14 Works

Prognostic and immunological significance of metastasis associated lung adenocarcinoma transcript 1 among different kinds of cancers

Lili Guo, Xiuwen Zhang, Hongli Pan, Yang Li, Jing Wang, Lin Li, Yafang Dong, Xinxin Du, Jun Chen & Fengjie Guo
LncRNAs belong to the type of noncoding RNA transcripts, which exceed 200 nucleotides in size. MALAT1 as one of the earlier identified lncRNAs in cancer is investigated by more and more scientific researchers. Expression, clinical significance and function of MALAT1 in pan-cancer exist as big difference. To detect the expression and clinical significance of MALAT1 gene precisely and comprehensively among different kinds of cancers, some classical databases such as GEPIA, TIMER, KM Plotter, and PrognoScan...

A dormant amoeba species can selectively sense and predate on different soil bacteria

Longfei Shu, Zhenzhen He, Xiaotong Guan, Xueqin Yang, Yuehui Tian, Siyi Zhang, Chenyuan Wu, Zhili He, Qingyun Yan, Cheng Wang & Yijing Shi
1. Soil protists are the invisible majority of soil eukaryotes, which are essential but often forgotten parts of the soil ecosystem. They play key roles in microbial food webs by predating on other soil microbes. However, it is not clear how dormant soil protists sense, recognize and feed on diverse microbial preys. 2. In this study, we used a soil amoeba, Dictyostelium discoideum, to study selective discrimination and predation of 14 different bacteria. We found...

Attenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model

Xinrong Zhou, Xinna Ge, Yongning Zhang, Jun Han, Xin Guo, Yanhong Chen, Lei Zhou & Hanchun Yang
Porcine deltacoronavirus (PDCoV) is a potentially emerging zoonotic pathogen that causes severe diarrhea in young pigs, with a risk of fatal dehydration. Its pathogenicity on neonatal piglet has been previously reported, however, it is less known if the coinfection with immunosuppressive pathogens can influence PDCoV disease manifestation. Here, a coinfection model of PDCoV and porcine reproductive and respiratory syndrome virus (PRRSV), a global-spread immunosuppressive virus, was set to study their interaction. Weaning pigs in the...

Comparative analysis of circRNA expression profile and circRNA-miRNA-mRNA regulatory network between palmitic and stearic acid-induced lipotoxicity to pancreatic β cells

Yunjin Zhang, Qingrui Zhao, Shenghan Su, Lingfeng Dan, Xuebei Li, Yu Wang, Yuqing Lin, Zhen Tian, Changhao Sun & Huimin Lu
Chronic exposure to high concentrations of circulating palmitic acid and stearic acid leads to impaired β cell function, which accelerates the development of type 2 diabetes. However, differences in the mechanisms underlying this process between these two saturated fatty acids remain largely unknown. In this study, we screened for potential circular RNAs (circRNAs) and their associated regulatory pathways in palmitic acid- and stearic acid-induced mouse β-TC6 cell dysfunction. CircRNA high-throughput sequencing, gene ontology enrichment and...

Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist

Dayana Salas-Leiva, Eelco Tromer, Bruce Curtis, Jon Jerlström-Hultqvist, Martin Kolisko, Zhenzhen Yi, Joan Salas-Leiva, Lucie Gallot-Lavallée, Shelby Williams, Geert Kops, John Archibald, Alastair Simpson & Andrew Roger
Cells replicate and segregate their DNA with precision. Previous studies showed that these regulated cell-cycle processes were present in the last eukaryotic common ancestor and that their core molecular parts are conserved across eukaryotes. However, some metamonad parasites have secondarily lost components of the DNA processing and segregation apparatuses. To clarify the evolutionary history of these systems in these unusual eukaryotes, we generated a genome assembly for the free-living metamonad Carpediemonas membranifera and carried out...

Attenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model

Xinrong Zhou, Xinna Ge, Yongning Zhang, Jun Han, Xin Guo, Yanhong Chen, Lei Zhou & Hanchun Yang
Porcine deltacoronavirus (PDCoV) is a potentially emerging zoonotic pathogen that causes severe diarrhea in young pigs, with a risk of fatal dehydration. Its pathogenicity on neonatal piglet has been previously reported, however, it is less known if the coinfection with immunosuppressive pathogens can influence PDCoV disease manifestation. Here, a coinfection model of PDCoV and porcine reproductive and respiratory syndrome virus (PRRSV), a global-spread immunosuppressive virus, was set to study their interaction. Weaning pigs in the...

Grylloblattidan insects from Sperbersbach and Cabarz (Germany), two new early Permian and insect-rich localities

Yingying Cui, Stephan Brauner, Joerg W. Schneider & Olivier Béthoux
New fossil insect specimens from two new localities in Germany, namely Sperbersbach and Cabarz (Goldlauter Formation; early Permian), belonging to the Grylloblattida, are described. Abundant material is assigned to Pictoborella clara n. gen. n. sp., regarded as closely related to Pictoborella germanica (Prokop et al., 2012) n. comb., from the Saar-Nahe Basin (Germany; early Permian). Liomopterum fuscatum n. sp., represented by fewer specimens, is delimited based on previously published and new data on various Liomopterum...

Functional traits explain the consistent resistance of biodiversity to plant invasion under nitrogen enrichment

Shao-Peng Li, Jia Pu, Shu-Ya Fan, Yingtong Wu, Xiang Liu, Yani Meng, Yue Li, Wen-Sheng Shu, Jin-Tian Li & Lin Jiang
Elton’s biotic resistance hypothesis, which posits that diverse communities should be more resistant to biological invasions, has received considerable experimental support. However, it remains unclear whether such a negative diversity–invasibility relationship would persist under anthropogenic environmental change. By using the common ragweed (Ambrosia artemisiifolia) as a model invader, our four-year grassland experiment demonstrated consistently negative relationships between resident species diversity and community invasibility, irrespective of nitrogen addition, a result further supported by a meta-analysis. Importantly,...

Hypophosphatemia is an independent risk factor for AKI among hospitalized patients with COVID-19 infection

Zijin Chen, Chenni Gao, Haijin Yu, Lin Lu, Jialin Liu, Wei Chen, Xiaogang Xiang, Hafiz Muhammad Jafar Hussain, Benjamin J. Lee, Chuanlei Li, Wenjie Wei, Yuhan Huang, Xiang Li, Zhengying Fang, Shuwen Yu, Qinjie Weng, Yan Ouyang, Xiaofan Hu, Jun Tong, Jian Liu, Li Lin, Mingyu Liu, Xiaoman Xu, Dan Liu, Yuan Song … & Jingyuan Xie
This study sought to investigate incidence and risk factors for acute kidney injury (AKI) in hospitalized COVID-19. In this retrospective study, we enrolled 823 COVID-19 patients with at least two evaluations of renal function during hospitalization from four hospitals in Wuhan, China between February 2020 and April 2020. Clinical and laboratory parameters at the time of admission and follow-up data were recorded. Systemic renal tubular dysfunction was evaluated via 24-h urine collections in a subgroup...

Hypophosphatemia is an independent risk factor for AKI among hospitalized patients with COVID-19 infection

Zijin Chen, Chenni Gao, Haijin Yu, Lin Lu, Jialin Liu, Wei Chen, Xiaogang Xiang, Hafiz Muhammad Jafar Hussain, Benjamin J. Lee, Chuanlei Li, Wenjie Wei, Yuhan Huang, Xiang Li, Zhengying Fang, Shuwen Yu, Qinjie Weng, Yan Ouyang, Xiaofan Hu, Jun Tong, Jian Liu, Li Lin, Mingyu Liu, Xiaoman Xu, Dan Liu, Yuan Song … & Jingyuan Xie
This study sought to investigate incidence and risk factors for acute kidney injury (AKI) in hospitalized COVID-19. In this retrospective study, we enrolled 823 COVID-19 patients with at least two evaluations of renal function during hospitalization from four hospitals in Wuhan, China between February 2020 and April 2020. Clinical and laboratory parameters at the time of admission and follow-up data were recorded. Systemic renal tubular dysfunction was evaluated via 24-h urine collections in a subgroup...

