Prostate cancer (PCa) is the second commonly diagnosed malignancy in men over the world. Although androgen deprivation therapy for advanced PCa patients has significantly improved their survival, the majority of these patients eventually develop castration-resistant prostate cancer (CRPC). Proscillaridin A (Pro A), a cardiac glycoside that is clinically used to treat various heart failure diseases, has been reported to have anticancer activity in several cancers. However, whether Pro A exerts an inhibitory effect on PCa...

Human coronavirus NL63 (HCoV-NL63) is primarily associated with common cold in children, elderly and immunocompromised individuals. Outbreaks caused by HCoV-NL63 are rare. Here we report a cluster of HCoV-NL63 cases with severe lower respiratory tract infection that arose in Guangzhou, China, in 2018. Twenty-three hospitalized children were confirmed to be HCoV-NL63 positive, and most of whom were hospitalized with severe pneumonia or acute bronchitis. Whole genomes of HCoV-NL63 were obtained using next-generation sequencing. Phylogenetic and...

Biochar-derived dissolved organic matter (BDOM) plays key roles in soil ecosystem by affecting soil physicochemical and biological properties and supplying nutrients to soil microbes. It can either enhance or suppress the growth of certain soil microorganisms, depending on its composition and content of labile organic compounds. This review aims to discuss and summarize the role of BDOM in modifying soil microbial functioning, microbial community structure, and enzymatic activity. We mainly focus on the role of...

Biochar-derived dissolved organic matter (BDOM) plays key roles in soil ecosystem by affecting soil physicochemical and biological properties and supplying nutrients to soil microbes. It can either enhance or suppress the growth of certain soil microorganisms, depending on its composition and content of labile organic compounds. This review aims to discuss and summarize the role of BDOM in modifying soil microbial functioning, microbial community structure, and enzymatic activity. We mainly focus on the role of...

Supplementary files for article Microstructural engineering of a dual-phase Ti-Al-V-Fe alloy via in situ alloying during laser powder bed fusion
When Ti-6Al-4V is processed by laser powder bed fusion (L-PBF), acicular martensitic α’-Ti grains are formed within the columnar prior β-Ti grains, resulting in inferior mechanical properties. The application of blended powders in L-PBF enables to tailor the microstructures and obtain a mixture of α’ + β phases. In this work, we demonstrate an...

The initial soil chemical properties of experiemental blocks (block 1-4).

Supplemental material, sj-xls-1-jcb-10.1177_0271678X231165653 for H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1 by Ting Lan, Liye Hu, Tingting Sun, Xuechun Wang, Zhongnan Xiao, Danmin Shen, Weihua Wu, Zhaoli Luo, Chao Wei, Xiaotong Wang, Meng Liu, Yi Guo, Liyong Wang, Yamei Wang, Yabin Lu, Yan Yu, Fei Yang, Chenguang Zhang and Qian Li in Journal of Cerebral Blood Flow & Metabolism

Data on biological activities (i.e., plant growth, soil microbial respiration, soil fauna feeding) and soil abotic conditions (i.e., soil temperature and soil moisture), presented in Table 1; Fig. 2, 3, 4; Supplementary Fig. 1, 4.

Data on the other explanatory variables (i.e., plant biomass, soil microbial biomass carbon, soil fauna biomass) are presented in Supplementary Fig. 2.

Precipitation might change rapidly and vary spatially, therefore, knowledge on spatio-temporal variation of precipitation plays a pivotal role in water resources management, hydrogeological hazard and risk assessment, and city resilience enhancement. However, precipitation monitoring data are collected through a limited number of precipitation stations in practice, and they are often sparse and discontinuous, particularly in spatial domain. Furthermore, regional precipitation data exhibits characteristics of seasonality, periodicity and highly non-stationarity on a long-time scale. Therefore, it...

Maiwa yak is a special breed of animal living on the Qinghai-Tibet Plateau, which has great economic value, but its fertility rate is low. The corpus luteum (CL) is a temporary tissue that plays a crucial role in maintaining the physiological cycle. However, little is known about the transcriptome profile in Maiwa yak CL. In the present study, the transcriptome of Maiwa yak CL at early (EYCL), middle (MYCL) and late-stages (LYCL) was studied employing...

Studies on aspirin’s effects on metabolic-associated fatty liver disease (MAFLD) are limited. The aim of this study was to assess the association between aspirin and all-cause and cardiovascular disease (CVD) mortality in individuals with MAFLD. Data were acquired from the National Health And Nutrition Examination Survey (NHANES) III. MAFLD diagnosis was consistent with that of international expert consensus. The independent association between aspirin and all-cause and CVD mortality in participants with MAFLD was evaluated by...

ABSTRACT Introduction: Knockdown of fat mass and obesity-associated gene (FTO) can induce N6-methyladenosine (m 6A) ribonucleic acid (RNA) methylation. The objective of this study was to explore the effect of m 6A RNA methylation on atherosclerotic vulnerable plaque by FTO knockdown. Methods: A total of 50 New Zealand white rabbits were randomly divided into pure high-fat group, sham operation group, vulnerable plaque group, empty load group, and FTO knockdown group (10 rabbits/group). Results: Flow cytometry...

https://www.tandfonline.com/doi/full/10.1080/13543784.2023.2178894

https://www.tandfonline.com/doi/full/10.1080/13543784.2023.2178894

Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but...

Supplementary Table 1 | Genes associated with risk scores.
Supplementary Table 2 | Expression levels and methylation levels of SNORA71B in gliomas (TCGA Database). Supplementary Table 3 | Fold change values of the 5 methylated snoRNA genes (TCGA Database).
Supplementary Table 4 | Methylation levels of five snoRNAs in gliomas (TCGA Database).
Supplementary Table 5 Clinic-pathological characteristics of 13 glioma patients.

Smart hydrogel with color responsiveness is envisioned as one of the most promising materials for advanced information encryption and decryption platform, but the illumination-dependent way of decrypting and reading information leads to the worrying of concealment in some particular scenarios. Herein, we proposed a smart hydrogel information platform with dual imaging modes by utilizing the accompanying behaviors in transparency change and heat releasing after crystallization of supercooled solution. For this smart hydrogel information platform, the...

Smart hydrogel with color responsiveness is envisioned as one of the most promising materials for advanced information encryption and decryption platform, but the illumination-dependent way of decrypting and reading information leads to the worrying of concealment in some particular scenarios. Herein, we proposed a smart hydrogel information platform with dual imaging modes by utilizing the accompanying behaviors in transparency change and heat releasing after crystallization of supercooled solution. For this smart hydrogel information platform, the...

A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...