78 Works

Dissociable use-dependent processes for volitional goal-directed reaching

Jonathan Tsay, Hyosub Kim, Arohi Saxena, Darius Parvin, Timothy Verstynen & Richard Ivry
Repetition of a specific movement biases subsequent actions towards the practiced movement, a phenomenon known as use-dependent learning (UDL). Recent experiments that impose strict constraints on planning time have revealed two sources of use-dependent biases, one arising from dynamic changes occurring during motor planning and another reflecting a stable shift in motor execution. Here, we used a distributional analysis to examine the contribution of these biases in reaching. To create the conditions for UDL, the...

Efficacy of nimodipine in the treatment of subarachnoid hemorrhage: a meta-analysis

Jianqiang Liu, Cuimei Sun, Ying Wang, Guangjun Nie, Qihao Dong, Jiebing You, Qiang Li & Mingyue Li
Abstract Background Subarachnoid hemorrhage (SAH) is an uncommon and serious subtype of stroke, which leads to the loss of the patient’s ability to produce and live for many years. Objective To investigate the clinical effect of nimodipine in the treatment of SAH. Methods Electronic databases including China National Knowledge Infrastructure (CNKI), VIP, SinoMed, China Master’s Theses Full-text Database (CMFD), China Doctoral Dissertations Full-text Database (CDFD), Cochrane Library, PubMed and Embase were searched from 2010 and...

Efficacy of nimodipine in the treatment of subarachnoid hemorrhage: a meta-analysis

Jianqiang Liu, Cuimei Sun, Ying Wang, Guangjun Nie, Qihao Dong, Jiebing You, Qiang Li & Mingyue Li
Abstract Background Subarachnoid hemorrhage (SAH) is an uncommon and serious subtype of stroke, which leads to the loss of the patient’s ability to produce and live for many years. Objective To investigate the clinical effect of nimodipine in the treatment of SAH. Methods Electronic databases including China National Knowledge Infrastructure (CNKI), VIP, SinoMed, China Master’s Theses Full-text Database (CMFD), China Doctoral Dissertations Full-text Database (CDFD), Cochrane Library, PubMed and Embase were searched from 2010 and...

Neuromotor control of walking balance in individuals with cerebral palsy

Ashwini Sansare & Hendrik Reimann
Individuals with cerebral palsy (CP) have deficits in processing of somatosensory and proprioceptive information. To compensate for these deficits, they tend to rely on vision over proprioception in single plane upper and lower limb movements and in standing. It is not known whether this also applies to walking, an activity where the threat to balance is higher. Through this study, we used visual perturbations to understand how individuals with and without CP integrate visual input...

Additional file 3 of Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease

Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan & Jiequn Li
Additional file 3: Table S3. Results of GO enrichment on differentially expressed genes from RNA-seq data.

Additional file 5 of Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease

Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan & Jiequn Li
Additional file 5: Table S5. Results of KEGG enrichment on differentially expressed genes from GSE159676 datasets.

Additional file 7 of Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease

Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan & Jiequn Li
Additional file 7: Table S7. Differentially expressed genes that appeared in both RNA-seq data and the GSE159676 datasets

Pest population dynamics are related to a continental overwintering gradient

Douglas Lawton, Anders S. Huseth, George G. Kennedy, Amy C. Morey, William D. Hutchison, Dominic D. Reisig, Seth J. Dorman, DeShae Dillard, Robert C. Venette, Russell L. Groves, John J. Adamczyk, Izailda Barbosa Dos Santos, Tracey Baute, Sebe Brown, Eric Burkness, Ashley Dean, Galen P. Dively, Hélène B. Doughty, Shelby J. Fleischer, Jessica Green, Jeremy K. Greene, Krista Hamilton, Erin Hodgson, Thomas Hunt, David Kerns … & Marion Zuefle
Overwintering success is an important determinant of arthropod populations that must be considered as climate change continues to influence the spatiotemporal population dynamics of agricultural pests. Using a long-term monitoring database and biologically relevant overwintering zones, we modeled the annual and seasonal population dynamics of a common pest, Helicoverpa zea (Boddie), based on three overwintering suitability zones throughout North America using four decades of soil temperatures: the southern range (able to persist through winter), transitional...

