68 Works

Site-specific SUMOylation of viral polymerase processivity factor: a way of localizingtoND10 subnuclear domains for restricted and self-controlled reproduction of herpesvirus

Shuyan Lai, Mengqiong Xu, Yaohao Wang, Ruilin Li, Chuan Xia, Sisi Xia & Jun Chen
Lytic replication of human cytomegalovirus (HCMV), a member of β-herpesvirus, is a highly complicated and organized process that requires its DNA polymerase processivity factor, UL44, the first-reported HCMV replication protein subjected to SUMO post-translational modification (PTM). SUMOylation plays a pleiotropic role in protein functions of host cells and infecting viruses. Particularly, formation of herpesviral replication compartments (RCs) upon infection is induced in proximity to ND10 subnuclear domains, the host cell’s intrinsic antiviral immune devices and...

Integrative analyses of hub genes and their association with immune infiltration in adipose tissue, liver tissue and skeletal muscle of obese patients after bariatric surgery

Kemin Yan, Pengyuan Zhang, Jiewen Jin, Xin Chen, Hongyu Guan, Yanbing Li & Hai Li
Bariatric surgery (BS) is an effective treatment for obesity. Adipose tissue, liver tissue and skeletal muscle are important metabolic tissues. This study investigated hub genes and their association with immune infiltration in these metabolic tissues of obese patients after BS by bioinformatic analysis with Gene Expression Omnibus datasets. Differentially expressed genes (DEGs) were identified, and a protein–protein interaction network was constructed to identify hub genes. As a result, 121 common DEGs were identified and mainly...

Additional file 13 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Additional file 13: Table S10: Two-way ANOVA test F-value of genes expression levels related to salicylic acid biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).

Additional file 8 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Additional file 8: Table S5: Two-way ANOVA test F-value of expression levels of the genes related to flowering time and flower development for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).

Additional file 9 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Additional file 9: Table S6: Two-way ANOVA test F-value of genes expression levels related to auxin biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).

Integrative analyses of hub genes and their association with immune infiltration in adipose tissue, liver tissue and skeletal muscle of obese patients after bariatric surgery

Kemin Yan, Pengyuan Zhang, Jiewen Jin, Xin Chen, Hongyu Guan, Yanbing Li & Hai Li
Bariatric surgery (BS) is an effective treatment for obesity. Adipose tissue, liver tissue and skeletal muscle are important metabolic tissues. This study investigated hub genes and their association with immune infiltration in these metabolic tissues of obese patients after BS by bioinformatic analysis with Gene Expression Omnibus datasets. Differentially expressed genes (DEGs) were identified, and a protein–protein interaction network was constructed to identify hub genes. As a result, 121 common DEGs were identified and mainly...

Additional file 3 of Complete chloroplast genomes of Sorbus sensu stricto (Rosaceae): comparative analyses and phylogenetic relationships

Chenqian Tang, Xin Chen, Yunfei Deng, Liyang Geng, Jianhui Ma & Xueyan Wei
Additional file 3: Table S3. Codon usage and relative synonymous codon usage (RSCU) values of protain-coding genes of the 16 Sorbus s.s. chloroplast genomes

Additional file 7 of Complete chloroplast genomes of Sorbus sensu stricto (Rosaceae): comparative analyses and phylogenetic relationships

Chenqian Tang, Xin Chen, Yunfei Deng, Liyang Geng, Jianhui Ma & Xueyan Wei
Additional file 7: Table S7. Information of species included in phylogenetic analyses

Additional file 1 of Tumor microenvironment-associated lactate metabolism regulates the prognosis and precise checkpoint immunotherapy outcomes of patients with lung adenocarcinoma

Song Qiu, Ying Wang, Hui Rao, Qiuyang Que, Yanyang Wu, Rui Zhu, Xiaofei Feng, Jun Chi, Weiling Lai, Yihang Sun, Qi Xiao, Huaqiu Shi & Yi Xiang
Additional file 1: Table S1. 26_lactate_metabolism_related_genes.

