20 Works

RETRACTED ARTICLE: Long noncoding RNA MAGI1-IT1 promoted invasion and metastasis of epithelial ovarian cancer via the miR-200a/ZEB axis

Hao Gao, Xiaofeng Li, Guangxi Zhan, Yong Zhu, Jing Yu, Jiapo Wang, Li Li, Weimin Wu, Na Liu & Xiaoqing Guo
We, the Editors and Publisher of the journal Cell Cycle, have retracted the following article: Hao Gao, Xiaofeng Li, Guangxi Zhan, Yong Zhu, Jing Yu, Jiapo Wang, Li Li, Weimin Wu, Na Liu and Xiaoqing Guo. Long noncoding RNA MAGI1-IT1 promoted invasion and metastasis of epithelial ovarian cancer via the miR-200a/ZEB axis. Cell Cycle. 2019;18(12):1393-1406. doi: 10.1080/15384101.2019.1618121 Since publication, concerns have been raised about the integrity of the data in the article. When approached for...

MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF

Hu Zhao, Xiaofeng Lai, Wei Zhang, Hehuan Zhu, Shenhang Zhang, Weizhen Wu, Shuiliang Wang, Minying Tang, Zhen Deng & Jianming Tan
MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel...

Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling

Dan Zhao, Cong Shen, Tingting Gao, Hong Li, Yueshuai Guo, Feng Li, Chenchen Liu, Yuanyuan Liu, Xia Chen, Xi Zhang, Yangyang Wu, Yi Yu, Meng Lin, Yan Yuan, Xiaofang Chen, Xiaoyan Huang, Shenmin Yang, Jun Yu, Jun Zhang & Bo Zheng
Myotubularin related protein 7 (MTMR7), a key member of the MTMR family, depicts phosphatase activity and is involved in myogenesis and tumor growth. We have previously identified MTMR7 in the proteomic profile of mouse spermatogonial stem cell (SSC) maturation and differentiation, implying that MTMR7 is associated with neonatal testicular development. In this study, to further explore the distribution and function of MTMR7 in mouse testis, we studied the effect of Mtmr7 knockdown on neonatal testicular...

Data and code for a high-resolution summary of Cambrian to Early Triassic marine invertebrate biodiversity

Jun-Xuan Fan, Shu-Zhong Shen, Xiang-Dong Wang, Yue Wang, Hua Zhang, Xu Chen, Guo-Xiang Li, Yi-Chun Zhang, Yu-Kun Shi, Dong-Xun Yuan, Qing Chen, Lin-Na Zhang, Ying-Ying Zhao, Jiao Yang, Xu-Dong Hou & Peter M. Sadler
Data compilation and standardization were conducted through the Geobiodiversity Database from 2013 to 2017. The raw dataset contained 266,110 local Cambrian to Triassic records of 45,318 taxonomic units from 3,766 published stratigraphic sections. These were collected from all major Chinese tectonic plates. The authors spent three years verifying the taxonomic assignments into a consistent paleontological taxonomic classification system. Identifications to genus or higher taxonomic ranks were omitted. All non-marine fossil groups (e.g., plants, vertebrates, pollen,...

Data from: Proximity to roads disrupts rodents’ contributions to seed dispersal services and subsequent recruitment dynamics

Wenwen Chen, Jie Zhong, Walter Carson, Zhanhui Tang, Zongqiang Xie, Shucun Sun & Youbing Zhou
1. Seed dispersal and subsequent recruitment dynamics play a crucially important role in regulating species coexistence and structuring tree diversity in diverse forests. Wildlife, which can dually shape the tree recruitment process by simultaneously functioning as natural enemies and seed dispersers, are undergoing widespread changes in population and behaviour due to the detrimental effects of expanding global road networks. However, the impact of these changes on recruitment dynamics through the alteration of seed dispersal processes...

Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling

Dan Zhao, Cong Shen, Tingting Gao, Hong Li, Yueshuai Guo, Feng Li, Chenchen Liu, Yuanyuan Liu, Xia Chen, Xi Zhang, Yangyang Wu, Yi Yu, Meng Lin, Yan Yuan, Xiaofang Chen, Xiaoyan Huang, Shenmin Yang, Jun Yu, Jun Zhang & Bo Zheng
Myotubularin related protein 7 (MTMR7), a key member of the MTMR family, depicts phosphatase activity and is involved in myogenesis and tumor growth. We have previously identified MTMR7 in the proteomic profile of mouse spermatogonial stem cell (SSC) maturation and differentiation, implying that MTMR7 is associated with neonatal testicular development. In this study, to further explore the distribution and function of MTMR7 in mouse testis, we studied the effect of Mtmr7 knockdown on neonatal testicular...