Data from: Subspecies delineation amid phenotypic, geographic, and genetic discordance in a songbird

Jennifer Walsh, Irby J. Lovette, Virginia Winder, Chris S. Elphick, Brian J. Olsen, W. Gregory Shriver, Adrienne I. Kovach & Gregory Shriver
Understanding the processes that drive divergence within and among species is a long-standing goal in evolutionary biology. Traditional approaches to assessing differentiation rely on phenotypes to identify intra- and interspecific variation, but many species express subtle morphological gradients in which boundaries among forms are unclear. This intraspecific variation may be driven by differential adaptation to local conditions and may thereby reflect the evolutionary potential within a species. Here, we combine genetic and morphological data to...

Data from: Population genetic data of a model symbiotic cnidarian system reveal remarkable symbiotic specificity and vectored introductions across ocean basins

Daniel J. Thornhill, Yu Xiang, Min Zhong, Scott R. Santos & D. Tye Pettay
The Aiptasia-Symbiodinium symbiosis is a promising model for experimental studies of cnidarian-dinoflagellate associations, yet relatively little is known regarding the genetic diversity of either symbiotic partner. To address this we collected Aiptasia from 17 localities throughout the world and examined the genetic diversity of both anemones and their endosymbionts. Based on newly-developed SCAR markers, Aiptasia consisted of two genetically-distinct populations, one Aiptasia lineage from Florida and a second network of Aiptasia genotypes found at other...

Data from: Quantifying the importance of geographic replication and representativeness when estimating demographic rates, using a coastal species as a case study

Christopher R. Field, Katharine J. Ruskin, Bri Benvenuti, Alyssa C. Borowske, Jonathan B. Cohen, Laura Garey, Thomas P. Hodgman, Rebecca A. Kern, Erin King, Alison R. Kocek, Adrienne I. Kovach, Kathleen M. O'Brien, Brian J. Olsen, Nancy Pau, Samuel G. Roberts, Emma Shelly, W. Gregory Shriver, Jennifer Walsh, Chris S. Elphick & Rebecca A. Longenecker
Demographic rates are rarely estimated over an entire species range, limiting empirical tests of ecological patterns and theories, and raising questions about the representativeness of studies that use data from a small part of a range. The uncertainty that results from using demographic rates from just a few sites is especially pervasive in population projections, which are critical for a wide range of questions in ecology and conservation. We developed a simple simulation to quantify...

Habitat openness and edge avoidance predict saltmarsh sparrow abundance better than habitat area

Hallie Marshall, Erik Blomberg, Valerie Watson, Meaghan Conway, Jonathan Cohen, Maureen Correll, Chris Elphick, Thomas Hodgman, Alison Kocek, Adrienne Kovach, W. Gregory Shriver, Whitney Wiest & Brian Olsen
The Saltmarsh Sparrow (Ammospiza caudacuta) is a tidal marsh bird facing rapid population decline throughout its range, largely caused by degradation and loss of breeding habitat. Thus there is a need to preserve tidal marshes in the northeastern United States, but to do so requires an understanding of the habitat features that support robust populations. Previous studies have shown Saltmarsh Sparrow abundance increases with marsh size, but in similar bird species, area sensitivity is more...

Data from: The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development

Archana D. Siddam, Carole Gautier-Courteille, Linette Perez-Campos, Deepti Anand, Atul Kakrana, Christine A. Dang, Vincent Legagneux, Agnès Méreau, Justine Viet, Jeffrey M. Gross, Luc Paillard & Salil A. Lachke
Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, presenting a fundamental question: does signaling/transcription sufficiently explain differentiation of cells progressing toward compromised transcriptional potential? We report that a conserved RNA-binding protein Celf1 post-transcriptionally controls key genes to regulate lens fiber cell differentiation. Celf1-targeted knockout mice and celf1-knockdown zebrafish and Xenopus morphants have severe eye defects/cataract. Celf1...