Additional file 1 of Tumor microenvironment-associated lactate metabolism regulates the prognosis and precise checkpoint immunotherapy outcomes of patients with lung adenocarcinoma

Song Qiu, Ying Wang, Hui Rao, Qiuyang Que, Yanyang Wu, Rui Zhu, Xiaofei Feng, Jun Chi, Weiling Lai, Yihang Sun, Qi Xiao, Huaqiu Shi & Yi Xiang
Additional file 1: Table S1. 26_lactate_metabolism_related_genes.

Additional file 2 of Identification of LsPIN1 gene and its potential functions in rhizome turning of Leymus secalinus

Jialin Li, Hongmei Li, Ning Yin, Xiaoyan Quan, Wenbo Wang, Qiuli Shan, Siqi Wang, Ramon Santos Bermudez & Wenxing He
Additional file 2: Table S1. The primers used in this study.

Additional file 2 of Identification of LsPIN1 gene and its potential functions in rhizome turning of Leymus secalinus

Jialin Li, Hongmei Li, Ning Yin, Xiaoyan Quan, Wenbo Wang, Qiuli Shan, Siqi Wang, Ramon Santos Bermudez & Wenxing He
Additional file 2: Table S1. The primers used in this study.

Additional file 3 of Tumor microenvironment-associated lactate metabolism regulates the prognosis and precise checkpoint immunotherapy outcomes of patients with lung adenocarcinoma

Song Qiu, Ying Wang, Hui Rao, Qiuyang Que, Yanyang Wu, Rui Zhu, Xiaofei Feng, Jun Chi, Weiling Lai, Yihang Sun, Qi Xiao, Huaqiu Shi & Yi Xiang
Additional file 3: Raw documents and tables in the process of data analysis.

Prognostic and immunological significance of metastasis associated lung adenocarcinoma transcript 1 among different kinds of cancers

Lili Guo, Xiuwen Zhang, Hongli Pan, Yang Li, Jing Wang, Lin Li, Yafang Dong, Xinxin Du, Jun Chen & Fengjie Guo
LncRNAs belong to the type of noncoding RNA transcripts, which exceed 200 nucleotides in size. MALAT1 as one of the earlier identified lncRNAs in cancer is investigated by more and more scientific researchers. Expression, clinical significance and function of MALAT1 in pan-cancer exist as big difference. To detect the expression and clinical significance of MALAT1 gene precisely and comprehensively among different kinds of cancers, some classical databases such as GEPIA, TIMER, KM Plotter, and PrognoScan...

Additional file 10 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Additional file 10: Table S7: Two-way ANOVA test F-value of genes expression levels related to cytokinin biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).

Additional file 14 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Additional file 14: Table S11: Two-way ANOVA test F-value of genes expression levels related to jasmonic biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).

Additional file 2 of Complete chloroplast genomes of Sorbus sensu stricto (Rosaceae): comparative analyses and phylogenetic relationships

Chenqian Tang, Xin Chen, Yunfei Deng, Liyang Geng, Jianhui Ma & Xueyan Wei
Additional file 2: TableS2. Genes annotated in 16 newly sequenced Sorbus s.s. chloroplast genomes

Additional file 6 of Complete chloroplast genomes of Sorbus sensu stricto (Rosaceae): comparative analyses and phylogenetic relationships

Chenqian Tang, Xin Chen, Yunfei Deng, Liyang Geng, Jianhui Ma & Xueyan Wei
Additional file 6: Table S6. The nucleotide variability (Pi) of 16 Sorbus s.s. chloroplast genomes

Additional file 8 of Complete chloroplast genomes of Sorbus sensu stricto (Rosaceae): comparative analyses and phylogenetic relationships

Chenqian Tang, Xin Chen, Yunfei Deng, Liyang Geng, Jianhui Ma & Xueyan Wei
Additional file 8: Table S8. 22 taxa in Sorbus s.l. with genes re-annotated

Additional file 6 of Integrated analysis to identify the AC005154.6/hsa-miR-29c-3p/CCNL2 axis as a novel prognostic biomarker associated with immune infiltration in prostate cancer

Qinyu Li, Bingliang Chen, Guoda Song, Kai Zeng, Xin Chen, Jianping Miao, Xianglin Yuan, Jihong Liu, Zhihua Wang & Bo Liu
Additional file 6. Prognosis model constructed by AC005154.6/hsa-miR-29c-3p/CCNL2 axis.