Data from: A new craniid brachiopod genus from the terminal Ordovician Hirnantia fauna of Myanmar and South China

Di Chen & Jiayu Rong
Hirnantian costate craniides are rare in the world and many have only been defined using open taxonomic nomenclature. Most of these craniides were assigned to the genera Acanthocrania and Philhedra. New material from South China and Myanmar forms the basis of a new genus Xenocrania, including its type species Palaeocyclus? haimei Reed from the Hirnantia fauna in northern Shan State, Myanmar. This genus is characterized by unique ornamentation with a large degree of intraspecific variation...

Data from: The shaping role of self-organization: linking vegetation patterning, plant traits and ecosystem functioning

Li-Xia Zhao, Chi Xu, Zhen-Ming Ge, Johan Van De Koppel & Quan-Xing Liu
Self-organized spatial patterns are increasingly recognized for their contribution to ecosystem functioning, in terms of enhanced productivity, ecosystem stability, and species diversity in terrestrial as well as marine ecosystems. Most studies on the impact of spatial self-organization have focused on systems that exhibit regular patterns. However, there is an abundance of patterns in many ecosystems which are not strictly regular. Understanding of how these patterns are formed and how they affect ecosystem function is crucial...

Data from: Gap initiation with 20.35 mm: an initiator integrating the Al/CuOx multilayer film and traditional electronic plug to enhance the ignition ability

Debin Ni, Guoqiang Yu, Shengnan Shi, Dong Xu, Enyi Chu, Chunpei Yu, Zilong Zhen & Wenchao Zhang
IIn order to enhance the ignition ability and reliability of traditional electronic initiators, a novel electronic initiator has been designed to integrate with a nanothermite multilayer film and an electrode plug. The Al/CuOx nanothermite multilayer film with different thickness is deposited on the surface of electrode plug by magnetron sputtering which used Pt-W wire as electronic resistance. The exothermicity of Al/CuOx nanothermite multilayer film is so favorable that the ignition ability of electronic initiator is...

MiR-150-5p retards the progression of myocardial fibrosis by targeting EGR1

Jie Shen, Wanhong Xing, Fangqi Gong, Wei Wang, Yufeng Yan, Yiying Zhang, Chunhong Xie & Songling Fu
To investigate the differential expression of microRNA-150-5p (miR-150-5p) and early growth response 1 (EGR1) in myocardial fibrosis (MF) cells, and determine the effect between miR-150-5p and EGR1 on MF. Human MF cells were generated via Trypanosoma cruzi (T. cruzi) infection, a mouse model of MF was generated via angiotensin II. The expression levels of miR-150-5p and EGR1 were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assay. The correlation between miR-150-5p and...

MiR-150-5p retards the progression of myocardial fibrosis by targeting EGR1

Jie Shen, Wanhong Xing, Fangqi Gong, Wei Wang, Yufeng Yan, Yiying Zhang, Chunhong Xie & Songling Fu
To investigate the differential expression of microRNA-150-5p (miR-150-5p) and early growth response 1 (EGR1) in myocardial fibrosis (MF) cells, and determine the effect between miR-150-5p and EGR1 on MF. Human MF cells were generated via Trypanosoma cruzi (T. cruzi) infection, a mouse model of MF was generated via angiotensin II. The expression levels of miR-150-5p and EGR1 were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assay. The correlation between miR-150-5p and...

Long noncoding RNA MAGI1-IT1 promoted invasion and metastasis of epithelial ovarian cancer via the miR-200a/ZEB axis

Hao Gao, Xiaofeng Li, Guangxi Zhan, Yong Zhu, Jing Yu, Jiapo Wang, Li Li, Weimin Wu, Na Liu & Xiaoqing Guo
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, and its vulnerability to metastasis contributes to the poor outcomes of EOC patients. Long noncoding RNAs (lncRNAs) were verified to play a pivotal role in EOC metastasis. However, the potential role of lncRNA membrane-associated guanylate kinase inverted 1 (MAGI1) intronic transcript (MAGI1-IT1) in EOC is largely unknown. In this study, the function and mechanisms of MAGI1-IT1 in EOC metastasis were explored profoundly. First, MAGI1-IT1 expression...

