4 Works

Data from: Nonsense-mediated decay enables intron gain in Drosophila

Ashley Farlow, Eshwar Meduri, Marlies Dolezal, Liushuai Hua & Christian Schlötterer
Intron number varies considerably among genomes, but despite their fundamental importance, the mutational mechanisms and evolutionary processes underlying the expansion of intron number remain unknown. Here we show that Drosophila, in contrast to most eukaryotic lineages, is still undergoing a dramatic rate of intron gain. These novel introns carry significantly weaker splice sites that may impede their identification by the spliceosome. Novel introns are more likely to encode a premature termination codon (PTC), indicating that...

Data from: Contrasting pattern of natural variation in global Drosophila melanogaster populations

Maria Nunes, Hannah Neumeier & Christian Schlötterer
Despite the popularity of Drosophila melanogaster in functional and evolutionary genetics, the global pattern of natural variation has not yet been comprehensively described in this species. For the first time, we report a combined survey using neutral microsatellites and mitochondrial sequence variation jointly. Thirty-five populations originating from five continents were compared. In agreement with previous microsatellite studies, sub-Saharan African populations were the most variable ones. Consistent with previous reports of a single 'out of Africa'...

Data from: Multiple hybridization events between Drosophila simulans and Drosophila mauritiana are supported by mtDNA introgression

Maria Nunes, Pablo Orozco-Ter Wengel, Michaela Kreissl, Christian Schlötterer, Maria Nunes, Pablo Orozco-Ter Wengel, Michaela Kreissl & Christian Schlötterer
The study of speciation has advanced considerably in the last decades due to the increased application of molecular tools. In particular the quantification of gene flow between recently diverged species could be addressed. D. simulans and D. mauritiana diverged, probably allopatrically, from a common ancestor approximately 250,000 years ago. However, these species share one mitochondrial DNA (mtDNA) haplotype indicative of a recent episode of introgression. To study the extent of gene flow between these species,...

Data from: Genealogical lineage sorting leads to significant, but incorrect Bayesian multilocus inference of population structure

Pablo Orozco-TerWengel, Jukka Corander & Christian Schlötterer
Over the past decades the use of molecular markers has revolutionized biology and led to the foundation of a new research discipline -- phylogeography. Of particular interest has been the inference of population structure and biogeography. While initial studies focused on mtDNA as a molecular marker, it has become apparent that selection and genealogical lineage sorting could lead to erroneous inferences. As it is not clear to what extent these forces affect a given marker,...

Registration Year

  • 2010
    4

Resource Types

  • Dataset
    4

Affiliations

  • University of Veterinary Medicine Vienna
    4
  • University of Helsinki
    1