Comparative analysis of circRNA expression profile and circRNA-miRNA-mRNA regulatory network between palmitic and stearic acid-induced lipotoxicity to pancreatic β cells

Yunjin Zhang, Qingrui Zhao, Shenghan Su, Lingfeng Dan, Xuebei Li, Yu Wang, Yuqing Lin, Zhen Tian, Changhao Sun & Huimin Lu
Chronic exposure to high concentrations of circulating palmitic acid and stearic acid leads to impaired β cell function, which accelerates the development of type 2 diabetes. However, differences in the mechanisms underlying this process between these two saturated fatty acids remain largely unknown. In this study, we screened for potential circular RNAs (circRNAs) and their associated regulatory pathways in palmitic acid- and stearic acid-induced mouse β-TC6 cell dysfunction. CircRNA high-throughput sequencing, gene ontology enrichment and...

Comparative analysis of circRNA expression profile and circRNA-miRNA-mRNA regulatory network between palmitic and stearic acid-induced lipotoxicity to pancreatic β cells

Yunjin Zhang, Qingrui Zhao, Shenghan Su, Lingfeng Dan, Xuebei Li, Yu Wang, Yuqing Lin, Zhen Tian, Changhao Sun & Huimin Lu
Chronic exposure to high concentrations of circulating palmitic acid and stearic acid leads to impaired β cell function, which accelerates the development of type 2 diabetes. However, differences in the mechanisms underlying this process between these two saturated fatty acids remain largely unknown. In this study, we screened for potential circular RNAs (circRNAs) and their associated regulatory pathways in palmitic acid- and stearic acid-induced mouse β-TC6 cell dysfunction. CircRNA high-throughput sequencing, gene ontology enrichment and...

Data from: Geological and climatic histories likely shaped the origins of terrestrial vertebrates endemic to the Tibetan Plateau

Jiekun He, Siliang Lin, Chenchen Ding, Jiehua Yu & Haisheng Jiang
Aim The Tibetan Plateau (TP) hosts many endemic species, but questions regarding when and from where these species originated have not been comprehensively answered. Here, we provide a synthesis of the biogeographical history of terrestrial vertebrates endemic to the TP and investigate the potential drivers of their spatio-temporal origins. Location Tibetan Plateau and its surrounding regions Time period Cenozoic Major taxa studied Terrestrial vertebrates Methods We used dispersal–extinction–cladogenesis models based on time-calibrated phylogenies to reconstruct...

Prognostic and immunological significance of metastasis associated lung adenocarcinoma transcript 1 among different kinds of cancers

Lili Guo, Xiuwen Zhang, Hongli Pan, Yang Li, Jing Wang, Lin Li, Yafang Dong, Xinxin Du, Jun Chen & Fengjie Guo
LncRNAs belong to the type of noncoding RNA transcripts, which exceed 200 nucleotides in size. MALAT1 as one of the earlier identified lncRNAs in cancer is investigated by more and more scientific researchers. Expression, clinical significance and function of MALAT1 in pan-cancer exist as big difference. To detect the expression and clinical significance of MALAT1 gene precisely and comprehensively among different kinds of cancers, some classical databases such as GEPIA, TIMER, KM Plotter, and PrognoScan...

Registration Year

  • 2021
    14

Resource Types

  • Dataset
    14

Affiliations

  • South China Normal University
    14
  • West China Hospital of Sichuan University
    7
  • Zhejiang University
    7
  • Fudan University Shanghai Cancer Center
    7
  • Fudan University
    7
  • Jilin University
    6
  • Hainan Medical University
    5
  • Sun Yat-sen University
    5
  • Wenzhou Medical University
    5
  • Central South University
    4