Data from: Bidirectional adaptive introgression between two ecologically divergent sparrow species

Jennifer Walsh, Adrienne I. Kovach, Brian Justin Olsen, W. Gregory Shriver & Irby J. Lovette
Natural hybrid zones can be used to dissect the mechanisms driving key evolutionary processes by allowing us to identify genomic regions important for establishing reproductive isolation and that allow for transfer of adaptive variation. We leverage whole-genome data in a system where two bird species, the saltmarsh (Ammospiza caudacutus) and Nelson’s (A. nelsoni) sparrow, hybridize despite their relatively high background genetic differentiation and past ecological divergence. Adaptive introgression is plausible in this system because Nelson’s...

A satellite-based mobile warning system to reduce interactions with an endangered species

Matthew Breece, Matthew Oliver, Dewayne Fox, Edward Hale, Danielle Haulsee, Matthew Shatley, Steven Bograd, Elliott Hazen & Heather Welch
Earth observing satellites are a major research tool for spatially explicit ecosystem nowcasting and forecasting. However, there are practical challenges when integrating satellite data into usable real-time products for stakeholders. The need of forecast immediacy and accuracy means that forecast systems must account for missing data and data latency while delivering a timely, accurate and actionable product to stakeholders. This is especially true for species that have legal protection. Acipenser oxyrinchus oxyrinchus (Atlantic Sturgeon) were...

Data from: Neural control of balance during walking

Hendrik Reimann, Tyler Fettrow, Elizabeth D. Thompson & John J. Jeka
Neural control of standing balance has been extensively studied. However, most falls occur during walking rather than standing, and findings from standing balance research do not necessarily carry over to walking. This is primarily due to the constraints of the gait cycle: Body configuration changes dramatically over the gait cycle, necessitating different responses as this configuration changes. Notably, certain responses can only be initiated at specific points in the gait cycle, leading to onset times...

A habitat-based approach to determining the effects of drought on aridland bird communities

Samuel Roberts, David Thoma, Dusty Perkins, Elizabeth Tymkiw, Zachary Ladin & Gregory Shriver
Aridland breeding bird communities of the United States are among the most vulnerable to drought, with many species showing significant population declines associated with decreasing precipitation and increasing temperature. Individual breeding bird species have varied responses to drought which suggests complex responses to changes in water availability. Here, we evaluated the influence of water deficit, an integrative metric of drought stress, on breeding bird communities within three distinct aridland habitat types: riparian, pinyon-juniper, and sagebrush...

Data from: Using terrestrial haematophagous leeches to enhance tropical biodiversity monitoring programmes in Bangladesh

Sarah R. Weiskopf, Kyle P. McCarthy, Michael Tessler, Hasan A. Rahman, Jennifer L. McCarthy, Rebecca Hersch, Mohammad M. Faisal & Mark E. Siddall
1. Measuring mammal biodiversity in tropical rainforests is challenging, and methods which reduce effort while maximizing success are crucial for long-term monitoring programmes. Commonly used methods to assess mammal biodiversity may require substantial sampling effort to be effective. Genetic methods are a new and important sampling tool on the horizon, but obtaining sufficient DNA samples can be a challenge. 2. We evaluated the efficacy of using parasitic leeches Haemadipsa spp., as compared to camera trapping,...

Photo-activatable Ub-PCNA probes reveal new structural features of the S. cerevisiae Polη/PCNA complex

Siqi Shen, Gregory A. Davidson, Kun Yang & Zhihao Zhuang
The Y-family DNA polymerase η (Polη) is critical for the synthesis past damaged DNA nucleotides in yeast through translesion DNA synthesis (TLS). TLS is initiated by monoubiquitination of proliferating cell nuclear antigen (PCNA) and the subsequent recruitment of TLS polymerases. Although individual structures of the Polη catalytic core and PCNA have been solved, a high-resolution structure of the complex of Polη/PCNA or Polη/monoubiquitinated PCNA (Ub-PCNA) still remains elusive, partly due to the disordered Polη C-terminal...

