3 Works

Data from: Describing complex structure-function relationships in biomolecules at equilibrium

Homme W. Hellinga & Malin J. Allert
One of the great ambitions of structural biology is to describe structure-function relationships quantitatively. Statistical thermodynamics is a powerful, general tool for computing the behavior of biological macromolecules at equilibrium, because it establishes a direct link between structure and function. Complex behavior emerges as equilibria of multiple reactions are coupled. Analytical treatment of linked equilibria scales poorly with increasing numbers of reactions and states as the algebraic constructs rapidly become unwieldy. We therefore developed a...

Phenotypic divergence among threespine stickleback that differ in nuptial coloration

Clara Jenck, Whitley Lehto, Brian Ketterman, Lukas Sloan, Aaron Sexton & Robin Tinghitella
By studying systems in their earliest stages of differentiation, we can learn about the evolutionary forces acting within and among populations and how those forces could contribute to reproductive isolation. Such an understanding would help us better discern and predict how selection leads to the maintenance of multiple morphs within a species, rather than speciation. The postglacial adaptive radiation of the threespine stickleback (Gasterosteus aculeatus) is one of the best-studied cases of evolutionary diversification and...

Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states

Kevin Bolding
Pattern completion, or the ability to retrieve stable neural activity patterns from noisy or partial cues, is a fundamental feature of memory. Theoretical studies indicate that recurrently connected auto-associative or discrete attractor networks can perform this process. Although pattern completion and attractor dynamics have been observed in various recurrent neural circuits, the role recurrent circuitry plays in implementing these processes remains unclear. In recordings from head-fixed mice, we found that odor responses in olfactory bulb...

Registration Year

  • 2020

Resource Types

  • Dataset


  • Duke University School of Medicine
  • University of Louisville
  • University of Denver
  • Michigan State University