Additional file 5 of MED12 mutation as a potential predictive biomarker for immune checkpoint inhibitors in pan-cancer

Yong Zhou, Yuan Tan, Qin Zhang, Qianqian Duan & Jun Chen
Additional file 5: Table S1. Detailed clinical information of the five WES cohorts and the MSKCC cohort.

Arabidopsis sucrose transporter 4 (AtSUC4) is involved in high sucrose-mediated inhibition of root elongation

Siwen Liu, Jianmei Long, Liding Zhang, Jiayu Gao, Tiantian Dong, Ying Wang & Changcao Peng
Sucrose transporters (SUCs/SUTs) play crucial roles in apoplast transport and long-distance distribution of sucrose throughout the whole plant. However, whether and how the Arabidopsis AtSUC4 modulates sucrose import from apoplast to cytosol remains unclear. In the present study, we found that AtSUC4 protein was localized to the plasma membrane in the root. Expression of AtSUC4 in roots was gradually induced with the increasing sucrose concentrations (0%, 2%, 4% and 6%). When feeding high concentrations (4%...

Additional file 3 of Complete chloroplast genomes of Sorbus sensu stricto (Rosaceae): comparative analyses and phylogenetic relationships

Chenqian Tang, Xin Chen, Yunfei Deng, Liyang Geng, Jianhui Ma & Xueyan Wei
Additional file 3: Table S3. Codon usage and relative synonymous codon usage (RSCU) values of protain-coding genes of the 16 Sorbus s.s. chloroplast genomes

Additional file 6 of Complete chloroplast genomes of Sorbus sensu stricto (Rosaceae): comparative analyses and phylogenetic relationships

Chenqian Tang, Xin Chen, Yunfei Deng, Liyang Geng, Jianhui Ma & Xueyan Wei
Additional file 6: Table S6. The nucleotide variability (Pi) of 16 Sorbus s.s. chloroplast genomes

FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation

Xinyi Yang, Xiaying Zhao, Yuqi Zhu, Jingna Xun, Qin Wen, Hanyu Pan, Jinlong Yang, Jing Wang, Zhimin Liang, Xiaoting Shen, Yue Liang, Qinru Lin, Huitong Liang, Min Li, Jun Chen, Shibo Jiang, Jianqing Xu, Hongzhou Lu & Huanzhang Zhu
Acquired immunodeficiency syndrome (AIDS) cannot be completely cured, mainly due to the existence of a latent HIV-1 reservoir. However, our current understanding of the molecular mechanisms underlying the establishment and maintenance of HIV-1 latent reservoir is not comprehensive. Here, using a genome-wide CRISPR-Cas9 activation library screening, we identified E3 ubiquitin ligase F-box protein 34 (FBXO34) and the substrate of FBXO34, heterogeneous nuclear ribonucleoprotein U (hnRNP U) was identified by affinity purification mass spectrometry, as new...

Registration Year

  • 2022
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  • 2021
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Resource Types

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Affiliations

  • Gannan Medical University
    68
  • Zhejiang University
    64
  • Huazhong University of Science and Technology
    62
  • Fudan University
    50
  • Central South University
    48
  • First Affiliated Hospital of Harbin Medical University
    48
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    46
  • Shanghai University of Traditional Chinese Medicine
    44
  • Chinese Academy of Sciences
    44
  • Second Affiliated Hospital of Dalian Medical University
    40