A Unified Framework for Specification Tests of Continuous Treatment Effect Models

Wei Huang, Oliver Linton & Zheng Zhang
We propose a general framework for the specification testing of continuous treatment effect models. We assume a general residual function, which includes the average and quantile treatment effect models as special cases. The null models are identified under the unconfoundedness condition and contain a nonparametric weighting function. We propose a test statistic for the null model in which the weighting function is estimated by solving an expanding set of moment equations. We establish the asymptotic...

Data from: Meta-analytic and economic approaches for evaluation of pesticide impact on Sclerotinia stem rot control and soybean yield in the North Central U.S.

Jaime F. Willbur, Paul Mitchell, Mamadou L. Fall, Adam M. Byrne, Scott Chapman, Crystal M. Floyd, Carl A. Bradley, Keith Ames, Martin I. Chilvers, Nathan Kleczewski, Dean Malvick, Brian Mueller, Daren Mueller, Mehdi Kabbage, Shawn P. Conley & Damon Smith
As complete host resistance in soybean has not been achieved, Sclerotinia stem rot (SSR) caused by Sclerotinia sclerotiorum continues to be of major economic concern for farmers. Thus, chemical control remains a prevalent disease management strategy. Pesticide evaluations were conducted in Illinois, Iowa, Michigan, Minnesota, New Jersey, and Wisconsin from 2009 to 2016, for a total of 25 site-years (n = 2057 plot-level data points). These studies were used in network meta-analyses to evaluate the...

Multiple cropping alone does not improve year-round food security among smallholders in rural India

Pinki Mondal, Ruth DeFries, Jessica Clark, Nicole Flowerhill, , Aurélie Harou, Shauna Downs & Jessica Fanzo
Achieving and maintaining food and nutrition security is an important Sustainable Development Goal (SDG), especially in countries with largely vulnerable population with high occurrence of hunger and malnutrition. By studying a small-scale agricultural system in India, we aim to understand the current state of dietary diversity and food insecurity among the farmer communities. The study landscape has witnessed a steady rise in multiple cropping along with irrigation over the last two decades. Whether this multiple...

Adaptation without specialization early in a host shift: fecundity data

Rafael Rodriguez, Thomas Wood, Frank Stearns, Robert Snyder, Kelley Tilmon, Michael Cast, Randy Hunt & Reginald Cocroft
Students of speciation debate the role of performance trade-offs across different environments early in speciation. We tested for early performance trade-offs with a host shift experiment using a member of the Enchenopa binotata species complex of treehoppers (Hemiptera: Membracidae). In this clade of plant-feeding insects, different species live on different host plants and exhibit strong behavioral and physiological host specialization. After five generations, the experimental host shifts resulted either in no adaptation or in adaptation...

Data from: Animal-mediated organic matter transformation: aquatic insects as a source of microbially bioavailable organic nutrients and energy

Thomas B. Parr, Krista A. Capps, Shreeram P. Inamdar & Kari A. Metcalf
1. Animal communities are essential drivers of energy and elemental flow in ecosystems. However, few studies have investigated the functional role of animals as sources of dissolved organic matter (DOM) and the subsequent utilization of that DOM by the microbial community. 2. In a small forested headwater stream, we tested the effects of taxonomy, feeding traits, and body size on the quality and quantity of dissolved organic carbon (DOC) and dissolved organic nitrogen (DON) excreted...

LncRNA-UCA1 regulates lung adenocarcinoma progression through competitive binding to miR-383

Li Tang, Sheng Wang, Yapeng Wang, Kang Li & Qiang Li
The present study aimed to assess the role of the long non-coding RNA-urothelial cancer associated 1 (lncRNA-UCA1)/microRNA (miR)-383/vascular endothelial growth factor A (VEGFA) axis in regulating lung adenocarcinoma physiology through in vivo and in vitro experiments. The expression profile of lncRNA-UCA1 was analyzed by genome-wide analysis from GSE146459. The cell counting Kit-8, colony formation, wound healing and transwell assays were performed to evaluate the effects of lncRNA-UCA1 in vitro. In addition, luciferase reporter assays were...

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