlled by the offspring. The main difference between these two strategies is the residual reproductive value of the parents or opportunities for future reproduction. Therefore, this could explain...

Data from: The importance of being genomic: non-coding and coding sequences suggest different models of toxin multi-gene family evolution

Anita Malhotra, Simon Creer, John B. Harris & Roger S. Thorpe
Studies of multi-gene protein families, including many toxins, are crucial for understanding the role of gene duplication in generating protein diversity in general. However, many evolutionary analyses of gene families are based on coding sequences, and do not take into account many potentially confounding evolutionary factors, such as recombination and convergence due to selection. We illustrate this using snake venom gene sequences from the Phospholipase A2 (PLA2) subfamily. Novel gene sequences from 20 species of...

Data from: The relative efficiency of modular and non-modular networks of different size

Colin R. Tosh & Luke McNally
Most biological networks are modular but previous work with small model networks has indicated that modularity does not necessarily lead to increased functional efficiency. Most biological networks are large, however, and here we examine the relative functional efficiency of modular and non-modular neural networks at a range of sizes. We conduct a detailed analysis of efficiency in networks of two size classes: ‘small’ and ‘large’, and a less detailed analysis across a range of network...

Data from: Reef flattening effects on total richness and species responses in the Caribbean

Steven P. Newman, Erik H. Meesters, Charlie S. Dryden, Stacey M. Williams, Cristina Sanchez, Peter J. Mumby, Nicholas V.C. Polunin & Nicholas V. C. Polunin
1. There has been ongoing flattening of Caribbean coral reefs with the loss of habitat having severe implications for these systems. Complexity and its structural components are important to fish species richness and community composition, but little is known about its role for other taxa or species-specific responses. 2. This study reveals the importance of reef habitat complexity and structural components to different taxa of macrofauna, total species richness, and individual coral and fish species...

Data from: A dynamic framework for the study of optimal birth intervals reveals the importance of sibling competition and mortality risks

Matthew G. Thomas, Daryl P. Shanley, Alasdair I. Houston, John M. McNamara, Ruth Mace & Tom B. L. Kirkwood
Human reproductive patterns have been well studied, but the mechanisms by which physiology, ecology and existing kin interact to affect the life history need quantification. Here, we create a model to investigate how age-specific interbirth intervals adapt to environmental and intrinsic mortality, and how birth patterns can be shaped by competition and help between siblings. The model provides a flexible framework for studying the processes underlying human reproductive scheduling. We developed a state-based optimality model...

Hydrological modelling and simulation data for the River Trent at Colwick under climate change

E.A. Byers, A. Leathard, G.M. O'Donnell, J.W. Hall & J.M. Amezaga
This data contains the time series flow discharge results of hydrological simulation of the River Trent at Colwick using UKCP09 Weather Generator inputs for a variety of time slices and emissions scenarios. The Weather Generator (WG) inputs were run on a hydrological model (Leathard et al., unpublished), calibrated using the observed record 1961-2002. Each simulation is derived from 100 30-year time series of weather at the WG location 4400355 for Control, Low, Medium and High...

Registration Year

  • 2015

Resource Types

  • Dataset


  • Newcastle University
  • Bangor University
  • Tokyo University of Agriculture and Technology
  • University of Queensland
  • Roslin Institute
  • University of Edinburgh
  • University College London
  • University of Costa Rica
  • University of Veterinary Medicine
  • University of Exeter