32 Works

Data from: Middle Permian fusulines from the Thitsipin Formation of Shan State, Myanmar and their palaeobiogeographical and palaeogeographical implications

Yichun Zhang, Kyipyar Aung, Shuzhong Shen, Hua Zhang, Than Zaw, Lin Ding, Fulong Cai & Kyain Sein
Fusuline faunas including 29 species belonging to 19 genera/subgenera are described from the Thitsipin Formation in eight sections/localities on the Shan Plateau in eastern Myanmar. These fusulines broadly indicate a Midian (middle Permian, Guadalupian) age. The lower diversity and the presence of some genera, such as Monodiexodina and Eopolydiexodina, suggest that the Sibumasu Block belonged to the palaeobiogeographic Cimmerian Province during the Midian. Furthermore, quantitative cluster analyses of middle Permian fusulines from the Shan Plateau...

Development of an automatic integrated gene detection system for novel severe acute respiratory syndrome-related coronavirus (SARS-CoV2)

Yuchang Li, Jing Li, Ying Zhang, Lizhong Dai, Lin Li, Juan Liu, Sen Zhang, Xiaoyan Wu, Yi Hu, Chengfeng Qin, Tao Jiang & Xiaoping Kang
In December 2019, Wuhan, China suffered a serious outbreak of a novel coronavirus infectious disease (COVID) caused by novel severe acute respiratory syndrome-related coronavirus (SARS-CoV 2). To quickly identify the pathogen, we designed and screened primer sets, and established a sensitive and specific qRT-PCR assay for SARS-CoV 2; the lower limit of detection (LOD) was 15 (95% CI: 9.8–21) copies per reaction. We combined this qRT-PCR assay with an automatic integration system for nucleic acid...

Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018

Yanqun Wang, Xin Li, Wenkuan Liu, Mian Gan, Lu Zhang, Jin Wang, Zhaoyong Zhang, Airu Zhu, Fang Li, Jing Sun, Guoxian Zhang, Zhen Zhuang, Jiaying Luo, Dehui Chen, Shuyan Qiu, Li Zhang, Duo Xu, Chris Ka Pun Mok, Fuchun Zhang, Jingxian Zhao, Rong Zhou & Jincun Zhao
Human coronavirus NL63 (HCoV-NL63) is primarily associated with common cold in children, elderly and immunocompromised individuals. Outbreaks caused by HCoV-NL63 are rare. Here we report a cluster of HCoV-NL63 cases with severe lower respiratory tract infection that arose in Guangzhou, China, in 2018. Twenty-three hospitalized children were confirmed to be HCoV-NL63 positive, and most of whom were hospitalized with severe pneumonia or acute bronchitis. Whole genomes of HCoV-NL63 were obtained using next-generation sequencing. Phylogenetic and...

Drought risk of global terrestrial gross primary productivity in recent 40 years detected by a remote sensing-driven process model

Qiaoning He, Weimin Ju, Shengpei Dai, Wei He, Lian Song, Songhan Wang, Xinchuan Li & Guangxiong Mao
Gross primary productivity (GPP) is the largest flux in the global terrestrial carbon cycle and affected by multiple factors. In recent decades, drought has significantly impacted global terrestrial GPP and been projected to occur with increasing frequency and intensity. However, the drought risk of global terrestrial GPP has not been well investigated. In this study, global terrestrial GPP over the period from 1981 to 2016 was simulated with the process-based Boreal Ecosystem Productivity Simulator (BEPS)...

Long non-coding RNA XIST promotes the progression of esophageal squamous cell carcinoma through sponging miR-129-5p and upregulating CCND1 expression

Haoran Wang, Haomiao Li, Yongkui Yu, Qingfeng Jiang, Ruixiang Zhang, Haibo Sun, Wenqun Xing & Yin Li
Long non-coding RNA (lncRNA) X inactive specific transcript (XIST) has been identified as an oncogenic lncRNA in a series of human cancers, including esophageal squamous cell carcinoma (ESCC). In this study, we aimed to further explore the underlying mechanism of XIST on ESCC progression. qRT-PCR assay was used to determine the levels of XIST and miR-129-5p. Western blot analysis was performed to assess cyclin D1 (CCND1) expression. Bioinformatic analysis was performed using starBase v2.0 software....

