14 Works

Alzheimer’s disease: Ablating single master site abolishes tau hyperphosphorylation

Kristie Stefanoska, Arne Ittner, Mehul Gajwani, Amanda RP Tan, Holly Ahel, Prita Asih, Alexander Volkerling & Anne Poljak
Hyperphosphorylation of the neuronal tau protein is a hallmark of neurodegenerative tauopathies such as Alzheimer’s disease. A central unanswered question is why tau becomes progressively hyperphosphorylated. Here, we show that tau phosphorylation is governed by interdependence— a mechanistic link between initial site-specific and subsequent multi-site phosphorylation. Systematic assessment of site interdependence identified distinct residues (threonine-50, threonine-69, and threonine-181) as master sites that determine propagation of phosphorylation at multiple epitopes. CRISPR point mutation and expression of...

Data from: Temporal dissonance between group size and its benefits requires whole-of-lifecycle measurements

Lucas Hearn
The benefits of living in groups drive the evolution of sociality, and these benefits could vary across a life-cycle. However, there may be experimental problems in linking group size at one time in a life-cycle to benefits that only become apparent later on when group size has changed, leading to what we call ‘temporal dissonance’. In the only known social colletid bee, Amphylaeus morosus, parasite pressures arise at various times throughout the life-cycle from different...

Data from: Cranial anatomy of the mekosuchine crocodylian Trilophosuchus rackhami Willis, 1993

Jorgo Ristevski, Vera Weisbecker, John D. Scanlon, Gilbert J. Price & Steven W. Salisbury
One of the best-preserved crocodylian fossil specimens from the Cenozoic of Australia is the holotype of the mekosuchine Trilophosuchus rackhami, from the middle Miocene (13.56 ± 0.67 Ma) Ringtail Site at Riversleigh, northwestern Queensland. Although lacking most of the snout, the holotype skull of T. rackhami (QMF16856) has an exceptionally well-preserved cranium. Micro-CT scanning of the holotype has allowed for all the preserved cranial bones to be digitally disarticulated, facilitating an unprecedented insight into the...

Expression of Long Non-Coding RNAs in Activated Human Retinal Vascular Endothelial Cells

Lisia Barros Ferreira, Liam M. Ashander, Binoy Appukuttan, Yuefang Ma, Keryn A. Williams & Justine R. Smith
Retinal endothelial cell activation is a central event in non-infectious posterior uveitis. There is recent interest in long non-coding (lnc)RNA-targeted therapeutics for retinal diseases. We aimed to identify human retinal endothelial cell lncRNAs that might be involved in activation. Eleven candidate lncRNAs were identified: GAS5, KCNQ1OT1, LINC00294, MALAT1, MEG3, MIR155HG, NEAT1, NORAD, OIP5-AS1, SENCR, TUG1. Expression was assessed by RT-PCR in human retinal endothelial cells, at baseline and following activation with interleukin (IL)-1β and tumor...

Proximity labeling of tau interactions in primary neurons and mouse brain

Arne Ittner
Microtubule-associated protein tau is a central factor in Alzheimer’s disease and other tauopathies. However, physiological functions of tau are unclear. Here, we used proximity labelling proteomics to chart functional tau interactomes in primary neurons and mouse brain in vivo. Here, we use proximity labelling with the biotin ligase BioID2 to map interactomes of tau in neurons. Data sets relate to mass spectrometry and protein identification of biotinylated proteins in primary neurons and in mouse brain...

Isotopic niche overlap between sympatric Australian snubfin and humpback dolphins

Guido J. Parra, Zachary Wojtkowiak, Katharina J. Peters & Daniele Cagnazzi
Ecological niche theory predicts the coexistence of closely related species is promoted by resource partitioning and leads to the use of different ecological niches. Australian snubfin (Orcaella heinsohni) and humpback (Sousa sahulensis) dolphins live in sympatry throughout most of their range in northern Australia. We compared stable isotope ratios of carbon (δ13C) and nitrogen (δ15N) in their skin to investigate resource partitioning between these ecologically similar species. Skin samples were collected from live Australian snubfin...

Expression of Long Non-Coding RNAs in Activated Human Retinal Vascular Endothelial Cells

Lisia Barros Ferreira, Liam M. Ashander, Binoy Appukuttan, Yuefang Ma, Keryn A. Williams & Justine R. Smith
Retinal endothelial cell activation is a central event in non-infectious posterior uveitis. There is recent interest in long non-coding (lnc)RNA-targeted therapeutics for retinal diseases. We aimed to identify human retinal endothelial cell lncRNAs that might be involved in activation. Eleven candidate lncRNAs were identified: GAS5, KCNQ1OT1, LINC00294, MALAT1, MEG3, MIR155HG, NEAT1, NORAD, OIP5-AS1, SENCR, TUG1. Expression was assessed by RT-PCR in human retinal endothelial cells, at baseline and following activation with interleukin (IL)-1β and tumor...