MicroRNA-10b controls the metastasis and proliferation of colorectal cancer cells by regulating Krüppel-like factor 4

Yue Xie, Jing Zhao, Yanling Liang, Min Chen, Yihong Luo, Xiaobing Cui, Bo Jiang, Liang Peng & Xinying Wang
Mir-10b has been reported as a key regulator of metastasis in many human tumours. Moreover, it has also been regarded as a prognostic marker and therapeutic target of colorectal cancer (CRC). Whether miR-10b could affect the metastasis and proliferation of CRC is unclear. MiR-10b expression was detected by qPCR in human CRC tissues and cell line, Luciferase activity was employed for miR-10b binding to the 3`UTR of KLF4, Genes expression were examined by western blot,...

MicroRNA-10b controls the metastasis and proliferation of colorectal cancer cells by regulating Krüppel-like factor 4

Yue Xie, Jing Zhao, Yanling Liang, Min Chen, Yihong Luo, Xiaobing Cui, Bo Jiang, Liang Peng & Xinying Wang
Mir-10b has been reported as a key regulator of metastasis in many human tumours. Moreover, it has also been regarded as a prognostic marker and therapeutic target of colorectal cancer (CRC). Whether miR-10b could affect the metastasis and proliferation of CRC is unclear. MiR-10b expression was detected by qPCR in human CRC tissues and cell line, Luciferase activity was employed for miR-10b binding to the 3`UTR of KLF4, Genes expression were examined by western blot,...

Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression

Haifeng Zhang, Xiaolong Wang, Baoli Hu, Feng Zhang, Haitao Wei & Li Li
Non-small-cell lung carcinoma (NSCLC) is the most common type of lung cancer. Circular RNA ZFR (circZFR) is an identified circular RNA (circRNA) that is correlated with cancer progression. However, the role of circZFR in NSCLC remains unknown. In the present study, we aimed to investigate the function of circZFR in NSCLC and the underlying mechanism. The expression patterns of circZFR were determined using qRT-PCR in NSCLC samples and cell lines. The subcellular distribution of circZFR...

Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression

Haifeng Zhang, Xiaolong Wang, Baoli Hu, Feng Zhang, Haitao Wei & Li Li
Non-small-cell lung carcinoma (NSCLC) is the most common type of lung cancer. Circular RNA ZFR (circZFR) is an identified circular RNA (circRNA) that is correlated with cancer progression. However, the role of circZFR in NSCLC remains unknown. In the present study, we aimed to investigate the function of circZFR in NSCLC and the underlying mechanism. The expression patterns of circZFR were determined using qRT-PCR in NSCLC samples and cell lines. The subcellular distribution of circZFR...

MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF

Hu Zhao, Wei Zhang, Xiaofeng Lai, Hehuan Zhu, Shenhang Zhang, Weizhen Wu, Shuiliang Wang, Minying Tang, Zhen Deng & Jianming Tan
MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel...

MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF

Hu Zhao, Wei Zhang, Xiaofeng Lai, Hehuan Zhu, Shenhang Zhang, Weizhen Wu, Shuiliang Wang, Minying Tang, Zhen Deng & Jianming Tan
MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel...

Future of the human climate niche

Chi Xu, Timothy Kohler, Timothy Lenton, Jens-Christian Svenning & Marten Scheffer
All species have an environmental niche, and despite technological advances, humans are unlikely to be an exception. Here, we demonstrate that for millennia, human populations have resided in the same narrow part of the climatic envelope available on the globe, characterized by a major mode around ∼11 °C to 15 °C mean annual temperature (MAT). Supporting the fundamental nature of this temperature niche, current production of crops and livestock is largely limited to the same...

Data from: Horizontal and vertical diversity jointly shape food web stability against small and large perturbations

Qinghua Zhao, Paul J. Van Den Brink, Camille Carpentier, Yingying. X. G. Wang, Pablo Rodríguez-Sánchez, Chi Xu, Silke Vollbrecht, Frits Gillissen, Marlies Vollebregt, Shaopeng Wang & Frederik De Laender
The biodiversity of food webs is composed of horizontal (i.e. within trophic levels) and vertical diversity (i.e. the number of trophic levels). Understanding their joint effect on stability is a key challenge. Theory mostly considers their individual effects and focuses on small perturbations near equilibrium in hypothetical food webs. Here, we study the joint effects of horizontal and vertical diversity on the stability of hypothetical (modelled) and empirical food webs. In modelled food webs, horizontal...

Registration Year

  • 2019
    20

Resource Types

  • Dataset
    20

Affiliations

  • Nanjing University
    19
  • Zhejiang University
    13
  • Chinese Academy of Sciences
    12
  • Sun Yat-sen University
    11
  • Central South University
    11
  • Capital Medical University
    11
  • Southern Medical University
    11
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    11
  • Second Affiliated Hospital of Chongqing Medical University
    9
  • Tongji University
    9