Experimental investigation of insect deposition in lentic environments and implications for formation of Konservat-Lagerstätten

Qingyi Tian, Shengyu Wang, Zixiao Yang, Maria McNamara, Michael Benton & Baoyu Jiang
Terrestrial insects are often remarkably well preserved in lacustrine Konservat-Lagerstätten. However, the assumption that carcasses should sink fast through the water column seems to contradict evidence that this scenario is unlikely due to excessive buoyancy and surface tension. The mechanisms that promote rapid and permanent emplacement onto the sediment surface (RPESS) of such terrestrial animal remains are not fully understood. Here we use taphonomic experiments to show that floating in water, growth of microbial biofilms...

Mapping the global potential transmission hotspots for severe fever with thrombocytopenia syndrome by machine learning methods

Dong Miao, Ke Dai, Guo-Ping Zhao, Xin-Lou Li, Wen-Qiang Shi, Jiu Song Zhang, Yang Yang, Wei Liu & Li-Qun Fang
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with increasing spread. Currently SFTS transmission has expanded beyond Asian countries, however, with definitive global extents and risk patterns remained obscure. Here we established an exhaustive database that included globally reported locations of human SFTS cases and the competent vector, Haemaphysalis longicornis (H. longicornis), as well as the explanatory environmental variables, based on which, the potential geographic range of H. longicornis and risk areas...

An infectious clone of enterovirus 71(EV71) that is capable of infecting neonatal immune competent mice without adaptive mutations

Huiying Zhang, Zhigang Song, Jingyi Zou, Yanling Feng, Jing Zhang, Lehao Ren, Xiaonan Zhang, Yunwen Hu, Zhenghong Yuan & Zhigang Yi
Enterovirus 71 (EV71) is a major pathogen that causes hand, foot and mouth disease (HFMD), which is a life threatening disease in certain children. The pathogenesis of EV71-caused HFMD is poorly defined due to the lack of simple and robust animal models with severe phenotypes that recapitulate symptoms observed in humans. Here, we generated the infectious clone of a clinical isolate from a severe HFMD patient. Virus rescued from the cDNA clone was infectious in...

Risks and features of secondary infections in severe and critical ill COVID-19 patients

Haocheng Zhang, Yi Zhang, Jing Wu, Yang Li, Xian Zhou, Xin Li, Haili Chen, Mingquan Guo, Shu Chen, Feng Sun, Richeng Mao, Chao Qiu, Zhaoqin Zhu, Jingwen Ai & Wenhong Zhang
Objectives Severe or critical COVID-19 is associated with intensive care unit admission, increased secondary infection rate, and would lead to significant worsened prognosis. Risks and characteristics relating to secondary infections in severe COVID-19 have not been described. Methods Severe and critical COVID-19 patients from Shanghai were included. We collected lower respiratory, urine, catheters, and blood samples according to clinical necessity and culture and mNGS were performed. Clinical and laboratory data were archived. Results We found...

Maximum carboxylation rate estimation with chlorophyll content as a proxy of rubisco content

Xuehe Lu, Weimin Ju, Jing Li, Holly Croft, Jing M. Chen, Yiqi Luo, Hua Yu & Haijing Hu
The maximum carboxylation rate (Vcmax) is a key parameter in determining the plant photosynthesis rate per unit leaf area. However, most terrestrial biosphere models currently treat Vcmax as constants changing only with plant functional types, leading to large uncertainties in modelled carbon fluxes. Vcmax is tightly linked with Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). Here we investigated the relationship between leaf chlorophyll content and Rubisco (Chl-Rub) within a winter wheat paddock. With chlorophyll as a proxy of Rubisco,...

Data from: Neighbourhood-dependent root distributions and the consequences on root separation in arid ecosystems

Bin J. W. Chen, Chi Xu, Mao-Song Liu, Zheng Y. X. Huang, Ming-Juan Zhang, Jian Tang & Niels P. R. Anten
1. Inter-specific root separation is an important example of spatial niche differentiation that drives species coexistence in many ecosystems. Particularly under water-stressed conditions, it is believed to be an inevitable outcome of species interactions. However, evidence for and against this idea has been found. So far, studies aiming at reconciling the debate mainly focus on abiotic determinants. It remains unclear if and to what extent root separation depends on the type and growth form of...

The type I-E CRISPR-Cas system influences the acquisition of blaKPC-IncF plasmid in Klebsiella pneumonia

Ying Zhou, Yu Tang, Pan Fu, Dongxing Tian, Lianhua Yu, Yunkun Huang, Gang Li, Meng Li, Yong Wang, Zehua Yang, Xiaogang Xu, Zhe Yin, Dongsheng Zhou, Laurent Poirel & Xiaofei Jiang
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and blaKPC-IncF plasmids. CRISPR-Cas system is an adaptive immune system that can hinder gene expansion driven by horizontal gene transfer. Because of blaKPC-IncF plasmids are favored by CG258 K. pneumoniae, it was of interest to examine the co-distribution of CRISPR and blaKPC-IncF plasmids...

