6 Works

Data from: Pathologic evaluation of type 2 porcine reproductive and respiratory syndrome virus infection at the maternal-fetal interface of late gestation pregnant gilts

Predrag Novakovic, John C.S. Harding, Ahmad N. Al-Dissi, Andrea Ladinig, Susan E. Detmer & John C. S. Harding
The pathogenesis of fetal death caused by reproductive porcine reproductive and respiratory syndrome virus (PRRSV) remains unclear. The objective of this study was to improve our understanding of the pathogenesis by assessing potential relationships between specific histopathological lesions and PRRSV RNA concentration in the fetuses and the maternal-fetal interface. Pregnant gilts were inoculated with PRRSV (n=114) or sham inoculated (n=19) at 85±1 days of gestation. Dams and their litters were humanely euthanized and necropsied 21...

Data from: Ancestral population reconstitution from isofemale lines as a tool for experimental evolution

Pierre Nouhaud, Ray Tobler, Viola Nolte & Christian Schlötterer
Experimental evolution is a powerful tool to study adaptation under controlled conditions. Laboratory natural selection experiments mimic adaptation in the wild with better-adapted genotypes having more offspring. Because the selected traits are frequently not known, adaptation is typically measured as fitness increase by comparing evolved populations against an unselected reference population maintained in a laboratory environment. With adaptation to the laboratory conditions and genetic drift, however, it is not clear to what extent such comparisons...

Data from: Uncovering the genetic signature of quantitative trait evolution with replicated time series data

Susanne U. Franssen, Robert Kofler & Christian Schloetterer
The genetic architecture of adaptation in natural populations has not yet been resolved: it is not clear to what extent the spread of beneficial mutations (selective sweeps) or the response of many quantitative trait loci drive adaptation to environmental changes. Although much attention has been given to the genomic footprint of selective sweeps, the importance of selection on quantitative traits is still not well studied, as the associated genomic signature is extremely difficult to detect....

Data from: Selection for brain size impairs innate, but not adaptive immune responses

Alexander Kotrschal, Niclas Kolm & Dustin J. Penn
The brain and the immune system are both energetically demanding organs, and when natural selection favors increased investment into one, then the size or performance of the other should be reduced. While comparative analyses have attempted to test this potential evolutionary trade-off, the results remain inconclusive. To test this hypothesis, we compared the tissue graft rejection (an assay for measuring innate and acquired immune responses) in guppies (Poecilia reticulata) artificially selected for large and small...

Data from: Suitability of different mapping algorithms for genome-wide polymorphism scans with Pool-Seq data.

Robert Kofler, Anna Maria Langmüller, Pierre Nouhaud, Kathrin Anna Otte & Christian Schlötterer
The cost-effectiveness of sequencing pools of individuals (Pool-Seq) provides the basis for the popularity and wide-spread use of this method for many research questions, ranging from unravelling the genetic basis of complex traits to the clonal evolution of cancer cells. Because the accuracy of Pool-Seq could be affected by many potential sources of error, several studies determined, for example, the influence of the sequencing technology, the library preparation protocol, and mapping parameters. Nevertheless, the impact...

Data from: Hybrid dysgenesis in Drosophila simulans associated with a rapid invasion of the P-element

Tom Hill, Christian Schlötterer & Andrea J. Betancourt
In a classic example of the invasion of a species by a selfish genetic element, the P-element was horizontally transferred from a distantly related species into Drosophila melanogaster. Despite causing ‘hybrid dysgenesis’, a syndrome of abnormal phenotypes that include sterility, the P-element spread globally in the course of a few decades in D. melanogaster. Until recently, its sister species, including D. simulans, remained P-element free. Here, we find a hybrid dysgenesis-like phenotype in the offspring...

Registration Year

  • 2016

Resource Types

  • Dataset


  • University of Veterinary Medicine Vienna
  • University of Saskatchewan
  • University of Veterinary Medicine
  • Stockholm University