Variation in intraspecific demography drives localised concordance but species-wide discordance in responses to Plio-Pleistocene climatic change

Sean Buckley, Chris Brauer, Peter Unmack, Michael Hammer & Luciano Beheregaray
Understanding how species biology may facilitate resilience to climate change remains a critical factor in detecting and protecting species at risk of extinction. Many studies have focused on the role of particular ecological traits in driving species responses, but less so on demographic history and levels of standing genetic variation. We used environmental and genomic datasets to reconstruct the phylogeographic histories of two ecologically similar and largely co-distributed freshwater fishes to assess the degree of...

Intrinsic traits, social context, local environment, and home range size and fidelity data from a field study of sleepy lizards, 2009 - 2017

Eric Payne, Orr Spiegel, David Sinn, Stephan Leu, Michael Gardner, Stephanie Godfrey, Caroline Wohlfeil & Andrew Sih
Home ranges, the region within which animals interact with their environment, constitute a fundamental aspect of their ecology. Home range (HR) sizes and locations commonly reflect costs and benefits associated with diverse social, biotic and abiotic factors. Less is known, however, about how these factors affect intra-specific variation in HR size or fidelity (the individual’s tendency to maintain the same HR location over time), or if variation in these features emerge from consistent differences among...

Extreme reproductive skew at the dawn of sociality is consistent with inclusive fitness theory but problematic for routes to eusociality

Lucas Hearn
To understand the earliest stages of social evolution we need to identify species that are undergoing the initial steps into sociality. Amphylaeus morosus is the only unambiguously known social species in the bee family Colletidae and represents an independent origin of sociality within the Apoidea. This allows us to investigate the selective factors promoting the transition from solitary to social nesting. Using genome-wide SNP genotyping, we infer robust pedigree relationships to identify maternity of brood...

Extensive polyploid clonality was a successful strategy for seagrass to expand into a newly submerged environment

Jane Edgeloe, Anita Severn-Ellis, Philipp Bayer, Shaghayegh Mehravi, Martin Breed, Siegfried Krauss, Jacqueline Batley, Gary Kendrick & Elizabeth Sinclair
Polyploidy has the potential to allow organisms to outcompete their diploid progenitor(s) and occupy new environments. Shark Bay, Western Australia, is a World Heritage Area dominated by temperate seagrass meadows including Poseidon’s ribbon weed, Posidonia australis. This seagrass is at the northern extent of its natural geographic range and experiences extreme temperatures and salinities. Our genomic and cytogenetic assessments of ten meadows identified geographically restricted, diploid clones (2n = 20) in a single location, and...

The impact of molecular data on the phylogenetic position of the putative oldest crown crocodilian and the age of the clade

Gusatvo Darlim, Michael Lee, Jules Walter & Márton Rabi
The use of molecular data for living groups is vital for interpreting fossils, especially when morphology-only analyses retrieve problematic phylogenies for living forms. These topological discrepancies impact on the inferred phylogenetic position of many fossil taxa. In Crocodylia, morphology-based phylogenetic inferences differ fundamentally in placing Gavialis basal to all other living forms, whereas molecular data consistently unite it with crocodylids. The Cenomanian Portugalosuchus azenhae was recently described as the oldest crown crocodilian, with affinities to...

Data from: Neuropeptide signalling shapes feeding and reproductive behaviours in male C. elegans

Matthew Gadenne, Iris Hardege, Eviatar Yemini, Djordji Suleski, Paris Jaggers, Isabel Beets, William Schafer & Yee Lian Chew
Sexual dimorphism occurs where different sexes of the same species display differences in characteristics not limited to reproduction. For the nematode Caenorhabditis elegans, in which the complete neuroanatomy has been solved for both hermaphrodites and males, sexually dimorphic features have been observed both in terms of the number of neurons and in synaptic connectivity. In addition, male behaviours, such as food-leaving to prioritise searching for mates, have been attributed to neuropeptides released from sex-shared or...

Morphometric analysis of lungfish endocasts elucidates early dipnoan palaeoneurological evolution

Alice Clement, Tom Challands, Richard Cloutier, Laurent Houle, Per Ahlberg, Shaun Collin & John Long
Lungfish (Dipnoi) are lobe-finned fish (Sarcopterygii) that have persisted for over 400 million years from the Devonian Period to present day. They are the extant sister group to tetrapods and thus have the ability to provide unique insight into the condition of the earliest tetrapods as well as their own evolutionary history. The evolution of their dermal skull and dentition is relatively well understood, but this is not the case for the central nervous system....

Registration Year

  • 2022
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  • Flinders University
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  • University of Wollongong
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  • University of Queensland
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  • MRC Laboratory of Molecular Biology
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