Risks and features of secondary infections in severe and critical ill COVID-19 patients

Haocheng Zhang, Yi Zhang, Jing Wu, Yang Li, Xian Zhou, Xin Li, Haili Chen, Mingquan Guo, Shu Chen, Feng Sun, Richeng Mao, Chao Qiu, Zhaoqin Zhu, Jingwen Ai & Wenhong Zhang
Objectives Severe or critical COVID-19 is associated with intensive care unit admission, increased secondary infection rate, and would lead to significant worsened prognosis. Risks and characteristics relating to secondary infections in severe COVID-19 have not been described. Methods Severe and critical COVID-19 patients from Shanghai were included. We collected lower respiratory, urine, catheters, and blood samples according to clinical necessity and culture and mNGS were performed. Clinical and laboratory data were archived. Results We found...

BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains

Xiaoli Wu, Yanrong Zheng, Mengru Liu, Yue Li, Shijia Ma, Weidong Tang, Wenping Yan, Ming Cao, Wanqing Zheng, Lei Jiang, Jiaying Wu, Feng Han, Zhenghong Qin, Liang Fang, Weiwei Hu, Zhong Chen & Xiangnan Zhang
Mitophagy, the elimination of damaged mitochondria through autophagy, promotes neuronal survival in cerebral ischemia. Previous studies found deficient mitophagy in ischemic neurons, but the mechanisms are still largely unknown. We determined that BNIP3L/NIX, a mitophagy receptor, was degraded by proteasomes, which led to mitophagy deficiency in both ischemic neurons and brains. BNIP3L exists as a monomer and homodimer in mammalian cells, but the effects of homodimer and monomer on mitophagy are unclear. Site-specific mutations in...

Development of an automatic integrated gene detection system for novel severe acute respiratory syndrome-related coronavirus (SARS-CoV2)

Yuchang Li, Jing Li, Ying Zhang, Lizhong Dai, Lin Li, Juan Liu, Sen Zhang, Xiaoyan Wu, Yi Hu, Chengfeng Qin, Tao Jiang & Xiaoping Kang
In December 2019, Wuhan, China suffered a serious outbreak of a novel coronavirus infectious disease (COVID) caused by novel severe acute respiratory syndrome-related coronavirus (SARS-CoV 2). To quickly identify the pathogen, we designed and screened primer sets, and established a sensitive and specific qRT-PCR assay for SARS-CoV 2; the lower limit of detection (LOD) was 15 (95% CI: 9.8–21) copies per reaction. We combined this qRT-PCR assay with an automatic integration system for nucleic acid...

Long non-coding RNA XIST promotes the progression of esophageal squamous cell carcinoma through sponging miR-129-5p and upregulating CCND1 expression

Haoran Wang, Haomiao Li, Yongkui Yu, Qingfeng Jiang, Ruixiang Zhang, Haibo Sun, Wenqun Xing & Yin Li
Long non-coding RNA (lncRNA) X inactive specific transcript (XIST) has been identified as an oncogenic lncRNA in a series of human cancers, including esophageal squamous cell carcinoma (ESCC). In this study, we aimed to further explore the underlying mechanism of XIST on ESCC progression. qRT-PCR assay was used to determine the levels of XIST and miR-129-5p. Western blot analysis was performed to assess cyclin D1 (CCND1) expression. Bioinformatic analysis was performed using starBase v2.0 software....

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes

Wei Zhang, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, Yan-Yi Wang, Geng-Fu Xiao, Bing Yan, Zheng-Li Shi & Peng Zhou
In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral–fecal route by...

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes

Wei Zhang, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, Yan-Yi Wang, Geng-Fu Xiao, Bing Yan, Zheng-Li Shi & Peng Zhou
In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral–fecal route by...

Data from: Conodont faunas across the Kasimovian–Gzhelian boundary (Late Pennsylvanian) in South China and implications for the selection of the stratotype for the base of the global Gzhelian Stage

Yuping Qi, James E. Barrick, Nicholas J. Hogancamp, Jitao Chen, Keyi Hu, Qiulai Wang & Xiangdong Wang
The upper Pennsylvanian Naqing and Narao carbonate successions were deposited in intra-platform slope to basinal settings across the Kasimovian-Gzhelian boundary in Guizhou, South China. Conodont faunas comprise a mixture of the endemic taxa of the Idiognathodus luodianensis group and cosmopolitan species of the I. simulator group. The I. luodianensis group includes the new species I. fengtingensis, I. luodianensis, I. naqingensis and I. naraoensis. Platform landmark analysis demonstrates that the species of the I. luodianensis group...

Data from: Harsh environmental regimes increase the functional significance of intraspecific variation in plant communities

Kechang Niu, Shiting Zhang & Martin Lechowicz
The relative importance of intraspecific trait variation (rITV) for functional diversity (FD) in plant communities is increasingly apparent, but the influence of abiotic factors on the balance between intraspecific and interspecific effects in contrasting environments is uncertain. We predicted that rITV would increase with environmental harshness as a result of decreasing interspecific variation (Inter_FD) and concomitant increases in between-population ITV(Intra_FD). We empirically tested this prediction in a comparison of rITV for five traits (mature plant...

Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China

Heng Wang, Wei-min Xu, Kuang-ji Zhu, Su-juan Zhu, Hong-fang Zhang, Jia Wang, Yang Yang, Feng-yao Shao, Neng-ming Jiang, Zhen-yang Tao, Hang-yi Jin, Yi Tang, Liang-liang Huo, Fang Dong, Zhen-jun Li, Hua Ding & Zhi-guo Liu
In the present study, a total of 7793 samples from 5 different types of hosts were collected and tested, with a seroprevalence of 2.4% (184/7793). Although the seroprevalence of human and animal brucellosis is relatively low, numbers of human brucellosis cases reported have increased continuously from 2004 to 2018. A total of 118 Brucella strains containing 4 biotypes were obtained, including Brucella melitensis bv.1 (n = 8) and bv.3 (n = 106), Brucella abortus bv.3...

The role of cloud–infrared radiation feedback in tropical cyclone development

J.H. Ruppert, A.A. Wing, X. Tang & E.L. Duran
This archive contains the data and code used by Ruppert et al. (2020) in their journal publication (DOI placeholder; "The role of cloud–infrared radiation feedback in tropical cyclone development"). It contains 1) the WRF model code and namelist files required to run the pre-processing and simulations of Typhoon Haiyan and Hurricane Maria, and 2) the forcing and circulation output from Sawyer–Eliassen equation computations. Gridded output files are in NetCDF format. Additional datasets required to conduct...

Development of an automatic integrated gene detection system for novel severe acute respiratory syndrome-related coronavirus (SARS-CoV2)

Yuchang Li, Jing Li, Ying Zhang, Lizhong Dai, Lin Li, Juan Liu, Sen Zhang, Xiaoyan Wu, Yi Hu, Chenfeng Qin, Tao Jiang & Xiaoping Kang
In December 2019, Wuhan, China suffered a serious outbreak of a novel coronavirus infectious disease (COVID) caused by novel severe acute respiratory syndrome-related coronavirus (SARS-CoV 2). To quickly identify the pathogen, we designed and screened primer sets, and established a sensitive and specific qRT-PCR assay for SARS-CoV 2; the lower limit of detection (LOD) was 14.8 (95% CI: 9.8–21) copies per reaction. We combined this qRT-PCR assay with an automatic integration system for nucleic acid...

Data from: Heterochronic origin of spherical fusulinid foraminifera in the Late Paleozoic

Yukun Shi
Heterochrony describes acceleration, displacement and/or retardation of descendants’ development events compared to ancestral states and has often been cited as an important process to bring about morphological novelty. It was coined one and half centuries ago and has been discussed by both paleobiologists and biologists frequently ever since. Many types of fossil organisms preserve aspects of their development histories in their bones or shells that have been used for heterochrony analyses, with body size being...

Supplemental Material, original_data - Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Supplemental Material, original_data for Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial by Haichun Lai, Wei Huang, Wei Chen and Desheng Wang in Ear, Nose & Throat Journal

Registration Year

  • 2020
    32

Resource Types

  • Dataset
    32

Affiliations

  • Nanjing University
    32
  • Chinese Academy of Sciences
    18
  • Sun Yat-sen University
    16
  • Zhejiang University
    14
  • Central South University
    14
  • Huazhong University of Science and Technology
    14
  • North West Agriculture and Forestry University
    13
  • Huazhong Agricultural University
    13
  • Air Force Medical University
    12
  • Sichuan University
    11